UniProtKB - F6UFH2 (F6UFH2_HORSE)
Protein
Carboxypeptidase D
Gene
CPD
Organism
Equus caballus (Horse)
Status
Functioni
Catalytic activityi
- Releases C-terminal Arg and Lys from polypeptides.ARBA annotation EC:3.4.17.22
Cofactori
Zn2+ARBA annotation
GO - Molecular functioni
- metallocarboxypeptidase activity Source: GO_Central
- zinc ion binding Source: InterPro
GO - Biological processi
- peptide metabolic process Source: GO_Central
- protein processing Source: GO_Central
Keywordsi
Molecular function | Hydrolase, MetalloproteaseARBA annotation, Protease |
Protein family/group databases
MEROPSi | M14.950 |
Names & Taxonomyi
Protein namesi | Recommended name: Carboxypeptidase DARBA annotation (EC:3.4.17.22ARBA annotation)Alternative name(s): Metallocarboxypeptidase DARBA annotation |
Gene namesi | Name:CPDImported |
Organismi | Equus caballus (Horse)Imported |
Taxonomic identifieri | 9796 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Perissodactyla › Equidae › Equus › |
Proteomesi |
|
Organism-specific databases
VGNCi | VGNC:16814, CPD |
Subcellular locationi
Extracellular region or secreted
- extracellular space Source: GO_Central
Other locations
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 1305 – 1328 | HelicalSequence analysisAdd BLAST | 24 |
Keywords - Cellular componenti
MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 34 | Sequence analysisAdd BLAST | 34 | |
ChainiPRO_5018593654 | 35 – 1385 | Carboxypeptidase DSequence analysisAdd BLAST | 1351 |
Proteomic databases
PaxDbi | F6UFH2 |
Expressioni
Gene expression databases
Bgeei | ENSECAG00000020432, Expressed in oviduct epithelium and 22 other tissues |
ExpressionAtlasi | F6UFH2, baseline |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 128 – 150 | Peptidase_M14InterPro annotationAdd BLAST | 23 | |
Domaini | 255 – 265 | Peptidase_M14InterPro annotationAdd BLAST | 11 | |
Domaini | 552 – 574 | Peptidase_M14InterPro annotationAdd BLAST | 23 | |
Domaini | 668 – 678 | Peptidase_M14InterPro annotationAdd BLAST | 11 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 187 – 230 | DisorderedSequence analysisAdd BLAST | 44 | |
Regioni | 872 – 893 | DisorderedSequence analysisAdd BLAST | 22 | |
Regioni | 1365 – 1385 | DisorderedSequence analysisAdd BLAST | 21 |
Sequence similaritiesi
Belongs to the peptidase M14 family.ARBA annotation
Keywords - Domaini
SignalSequence analysis, Transmembrane, Transmembrane helixSequence analysisPhylogenomic databases
GeneTreei | ENSGT00940000156919 |
HOGENOMi | CLU_002495_1_0_1 |
InParanoidi | F6UFH2 |
TreeFami | TF315592 |
Family and domain databases
CDDi | cd03863, M14_CPD_II, 1 hit |
InterProi | View protein in InterPro IPR008969, CarboxyPept-like_regulatory IPR034224, M14_CPD_II IPR015567, Pept_M14B_carboxypept_D2 IPR000834, Peptidase_M14 |
PANTHERi | PTHR11532:SF73, PTHR11532:SF73, 3 hits |
Pfami | View protein in Pfam PF00246, Peptidase_M14, 3 hits |
PRINTSi | PR00765, CRBOXYPTASEA |
SMARTi | View protein in SMART SM00631, Zn_pept, 3 hits |
SUPFAMi | SSF49464, SSF49464, 3 hits |
PROSITEi | View protein in PROSITE PS00132, CARBOXYPEPT_ZN_1, 2 hits PS00133, CARBOXYPEPT_ZN_2, 2 hits |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All
F6UFH2-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MASGWDARPP WRPGRLPLLL CMLLLLRLRS PARAAHIKKA EATTTTTSSG
60 70 80 90 100
AEADEGRFDR YYHEEELGSA LREAAAAGPP GLARLFSIGR SVEGRPLWVL
110 120 130 140 150
RLTAGLGPPP PDGDEGPDAA GPLLPGRPQV KLVGNMHGDE TVSRQVLVYL
160 170 180 190 200
ARELAAGYRR GDPRLVRLLN TTDVYVLPSL NPDGFERARE GDCGLGDGGP
210 220 230 240 250
PGASGRDNSR GRDLNRSFPD QFSTGEPPAL DDVPEVRALI DWIRRNKFVL
260 270 280 290 300
SGNLHGGSVV ASYPFDDSPE HEATGVYSKT SDDEVFKYLA KAYASNHPIM
310 320 330 340 350
KTGTPHCPGD EDETFKDGIT NGAHWYDVEG GMQDYNYVWA NCFEITLELS
360 370 380 390 400
CCKYPPASQL RQEWENNRES LITLIEKVHI GVKGFVKDLV TGSGLENATI
410 420 430 440 450
SVAGINHNIT TGRFGDFHRL LLPGTYNITA ALTGYMPLTV NNIIVKEGPA
460 470 480 490 500
AKVNFSLRPT VTSVISDTTD VVTASTVAIL NIPPGTQSSH QPIQPKDFHH
510 520 530 540 550
HHFPDMEIFL RRFANEYPNI TRLYSLGKSV ESRELYVMEI SDNPGVHEPG
560 570 580 590 600
EPEFKYIGNM HGNEVVGREL LLNLIEYLCK NFGTDPEVTD LVQSTRIHLM
610 620 630 640 650
PSMNPDGYEK AQEGDSVSVI GRNNSNNFDL NRNFPDQFVQ ITDPTQPETI
660 670 680 690 700
AVMSWMKAYP FVLSANLHGG SLVVNYPFDD DEQGVATYSK SPDDAVFQQI
710 720 730 740 750
ALSYSKENSQ MFQGRPCKNM YPNEYFPHGI TNGASWYNVP GGMQDWNYLQ
760 770 780 790 800
TNCFEVTIEL GCVKYPFEKD LPKFWEQNRR SLIQFMKQVH QGVKGFVLDA
810 820 830 840 850
TDGRGILNAT ISVAEINHPV TTYKTGDYWR LLVPGTYKIT ASARGYNPVT
860 870 880 890 900
KNVTVKGEGA IQVNFTLVRS SADSNNESKK GKGDSTNTED ASDPTTKVFE
910 920 930 940 950
TLIKDLSAEN GLEALILRSS SNLALYRYHS YKDLSEFLRG LVMNYPHITN
960 970 980 990 1000
LTNLGQSAEY RHIWSLEISN KPNVSEPEEP KIRFVAGIHG NAPVGTELLL
1010 1020 1030 1040 1050
ALAEFLCLNY KRNPALTQLV DRTRIVIVPS LNPDGRERAQ EKDCTSKIGR
1060 1070 1080 1090 1100
TNARGKDLDT DFTSYGYKVQ MNTDNASQPE TKAIIENLIQ RQDFSLSVAL
1110 1120 1130 1140 1150
DGGSVLVTYP YDKPVQTVEN KETLKHLASL YASNHPSMHL GQPGCPNKSD
1160 1170 1180 1190 1200
ENIPGGVMRG AEWHSHLGSM KDYSVTYGHC PEITVYTSCC YFPSATQLPS
1210 1220 1230 1240 1250
LWAENRKSLL SMLVEVHKGV HGFVKDKTGK PISKAVIVLN EGIKVHTKEG
1260 1270 1280 1290 1300
GYFHVLLAPG VHNINAIADG YQQQHSQVFV HHDAASSVVI VFDTDNRIFG
1310 1320 1330 1340 1350
LPRELVVTVS GATMSALILT AGIIWCICSI KSNRHKDGFH RLRQHHDEYE
1360 1370 1380
DEIRMMSTGS KKSLLSHEFQ DETDTEEETL YSSKH
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketA0A3Q2GVB6 | A0A3Q2GVB6_HORSE | Carboxypeptidase D | CPD | 1,375 | Annotation score: | ||
A0A3Q2GXR4 | A0A3Q2GXR4_HORSE | Carboxypeptidase D | CPD | 1,130 | Annotation score: |
Genome annotation databases
Ensembli | ENSECAT00000022002; ENSECAP00000018163; ENSECAG00000020432 |
Similar proteinsi
Cross-referencesi
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein family/group databases
MEROPSi | M14.950 |
Proteomic databases
PaxDbi | F6UFH2 |
Genome annotation databases
Ensembli | ENSECAT00000022002; ENSECAP00000018163; ENSECAG00000020432 |
Organism-specific databases
VGNCi | VGNC:16814, CPD |
Phylogenomic databases
GeneTreei | ENSGT00940000156919 |
HOGENOMi | CLU_002495_1_0_1 |
InParanoidi | F6UFH2 |
TreeFami | TF315592 |
Gene expression databases
Bgeei | ENSECAG00000020432, Expressed in oviduct epithelium and 22 other tissues |
ExpressionAtlasi | F6UFH2, baseline |
Family and domain databases
CDDi | cd03863, M14_CPD_II, 1 hit |
InterProi | View protein in InterPro IPR008969, CarboxyPept-like_regulatory IPR034224, M14_CPD_II IPR015567, Pept_M14B_carboxypept_D2 IPR000834, Peptidase_M14 |
PANTHERi | PTHR11532:SF73, PTHR11532:SF73, 3 hits |
Pfami | View protein in Pfam PF00246, Peptidase_M14, 3 hits |
PRINTSi | PR00765, CRBOXYPTASEA |
SMARTi | View protein in SMART SM00631, Zn_pept, 3 hits |
SUPFAMi | SSF49464, SSF49464, 3 hits |
PROSITEi | View protein in PROSITE PS00132, CARBOXYPEPT_ZN_1, 2 hits PS00133, CARBOXYPEPT_ZN_2, 2 hits |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | F6UFH2_HORSE | |
Accessioni | F6UFH2Primary (citable) accession number: F6UFH2 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | July 27, 2011 |
Last sequence update: | April 10, 2019 | |
Last modified: | December 2, 2020 | |
This is version 59 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |