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Entry version 59 (02 Dec 2020)
Sequence version 2 (10 Apr 2019)
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Protein

Carboxypeptidase D

Gene

CPD

Organism
Equus caballus (Horse)
Status
Unreviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

  • Releases C-terminal Arg and Lys from polypeptides.ARBA annotation EC:3.4.17.22

<p>This subsection of the 'Function' section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

Zn2+ARBA annotation

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHydrolase, MetalloproteaseARBA annotation, Protease

Protein family/group databases

MEROPS protease database

More...
MEROPSi
M14.950

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Carboxypeptidase DARBA annotation (EC:3.4.17.22ARBA annotation)
Alternative name(s):
Metallocarboxypeptidase DARBA annotation
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:CPDImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiEquus caballus (Horse)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9796 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaPerissodactylaEquidaeEquus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002281 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 11

Organism-specific databases

Vertebrate Gene Nomenclature Database

More...
VGNCi
VGNC:16814, CPD

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei1305 – 1328HelicalSequence analysisAdd BLAST24

Keywords - Cellular componenti

Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 34Sequence analysisAdd BLAST34
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_501859365435 – 1385Carboxypeptidase DSequence analysisAdd BLAST1351

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
F6UFH2

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSECAG00000020432, Expressed in oviduct epithelium and 22 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
F6UFH2, baseline

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini128 – 150Peptidase_M14InterPro annotationAdd BLAST23
Domaini255 – 265Peptidase_M14InterPro annotationAdd BLAST11
Domaini552 – 574Peptidase_M14InterPro annotationAdd BLAST23
Domaini668 – 678Peptidase_M14InterPro annotationAdd BLAST11

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni187 – 230DisorderedSequence analysisAdd BLAST44
Regioni872 – 893DisorderedSequence analysisAdd BLAST22
Regioni1365 – 1385DisorderedSequence analysisAdd BLAST21

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the peptidase M14 family.ARBA annotation

Keywords - Domaini

SignalSequence analysis, Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000156919

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_002495_1_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
F6UFH2

TreeFam database of animal gene trees

More...
TreeFami
TF315592

Family and domain databases

Conserved Domains Database

More...
CDDi
cd03863, M14_CPD_II, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR008969, CarboxyPept-like_regulatory
IPR034224, M14_CPD_II
IPR015567, Pept_M14B_carboxypept_D2
IPR000834, Peptidase_M14

The PANTHER Classification System

More...
PANTHERi
PTHR11532:SF73, PTHR11532:SF73, 3 hits

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00246, Peptidase_M14, 3 hits

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00765, CRBOXYPTASEA

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00631, Zn_pept, 3 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF49464, SSF49464, 3 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00132, CARBOXYPEPT_ZN_1, 2 hits
PS00133, CARBOXYPEPT_ZN_2, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

F6UFH2-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MASGWDARPP WRPGRLPLLL CMLLLLRLRS PARAAHIKKA EATTTTTSSG
60 70 80 90 100
AEADEGRFDR YYHEEELGSA LREAAAAGPP GLARLFSIGR SVEGRPLWVL
110 120 130 140 150
RLTAGLGPPP PDGDEGPDAA GPLLPGRPQV KLVGNMHGDE TVSRQVLVYL
160 170 180 190 200
ARELAAGYRR GDPRLVRLLN TTDVYVLPSL NPDGFERARE GDCGLGDGGP
210 220 230 240 250
PGASGRDNSR GRDLNRSFPD QFSTGEPPAL DDVPEVRALI DWIRRNKFVL
260 270 280 290 300
SGNLHGGSVV ASYPFDDSPE HEATGVYSKT SDDEVFKYLA KAYASNHPIM
310 320 330 340 350
KTGTPHCPGD EDETFKDGIT NGAHWYDVEG GMQDYNYVWA NCFEITLELS
360 370 380 390 400
CCKYPPASQL RQEWENNRES LITLIEKVHI GVKGFVKDLV TGSGLENATI
410 420 430 440 450
SVAGINHNIT TGRFGDFHRL LLPGTYNITA ALTGYMPLTV NNIIVKEGPA
460 470 480 490 500
AKVNFSLRPT VTSVISDTTD VVTASTVAIL NIPPGTQSSH QPIQPKDFHH
510 520 530 540 550
HHFPDMEIFL RRFANEYPNI TRLYSLGKSV ESRELYVMEI SDNPGVHEPG
560 570 580 590 600
EPEFKYIGNM HGNEVVGREL LLNLIEYLCK NFGTDPEVTD LVQSTRIHLM
610 620 630 640 650
PSMNPDGYEK AQEGDSVSVI GRNNSNNFDL NRNFPDQFVQ ITDPTQPETI
660 670 680 690 700
AVMSWMKAYP FVLSANLHGG SLVVNYPFDD DEQGVATYSK SPDDAVFQQI
710 720 730 740 750
ALSYSKENSQ MFQGRPCKNM YPNEYFPHGI TNGASWYNVP GGMQDWNYLQ
760 770 780 790 800
TNCFEVTIEL GCVKYPFEKD LPKFWEQNRR SLIQFMKQVH QGVKGFVLDA
810 820 830 840 850
TDGRGILNAT ISVAEINHPV TTYKTGDYWR LLVPGTYKIT ASARGYNPVT
860 870 880 890 900
KNVTVKGEGA IQVNFTLVRS SADSNNESKK GKGDSTNTED ASDPTTKVFE
910 920 930 940 950
TLIKDLSAEN GLEALILRSS SNLALYRYHS YKDLSEFLRG LVMNYPHITN
960 970 980 990 1000
LTNLGQSAEY RHIWSLEISN KPNVSEPEEP KIRFVAGIHG NAPVGTELLL
1010 1020 1030 1040 1050
ALAEFLCLNY KRNPALTQLV DRTRIVIVPS LNPDGRERAQ EKDCTSKIGR
1060 1070 1080 1090 1100
TNARGKDLDT DFTSYGYKVQ MNTDNASQPE TKAIIENLIQ RQDFSLSVAL
1110 1120 1130 1140 1150
DGGSVLVTYP YDKPVQTVEN KETLKHLASL YASNHPSMHL GQPGCPNKSD
1160 1170 1180 1190 1200
ENIPGGVMRG AEWHSHLGSM KDYSVTYGHC PEITVYTSCC YFPSATQLPS
1210 1220 1230 1240 1250
LWAENRKSLL SMLVEVHKGV HGFVKDKTGK PISKAVIVLN EGIKVHTKEG
1260 1270 1280 1290 1300
GYFHVLLAPG VHNINAIADG YQQQHSQVFV HHDAASSVVI VFDTDNRIFG
1310 1320 1330 1340 1350
LPRELVVTVS GATMSALILT AGIIWCICSI KSNRHKDGFH RLRQHHDEYE
1360 1370 1380
DEIRMMSTGS KKSLLSHEFQ DETDTEEETL YSSKH
Length:1,385
Mass (Da):153,563
Last modified:April 10, 2019 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iEE3C3F8B18978648
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A3Q2GVB6A0A3Q2GVB6_HORSE
Carboxypeptidase D
CPD
1,375Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A3Q2GXR4A0A3Q2GXR4_HORSE
Carboxypeptidase D
CPD
1,130Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSECAT00000022002; ENSECAP00000018163; ENSECAG00000020432

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein family/group databases

MEROPSiM14.950

Proteomic databases

PaxDbiF6UFH2

Genome annotation databases

EnsembliENSECAT00000022002; ENSECAP00000018163; ENSECAG00000020432

Organism-specific databases

VGNCiVGNC:16814, CPD

Phylogenomic databases

GeneTreeiENSGT00940000156919
HOGENOMiCLU_002495_1_0_1
InParanoidiF6UFH2
TreeFamiTF315592

Gene expression databases

BgeeiENSECAG00000020432, Expressed in oviduct epithelium and 22 other tissues
ExpressionAtlasiF6UFH2, baseline

Family and domain databases

CDDicd03863, M14_CPD_II, 1 hit
InterProiView protein in InterPro
IPR008969, CarboxyPept-like_regulatory
IPR034224, M14_CPD_II
IPR015567, Pept_M14B_carboxypept_D2
IPR000834, Peptidase_M14
PANTHERiPTHR11532:SF73, PTHR11532:SF73, 3 hits
PfamiView protein in Pfam
PF00246, Peptidase_M14, 3 hits
PRINTSiPR00765, CRBOXYPTASEA
SMARTiView protein in SMART
SM00631, Zn_pept, 3 hits
SUPFAMiSSF49464, SSF49464, 3 hits
PROSITEiView protein in PROSITE
PS00132, CARBOXYPEPT_ZN_1, 2 hits
PS00133, CARBOXYPEPT_ZN_2, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiF6UFH2_HORSE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: F6UFH2
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: July 27, 2011
Last sequence update: April 10, 2019
Last modified: December 2, 2020
This is version 59 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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