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Protein

DNA primase large subunit

Gene

PRIM2

Organism
Equus caballus (Horse)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments made during discontinuous DNA replication.UniRule annotation

Cofactori

[4Fe-4S] clusterUniRule annotationNote: Binds 1 [4Fe-4S] cluster.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi287Iron-sulfur (4Fe-4S)UniRule annotation1
Metal bindingi367Iron-sulfur (4Fe-4S)UniRule annotation1
Metal bindingi384Iron-sulfur (4Fe-4S)UniRule annotation1
Metal bindingi424Iron-sulfur (4Fe-4S)UniRule annotation1

GO - Molecular functioni

Keywordsi

Molecular functionDNA-bindingUniRule annotation, NucleotidyltransferaseUniRule annotation, Transferase
Biological processDNA replicationUniRule annotation, Transcription
Ligand4Fe-4SUniRule annotation, Iron, Iron-sulfur, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
DNA primase large subunitUniRule annotation (EC:2.7.7.-UniRule annotation)
Gene namesi
Name:PRIM2Imported
OrganismiEquus caballus (Horse)Imported
Taxonomic identifieri9796 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaPerissodactylaEquidaeEquus
Proteomesi
  • UP000002281 Componenti: Chromosome 20

Organism-specific databases

VGNCiVGNC:50492 PRIM2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

DNA-directed RNA polymeraseUniRule annotation, PrimosomeUniRule annotation

PTM / Processingi

Proteomic databases

PaxDbiF6UDJ9

Expressioni

Gene expression databases

BgeeiENSECAG00000015791

Interactioni

Protein-protein interaction databases

STRINGi9796.ENSECAP00000013575

Family & Domainsi

Sequence similaritiesi

Belongs to the eukaryotic-type primase large subunit family.UniRule annotation

Phylogenomic databases

eggNOGiKOG2267 Eukaryota
COG2219 LUCA
GeneTreeiENSGT00390000009790
InParanoidiF6UDJ9
KOiK02685
OMAiDCHGCPY
OrthoDBiEOG091G08G7
TreeFamiTF105893

Family and domain databases

CDDicd07322 PriL_PriS_Eukaryotic, 1 hit
InterProiView protein in InterPro
IPR016558 DNA_primase_lsu_euk
IPR007238 DNA_primase_lsu_euk/arc
PANTHERiPTHR10537 PTHR10537, 1 hit
PfamiView protein in Pfam
PF04104 DNA_primase_lrg, 1 hit
PIRSFiPIRSF009449 DNA_primase_large_subunit, 1 hit

Sequencei

Sequence statusi: Complete.

F6UDJ9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEFSGVKRRK PWLIGDQRKA SYPHSLQFYL QPPSENISLI EFENLAIDRL
60 70 80 90 100
KLLKSVENLG VSYVKGTELY QSKLEAEIRR LKFSYRESLE DEYEPRRKDH
110 120 130 140 150
ISHFILRLAY CQSEDLRRWF IQQEMDLLRF RFSILPKDKI QSFLQDSHLH
160 170 180 190 200
FEAISEEEKN LREQEIIASS TSLGGPKLEL EYVYKIPFAD ALDLFRGRKV
210 220 230 240 250
YLENGFAYVP LKDIVAIILN EFRAKLSKAL ALTARSLPAV QSDERLQPLL
260 270 280 290 300
NHLSHSYIGQ DYSIQGNAGK ISLDQIDSLS TKSFPPCMRQ LHKALRENHH
310 320 330 340 350
LRHGGRMQYG LFLKGIGLTL EQALQFWKQE FIKGKMDPDK FDKGYSYNIR
360 370 380 390 400
HSFGKEGKRT DYTPFSCLKI ILTNPPSQGD YHGCPFRHSD PELLKQKLQS
410 420 430 440 450
YKITPGGISQ ILDLVKGTHY QVACQKYFEM THNVDDCGFS LNHPNQFFVE
460 470 480 490 500
SQRVLNGGKD IKKESIPPET PQPKQSAQKT KNASSALASL NSSLEMDMEG

LEDYFSE
Length:507
Mass (Da):58,530
Last modified:July 27, 2011 - v1
Checksum:i893166D0225B69E2
GO

Sequence databases

RefSeqiXP_014590004.1, XM_014734518.1
XP_014590005.1, XM_014734519.1

Genome annotation databases

EnsembliENSECAT00000016787; ENSECAP00000013575; ENSECAG00000015791
GeneIDi100056923
KEGGiecb:100056923

Similar proteinsi

Entry informationi

Entry nameiF6UDJ9_HORSE
AccessioniPrimary (citable) accession number: F6UDJ9
Entry historyiIntegrated into UniProtKB/TrEMBL: July 27, 2011
Last sequence update: July 27, 2011
Last modified: May 23, 2018
This is version 34 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

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