UniProtKB - F6U401 (F6U401_HORSE)
Protein
Submitted name:
Ubiquitin conjugating enzyme E2 Z
Gene
UBE2Z
Organism
Equus caballus (Horse)
Status
Functioni
GO - Molecular functioni
- cysteine-type endopeptidase inhibitor activity Source: GO_Central
- ubiquitin conjugating enzyme activity Source: GO_Central
GO - Biological processi
- negative regulation of apoptotic process Source: GO_Central
- positive regulation of apoptotic process Source: Ensembl
- ubiquitin-dependent protein catabolic process Source: Ensembl
Names & Taxonomyi
Protein namesi | Submitted name: Ubiquitin conjugating enzyme E2 ZImported |
Gene namesi | Name:UBE2ZImported |
Organismi | Equus caballus (Horse)Imported |
Taxonomic identifieri | 9796 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Perissodactyla › Equidae › Equus › |
Proteomesi |
|
Organism-specific databases
VGNCi | VGNC:24729, UBE2Z |
Subcellular locationi
Cytosol
- cytosol Source: Ensembl
Nucleus
- nucleoplasm Source: Ensembl
- nucleus Source: GO_Central
Expressioni
Gene expression databases
Bgeei | ENSECAG00000021160, Expressed in articular cartilage of joint and 22 other tissues |
ExpressionAtlasi | F6U401, baseline |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 284 – 408 | UBC coreInterPro annotationAdd BLAST | 125 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 82 – 114 | DisorderedSequence analysisAdd BLAST | 33 | |
Regioni | 176 – 200 | DisorderedSequence analysisAdd BLAST | 25 | |
Regioni | 514 – 536 | DisorderedSequence analysisAdd BLAST | 23 |
Phylogenomic databases
GeneTreei | ENSGT00940000159091 |
HOGENOMi | CLU_025097_2_0_1 |
InParanoidi | F6U401 |
TreeFami | TF101128 |
Family and domain databases
CDDi | cd00195, UBCc, 1 hit |
Gene3Di | 3.10.110.10, 1 hit |
InterProi | View protein in InterPro IPR000608, UBQ-conjugat_E2 IPR016135, UBQ-conjugating_enzyme/RWD |
Pfami | View protein in Pfam PF00179, UQ_con, 1 hit |
SUPFAMi | SSF54495, SSF54495, 1 hit |
PROSITEi | View protein in PROSITE PS50127, UBIQUITIN_CONJUGAT_2, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All
F6U401-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MAACPPWVRV RREIRAFRTG RALSESTHLP STSLQGSWIP RPTPWAHLRA
60 70 80 90 100
ALLKRKYGPP FLPFQHLKIK YFTELGPQLH RGVPTRLRTS PAKPRTNAGP
110 120 130 140 150
EPSRGPLVPP PPAVEDRGWT LLQSASRWSG RGWAEPARPG LWKRRVGTLW
160 170 180 190 200
PGSRWCGSGR EQRPLWSADV LRSSPGSEAA MAESPTEEAA TATAGAGAAG
210 220 230 240 250
PGASGVAGVV GVSGSGGGFG PPFLPDVWAA AAAAGGAGGP GSGLAPLPGL
260 270 280 290 300
PPSAAAHGAA LLSHWDPTLS SDWDGERTAP QCLLRIKRDI MSIYKEPPPG
310 320 330 340 350
MFVVPDTVDM TKIHALITGP FDTPYEGGFF LFVFRCPPDY PIHPPRVKLM
360 370 380 390 400
TTGNNTVRFN PNFYRNGKVC LSILGTWTGP AWSPAQSISS VLISIQSLMT
410 420 430 440 450
ENPYHNEPGF EQERHPGDSK NYNECIRHET IRVAVCDMME GKCPCPEPLR
460 470 480 490 500
GVMEKSFLEY YDFYEVACKD RLHLQGQTMQ DPFGEKRGHF DYQSLLMRLG
510 520 530
LIRQKVLERL HNENAEMDSD SSSSGTETDL HGSLRV
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketA0A3Q2HM89 | A0A3Q2HM89_HORSE | Ubiquitin conjugating enzyme E2 Z | UBE2Z | 449 | Annotation score: | ||
A0A3Q2HD88 | A0A3Q2HD88_HORSE | Ubiquitin conjugating enzyme E2 Z | UBE2Z | 436 | Annotation score: |
Genome annotation databases
Ensembli | ENSECAT00000022608; ENSECAP00000018692; ENSECAG00000021160 |
Similar proteinsi
Cross-referencesi
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Proteomic databases
PaxDbi | F6U401 |
PRIDEi | F6U401 |
Genome annotation databases
Ensembli | ENSECAT00000022608; ENSECAP00000018692; ENSECAG00000021160 |
Organism-specific databases
VGNCi | VGNC:24729, UBE2Z |
Phylogenomic databases
GeneTreei | ENSGT00940000159091 |
HOGENOMi | CLU_025097_2_0_1 |
InParanoidi | F6U401 |
TreeFami | TF101128 |
Gene expression databases
Bgeei | ENSECAG00000021160, Expressed in articular cartilage of joint and 22 other tissues |
ExpressionAtlasi | F6U401, baseline |
Family and domain databases
CDDi | cd00195, UBCc, 1 hit |
Gene3Di | 3.10.110.10, 1 hit |
InterProi | View protein in InterPro IPR000608, UBQ-conjugat_E2 IPR016135, UBQ-conjugating_enzyme/RWD |
Pfami | View protein in Pfam PF00179, UQ_con, 1 hit |
SUPFAMi | SSF54495, SSF54495, 1 hit |
PROSITEi | View protein in PROSITE PS50127, UBIQUITIN_CONJUGAT_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | F6U401_HORSE | |
Accessioni | F6U401Primary (citable) accession number: F6U401 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | July 27, 2011 |
Last sequence update: | April 10, 2019 | |
Last modified: | February 10, 2021 | |
This is version 55 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |