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UniProtKB - F6ULY3 (TOPZ1_MACMU)

Entry version 40 (02 Dec 2020)
Sequence version 1 (27 Jul 2011)
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Protein

Protein TOPAZ1

Gene

TOPAZ1

Organism
Macaca mulatta (Rhesus macaque)
Status
Reviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Important for normal spermatogenesis and male fertility. Specifically required for progression to the post-meiotic stages of spermatocyte development. Seems to be necessary for normal expression levels of a number of testis-expressed gene transcripts, although its role in this process is unclear.By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processDifferentiation, Spermatogenesis

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Protein TOPAZ1By similarity
Alternative name(s):
Testis- and ovary-specific PAZ domain-containing protein 1By similarity
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:TOPAZ1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMacaca mulatta (Rhesus macaque)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9544 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Cercopithecidae › Cercopithecinae › Macaca
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000006718 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unplaced

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cytoplasm

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00004160601 – 1687Protein TOPAZ1Add BLAST1687

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSMMUG00000015127, Expressed in spermatocyte and 3 other tissues

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...STRINGi		9544.ENSMMUP00000019824

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		ENOG502QPIV, Eukaryota

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_003190_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		F6ULY3

Identification of Orthologs from Complete Genome Data

More...OMAi		NIFMEYY

TreeFam database of animal gene trees

More...TreeFami		TF338635

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR038952, TOPAZ1
IPR029435, TOPAZ1_dom

The PANTHER Classification System

More...PANTHERi		PTHR35671, PTHR35671, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF14669, Asp_Glu_race_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

F6ULY3-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MRRPPPLGPT TASGPEGNVR NLRKRQAPGP GAAGGCGPEA GGRGENRQKR 
        60         70         80         90        100
RMVARATPGR GEVKSDKSVA ASGAGKAARR RVEGRRGQVS PSDRRGLEAA 
       110        120        130        140        150
KEAEFPLQTE RHTKEKRKVT EASTDDPQPG FDLVRKESLT SSESFQTVEC 
       160        170        180        190        200
LRSLGKEGIV EGIKRRIRNK KLKSLENPPL KITENEATQN IKVEFQDELY 
       210        220        230        240        250
KNTLKYSCNI LSPEVENNFV FKLRDCNCFP HSKDCNDENN LPYEPDGGCM 
       260        270        280        290        300
HVAENFSKKE NFRSLAEKSD TNNIPQLLQT EENVMGVNKL LPEESDLYQS 
       310        320        330        340        350
KINGLLPCLQ REKNKYSIEE SSVGRKPRKR MKLSEKADET VTQMNFSNEY 
       360        370        380        390        400
NKSELMLQEN QMIADGKEAE AKSPLNVLRK VSHNTVSLMD HLLSVPEMVE 
       410        420        430        440        450
KETSSEHHVN AVFQKTIEPL LKEETENASE PLGYENMALK EDFKSKSCIG 
       460        470        480        490        500
KSPEYHIERR SSREDLRSDS EELKLSCQRT IPMTGKRTWP YYSCARISAW 
       510        520        530        540        550
CWKKASLPES SYFLPGSQKS CKKVDVPKHQ TNKTHLTDSK LLLQSSLTET 
       560        570        580        590        600
NTESSSKEKL DSNLNCLFSV SAVEHTLMVI KEPIIKDDKK IKSEELSRSG 
       610        620        630        640        650
SEVISNTTED TQLTSDTQSL TGNKKRDRGN LTKLNLTAAS KDGQEANNST 
       660        670        680        690        700
GKTIHRKACV AKQTFVVPDL VKILNTGRLT NFKIPLLKNK TKKRKEVNAK 
       710        720        730        740        750
SSEREAYSPL ELLDNLSGAD TRQNRSKENV SMTMLGPQTL SIQNSVTPVQ 
       760        770        780        790        800
ASSDSFYNKN SCSISPSFTK HGNSSKPSNH FSEPGNIVSN KEVASLTVEN 
       810        820        830        840        850
NAFSSDPGYV EKSPSFCCNK QETFRPVSSE VRGRKITKNF SEVGFPDILK 
       860        870        880        890        900
AYEDDVLLID VIQDDPDLFG VSNEGELSFT SEVPRISQEP NVPGEHQLTD 
       910        920        930        940        950
SKYVETPVKK EPSDDLRELP VLDCGPIKPD ICASNSAASE IRHDPKDANT 
       960        970        980        990       1000
SLGEVANETS ENETLGDFSE QIKGSDLDEK HRFTDKVITK EEKENIYEVR 
      1010       1020       1030       1040       1050
KSKDSRNADI MVGECQFAAP VPKPLCLLVP PLNLSGHQED TILNTWMNDF 
      1060       1070       1080       1090       1100
RFLGKHSVLK LQNPETCEIF KREKNVGVFQ KSLGLMIPYK YCKFHFNTLR 
      1110       1120       1130       1140       1150
GCERPLCKFA HVPEQGDEKV CMDVFKKYIN INELCLLQRA VNVFMEYYRK 
      1160       1170       1180       1190       1200
FPPGIYFDLQ VLNDLLNSLL KHCLLKEVFQ IVNLSIMVKM LPSLKILLNI 
      1210       1220       1230       1240       1250
FEHVATMKLR NAVPALIDIF CKLVEAGMVL DPEHFNYIVK LLYQVQASKQ 
      1260       1270       1280       1290       1300
EITAVLEMKS RLQMRQFKKN WKCDLDSALN KLEHCKEKGD WTKLGKLYIN 
      1310       1320       1330       1340       1350
VKMGCEKFAD FQTFCACIAE TLTKNCEDER PDTPFCEFAE TVSKDPQNSK 
      1360       1370       1380       1390       1400
VDKGVLGRIG ISAMYFYHKL LQWSKGRKVL DKLYELKIHF ASLKGLIGPE 
      1410       1420       1430       1440       1450
KLASRCQIVN VAAEIFLKSG SLDGALWVMR ESEWIIDTPL WPCDRLDVLN 
      1460       1470       1480       1490       1500
RHNLLCTIAH ETLAKSLYRQ TFEVLQNLPG FQNSQETVEV SQYSLLFNKL 
      1510       1520       1530       1540       1550
LGSCIESNSL GMSSSVAEFM ISKSIPIDFS FLRRLITSLG RSRLWLKARA 
      1560       1570       1580       1590       1600
HYKSALSLGC YPPLEGNLYR KLLLIPSYLS EIEMLLAIEI FMVSNASSIQ 
      1610       1620       1630       1640       1650
SPGTSTQILQ IVLKRCEDNQ SRSNDDYQAA VERLIMAARI SDPKLFVKHM 
      1660       1670       1680 
TVNVNKEQVY SLEHCSALKW LKENMKWAGK VWLFSNH
Length:1,687
Mass (Da):190,504
Last modified:July 27, 2011 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iA8FD5DBB8DFE7044
GO

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

3D structure databases

Database of comparative protein structure models

More...ModBasei		Search...

SWISS-MODEL Interactive Workspace

More...SWISS-MODEL-Workspacei		Submit a new modelling project...

Protein-protein interaction databases

STRINGi9544.ENSMMUP00000019824

Phylogenomic databases

eggNOGiENOG502QPIV, Eukaryota
HOGENOMiCLU_003190_0_0_1
InParanoidiF6ULY3
OMAiNIFMEYY
TreeFamiTF338635

Gene expression databases

BgeeiENSMMUG00000015127, Expressed in spermatocyte and 3 other tissues

Family and domain databases

InterProiView protein in InterPro
IPR038952, TOPAZ1
IPR029435, TOPAZ1_dom
PANTHERiPTHR35671, PTHR35671, 1 hit
PfamiView protein in Pfam
PF14669, Asp_Glu_race_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTOPZ1_MACMU
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: F6ULY3
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 21, 2012
Last sequence update: July 27, 2011
Last modified: December 2, 2020
This is version 40 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome
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