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Protein

Receptor protein-tyrosine kinase

Gene

egfr

Organism
Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.SAAS annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei748ATPUniRule annotation1
Active sitei840Proton acceptorUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi721 – 729ATPUniRule annotation9

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinase, Transferase, Tyrosine-protein kinaseSAAS annotation
LigandATP-bindingUniRule annotationSAAS annotation, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-XTR-1227986 Signaling by ERBB2
R-XTR-1236394 Signaling by ERBB4
R-XTR-1250196 SHC1 events in ERBB2 signaling
R-XTR-1257604 PIP3 activates AKT signaling
R-XTR-177929 Signaling by EGFR
R-XTR-179812 GRB2 events in EGFR signaling
R-XTR-180292 GAB1 signalosome
R-XTR-180336 SHC1 events in EGFR signaling
R-XTR-182971 EGFR downregulation
R-XTR-1963642 PI3K events in ERBB2 signaling
R-XTR-212718 EGFR interacts with phospholipase C-gamma
R-XTR-2179392 EGFR Transactivation by Gastrin
R-XTR-445144 Signal transduction by L1
R-XTR-5673001 RAF/MAP kinase cascade
R-XTR-6785631 ERBB2 Regulates Cell Motility
R-XTR-6811558 PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
R-XTR-8847993 ERBB2 Activates PTK6 Signaling
R-XTR-8856825 Cargo recognition for clathrin-mediated endocytosis
R-XTR-8856828 Clathrin-mediated endocytosis
R-XTR-8857538 PTK6 promotes HIF1A stabilization
R-XTR-8863795 Downregulation of ERBB2 signaling
R-XTR-9013507 NOTCH3 Activation and Transmission of Signal to the Nucleus

Names & Taxonomyi

Protein namesi
Recommended name:
Receptor protein-tyrosine kinaseSAAS annotation (EC:2.7.10.1SAAS annotation)
Gene namesi
Name:egfrImported
OrganismiXenopus tropicalis (Western clawed frog) (Silurana tropicalis)Imported
Taxonomic identifieri8364 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusSilurana
Proteomesi
  • UP000008143 Componenti: Unassembled WGS sequence

Organism-specific databases

XenbaseiXB-GENE-6067152 egfr

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei649 – 671HelicalSequence analysisAdd BLAST23

Keywords - Cellular componenti

Membrane

PTM / Processingi

Proteomic databases

PaxDbiF6UFM4

Expressioni

Gene expression databases

BgeeiENSXETG00000015826 Expressed in 12 organ(s), highest expression level in embryo

Interactioni

Protein-protein interaction databases

STRINGi8364.ENSXETP00000034519

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini715 – 972Protein kinaseInterPro annotationAdd BLAST258

Sequence similaritiesi

Belongs to the protein kinase superfamily. Tyr protein kinase family.SAAS annotation

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

eggNOGiKOG1025 Eukaryota
ENOG410XNSR LUCA
GeneTreeiENSGT00760000118799
InParanoidiF6UFM4
OMAiMRRRHIV
OrthoDBiEOG091G00NO
TreeFamiTF106002

Family and domain databases

CDDicd00064 FU, 3 hits
Gene3Di3.80.20.20, 2 hits
InterProiView protein in InterPro
IPR006211 Furin-like_Cys-rich_dom
IPR006212 Furin_repeat
IPR032778 GF_recep_IV
IPR009030 Growth_fac_rcpt_cys_sf
IPR011009 Kinase-like_dom_sf
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR000494 Rcpt_L-dom
IPR036941 Rcpt_L-dom_sf
IPR001245 Ser-Thr/Tyr_kinase_cat_dom
IPR008266 Tyr_kinase_AS
IPR020635 Tyr_kinase_cat_dom
IPR016245 Tyr_kinase_EGF/ERB/XmrK_rcpt
PfamiView protein in Pfam
PF00757 Furin-like, 1 hit
PF14843 GF_recep_IV, 1 hit
PF07714 Pkinase_Tyr, 1 hit
PF01030 Recep_L_domain, 2 hits
PIRSFiPIRSF000619 TyrPK_EGF-R, 2 hits
PRINTSiPR00109 TYRKINASE
SMARTiView protein in SMART
SM00261 FU, 5 hits
SM00219 TyrKc, 1 hit
SUPFAMiSSF56112 SSF56112, 1 hit
SSF57184 SSF57184, 2 hits
PROSITEiView protein in PROSITE
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00109 PROTEIN_KINASE_TYR, 1 hit

Sequencei

Sequence statusi: Complete.

F6UFM4-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKTSILNQTA SLISILSLKY QPSYCFSFFL VCLGNNNRLN QLGNTDEHYA
60 70 80 90 100
SLKRMYDGCE IVLGNLEITY LDRLNDTSFL RNIQEVGGYV LIAINSVRSI
110 120 130 140 150
HLENLQIVRG NMLYKSTYAL AIVSNESLNT TNALEELHMG RLTEILNGGV
160 170 180 190 200
LISKNRKLCY LNTIQWNDIV HTDNPINKIS VDKSFSPQCP KCDAESCNGS
210 220 230 240 250
CWGPGQGNCQ KLTKLTCAQQ CSGRCRGPLP SDCCHSQCAS GCTGPRENNC
260 270 280 290 300
LACRKFRDGE TCKEGCPQLQ IYNPATYQMD LNPDGKYSFG ASCVKKCPHN
310 320 330 340 350
YVVTDHGSCV RTCNSDSQEV EENGIRICKK CDGSCNKDKV CDGINMGKLK
360 370 380 390 400
SVLSVNASNI DLFQNCTKVN GDVAILHVAG YGDPFTNTSK LDPAKLSVFK
410 420 430 440 450
SVREITGSLL IQWWPDNYTD LSVFENLETI RGRTKQHGIY SLAIVKRSIT
460 470 480 490 500
SLGLRSLKEV SDGDVIIKTN KNLCFVNTIN FTNIFRIPKQ ARIIEDNKSP
510 520 530 540 550
EQCESEGNVC DPLCSEEGCW GPGPFQCVSC RKYMRGRECV ENCNFLSGEP
560 570 580 590 600
REYTEDGKCF ACNAECLQLN ETQTCSGPGA DECFKCGHNS DGPFCVKTCP
610 620 630 640 650
AGIQGENSTL IWKYPDETGA CQLCHPECKL GCVGHGLDGC PLPWSSHSVA
660 670 680 690 700
AGVVGGILGA VVIGLVAFFF IRRSRINRKR TLRRILQERE LVEPVTPSGE
710 720 730 740 750
APNQALLRIL KETEFKKIKV LGSGAFGTVY QGLWIPEGEG IKIPVAIKEL
760 770 780 790 800
REATSPKANK EILDEAYVMA SVENPYVCRL LGICLTSTVQ LITQLMPFGC
810 820 830 840 850
LLDYVRDNKD NIGSQHLLNW CVQIAKGMNY LEERRLVHRD LAARNVLVKG
860 870 880 890 900
PQHVKITDFG LAKLLGADEK AYHAEGGKVP IKWMALESIL HRTYTHQSDV
910 920 930 940 950
WSYGVTVWEL MTFGLKPYDG IPASEISNIL EKGERLPQPP ICTIDVYMIM
960 970 980 990 1000
VKCWMIDAES RPKFRELSAE FTKMARDPTR YLVIQGDDRM HLPSPVESKI
1010 1020 1030 1040 1050
HPALVQEGLG DIVDAEEYLL PHQGFFTSPS NSRTPLLSTM SSTSNNSPVI
1060 1070 1080 1090 1100
CTMRNGGPPV REDSFVQRYS TDPTVILEDS IDDEFLPVPE YVNQMVPKPI
1110 1120 1130 1140 1150
VETQTNAVYQ NLVPLGNTVS PKETLYQNSH SNGLNNPEYL NTGHTLVPKT
1160 1170 1180 1190 1200
DFDYSSIWDQ KANLQINLDN PDYQQDFFPK EPKTNGHFKI PAAQNPEYLG
1210
LAPVSDYIEA S
Length:1,211
Mass (Da):134,610
Last modified:July 27, 2011 - v1
Checksum:i5823E9458CD9167C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAMC01097495 Genomic DNA No translation available.
AAMC01097496 Genomic DNA No translation available.
AAMC01097497 Genomic DNA No translation available.

Genome annotation databases

EnsembliENSXETT00000034519; ENSXETP00000034519; ENSXETG00000015826

Similar proteinsi

Entry informationi

Entry nameiF6UFM4_XENTR
AccessioniPrimary (citable) accession number: F6UFM4
Entry historyiIntegrated into UniProtKB/TrEMBL: July 27, 2011
Last sequence update: July 27, 2011
Last modified: September 12, 2018
This is version 52 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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