Fork-head domain-containing protein

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functionⁱ

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functionⁱ

• DNA-binding transcription activator activity, RNA polymerase II-specific Source: Ensembl
• DNA-binding transcription factor activity, RNA polymerase II-specific Source: GO_Central <p>Inferred from Biological aspect of Ancestor</p> <p>A type of phylogenetic evidence whereby an aspect of a descendent is inferred through the characterization of an aspect of a ancestral gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#iba">GO evidence code guide</a></p> Inferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief Bioinform 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: Ensembl

GO - Biological processⁱ

• cardiac left ventricle morphogenesis Source: Ensembl
• cell-cell adhesion Source: Ensembl
• cellular response to cytokine stimulus Source: Ensembl
• cellular response to organic cyclic compound Source: Ensembl
• detection of wounding Source: Ensembl
• determination of left/right symmetry Source: Ensembl
• ductus arteriosus closure Source: Ensembl
• embryonic ectodermal digestive tract morphogenesis Source: Ensembl
• embryonic foregut morphogenesis Source: Ensembl
• endocardial cushion development Source: Ensembl
• epithelial cell differentiation involved in mammary gland alveolus development Source: Ensembl
• epithelial tube branching involved in lung morphogenesis Source: Ensembl
• establishment of epithelial cell apical/basal polarity Source: Ensembl
• extracellular matrix organization Source: Ensembl
• in utero embryonic development Source: Ensembl
• lateral mesodermal cell differentiation Source: Ensembl
• lung alveolus development Source: Ensembl
• lung lobe morphogenesis Source: Ensembl
• lung vasculature development Source: Ensembl
• mesenchyme migration Source: Ensembl
• midgut development Source: Ensembl
• negative regulation of inflammatory response Source: Ensembl
• negative regulation of mast cell degranulation Source: Ensembl
• negative regulation of transcription by RNA polymerase II Source: Ensembl
• pancreas development Source: Ensembl
• positive regulation of cell migration Source: Ensembl
• positive regulation of cell-substrate adhesion Source: Ensembl
• positive regulation of mesenchymal cell proliferation Source: Ensembl
• right lung morphogenesis Source: Ensembl
• smoothened signaling pathway Source: Ensembl
• smooth muscle cell differentiation Source: Ensembl
• somitogenesis Source: Ensembl
• trachea development Source: Ensembl
• ureter development Source: Ensembl
• vasculogenesis Source: Ensembl
• venous blood vessel development Source: Ensembl

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsⁱ

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyⁱ

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationⁱ

Keywords - Cellular componentⁱ

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressionⁱ

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactionⁱ

Protein-protein interaction databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsⁱ

Domains and Repeats

Region

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequenceⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusⁱ: Complete.

        10         20         30         40         50
MSSVPEKAQQ HGGHSSGGGG GGGGSAMDPA SSTTSKAKKT NAGIRRPEKP 
        60         70         80         90        100
PYSYIALIVM AIQSSPTKRL TLSEIYQFLQ SRFPFFRGSY QGWKNSVRHN 
       110        120        130        140        150
LSLNECFIKL PKGLGRPGKG HYWTIDPASE FMFEEGSFRR RPRGFRRKCQ 
       160        170        180        190        200
ALKPMYSMMN GLGFNHLPDT YSFQGSAGAI SCPPNSLALE GGIGMMNGHL 
       210        220        230        240        250
PGNVDGLGLP GHSVPHLPAN GGHSYMGSCA GSAGAEYPHP EGSVSASPLL 
       260        270        280        290        300
ASGGVMEPHS VYSGSASAWP PSASAAALNS GASYIKQQPL SPCNPAANPL 
       310        320        330        340        350
SSSLPTHSLE QPYLHQNSHN PAELQGIPRY HSQSPSMCDR KEFVFSFNAM 
       360        370 
ASSSMHSASS GSYYHQQVTY QDIKPCVM                         

Sequence databases

Genome annotation databases

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsⁱ

• 90% Identity
• 50% Identity

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesⁱ

Sequence databases

3D structure databases

Protein-protein interaction databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationⁱ

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousⁱ

Keywords - Technical termⁱ