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Protein
Submitted name:

Notch 1

Gene

NOTCH1

Organism
Equus caballus (Horse)
Status
Unreviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.PROSITE-ProRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the ‘Description’ field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi410Calcium 1; via carbonyl oxygenUniRule annotation1
Metal bindingi413Calcium 1; via amide nitrogenUniRule annotation1
Metal bindingi430Calcium 2UniRule annotation1
Metal bindingi431Calcium 2; via carbonyl oxygenUniRule annotation1
Metal bindingi433Calcium 2UniRule annotation1
Metal bindingi447Calcium 2UniRule annotation1
Metal bindingi448Calcium 2; via carbonyl oxygenUniRule annotation1
Metal bindingi468Calcium 3UniRule annotation1
Metal bindingi469Calcium 3; via carbonyl oxygenUniRule annotation1
Metal bindingi471Calcium 3UniRule annotation1
Metal bindingi485Calcium 3UniRule annotation1
Metal bindingi486Calcium 3; via carbonyl oxygenUniRule annotation1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

LigandCalciumUniRule annotation, Metal-bindingUniRule annotation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Notch 1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:NOTCH1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiEquus caballus (Horse)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9796 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaPerissodactylaEquidaeEquus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002281 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 25

Organism-specific databases

Vertebrate Gene Nomenclature Database

More...
VGNCi
VGNC:20817 NOTCH1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi26 ↔ 35PROSITE-ProRule annotation
Disulfide bondi67 ↔ 76PROSITE-ProRule annotation
Disulfide bondi107 ↔ 116PROSITE-ProRule annotation
Disulfide bondi144 ↔ 153PROSITE-ProRule annotation
Disulfide bondi184 ↔ 193PROSITE-ProRule annotation
Disulfide bondi223 ↔ 232PROSITE-ProRule annotation
Disulfide bondi261 ↔ 270PROSITE-ProRule annotation
Disulfide bondi301 ↔ 310PROSITE-ProRule annotation
Disulfide bondi339 ↔ 348PROSITE-ProRule annotation
Disulfide bondi359 ↔ 376PROSITE-ProRule annotation
Disulfide bondi378 ↔ 387PROSITE-ProRule annotation
Disulfide bondi394 ↔ 407UniRule annotation
Disulfide bondi401 ↔ 416UniRule annotation
Disulfide bondi418 ↔ 427UniRule annotation
Disulfide bondi434 ↔ 445UniRule annotation
Disulfide bondi439 ↔ 454UniRule annotation
Disulfide bondi456 ↔ 465UniRule annotation
Disulfide bondi472 ↔ 483UniRule annotation
Disulfide bondi477 ↔ 492UniRule annotation
Disulfide bondi560 ↔ 569PROSITE-ProRule annotation
Disulfide bondi598 ↔ 607PROSITE-ProRule annotation
Disulfide bondi614 ↔ 624PROSITE-ProRule annotation
Disulfide bondi635 ↔ 644PROSITE-ProRule annotation
Disulfide bondi673 ↔ 682PROSITE-ProRule annotation
Disulfide bondi689 ↔ 699PROSITE-ProRule annotation
Disulfide bondi710 ↔ 719PROSITE-ProRule annotation
Disulfide bondi748 ↔ 757PROSITE-ProRule annotation
Disulfide bondi786 ↔ 795PROSITE-ProRule annotation
Disulfide bondi807 ↔ 824PROSITE-ProRule annotation
Disulfide bondi826 ↔ 835PROSITE-ProRule annotation
Disulfide bondi864 ↔ 873PROSITE-ProRule annotation
Disulfide bondi902 ↔ 911PROSITE-ProRule annotation
Disulfide bondi940 ↔ 949PROSITE-ProRule annotation
Disulfide bondi978 ↔ 987PROSITE-ProRule annotation
Disulfide bondi1016 ↔ 1025PROSITE-ProRule annotation
Disulfide bondi1054 ↔ 1063PROSITE-ProRule annotation
Disulfide bondi1102 ↔ 1111PROSITE-ProRule annotation
Disulfide bondi1140 ↔ 1149PROSITE-ProRule annotation
Disulfide bondi1178 ↔ 1187PROSITE-ProRule annotation
Disulfide bondi1224 ↔ 1233PROSITE-ProRule annotation
Disulfide bondi1245 ↔ 1262PROSITE-ProRule annotation
Disulfide bondi1264 ↔ 1273PROSITE-ProRule annotation
Disulfide bondi1305 ↔ 1314PROSITE-ProRule annotation
Disulfide bondi1343 ↔ 1352PROSITE-ProRule annotation
Disulfide bondi1366 ↔ 1383PROSITE-ProRule annotation
Disulfide bondi1385 ↔ 1394PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bondUniRule annotationSAAS annotation

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
F6TZ18

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSECAG00000022405 Expressed in 3 organ(s), highest expression level in adult mammalian kidney

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
F6TZ18 baseline

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
9796.ENSECAP00000020734

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1 – 36EGF-likeInterPro annotationAdd BLAST36
Domaini37 – 77EGF-likeInterPro annotationAdd BLAST41
Domaini80 – 117EGF-likeInterPro annotationAdd BLAST38
Domaini118 – 154EGF-likeInterPro annotationAdd BLAST37
Domaini156 – 194EGF-likeInterPro annotationAdd BLAST39
Domaini196 – 233EGF-likeInterPro annotationAdd BLAST38
Domaini235 – 271EGF-likeInterPro annotationAdd BLAST37
Domaini273 – 311EGF-likeInterPro annotationAdd BLAST39
Domaini313 – 349EGF-likeInterPro annotationAdd BLAST37
Domaini350 – 388EGF-likeInterPro annotationAdd BLAST39
Domaini390 – 428EGF-likeInterPro annotationAdd BLAST39
Domaini430 – 466EGF-likeInterPro annotationAdd BLAST37
Domaini468 – 504EGF-likeInterPro annotationAdd BLAST37
Domaini523 – 570EGF-likeInterPro annotationAdd BLAST48
Domaini572 – 608EGF-likeInterPro annotationAdd BLAST37
Domaini610 – 645EGF-likeInterPro annotationAdd BLAST36
Domaini647 – 683EGF-likeInterPro annotationAdd BLAST37
Domaini685 – 720EGF-likeInterPro annotationAdd BLAST36
Domaini722 – 758EGF-likeInterPro annotationAdd BLAST37
Domaini760 – 796EGF-likeInterPro annotationAdd BLAST37
Domaini798 – 836EGF-likeInterPro annotationAdd BLAST39
Domaini838 – 874EGF-likeInterPro annotationAdd BLAST37
Domaini876 – 912EGF-likeInterPro annotationAdd BLAST37
Domaini914 – 950EGF-likeInterPro annotationAdd BLAST37
Domaini952 – 988EGF-likeInterPro annotationAdd BLAST37
Domaini990 – 1026EGF-likeInterPro annotationAdd BLAST37
Domaini1028 – 1064EGF-likeInterPro annotationAdd BLAST37
Domaini1075 – 1112EGF-likeInterPro annotationAdd BLAST38
Domaini1114 – 1150EGF-likeInterPro annotationAdd BLAST37
Domaini1152 – 1188EGF-likeInterPro annotationAdd BLAST37
Domaini1197 – 1234EGF-likeInterPro annotationAdd BLAST38
Domaini1236 – 1274EGF-likeInterPro annotationAdd BLAST39
Domaini1276 – 1315EGF-likeInterPro annotationAdd BLAST40
Domaini1317 – 1353EGF-likeInterPro annotationAdd BLAST37
Domaini1356 – 1395EGF-likeInterPro annotationAdd BLAST40
Domaini1418 – 1458LNRInterPro annotationAdd BLAST41
Domaini1459 – 1500LNRInterPro annotationAdd BLAST42
Domaini1501 – 1540LNRInterPro annotationAdd BLAST40
Domaini1841 – 2081ANK_REP_REGIONInterPro annotationAdd BLAST241
<p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati1895 – 1927ANKPROSITE-ProRule annotationAdd BLAST33
Repeati1962 – 1994ANKPROSITE-ProRule annotationAdd BLAST33
Repeati1995 – 2027ANKPROSITE-ProRule annotationAdd BLAST33
Repeati2028 – 2060ANKPROSITE-ProRule annotationAdd BLAST33

Keywords - Domaini

ANK repeatPROSITE-ProRule annotation, EGF-like domainPROSITE-ProRule annotationSAAS annotation, RepeatSAAS annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IR7G Eukaryota
COG0666 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000157157

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
F6TZ18

Identification of Orthologs from Complete Genome Data

More...
OMAi
GRDCESK

TreeFam database of animal gene trees

More...
TreeFami
TF351641

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00204 ANK, 2 hits

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.25.40.20, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR002110 Ankyrin_rpt
IPR020683 Ankyrin_rpt-contain_dom
IPR036770 Ankyrin_rpt-contain_sf
IPR024600 DUF3454_notch
IPR001881 EGF-like_Ca-bd_dom
IPR013032 EGF-like_CS
IPR000742 EGF-like_dom
IPR000152 EGF-type_Asp/Asn_hydroxyl_site
IPR018097 EGF_Ca-bd_CS
IPR009030 Growth_fac_rcpt_cys_sf
IPR008297 Notch
IPR035993 Notch-like_dom_sf
IPR022362 Notch_1
IPR000800 Notch_dom
IPR010660 Notch_NOD_dom
IPR011656 Notch_NODP_dom

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF12796 Ank_2, 2 hits
PF11936 DUF3454, 1 hit
PF00008 EGF, 23 hits
PF07645 EGF_CA, 4 hits
PF12661 hEGF, 3 hits
PF06816 NOD, 1 hit
PF07684 NODP, 1 hit
PF00066 Notch, 3 hits

PIRSF; a whole-protein classification database

More...
PIRSFi
PIRSF002279 Notch, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR01452 LNOTCHREPEAT
PR01984 NOTCH1

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00248 ANK, 6 hits
SM01334 DUF3454, 1 hit
SM00181 EGF, 35 hits
SM00179 EGF_CA, 31 hits
SM00004 NL, 3 hits
SM01338 NOD, 1 hit
SM01339 NODP, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48403 SSF48403, 1 hit
SSF57184 SSF57184, 5 hits
SSF90193 SSF90193, 3 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50297 ANK_REP_REGION, 1 hit
PS50088 ANK_REPEAT, 4 hits
PS00010 ASX_HYDROXYL, 20 hits
PS00022 EGF_1, 33 hits
PS01186 EGF_2, 26 hits
PS50026 EGF_3, 35 hits
PS01187 EGF_CA, 9 hits
PS50258 LNR, 3 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

F6TZ18-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
CSQPGESCLN GGKCEVLANG TEACICSGAF AGQRCQVPNP CLSAPCKNGG
60 70 80 90 100
TCHMVDRGGL VDYACSCSLG FSGPLCLTPQ DNACLANPCR NGGTCDLLTL
110 120 130 140 150
TDYKCRCPPG WSGKTCQQAD PCASNPCANG GQCLPFEASY ICGCPPGFHG
160 170 180 190 200
PTCKQDINEC SQSPGLCRNG GTCHNEVGSY RCACRATHTG PHCELPYVPC
210 220 230 240 250
SPSPCQNGGT CRPTGDTTHE CACLPGFTGQ NCEENIDDCP GNSCKNGGAC
260 270 280 290 300
VDGVNTYNCR CPPEWTGMYC TEDVDECQLM PNACQNGGTC HNSHGGYNCV
310 320 330 340 350
CVNGWTGEDC SENIDDCASA SCFHGATCHD RVASFYCECP HGRTGLLCHL
360 370 380 390 400
NDACISNPCN EGSNCDTNPV NGKAICTCPS GYTGPACSQD VDECSLGANP
410 420 430 440 450
CEHAGKCINT LGSFECQCLQ GYTGPRCEID VNECVSNPCQ NDATCLDQIG
460 470 480 490 500
EFQCICMPGY EGVHCEVNTD ECASSPCLQN GRCLDKINEF LCECPTGQAG
510 520 530 540 550
HLAAYAHWGC PSLPCPPGLS LRGGPVCHRG GPGAHQAHRH CRSEPWASRD
560 570 580 590 600
DGVATFTCLC RPGYTGHHCE TNINECHSQP CRHGGTCQDR DNAYLCFCLK
610 620 630 640 650
GTTGPNCEIN LDDCASNPCD SGTCLDKIDG YECACEPGYT GSMCNINIDE
660 670 680 690 700
CAGNPCHNGG TCEDGINGFT CRCPEGYHDP TCLSEVNECN SDPCIHGACR
710 720 730 740 750
DSLNGYKCDC DPGWSGANCD INNNECESNP CVNGGTCKDM TSGYVCTCRE
760 770 780 790 800
GFSGPNCQTN INECASNPCL NQGTCIDDVA GYKCNCLLPY TGATCEVVLA
810 820 830 840 850
PCAPGPCRNG GECRESEDFE SFSCVCPVGW QGQTCEIDIN ECVKSPCRHG
860 870 880 890 900
ASCQNTNGGY RCHCQAGYTG RNCETDIDDC RPNPCHNGGS CTDGINAAFC
910 920 930 940 950
DCLPGFQGAF CEEDINECAS SPCRNGANCT DCVDSYTCTC PPGFGGIHCE
960 970 980 990 1000
NNTPDCTESS CFNGGTCVDG INSFTCLCPP GFTGSYCQHD VNECDSRPCL
1010 1020 1030 1040 1050
HGGTCQDSYG TYKCTCPQGY TGLNCQSLVR WCDSSPCKNG GKCWQTNALY
1060 1070 1080 1090 1100
RCECHSGWTG LYCDVPSVSC EVAARLQDVN VSRLCRNGGL CENEGSTHHC
1110 1120 1130 1140 1150
HCQAGYTGSY CEDQVDECSP SPCQNGATCT DYPGGYSCEC VAGYHGVNCS
1160 1170 1180 1190 1200
EEINECLSHP CQNGGTCIDL TNSYKCSCPR GTQGVHCEIN MDDCTPPVDP
1210 1220 1230 1240 1250
VSRGPKCFNN GTCVDQVGGY SCTCPPGFVG ERCEGDVNEC LSNPCDARGT
1260 1270 1280 1290 1300
QNCVQRVNDF HCECRAGHTG RRCESVINGC KGKPCKNGGT CAVASNTARG
1310 1320 1330 1340 1350
FICRCPAGYE GATCENDARA CGSLRCLNGG TCISGPRSPT CLCLGPFTGP
1360 1370 1380 1390 1400
ECQFPASSPC VGGNPCYNQG TCEPTSESPF YRCLCPAKFN GLLCHILDYS
1410 1420 1430 1440 1450
FGGGVGLDIP PPQIEEACEL PACREEAGNK VCSVRCNNHA CGWDGGDCSL
1460 1470 1480 1490 1500
NFNDPWQNCT QSLQCWKYFS NGHCDSQCNS AGCLFDGFDC QRAEGQCNPL
1510 1520 1530 1540 1550
YDQYCKDHFS DGHCDQGCNS AECEWDGLDC AEHVPERLAA GTLVVVVLMP
1560 1570 1580 1590 1600
PEQLRNNSFH FLRELSRLLH TNVVFKRDAS GQQMIFPYYG REEELRKHPI
1610 1620 1630 1640 1650
RRSVDGWATP GSLLGHMKAS LLPGSGGGRQ RRELDPMDIR GSIVYLEIDN
1660 1670 1680 1690 1700
RQCVQSSSQC FQSTTDVAAF LGALASLGSL NIPYKIEAVQ SESVEPPPPP
1710 1720 1730 1740 1750
PLHFMYVAVA AFVLLFFVGC GVLLSRKRRR QHGQLWFPEG FKVSEASKKK
1760 1770 1780 1790 1800
RREPLGEDSV GLKPLKNASD GALMDDNQNE WGDEDLETKK FRFEESVVLP
1810 1820 1830 1840 1850
DLDDQTDHRQ WTQQHLDAAD LRVSAMAPTP PQGEADTDCM DVNVRGPDGF
1860 1870 1880 1890 1900
TPLMIASCSG GGLETGNSEE EEDAPAVISD FIYQGASLHN QTDRTGETAL
1910 1920 1930 1940 1950
HLAARYSRSD AAKRLLEASA DANIQDNMGR TPLHAAVSAD AQGVFQILIR
1960 1970 1980 1990 2000
NRATDLDARM HDGTTPLILA ARLAVEGMLE DLINSHADVN AVDDLGKSAL
2010 2020 2030 2040 2050
HWAAAVNNVE AAIVLLKNGA NKDMQNNKEE TPLFLAAREG SYETAKVLLD
2060 2070 2080 2090 2100
HFANRDITDH MDRLPRDIAQ ERMHHDIVRL LDEYSLVRSP QLHGATLGGT
2110 2120 2130 2140 2150
PTLSPPLCSP NGYLGNLKPT VQGKKARKPS TKGLACGGKE AKDLKARRKK
2160 2170 2180 2190 2200
SQDGKGCLLD SSSVLSPVDS LESPHGYLSD VASPPLLPSP FQQSPSVPLN
2210 2220 2230 2240 2250
HLPGMPDTHL GVSHLSVAAK PEMATLGGGG RLAFEAGPPR LSHLPVASST
2260 2270 2280 2290 2300
STVLGPGGGS GVMNFTVGGA TGLNSQCEWL SRLQNGLVPN QYNPLRGSVA
2310 2320 2330 2340 2350
PSTLSTQAPA LQHGMMGPMH GGLSASALSQ MMSYQALPNT RLATQPHLVQ
2360 2370 2380 2390 2400
TQQLQQQQQQ QQPQQNLQPP NIQPQQNLQP QPPPPHLGVS SAANGHMGRS
2410 2420 2430 2440 2450
FLGGEPSQAD VQPLGPSSLA VHTILPQDSQ VLPTSLPSSL APPMTTAQFL
2460 2470 2480 2490 2500
TPPSQHSYSS SPVDNTPSHQ LQVPEHPFLT PSPESPDQWS SSSPHSNISD
2510 2520
WSEGISSPPT SMQSQIAHIP EAFK
Length:2,524
Mass (Da):269,260
Last modified:July 27, 2011 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iB14C180F6F7ED3B3
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F6TJ52F6TJ52_HORSE
Notch 1
NOTCH1
2,493Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSECAT00000024936; ENSECAP00000020734; ENSECAG00000022405

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

3D structure databases

Database of comparative protein structure models

More...
ModBasei
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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Protein-protein interaction databases

STRINGi9796.ENSECAP00000020734

Proteomic databases

PaxDbiF6TZ18

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSECAT00000024936; ENSECAP00000020734; ENSECAG00000022405

Organism-specific databases

VGNCiVGNC:20817 NOTCH1

Phylogenomic databases

eggNOGiENOG410IR7G Eukaryota
COG0666 LUCA
GeneTreeiENSGT00940000157157
InParanoidiF6TZ18
OMAiGRDCESK
TreeFamiTF351641

Gene expression databases

BgeeiENSECAG00000022405 Expressed in 3 organ(s), highest expression level in adult mammalian kidney
ExpressionAtlasiF6TZ18 baseline

Family and domain databases

CDDicd00204 ANK, 2 hits
Gene3Di1.25.40.20, 1 hit
InterProiView protein in InterPro
IPR002110 Ankyrin_rpt
IPR020683 Ankyrin_rpt-contain_dom
IPR036770 Ankyrin_rpt-contain_sf
IPR024600 DUF3454_notch
IPR001881 EGF-like_Ca-bd_dom
IPR013032 EGF-like_CS
IPR000742 EGF-like_dom
IPR000152 EGF-type_Asp/Asn_hydroxyl_site
IPR018097 EGF_Ca-bd_CS
IPR009030 Growth_fac_rcpt_cys_sf
IPR008297 Notch
IPR035993 Notch-like_dom_sf
IPR022362 Notch_1
IPR000800 Notch_dom
IPR010660 Notch_NOD_dom
IPR011656 Notch_NODP_dom
PfamiView protein in Pfam
PF12796 Ank_2, 2 hits
PF11936 DUF3454, 1 hit
PF00008 EGF, 23 hits
PF07645 EGF_CA, 4 hits
PF12661 hEGF, 3 hits
PF06816 NOD, 1 hit
PF07684 NODP, 1 hit
PF00066 Notch, 3 hits
PIRSFiPIRSF002279 Notch, 1 hit
PRINTSiPR01452 LNOTCHREPEAT
PR01984 NOTCH1
SMARTiView protein in SMART
SM00248 ANK, 6 hits
SM01334 DUF3454, 1 hit
SM00181 EGF, 35 hits
SM00179 EGF_CA, 31 hits
SM00004 NL, 3 hits
SM01338 NOD, 1 hit
SM01339 NODP, 1 hit
SUPFAMiSSF48403 SSF48403, 1 hit
SSF57184 SSF57184, 5 hits
SSF90193 SSF90193, 3 hits
PROSITEiView protein in PROSITE
PS50297 ANK_REP_REGION, 1 hit
PS50088 ANK_REPEAT, 4 hits
PS00010 ASX_HYDROXYL, 20 hits
PS00022 EGF_1, 33 hits
PS01186 EGF_2, 26 hits
PS50026 EGF_3, 35 hits
PS01187 EGF_CA, 9 hits
PS50258 LNR, 3 hits

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiF6TZ18_HORSE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: F6TZ18
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: July 27, 2011
Last sequence update: July 27, 2011
Last modified: January 16, 2019
This is version 64 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
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