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Protein
Submitted name:

Notch 1

Gene

NOTCH1

Organism
Equus caballus (Horse)
Status
Unreviewed-Annotation score: -Protein predictedi

Functioni

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.PROSITE-ProRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi410Calcium 1; via carbonyl oxygenUniRule annotation1
Metal bindingi413Calcium 1; via amide nitrogenUniRule annotation1
Metal bindingi430Calcium 2UniRule annotation1
Metal bindingi431Calcium 2; via carbonyl oxygenUniRule annotation1
Metal bindingi433Calcium 2UniRule annotation1
Metal bindingi447Calcium 2UniRule annotation1
Metal bindingi448Calcium 2; via carbonyl oxygenUniRule annotation1
Metal bindingi468Calcium 3UniRule annotation1
Metal bindingi469Calcium 3; via carbonyl oxygenUniRule annotation1
Metal bindingi471Calcium 3UniRule annotation1
Metal bindingi485Calcium 3UniRule annotation1
Metal bindingi486Calcium 3; via carbonyl oxygenUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

LigandCalciumUniRule annotation, Metal-bindingUniRule annotation

Names & Taxonomyi

Protein namesi
Submitted name:
Notch 1Imported
Gene namesi
Name:NOTCH1Imported
OrganismiEquus caballus (Horse)Imported
Taxonomic identifieri9796 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaPerissodactylaEquidaeEquus
Proteomesi
  • UP000002281 Componenti: Chromosome 25

Organism-specific databases

VGNCiVGNC:20817 NOTCH1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi26 ↔ 35PROSITE-ProRule annotation
Disulfide bondi67 ↔ 76PROSITE-ProRule annotation
Disulfide bondi107 ↔ 116PROSITE-ProRule annotation
Disulfide bondi144 ↔ 153PROSITE-ProRule annotation
Disulfide bondi184 ↔ 193PROSITE-ProRule annotation
Disulfide bondi223 ↔ 232PROSITE-ProRule annotation
Disulfide bondi261 ↔ 270PROSITE-ProRule annotation
Disulfide bondi301 ↔ 310PROSITE-ProRule annotation
Disulfide bondi339 ↔ 348PROSITE-ProRule annotation
Disulfide bondi359 ↔ 376PROSITE-ProRule annotation
Disulfide bondi378 ↔ 387PROSITE-ProRule annotation
Disulfide bondi394 ↔ 407UniRule annotation
Disulfide bondi401 ↔ 416UniRule annotation
Disulfide bondi418 ↔ 427UniRule annotation
Disulfide bondi434 ↔ 445UniRule annotation
Disulfide bondi439 ↔ 454UniRule annotation
Disulfide bondi456 ↔ 465UniRule annotation
Disulfide bondi472 ↔ 483UniRule annotation
Disulfide bondi477 ↔ 492UniRule annotation
Disulfide bondi560 ↔ 569PROSITE-ProRule annotation
Disulfide bondi598 ↔ 607PROSITE-ProRule annotation
Disulfide bondi614 ↔ 624PROSITE-ProRule annotation
Disulfide bondi635 ↔ 644PROSITE-ProRule annotation
Disulfide bondi673 ↔ 682PROSITE-ProRule annotation
Disulfide bondi689 ↔ 699PROSITE-ProRule annotation
Disulfide bondi710 ↔ 719PROSITE-ProRule annotation
Disulfide bondi748 ↔ 757PROSITE-ProRule annotation
Disulfide bondi786 ↔ 795PROSITE-ProRule annotation
Disulfide bondi807 ↔ 824PROSITE-ProRule annotation
Disulfide bondi826 ↔ 835PROSITE-ProRule annotation
Disulfide bondi864 ↔ 873PROSITE-ProRule annotation
Disulfide bondi902 ↔ 911PROSITE-ProRule annotation
Disulfide bondi940 ↔ 949PROSITE-ProRule annotation
Disulfide bondi978 ↔ 987PROSITE-ProRule annotation
Disulfide bondi1016 ↔ 1025PROSITE-ProRule annotation
Disulfide bondi1054 ↔ 1063PROSITE-ProRule annotation
Disulfide bondi1102 ↔ 1111PROSITE-ProRule annotation
Disulfide bondi1140 ↔ 1149PROSITE-ProRule annotation
Disulfide bondi1178 ↔ 1187PROSITE-ProRule annotation
Disulfide bondi1224 ↔ 1233PROSITE-ProRule annotation
Disulfide bondi1245 ↔ 1262PROSITE-ProRule annotation
Disulfide bondi1264 ↔ 1273PROSITE-ProRule annotation
Disulfide bondi1305 ↔ 1314PROSITE-ProRule annotation
Disulfide bondi1343 ↔ 1352PROSITE-ProRule annotation
Disulfide bondi1366 ↔ 1383PROSITE-ProRule annotation
Disulfide bondi1385 ↔ 1394PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bondUniRule annotationSAAS annotation

Proteomic databases

PaxDbiF6TZ18

Expressioni

Gene expression databases

BgeeiENSECAG00000022405 Expressed in 3 organ(s), highest expression level in adult mammalian kidney
ExpressionAtlasiF6TZ18 baseline

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9796.ENSECAP00000020734

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 36EGF-likeInterPro annotationAdd BLAST36
Domaini37 – 77EGF-likeInterPro annotationAdd BLAST41
Domaini80 – 117EGF-likeInterPro annotationAdd BLAST38
Domaini118 – 154EGF-likeInterPro annotationAdd BLAST37
Domaini156 – 194EGF-likeInterPro annotationAdd BLAST39
Domaini196 – 233EGF-likeInterPro annotationAdd BLAST38
Domaini235 – 271EGF-likeInterPro annotationAdd BLAST37
Domaini273 – 311EGF-likeInterPro annotationAdd BLAST39
Domaini313 – 349EGF-likeInterPro annotationAdd BLAST37
Domaini350 – 388EGF-likeInterPro annotationAdd BLAST39
Domaini390 – 428EGF-likeInterPro annotationAdd BLAST39
Domaini430 – 466EGF-likeInterPro annotationAdd BLAST37
Domaini468 – 504EGF-likeInterPro annotationAdd BLAST37
Domaini523 – 570EGF-likeInterPro annotationAdd BLAST48
Domaini572 – 608EGF-likeInterPro annotationAdd BLAST37
Domaini610 – 645EGF-likeInterPro annotationAdd BLAST36
Domaini647 – 683EGF-likeInterPro annotationAdd BLAST37
Domaini685 – 720EGF-likeInterPro annotationAdd BLAST36
Domaini722 – 758EGF-likeInterPro annotationAdd BLAST37
Domaini760 – 796EGF-likeInterPro annotationAdd BLAST37
Domaini798 – 836EGF-likeInterPro annotationAdd BLAST39
Domaini838 – 874EGF-likeInterPro annotationAdd BLAST37
Domaini876 – 912EGF-likeInterPro annotationAdd BLAST37
Domaini914 – 950EGF-likeInterPro annotationAdd BLAST37
Domaini952 – 988EGF-likeInterPro annotationAdd BLAST37
Domaini990 – 1026EGF-likeInterPro annotationAdd BLAST37
Domaini1028 – 1064EGF-likeInterPro annotationAdd BLAST37
Domaini1075 – 1112EGF-likeInterPro annotationAdd BLAST38
Domaini1114 – 1150EGF-likeInterPro annotationAdd BLAST37
Domaini1152 – 1188EGF-likeInterPro annotationAdd BLAST37
Domaini1197 – 1234EGF-likeInterPro annotationAdd BLAST38
Domaini1236 – 1274EGF-likeInterPro annotationAdd BLAST39
Domaini1276 – 1315EGF-likeInterPro annotationAdd BLAST40
Domaini1317 – 1353EGF-likeInterPro annotationAdd BLAST37
Domaini1356 – 1395EGF-likeInterPro annotationAdd BLAST40
Domaini1418 – 1458LNRInterPro annotationAdd BLAST41
Domaini1459 – 1500LNRInterPro annotationAdd BLAST42
Domaini1501 – 1540LNRInterPro annotationAdd BLAST40
Domaini1841 – 2081ANK_REP_REGIONInterPro annotationAdd BLAST241
Repeati1895 – 1927ANKPROSITE-ProRule annotationAdd BLAST33
Repeati1962 – 1994ANKPROSITE-ProRule annotationAdd BLAST33
Repeati1995 – 2027ANKPROSITE-ProRule annotationAdd BLAST33
Repeati2028 – 2060ANKPROSITE-ProRule annotationAdd BLAST33

Keywords - Domaini

ANK repeatPROSITE-ProRule annotation, EGF-like domainPROSITE-ProRule annotationSAAS annotation, RepeatSAAS annotation

Phylogenomic databases

eggNOGiENOG410IR7G Eukaryota
COG0666 LUCA
GeneTreeiENSGT00810000125346
InParanoidiF6TZ18
OMAiGRDCESK
OrthoDBiEOG091G01NU
TreeFamiTF351641

Family and domain databases

CDDicd00204 ANK, 2 hits
Gene3Di1.25.40.20, 1 hit
InterProiView protein in InterPro
IPR002110 Ankyrin_rpt
IPR020683 Ankyrin_rpt-contain_dom
IPR036770 Ankyrin_rpt-contain_sf
IPR024600 DUF3454_notch
IPR001881 EGF-like_Ca-bd_dom
IPR013032 EGF-like_CS
IPR000742 EGF-like_dom
IPR000152 EGF-type_Asp/Asn_hydroxyl_site
IPR018097 EGF_Ca-bd_CS
IPR009030 Growth_fac_rcpt_cys_sf
IPR008297 Notch
IPR035993 Notch-like_dom_sf
IPR022362 Notch_1
IPR000800 Notch_dom
IPR010660 Notch_NOD_dom
IPR011656 Notch_NODP_dom
PfamiView protein in Pfam
PF12796 Ank_2, 2 hits
PF11936 DUF3454, 1 hit
PF00008 EGF, 23 hits
PF07645 EGF_CA, 4 hits
PF12661 hEGF, 3 hits
PF06816 NOD, 1 hit
PF07684 NODP, 1 hit
PF00066 Notch, 3 hits
PIRSFiPIRSF002279 Notch, 1 hit
PRINTSiPR01452 LNOTCHREPEAT
PR01984 NOTCH1
SMARTiView protein in SMART
SM00248 ANK, 6 hits
SM01334 DUF3454, 1 hit
SM00181 EGF, 35 hits
SM00179 EGF_CA, 31 hits
SM00004 NL, 3 hits
SM01338 NOD, 1 hit
SM01339 NODP, 1 hit
SUPFAMiSSF48403 SSF48403, 1 hit
SSF57184 SSF57184, 5 hits
SSF90193 SSF90193, 3 hits
PROSITEiView protein in PROSITE
PS50297 ANK_REP_REGION, 1 hit
PS50088 ANK_REPEAT, 4 hits
PS00010 ASX_HYDROXYL, 20 hits
PS00022 EGF_1, 33 hits
PS01186 EGF_2, 26 hits
PS50026 EGF_3, 35 hits
PS01187 EGF_CA, 9 hits
PS50258 LNR, 3 hits

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

F6TZ18-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
CSQPGESCLN GGKCEVLANG TEACICSGAF AGQRCQVPNP CLSAPCKNGG
60 70 80 90 100
TCHMVDRGGL VDYACSCSLG FSGPLCLTPQ DNACLANPCR NGGTCDLLTL
110 120 130 140 150
TDYKCRCPPG WSGKTCQQAD PCASNPCANG GQCLPFEASY ICGCPPGFHG
160 170 180 190 200
PTCKQDINEC SQSPGLCRNG GTCHNEVGSY RCACRATHTG PHCELPYVPC
210 220 230 240 250
SPSPCQNGGT CRPTGDTTHE CACLPGFTGQ NCEENIDDCP GNSCKNGGAC
260 270 280 290 300
VDGVNTYNCR CPPEWTGMYC TEDVDECQLM PNACQNGGTC HNSHGGYNCV
310 320 330 340 350
CVNGWTGEDC SENIDDCASA SCFHGATCHD RVASFYCECP HGRTGLLCHL
360 370 380 390 400
NDACISNPCN EGSNCDTNPV NGKAICTCPS GYTGPACSQD VDECSLGANP
410 420 430 440 450
CEHAGKCINT LGSFECQCLQ GYTGPRCEID VNECVSNPCQ NDATCLDQIG
460 470 480 490 500
EFQCICMPGY EGVHCEVNTD ECASSPCLQN GRCLDKINEF LCECPTGQAG
510 520 530 540 550
HLAAYAHWGC PSLPCPPGLS LRGGPVCHRG GPGAHQAHRH CRSEPWASRD
560 570 580 590 600
DGVATFTCLC RPGYTGHHCE TNINECHSQP CRHGGTCQDR DNAYLCFCLK
610 620 630 640 650
GTTGPNCEIN LDDCASNPCD SGTCLDKIDG YECACEPGYT GSMCNINIDE
660 670 680 690 700
CAGNPCHNGG TCEDGINGFT CRCPEGYHDP TCLSEVNECN SDPCIHGACR
710 720 730 740 750
DSLNGYKCDC DPGWSGANCD INNNECESNP CVNGGTCKDM TSGYVCTCRE
760 770 780 790 800
GFSGPNCQTN INECASNPCL NQGTCIDDVA GYKCNCLLPY TGATCEVVLA
810 820 830 840 850
PCAPGPCRNG GECRESEDFE SFSCVCPVGW QGQTCEIDIN ECVKSPCRHG
860 870 880 890 900
ASCQNTNGGY RCHCQAGYTG RNCETDIDDC RPNPCHNGGS CTDGINAAFC
910 920 930 940 950
DCLPGFQGAF CEEDINECAS SPCRNGANCT DCVDSYTCTC PPGFGGIHCE
960 970 980 990 1000
NNTPDCTESS CFNGGTCVDG INSFTCLCPP GFTGSYCQHD VNECDSRPCL
1010 1020 1030 1040 1050
HGGTCQDSYG TYKCTCPQGY TGLNCQSLVR WCDSSPCKNG GKCWQTNALY
1060 1070 1080 1090 1100
RCECHSGWTG LYCDVPSVSC EVAARLQDVN VSRLCRNGGL CENEGSTHHC
1110 1120 1130 1140 1150
HCQAGYTGSY CEDQVDECSP SPCQNGATCT DYPGGYSCEC VAGYHGVNCS
1160 1170 1180 1190 1200
EEINECLSHP CQNGGTCIDL TNSYKCSCPR GTQGVHCEIN MDDCTPPVDP
1210 1220 1230 1240 1250
VSRGPKCFNN GTCVDQVGGY SCTCPPGFVG ERCEGDVNEC LSNPCDARGT
1260 1270 1280 1290 1300
QNCVQRVNDF HCECRAGHTG RRCESVINGC KGKPCKNGGT CAVASNTARG
1310 1320 1330 1340 1350
FICRCPAGYE GATCENDARA CGSLRCLNGG TCISGPRSPT CLCLGPFTGP
1360 1370 1380 1390 1400
ECQFPASSPC VGGNPCYNQG TCEPTSESPF YRCLCPAKFN GLLCHILDYS
1410 1420 1430 1440 1450
FGGGVGLDIP PPQIEEACEL PACREEAGNK VCSVRCNNHA CGWDGGDCSL
1460 1470 1480 1490 1500
NFNDPWQNCT QSLQCWKYFS NGHCDSQCNS AGCLFDGFDC QRAEGQCNPL
1510 1520 1530 1540 1550
YDQYCKDHFS DGHCDQGCNS AECEWDGLDC AEHVPERLAA GTLVVVVLMP
1560 1570 1580 1590 1600
PEQLRNNSFH FLRELSRLLH TNVVFKRDAS GQQMIFPYYG REEELRKHPI
1610 1620 1630 1640 1650
RRSVDGWATP GSLLGHMKAS LLPGSGGGRQ RRELDPMDIR GSIVYLEIDN
1660 1670 1680 1690 1700
RQCVQSSSQC FQSTTDVAAF LGALASLGSL NIPYKIEAVQ SESVEPPPPP
1710 1720 1730 1740 1750
PLHFMYVAVA AFVLLFFVGC GVLLSRKRRR QHGQLWFPEG FKVSEASKKK
1760 1770 1780 1790 1800
RREPLGEDSV GLKPLKNASD GALMDDNQNE WGDEDLETKK FRFEESVVLP
1810 1820 1830 1840 1850
DLDDQTDHRQ WTQQHLDAAD LRVSAMAPTP PQGEADTDCM DVNVRGPDGF
1860 1870 1880 1890 1900
TPLMIASCSG GGLETGNSEE EEDAPAVISD FIYQGASLHN QTDRTGETAL
1910 1920 1930 1940 1950
HLAARYSRSD AAKRLLEASA DANIQDNMGR TPLHAAVSAD AQGVFQILIR
1960 1970 1980 1990 2000
NRATDLDARM HDGTTPLILA ARLAVEGMLE DLINSHADVN AVDDLGKSAL
2010 2020 2030 2040 2050
HWAAAVNNVE AAIVLLKNGA NKDMQNNKEE TPLFLAAREG SYETAKVLLD
2060 2070 2080 2090 2100
HFANRDITDH MDRLPRDIAQ ERMHHDIVRL LDEYSLVRSP QLHGATLGGT
2110 2120 2130 2140 2150
PTLSPPLCSP NGYLGNLKPT VQGKKARKPS TKGLACGGKE AKDLKARRKK
2160 2170 2180 2190 2200
SQDGKGCLLD SSSVLSPVDS LESPHGYLSD VASPPLLPSP FQQSPSVPLN
2210 2220 2230 2240 2250
HLPGMPDTHL GVSHLSVAAK PEMATLGGGG RLAFEAGPPR LSHLPVASST
2260 2270 2280 2290 2300
STVLGPGGGS GVMNFTVGGA TGLNSQCEWL SRLQNGLVPN QYNPLRGSVA
2310 2320 2330 2340 2350
PSTLSTQAPA LQHGMMGPMH GGLSASALSQ MMSYQALPNT RLATQPHLVQ
2360 2370 2380 2390 2400
TQQLQQQQQQ QQPQQNLQPP NIQPQQNLQP QPPPPHLGVS SAANGHMGRS
2410 2420 2430 2440 2450
FLGGEPSQAD VQPLGPSSLA VHTILPQDSQ VLPTSLPSSL APPMTTAQFL
2460 2470 2480 2490 2500
TPPSQHSYSS SPVDNTPSHQ LQVPEHPFLT PSPESPDQWS SSSPHSNISD
2510 2520
WSEGISSPPT SMQSQIAHIP EAFK
Length:2,524
Mass (Da):269,260
Last modified:July 27, 2011 - v1
Checksum:iB14C180F6F7ED3B3
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F6TJ52F6TJ52_HORSE
Notch 1
NOTCH1
2,493Annotation score:

Genome annotation databases

EnsembliENSECAT00000024936; ENSECAP00000020734; ENSECAG00000022405

Similar proteinsi

Cross-referencesi

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9796.ENSECAP00000020734

Proteomic databases

PaxDbiF6TZ18

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSECAT00000024936; ENSECAP00000020734; ENSECAG00000022405

Organism-specific databases

VGNCiVGNC:20817 NOTCH1

Phylogenomic databases

eggNOGiENOG410IR7G Eukaryota
COG0666 LUCA
GeneTreeiENSGT00810000125346
InParanoidiF6TZ18
OMAiGRDCESK
OrthoDBiEOG091G01NU
TreeFamiTF351641

Gene expression databases

BgeeiENSECAG00000022405 Expressed in 3 organ(s), highest expression level in adult mammalian kidney
ExpressionAtlasiF6TZ18 baseline

Family and domain databases

CDDicd00204 ANK, 2 hits
Gene3Di1.25.40.20, 1 hit
InterProiView protein in InterPro
IPR002110 Ankyrin_rpt
IPR020683 Ankyrin_rpt-contain_dom
IPR036770 Ankyrin_rpt-contain_sf
IPR024600 DUF3454_notch
IPR001881 EGF-like_Ca-bd_dom
IPR013032 EGF-like_CS
IPR000742 EGF-like_dom
IPR000152 EGF-type_Asp/Asn_hydroxyl_site
IPR018097 EGF_Ca-bd_CS
IPR009030 Growth_fac_rcpt_cys_sf
IPR008297 Notch
IPR035993 Notch-like_dom_sf
IPR022362 Notch_1
IPR000800 Notch_dom
IPR010660 Notch_NOD_dom
IPR011656 Notch_NODP_dom
PfamiView protein in Pfam
PF12796 Ank_2, 2 hits
PF11936 DUF3454, 1 hit
PF00008 EGF, 23 hits
PF07645 EGF_CA, 4 hits
PF12661 hEGF, 3 hits
PF06816 NOD, 1 hit
PF07684 NODP, 1 hit
PF00066 Notch, 3 hits
PIRSFiPIRSF002279 Notch, 1 hit
PRINTSiPR01452 LNOTCHREPEAT
PR01984 NOTCH1
SMARTiView protein in SMART
SM00248 ANK, 6 hits
SM01334 DUF3454, 1 hit
SM00181 EGF, 35 hits
SM00179 EGF_CA, 31 hits
SM00004 NL, 3 hits
SM01338 NOD, 1 hit
SM01339 NODP, 1 hit
SUPFAMiSSF48403 SSF48403, 1 hit
SSF57184 SSF57184, 5 hits
SSF90193 SSF90193, 3 hits
PROSITEiView protein in PROSITE
PS50297 ANK_REP_REGION, 1 hit
PS50088 ANK_REPEAT, 4 hits
PS00010 ASX_HYDROXYL, 20 hits
PS00022 EGF_1, 33 hits
PS01186 EGF_2, 26 hits
PS50026 EGF_3, 35 hits
PS01187 EGF_CA, 9 hits
PS50258 LNR, 3 hits
ProtoNetiSearch...

Entry informationi

Entry nameiF6TZ18_HORSE
AccessioniPrimary (citable) accession number: F6TZ18
Entry historyiIntegrated into UniProtKB/TrEMBL: July 27, 2011
Last sequence update: July 27, 2011
Last modified: November 7, 2018
This is version 62 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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