UniProtKB - F6U5B3 (F6U5B3_HORSE)
Protein
Homogentisate 1,2-dioxygenase
Gene
HGD
Organism
Equus caballus (Horse)
Status
Functioni
Catalytic activityi
- EC:1.13.11.5ARBA annotation
Cofactori
Fe cationARBA annotation
: L-phenylalanine degradation Pathwayi
This protein is involved in step 4 of the subpathway that synthesizes acetoacetate and fumarate from L-phenylalanine.ARBA annotationProteins known to be involved in the 6 steps of the subpathway in this organism are:
- Phe-4-monooxygenase (PAH), Phe-4-monooxygenase (PAH), Phe-4-monooxygenase (PAH), Phe-4-monooxygenase (PAH)
- Tyrosine aminotransferase (TAT), Tyrosine aminotransferase (TAT)
- no protein annotated in this organism
- Homogentisate 1,2-dioxygenase (HGD), Homogentisate 1,2-dioxygenase (HGD)
- Maleylacetoacetate isomerase (GSTZ1), Maleylacetoacetate isomerase (GSTZ1), Maleylacetoacetate isomerase (GSTZ1)
- Fumarylacetoacetase (FAH)
View all proteins of this organism that are known to be involved in the subpathway that synthesizes acetoacetate and fumarate from L-phenylalanine, the pathway L-phenylalanine degradation and in Amino-acid degradation.
GO - Molecular functioni
- homogentisate 1,2-dioxygenase activity Source: UniProtKB-EC
- metal ion binding Source: UniProtKB-KW
GO - Biological processi
- L-phenylalanine catabolic process Source: UniProtKB-UniPathway
- tyrosine metabolic process Source: InterPro
Keywordsi
Ligand | Metal-bindingARBA annotation |
Enzyme and pathway databases
UniPathwayi | UPA00139;UER00339 |
Names & Taxonomyi
Protein namesi | Recommended name: Homogentisate 1,2-dioxygenaseARBA annotation (EC:1.13.11.5ARBA annotation)Alternative name(s): Homogentisate oxygenaseARBA annotation Homogentisic acid oxidaseARBA annotation HomogentisicaseARBA annotation |
Gene namesi | Name:HGDImported |
Organismi | Equus caballus (Horse)Imported |
Taxonomic identifieri | 9796 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Perissodactyla › Equidae › Equus › |
Proteomesi |
|
Organism-specific databases
VGNCi | VGNC:18768, HGD |
Expressioni
Gene expression databases
Bgeei | ENSECAG00000023083, Expressed in liver and 13 other tissues |
Family & Domainsi
Sequence similaritiesi
Belongs to the homogentisate dioxygenase family.ARBA annotation
Phylogenomic databases
GeneTreei | ENSGT00390000004601 |
HOGENOMi | CLU_027174_0_0_1 |
InParanoidi | F6U5B3 |
OMAi | FESIDQG |
OrthoDBi | 795654at2759 |
TreeFami | TF300490 |
Family and domain databases
Gene3Di | 2.60.120.10, 1 hit |
InterProi | View protein in InterPro IPR005708, Homogentis_dOase IPR014710, RmlC-like_jellyroll IPR011051, RmlC_Cupin_sf |
PANTHERi | PTHR11056, PTHR11056, 1 hit |
Pfami | View protein in Pfam PF04209, HgmA, 1 hit |
SUPFAMi | SSF51182, SSF51182, 1 hit |
TIGRFAMsi | TIGR01015, hmgA, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
F6U5B3-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MAELKYISGF GNECASEDPR CPGALPEGQN NPQVCPYNLY AEQLSGSAFT
60 70 80 90 100
CPRSTNKRSW LYRILPSVSH KPFESTDQGH VTHNWDEVDP DPNQLRWKPF
110 120 130 140 150
EIPKASQKKA DFVSGLHTLC GAGDIRSNNG LAIHIFLCNV SMEDRCFCNS
160 170 180 190 200
DGDFLIVPQK GKLLIYTEFG KMLVQPNEIC VIQRGMRFSI DVFEETRGYI
210 220 230 240 250
LEVYGVHFEL PDLGPIGANG LANPRDFLIP VAWYEDRQVP GGYTVINKYQ
260 270 280 290 300
GKLFAAKQDV SPFNVVAWHG NYTPYKYNLE NFMVINSVAF DHADPSIFTV
310 320 330 340 350
LTAKSVRPGV AIADFVIFPP RWGVADKTFR PPYYHRNCMS EFMGLIKGHY
360 370 380 390 400
EAKEGGFLPG GGSLHSSMTP HGPDADCFEK ASRAKLAPER VADGTMAFMF
410 420 430 440
ESSLSMAVTK WGLKTSNCLD ENYYKCWEPL KSHFTPNSRN PAGRI
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketA0A3Q2H2J4 | A0A3Q2H2J4_HORSE | Homogentisate 1,2-dioxygenase | HGD | 446 | Annotation score: |
Sequence databases
RefSeqi | XP_001502449.1, XM_001502399.5 |
Genome annotation databases
Ensembli | ENSECAT00000024926; ENSECAP00000020726; ENSECAG00000023083 |
GeneIDi | 100060993 |
KEGGi | ecb:100060993 |
Similar proteinsi
Cross-referencesi
Sequence databases
RefSeqi | XP_001502449.1, XM_001502399.5 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Proteomic databases
PaxDbi | F6U5B3 |
Genome annotation databases
Ensembli | ENSECAT00000024926; ENSECAP00000020726; ENSECAG00000023083 |
GeneIDi | 100060993 |
KEGGi | ecb:100060993 |
Organism-specific databases
CTDi | 3081 |
VGNCi | VGNC:18768, HGD |
Phylogenomic databases
GeneTreei | ENSGT00390000004601 |
HOGENOMi | CLU_027174_0_0_1 |
InParanoidi | F6U5B3 |
OMAi | FESIDQG |
OrthoDBi | 795654at2759 |
TreeFami | TF300490 |
Enzyme and pathway databases
UniPathwayi | UPA00139;UER00339 |
Gene expression databases
Bgeei | ENSECAG00000023083, Expressed in liver and 13 other tissues |
Family and domain databases
Gene3Di | 2.60.120.10, 1 hit |
InterProi | View protein in InterPro IPR005708, Homogentis_dOase IPR014710, RmlC-like_jellyroll IPR011051, RmlC_Cupin_sf |
PANTHERi | PTHR11056, PTHR11056, 1 hit |
Pfami | View protein in Pfam PF04209, HgmA, 1 hit |
SUPFAMi | SSF51182, SSF51182, 1 hit |
TIGRFAMsi | TIGR01015, hmgA, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | F6U5B3_HORSE | |
Accessioni | F6U5B3Primary (citable) accession number: F6U5B3 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | July 27, 2011 |
Last sequence update: | July 27, 2011 | |
Last modified: | December 2, 2020 | |
This is version 49 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |