UniProtKB - F6U4P2 (F6U4P2_HORSE)
Protein
Submitted name:
Phosphofructokinase, platelet
Gene
PFKP
Organism
Equus caballus (Horse)
Status
Functioni
Catalytic activityi
- EC:2.7.1.11ARBA annotation
Cofactori
Mg2+ARBA annotation
: glycolysis Pathwayi
This protein is involved in step 3 of the subpathway that synthesizes D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose.ARBA annotationProteins known to be involved in the 4 steps of the subpathway in this organism are:
- Phosphotransferase (GCK), Hexokinase (HK1), Hexokinase (HK3), Hexokinase (HKDC1), Hexokinase (HK1), Hexokinase-2 (HK2), Hexokinase (HK1), Hexokinase (HK1), Phosphotransferase (GCK), Hexokinase (HK2), Hexokinase (HK2), Hexokinase (HK3), Phosphotransferase (GCK), Hexokinase (HK1), Hexokinase (HKDC1), Hexokinase (HK1)
- Glucose-6-phosphate isomerase (GPI), Glucose-6-phosphate isomerase (GPI), Glucose-6-phosphate isomerase
- 6-phosphofructokinase (PFKP), Phosphofructokinase, platelet (PFKP), ATP-dependent 6-phosphofructokinase (PFKP), ATP-dependent 6-phosphofructokinase (PFKM), ATP-dependent 6-phosphofructokinase (PFKP), ATP-dependent 6-phosphofructokinase (PFKL), ATP-dependent 6-phosphofructokinase, muscle type (PFKM), ATP-dependent 6-phosphofructokinase (PFKM), ATP-dependent 6-phosphofructokinase (PFKM), 6-phosphofructokinase (PFKP), ATP-dependent 6-phosphofructokinase (PFKM)
- Fructose-bisphosphate aldolase (ALDOC), Fructose-bisphosphate aldolase (ALDOA), Fructose-bisphosphate aldolase (ALDOA), Fructose-bisphosphate aldolase (ALDOA), Fructose-bisphosphate aldolase, Fructose-bisphosphate aldolase (ALDOB), Fructose-bisphosphate aldolase (ALDOC)
View all proteins of this organism that are known to be involved in the subpathway that synthesizes D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose, the pathway glycolysis and in Carbohydrate degradation.
GO - Molecular functioni
- 6-phosphofructokinase activity Source: UniProtKB-EC
- ATP binding Source: InterPro
- metal ion binding Source: UniProtKB-KW
GO - Biological processi
- fructose 6-phosphate metabolic process Source: InterPro
Keywordsi
Molecular function | KinaseARBA annotation, Transferase |
Biological process | GlycolysisARBA annotation |
Ligand | MagnesiumARBA annotation, Metal-bindingARBA annotation |
Enzyme and pathway databases
UniPathwayi | UPA00109;UER00182 |
Names & Taxonomyi
Protein namesi | Submitted name: Phosphofructokinase, plateletImported |
Gene namesi | Name:PFKPImported |
Organismi | Equus caballus (Horse)Imported |
Taxonomic identifieri | 9796 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Perissodactyla › Equidae › Equus › |
Proteomesi |
|
Organism-specific databases
VGNCi | VGNC:21342, PFKP |
Subcellular locationi
Other locations
- cytoplasm Source: UniProtKB-KW
Keywords - Cellular componenti
CytoplasmARBA annotationPTM / Processingi
Keywords - PTMi
AcetylationARBA annotation, PhosphoproteinARBA annotationProteomic databases
PaxDbi | F6U4P2 |
PRIDEi | F6U4P2 |
Expressioni
Gene expression databases
Bgeei | ENSECAG00000020055, Expressed in cerebellum and 23 other tissues |
ExpressionAtlasi | F6U4P2, baseline |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 122 – 393 | PFKInterPro annotationAdd BLAST | 272 | |
Domaini | 571 – 707 | PFKInterPro annotationAdd BLAST | 137 |
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 622 – 642 | Sequence analysisAdd BLAST | 21 |
Keywords - Domaini
Coiled coilSequence analysisPhylogenomic databases
GeneTreei | ENSGT00940000155002 |
HOGENOMi | CLU_011053_0_0_1 |
InParanoidi | F6U4P2 |
TreeFami | TF300411 |
Family and domain databases
InterProi | View protein in InterPro IPR009161, 6-Pfructokinase_euk IPR022953, ATP_PFK IPR015912, Phosphofructokinase_CS IPR000023, Phosphofructokinase_dom IPR035966, PKF_sf |
Pfami | View protein in Pfam PF00365, PFK, 2 hits |
PRINTSi | PR00476, PHFRCTKINASE |
SUPFAMi | SSF53784, SSF53784, 2 hits |
TIGRFAMsi | TIGR02478, 6PF1K_euk, 1 hit |
PROSITEi | View protein in PROSITE PS00433, PHOSPHOFRUCTOKINASE, 2 hits |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show allAlign All
F6U4P2-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MPGHAEAPTR MLSPVIDTTV AMCATNSFRV DVSLFSISGT IRQQAHCPPS
60 70 80 90 100
FSGRVWVESP LFEVTLKRPF RHLRLYQHWY RVGSNPEEPR FVVICISILP
110 120 130 140 150
SVGSVIVSAE RSPVLRRSPS LPQGYQGMVD GGSNIVEADW ESVSSILQVG
160 170 180 190 200
GTIIGSARCK AFRSREGRLQ AARNLVQLGI TNLCVIGGDG SLTGANIFRK
210 220 230 240 250
EWSGLLEELA QNGQINKEEV EKYSYLNVVG MVGSIDNDFC GTDMTIGTDS
260 270 280 290 300
ALHRIIEVID AIMTTAQSHQ RTFVLEVMGR HCGYLALVSA LACGADWVFL
310 320 330 340 350
PESPPEEGWQ ENMCVKLSEN RARKKRLNII IVAEGAIDTQ NKPITSEQIK
360 370 380 390 400
ELVVTQLGYD TRVTILGHVQ RGGTPSAFDR ILASRMGVEA VVALLQATPE
410 420 430 440 450
TPACVVSLSG NQAVRLPLVK CVQMTQDVQK AMDERRFKDA VQLRGRSFEN
460 470 480 490 500
NLNTYKRLAI KMPDTQIPKS NCNVGVINVG APAAGMNAAV RAAVRVGIAD
510 520 530 540 550
GHKMFAVYDG FEGFAKGQIK EIGWGDVGGW TGQGGSILGT KRTLPGKYLT
560 570 580 590 600
EIAGQMRTHS INALLIIGGF ETCDRIKQSA SGTKRRVFII ETMGGYCGYL
610 620 630 640 650
ANMGGLAAGA DAAYIFEEPF DIRDLQANVE HLTEKMKTTI QRGLVLRNES
660 670 680 690 700
CSENYTTDFI YQLYSEEGKG VFDCRKNVLG HMQQGGAPSP FDRNFGTKMS
710 720 730 740 750
ARAMQWITTK LKESQGKGRR FVSDDSICVL GISKRNLVFR PVAELKKETD
760 770 780 790 800
FEHRIPKEQW WLKLRPLMKI LAKYKASFEV SDSEELEHVH HRGHEEPAAI
Computationally mapped potential isoform sequencesi
There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketA0A3Q2H4I5 | A0A3Q2H4I5_HORSE | ATP-dependent 6-phosphofructokinase | PFKP | 851 | Annotation score: | ||
A0A5F5PZA2 | A0A5F5PZA2_HORSE | ATP-dependent 6-phosphofructokinase | PFKP | 851 | Annotation score: | ||
A0A3Q2H4G7 | A0A3Q2H4G7_HORSE | 6-phosphofructokinase | PFKP | 902 | Annotation score: | ||
A0A3Q2L2A5 | A0A3Q2L2A5_HORSE | 6-phosphofructokinase | PFKP | 766 | Annotation score: |
Genome annotation databases
Ensembli | ENSECAT00000022588; ENSECAP00000018673; ENSECAG00000020055 |
Similar proteinsi
Cross-referencesi
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Proteomic databases
PaxDbi | F6U4P2 |
PRIDEi | F6U4P2 |
Genome annotation databases
Ensembli | ENSECAT00000022588; ENSECAP00000018673; ENSECAG00000020055 |
Organism-specific databases
VGNCi | VGNC:21342, PFKP |
Phylogenomic databases
GeneTreei | ENSGT00940000155002 |
HOGENOMi | CLU_011053_0_0_1 |
InParanoidi | F6U4P2 |
TreeFami | TF300411 |
Enzyme and pathway databases
UniPathwayi | UPA00109;UER00182 |
Gene expression databases
Bgeei | ENSECAG00000020055, Expressed in cerebellum and 23 other tissues |
ExpressionAtlasi | F6U4P2, baseline |
Family and domain databases
InterProi | View protein in InterPro IPR009161, 6-Pfructokinase_euk IPR022953, ATP_PFK IPR015912, Phosphofructokinase_CS IPR000023, Phosphofructokinase_dom IPR035966, PKF_sf |
Pfami | View protein in Pfam PF00365, PFK, 2 hits |
PRINTSi | PR00476, PHFRCTKINASE |
SUPFAMi | SSF53784, SSF53784, 2 hits |
TIGRFAMsi | TIGR02478, 6PF1K_euk, 1 hit |
PROSITEi | View protein in PROSITE PS00433, PHOSPHOFRUCTOKINASE, 2 hits |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | F6U4P2_HORSE | |
Accessioni | F6U4P2Primary (citable) accession number: F6U4P2 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | July 27, 2011 |
Last sequence update: | April 10, 2019 | |
Last modified: | October 7, 2020 | |
This is version 66 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |