UniProtKB - F6U8P0 (F6U8P0_HORSE)
Protein
Protein tweety homolog
Gene
TTYH2
Organism
Equus caballus (Horse)
Status
Functioni
Probable chloride channel.UniRule annotation
GO - Molecular functioni
- intracellular calcium activated chloride channel activity Source: GO_Central
- volume-sensitive chloride channel activity Source: GO_Central
Keywordsi
Molecular function | Chloride channelUniRule annotation, Ion channel |
Biological process | Ion transport, Transport |
Ligand | Chloride |
Names & Taxonomyi
Protein namesi | Recommended name: Protein tweety homologUniRule annotation |
Gene namesi | Name:TTYH2Imported |
Organismi | Equus caballus (Horse)Imported |
Taxonomic identifieri | 9796 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Perissodactyla › Equidae › Equus › |
Proteomesi |
|
Organism-specific databases
VGNCi | VGNC:56506, TTYH2 |
Subcellular locationi
Plasma membrane
- Cell membrane UniRule annotationARBA annotation; Multi-pass membrane protein UniRule annotationARBA annotation
Other locations
- Membrane ARBA annotation; Multi-pass membrane protein ARBA annotation
Plasma Membrane
- plasma membrane Source: GO_Central
Other locations
- chloride channel complex Source: UniProtKB-UniRule
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 46 – 69 | HelicalUniRule annotationAdd BLAST | 24 | |
Transmembranei | 89 – 110 | HelicalUniRule annotationAdd BLAST | 22 | |
Transmembranei | 214 – 235 | HelicalUniRule annotationAdd BLAST | 22 | |
Transmembranei | 242 – 261 | HelicalUniRule annotationAdd BLAST | 20 | |
Transmembranei | 390 – 411 | HelicalUniRule annotationAdd BLAST | 22 |
Keywords - Cellular componenti
MembraneExpressioni
Gene expression databases
Bgeei | ENSECAG00000022780, Expressed in prefrontal cortex and 22 other tissues |
ExpressionAtlasi | F6U8P0, baseline |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 33 | DisorderedSequence analysisAdd BLAST | 33 |
Sequence similaritiesi
Keywords - Domaini
Transmembrane, Transmembrane helixUniRule annotationARBA annotationPhylogenomic databases
GeneTreei | ENSGT00950000183060 |
HOGENOMi | CLU_023758_0_1_1 |
InParanoidi | F6U8P0 |
TreeFami | TF319025 |
Family and domain databases
CDDi | cd07912, Tweety_N, 1 hit |
InterProi | View protein in InterPro IPR006990, Tweety |
PANTHERi | PTHR12424, PTHR12424, 1 hit |
Pfami | View protein in Pfam PF04906, Tweety, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All
F6U8P0-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MGDRQLSPGS CTHSPRGSSG PRGRALPPHP PMGPSADPWP LPLQSLLFLG
60 70 80 90 100
LVAAVCLGLH LILLTAYLVC VCCCRQDDAV QAKRRSSCCV TWTAVVAGLI
110 120 130 140 150
CCAAVGVGFY GNSETNDGVY QLIYSLDNAN HTFSGIDTLV SGTTQKMKVE
160 170 180 190 200
LEQHLTRLSE IFAARGDYIQ TLKFMQQMAG NILGQLSGFP EWGEVTAELT
210 220 230 240 250
KLSDQTGYVE YYRWLSYLLL FILDLVLCFI ACLGLAKRSR CLLALMLCCG
260 270 280 290 300
LLALLLSWTS LAADTATAVA TSDFCVAPDT FILNITEGQI RTEVTRYYLY
310 320 330 340 350
CSQSLSSPFQ QALTIFQRSL TTMQIQVVGL LQFAVPLFPT AEKDLLGIQL
360 370 380 390 400
LLNSSESSLH QLTAMLDCRG LHKDYLDALT GICYDGIEGL LYLGLFSLLA
410 420 430 440 450
ALAFSTVICA GPRAWKHLTT RDRDYDDIDD DDPFNPQARR IAAHNPPRGQ
460 470 480 490 500
LRSFCSYSSG LGSQTSLQPP AQTISNAPVS EYMNQAVLFG GNPRYENVPL
510 520 530
IGRGSPPPTY SPSMRATYLS VADEHLRHYG NEFPA
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketA0A5F5PP29 | A0A5F5PP29_HORSE | Protein tweety homolog | TTYH2 | 637 | Annotation score: | ||
A0A3Q2L281 | A0A3Q2L281_HORSE | Protein tweety homolog | TTYH2 | 636 | Annotation score: |
Genome annotation databases
Ensembli | ENSECAT00000024658; ENSECAP00000020492; ENSECAG00000022780 |
Similar proteinsi
Cross-referencesi
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Proteomic databases
PaxDbi | F6U8P0 |
Genome annotation databases
Ensembli | ENSECAT00000024658; ENSECAP00000020492; ENSECAG00000022780 |
Organism-specific databases
VGNCi | VGNC:56506, TTYH2 |
Phylogenomic databases
GeneTreei | ENSGT00950000183060 |
HOGENOMi | CLU_023758_0_1_1 |
InParanoidi | F6U8P0 |
TreeFami | TF319025 |
Gene expression databases
Bgeei | ENSECAG00000022780, Expressed in prefrontal cortex and 22 other tissues |
ExpressionAtlasi | F6U8P0, baseline |
Family and domain databases
CDDi | cd07912, Tweety_N, 1 hit |
InterProi | View protein in InterPro IPR006990, Tweety |
PANTHERi | PTHR12424, PTHR12424, 1 hit |
Pfami | View protein in Pfam PF04906, Tweety, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | F6U8P0_HORSE | |
Accessioni | F6U8P0Primary (citable) accession number: F6U8P0 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | July 27, 2011 |
Last sequence update: | April 10, 2019 | |
Last modified: | December 2, 2020 | |
This is version 43 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |