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Protein

Galactose-1-phosphate uridylyltransferase

Gene

GALT

Organism
Equus caballus (Horse)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

UDP-alpha-D-glucose + alpha-D-galactose 1-phosphate = alpha-D-glucose 1-phosphate + UDP-alpha-D-galactose.PROSITE-ProRule annotation

Cofactori

Fe cationUniRule annotationNote: Binds 1 Fe cation per subunit.UniRule annotation

Pathwayi: galactose metabolism

This protein is involved in the pathway galactose metabolism, which is part of Carbohydrate metabolism.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway galactose metabolism and in Carbohydrate metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi184ZincPROSITE-ProRule annotation1
Active sitei186Tele-UMP-histidine intermediateUniRule annotation1
Metal bindingi202IronUniRule annotation1
Metal bindingi301IronUniRule annotation1
Metal bindingi319IronUniRule annotation1
Metal bindingi321IronUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionNucleotidyltransferaseUniRule annotation, Transferase
Biological processCarbohydrate metabolism, Galactose metabolismUniRule annotation
LigandIronUniRule annotation, Metal-bindingUniRule annotation

Enzyme and pathway databases

UniPathwayi
UPA00214

Names & Taxonomyi

Protein namesi
Recommended name:
Galactose-1-phosphate uridylyltransferaseUniRule annotation (EC:2.7.7.12UniRule annotation)
Gene namesi
Name:GALTImported
OrganismiEquus caballus (Horse)Imported
Taxonomic identifieri9796 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaPerissodactylaEquidaeEquus
Proteomesi
  • UP000002281 Componenti: Chromosome 23

Organism-specific databases

VGNCiVGNC:18238 GALT

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Proteomic databases

PaxDbiF6TXX5

Expressioni

Gene expression databases

BgeeiENSECAG00000008176 Expressed in 3 organ(s), highest expression level in liver

Interactioni

Protein-protein interaction databases

STRINGi9796.ENSECAP00000006460

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini24 – 196GalP_UDP_transfInterPro annotationAdd BLAST173
Domaini203 – 368GalP_UDP_tr_CInterPro annotationAdd BLAST166

Sequence similaritiesi

Belongs to the galactose-1-phosphate uridylyltransferase type 1 family.UniRule annotation

Phylogenomic databases

eggNOGiKOG2958 Eukaryota
COG1085 LUCA
GeneTreeiENSGT00390000016188
InParanoidiF6TXX5
OMAiHAIYYPP
OrthoDBiEOG091G0ER8
TreeFamiTF300018

Family and domain databases

CDDicd00608 GalT, 1 hit
Gene3Di3.30.428.10, 2 hits
InterProiView protein in InterPro
IPR001937 GalP_UDPtransf1
IPR019779 GalP_UDPtransf1_His-AS
IPR005850 GalP_Utransf_C
IPR005849 GalP_Utransf_N
IPR036265 HIT-like_sf
PANTHERiPTHR11943 PTHR11943, 1 hit
PfamiView protein in Pfam
PF02744 GalP_UDP_tr_C, 1 hit
PF01087 GalP_UDP_transf, 1 hit
PIRSFiPIRSF000808 GalT, 1 hit
SUPFAMiSSF54197 SSF54197, 2 hits
TIGRFAMsiTIGR00209 galT_1, 1 hit
PROSITEiView protein in PROSITE
PS00117 GAL_P_UDP_TRANSF_I, 1 hit

Sequencei

Sequence statusi: Complete.

F6TXX5-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSRNEEGPEQ RQQASEADAT ATAFRASEHQ HIRYNPLQDE WVLVSAHRMK
60 70 80 90 100
RPWQGQVEPS LLKTVPRHDP HNPLCPGATR ANGEVNPHYD GTFLFDNDFP
110 120 130 140 150
ALQPDAPNPG PSDHPLFQAE AARGVCKVMC FHPWSDVTLP LMSVPEIRAV
160 170 180 190 200
VDAWASVIEE LGAQYPWVQI FENKGAMMGC SNPHPHCQVW ASSFLPDVAQ
210 220 230 240 250
REERSQQAYQ SQHGEPLLME YGRQELLRKE RLVLTSEHWL VLVPFWAVWP
260 270 280 290 300
FQTLLLPRRH VRRLPELTSA ERDDLASIMK KLLTKYDNLF ETSFPYSMGW
310 320 330 340 350
HGAPTGSEAG ANWDHWQLHA HYYPPLLRSA TVRKFMVGYE MLAQAQRDLT
360 370
PEQAAERLRA LPEVHYSLGQ KDRETAAIA
Length:379
Mass (Da):43,273
Last modified:July 27, 2011 - v1
Checksum:i174C7E88D2CC23FC
GO

Sequence databases

RefSeqiXP_005605132.1, XM_005605075.2

Genome annotation databases

EnsembliENSECAT00000008606; ENSECAP00000006460; ENSECAG00000008176
GeneIDi100068493

Similar proteinsi

Cross-referencesi

Sequence databases

RefSeqiXP_005605132.1, XM_005605075.2

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9796.ENSECAP00000006460

Proteomic databases

PaxDbiF6TXX5

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSECAT00000008606; ENSECAP00000006460; ENSECAG00000008176
GeneIDi100068493

Organism-specific databases

CTDi2592
VGNCiVGNC:18238 GALT

Phylogenomic databases

eggNOGiKOG2958 Eukaryota
COG1085 LUCA
GeneTreeiENSGT00390000016188
InParanoidiF6TXX5
OMAiHAIYYPP
OrthoDBiEOG091G0ER8
TreeFamiTF300018

Enzyme and pathway databases

UniPathwayi
UPA00214

Gene expression databases

BgeeiENSECAG00000008176 Expressed in 3 organ(s), highest expression level in liver

Family and domain databases

CDDicd00608 GalT, 1 hit
Gene3Di3.30.428.10, 2 hits
InterProiView protein in InterPro
IPR001937 GalP_UDPtransf1
IPR019779 GalP_UDPtransf1_His-AS
IPR005850 GalP_Utransf_C
IPR005849 GalP_Utransf_N
IPR036265 HIT-like_sf
PANTHERiPTHR11943 PTHR11943, 1 hit
PfamiView protein in Pfam
PF02744 GalP_UDP_tr_C, 1 hit
PF01087 GalP_UDP_transf, 1 hit
PIRSFiPIRSF000808 GalT, 1 hit
SUPFAMiSSF54197 SSF54197, 2 hits
TIGRFAMsiTIGR00209 galT_1, 1 hit
PROSITEiView protein in PROSITE
PS00117 GAL_P_UDP_TRANSF_I, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiF6TXX5_HORSE
AccessioniPrimary (citable) accession number: F6TXX5
Entry historyiIntegrated into UniProtKB/TrEMBL: July 27, 2011
Last sequence update: July 27, 2011
Last modified: October 10, 2018
This is version 50 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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