UniProtKB - F6U439 (F6U439_HORSE)
Protein
Submitted name:
Potassium voltage-gated channel subfamily Q member 4
Gene
KCNQ4
Organism
Equus caballus (Horse)
Status
Functioni
GO - Molecular functioni
- voltage-gated potassium channel activity Source: InterPro
GO - Biological processi
- regulation of ion transmembrane transport Source: UniProtKB-KW
Keywordsi
Molecular function | Ion channel, Potassium channelARBA annotation, Voltage-gated channelARBA annotation |
Biological process | Ion transport, Potassium transport, Transport |
Ligand | Potassium |
Names & Taxonomyi
Protein namesi | Submitted name: Potassium voltage-gated channel subfamily Q member 4Imported |
Gene namesi | Name:KCNQ4Imported |
Organismi | Equus caballus (Horse)Imported |
Taxonomic identifieri | 9796 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Perissodactyla › Equidae › Equus › |
Proteomesi |
|
Organism-specific databases
VGNCi | VGNC:58633, KCNQ4 |
Subcellular locationi
Plasma membrane
- Cell membrane ARBA annotation; Multi-pass membrane protein ARBA annotation
Other locations
- Membrane ARBA annotation; Multi-pass membrane protein ARBA annotation
Plasma Membrane
- voltage-gated potassium channel complex Source: InterPro
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 99 – 121 | HelicalSequence analysisAdd BLAST | 23 | |
Transmembranei | 133 – 153 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 174 – 199 | HelicalSequence analysisAdd BLAST | 26 | |
Transmembranei | 239 – 258 | HelicalSequence analysisAdd BLAST | 20 | |
Transmembranei | 299 – 324 | HelicalSequence analysisAdd BLAST | 26 |
Keywords - Cellular componenti
MembraneExpressioni
Gene expression databases
Bgeei | ENSECAG00000021257, Expressed in oviduct epithelium and 19 other tissues |
ExpressionAtlasi | F6U439, baseline |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 100 – 324 | Ion_transInterPro annotationAdd BLAST | 225 | |
Domaini | 425 – 606 | KCNQ_channelInterPro annotationAdd BLAST | 182 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 400 – 442 | DisorderedSequence analysisAdd BLAST | 43 | |
Regioni | 457 – 477 | DisorderedSequence analysisAdd BLAST | 21 | |
Regioni | 548 – 568 | DisorderedSequence analysisAdd BLAST | 21 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 428 – 442 | PolarSequence analysisAdd BLAST | 15 | |
Compositional biasi | 549 – 568 | PolyampholyteSequence analysisAdd BLAST | 20 |
Keywords - Domaini
Transmembrane, Transmembrane helixSequence analysisARBA annotationPhylogenomic databases
GeneTreei | ENSGT00940000159209 |
HOGENOMi | CLU_011722_8_3_1 |
InParanoidi | F6U439 |
TreeFami | TF315186 |
Family and domain databases
InterProi | View protein in InterPro IPR005821, Ion_trans_dom IPR003937, K_chnl_volt-dep_KCNQ IPR013821, K_chnl_volt-dep_KCNQ_C IPR015573, KCQN4 IPR028325, VG_K_chnl |
PANTHERi | PTHR11537, PTHR11537, 2 hits PTHR11537:SF4, PTHR11537:SF4, 2 hits |
Pfami | View protein in Pfam PF00520, Ion_trans, 1 hit PF03520, KCNQ_channel, 1 hit |
PRINTSi | PR01459, KCNQCHANNEL |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All
F6U439-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MAEAPPRRLG LAPPPGDAPR AELVALTAVQ SERGEAGGGG SPRRLGLLGS
60 70 80 90 100
PLPPGAPLPG PGSGSGSACG QRSSAAYKRY RRLQNWVYNV LERPRGWAFV
110 120 130 140 150
YHVFIFLLVF SCLVLSVLST IQEHQELANE CLLILEFVMI VVFGLEYIIR
160 170 180 190 200
VWSAGCCCRY RGWQGRLRFA RKPFCVIDFI VFVASVAVIA AGTQGNIFAT
210 220 230 240 250
SALRSMRFLQ ILRMVRMDRR GGTWKLLGSV VYAHSKELIT AWYIGFLVLI
260 270 280 290 300
FASFLVYLAE KDANSDFSSY ADSLWWGTIT LTTIGYGDKT PHTWLGRVLA
310 320 330 340 350
AGFALLGISF FALPAGILGS GFALKVQEQH RQKHFEKRRM PAANLIQAAW
360 370 380 390 400
RLYSTDTSRA YLTATWYYYD SILPSFSWRE EEAAGHRCLR LSSRMGIKDR
410 420 430 440 450
IRMGSSQRRT GPSKQHLAPP PMPASPSSEQ VGEGTSPTKV QKSWSFNDRT
460 470 480 490 500
RFRASLRLKP RTSAEEGPSE EVAEEKSYQC ELTVDDVMPA VKTVIRSVRI
510 520 530 540 550
LKFLVAKRKF KETLRPYDVK DVIEQYSAGH LDMLGRIKSL QARVDQIVGR
560 570 580 590 600
GPGDRKTREK GDKPSDSEAV DEISMMGRVV KVEKQVQSIE HKLDLLLGFY
610 620 630 640 650
SRCLRSGTSA SLGAVQVPLF DPDITSDYHS PVDHEDISAS AQTLSISRSV
STNMD
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketA0A3Q2H524 | A0A3Q2H524_HORSE | Potassium voltage-gated channel sub... | KCNQ4 | 694 | Annotation score: | ||
A0A5F5PXY4 | A0A5F5PXY4_HORSE | Potassium voltage-gated channel sub... | KCNQ4 | 640 | Annotation score: |
Genome annotation databases
Ensembli | ENSECAT00000022603; ENSECAP00000018687; ENSECAG00000021257 |
Similar proteinsi
Cross-referencesi
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Proteomic databases
PaxDbi | F6U439 |
Genome annotation databases
Ensembli | ENSECAT00000022603; ENSECAP00000018687; ENSECAG00000021257 |
Organism-specific databases
VGNCi | VGNC:58633, KCNQ4 |
Phylogenomic databases
GeneTreei | ENSGT00940000159209 |
HOGENOMi | CLU_011722_8_3_1 |
InParanoidi | F6U439 |
TreeFami | TF315186 |
Gene expression databases
Bgeei | ENSECAG00000021257, Expressed in oviduct epithelium and 19 other tissues |
ExpressionAtlasi | F6U439, baseline |
Family and domain databases
InterProi | View protein in InterPro IPR005821, Ion_trans_dom IPR003937, K_chnl_volt-dep_KCNQ IPR013821, K_chnl_volt-dep_KCNQ_C IPR015573, KCQN4 IPR028325, VG_K_chnl |
PANTHERi | PTHR11537, PTHR11537, 2 hits PTHR11537:SF4, PTHR11537:SF4, 2 hits |
Pfami | View protein in Pfam PF00520, Ion_trans, 1 hit PF03520, KCNQ_channel, 1 hit |
PRINTSi | PR01459, KCNQCHANNEL |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | F6U439_HORSE | |
Accessioni | F6U439Primary (citable) accession number: F6U439 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | July 27, 2011 |
Last sequence update: | April 10, 2019 | |
Last modified: | October 7, 2020 | |
This is version 54 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |