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Entry version 74 (29 Sep 2021)
Sequence version 2 (10 Apr 2019)
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Protein
Submitted name:

Vav guanine nucleotide exchange factor 2

Gene

VAV2

Organism
Equus caballus (Horse)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionGuanine-nucleotide releasing factorARBA annotation
LigandMetal-binding, Zinc

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Vav guanine nucleotide exchange factor 2Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:VAV2Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiEquus caballus (Horse)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9796 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaPerissodactylaEquidaeEquus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002281 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 25

Organism-specific databases

Vertebrate Gene Nomenclature Database

More...
VGNCi
VGNC:24889, VAV2

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Keywords - PTMi

PhosphoproteinARBA annotation

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
F6TWZ5

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSECAG00000015126, Expressed in articular cartilage of joint and 24 other tissues

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1 – 120Calponin-homology (CH)InterPro annotationAdd BLAST120
Domaini170 – 348DHInterPro annotationAdd BLAST179
Domaini377 – 479PHInterPro annotationAdd BLAST103
Domaini490 – 539Phorbol-ester/DAG-typeInterPro annotationAdd BLAST50
Domaini554 – 620SH3InterPro annotationAdd BLAST67
Domaini641 – 735SH2InterPro annotationAdd BLAST95
Domaini784 – 845SH3InterPro annotationAdd BLAST62

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili262 – 282Sequence analysisAdd BLAST21

Keywords - Domaini

Coiled coilSequence analysis, SH2 domainPROSITE-ProRule annotationARBA annotation, SH3 domainPROSITE-ProRule annotationARBA annotation, Zinc-fingerARBA annotation

Phylogenomic databases

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000159718

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
F6TWZ5

Identification of Orthologs from Complete Genome Data

More...
OMAi
MYTFDRT

TreeFam database of animal gene trees

More...
TreeFami
TF316171

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00029, C1, 1 hit
cd00014, CH, 1 hit
cd01223, PH_Vav, 1 hit
cd00160, RhoGEF, 1 hit
cd10406, SH2_Vav2, 1 hit
cd11980, SH3_VAV2_1, 1 hit
cd11977, SH3_VAV2_2, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.418.10, 1 hit
1.20.900.10, 1 hit
2.30.29.30, 1 hit
3.30.505.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR022613, CAMSAP_CH
IPR001715, CH-domain
IPR036872, CH_dom_sf
IPR035899, DBL_dom_sf
IPR000219, DH-domain
IPR001331, GDS_CDC24_CS
IPR002219, PE/DAG-bd
IPR011993, PH-like_dom_sf
IPR001849, PH_domain
IPR037832, PH_Vav
IPR000980, SH2
IPR036860, SH2_dom_sf
IPR036028, SH3-like_dom_sf
IPR001452, SH3_domain
IPR035880, VAV2_SH2
IPR035733, VAV2_SH3_1
IPR035732, VAV2_SH3_2

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00130, C1_1, 1 hit
PF11971, CAMSAP_CH, 1 hit
PF00169, PH, 1 hit
PF00621, RhoGEF, 1 hit
PF00017, SH2, 1 hit
PF07653, SH3_2, 2 hits

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00401, SH2DOMAIN
PR00452, SH3DOMAIN

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00109, C1, 1 hit
SM00033, CH, 1 hit
SM00233, PH, 1 hit
SM00325, RhoGEF, 1 hit
SM00252, SH2, 1 hit
SM00326, SH3, 2 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF47576, SSF47576, 1 hit
SSF48065, SSF48065, 1 hit
SSF50044, SSF50044, 2 hits
SSF55550, SSF55550, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50021, CH, 1 hit
PS00741, DH_1, 1 hit
PS50010, DH_2, 1 hit
PS50003, PH_DOMAIN, 1 hit
PS50001, SH2, 1 hit
PS50002, SH3, 2 hits
PS00479, ZF_DAG_PE_1, 1 hit
PS50081, ZF_DAG_PE_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 5 potential isoforms that are computationally mapped.Show allAlign All

F6TWZ5-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEQWRQCGRW LIDCKVLPPN HRVVWPSAVV FDLAQALRDG VLLCQLLHNL
60 70 80 90 100
SPGSIDLKDI NFRPQMSQFL CLKNIRTFLK VCHDKFGLRN SELFDPFDLF
110 120 130 140 150
DVRDFGKVIS AVSRLSLHNV AQNKGISEHD LGEDIYDCVP CEDEGDDIYE
160 170 180 190 200
DIIKVEVQQP MKMGMTEDDK RNCCLLEIQE TEAKYYRTLE DIEKNYMAPL
210 220 230 240 250
RLVLSPADMA AIFINLEDLI KVHHSFLRAI DVSMMAGGST LAKVFLDFKE
260 270 280 290 300
RLLIYGEYCS HMEHAQNTLN QLLAGREDFR QKVEECTLKV QDGKFKLQDL
310 320 330 340 350
LVVPMQRVLK YHLLLKELLS HSTDRPERQQ LKEALEAMQD LAMYINEVKR
360 370 380 390 400
DKETLKKISE FQSSIENLQV KLEEFGRPKI DGELKVRSIV NHTKQDRYLF
410 420 430 440 450
LFDKVVIVCK RRGYSYELKE IIELLFHKMT DDPMNNKDVK KWSYGFYLIH
460 470 480 490 500
LQGKQGFQFF CKTEDMKRKW MEQFEMAMSN IRPDKANANH HSFQMYTFDK
510 520 530 540 550
TTNCKACRMF LRGTFYQGYL CTKCGVGAHK ECLEVTPPCK ISSPADLDTS
560 570 580 590 600
GAGPAGPKMV AVQNYHGNPP PPGKPVLTFQ TGDVIELLRG DPASPWWEGR
610 620 630 640 650
LVQTRKSGYF PSLSVKPCPV DGRPPIGRPP SREIDYTAYP WFAGNMERQQ
660 670 680 690 700
TDNLLKSHAS GTYLIRERPA EAERFAISIK FNDEVKHIKV VEKDSWIHIT
710 720 730 740 750
EAKKFESLLE LVEYYQCHSL KESFKQLDTT LKYPYKARER AASRASSRSP
760 770 780 790 800
ASCASYNFSL LSPQGLSFAS QGSSAPFWSV FTPRVIGTAV ARYNFAARDM
810 820 830 840
RELSLREGDV VKIYSRIGGD QGWWKGETNG RIGWFPSTYV EEEGVQ
Length:846
Mass (Da):97,287
Last modified:April 10, 2019 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i7D856CC6C80B33EB
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A5F5Q0A3A0A5F5Q0A3_HORSE
Vav guanine nucleotide exchange fac...
VAV2
879Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F6TWI8F6TWI8_HORSE
Vav guanine nucleotide exchange fac...
VAV2
850Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F6TWV8F6TWV8_HORSE
Vav guanine nucleotide exchange fac...
VAV2
874Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A3Q2HNQ8A0A3Q2HNQ8_HORSE
Vav guanine nucleotide exchange fac...
VAV2
844Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A5F5PQZ9A0A5F5PQZ9_HORSE
Vav guanine nucleotide exchange fac...
VAV2
874Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSECAT00000017052; ENSECAP00000013813; ENSECAG00000015126

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Proteomic databases

PaxDbiF6TWZ5

Genome annotation databases

EnsembliENSECAT00000017052; ENSECAP00000013813; ENSECAG00000015126

Organism-specific databases

VGNCiVGNC:24889, VAV2

Phylogenomic databases

GeneTreeiENSGT00940000159718
InParanoidiF6TWZ5
OMAiMYTFDRT
TreeFamiTF316171

Gene expression databases

BgeeiENSECAG00000015126, Expressed in articular cartilage of joint and 24 other tissues

Family and domain databases

CDDicd00029, C1, 1 hit
cd00014, CH, 1 hit
cd01223, PH_Vav, 1 hit
cd00160, RhoGEF, 1 hit
cd10406, SH2_Vav2, 1 hit
cd11980, SH3_VAV2_1, 1 hit
cd11977, SH3_VAV2_2, 1 hit
Gene3Di1.10.418.10, 1 hit
1.20.900.10, 1 hit
2.30.29.30, 1 hit
3.30.505.10, 1 hit
InterProiView protein in InterPro
IPR022613, CAMSAP_CH
IPR001715, CH-domain
IPR036872, CH_dom_sf
IPR035899, DBL_dom_sf
IPR000219, DH-domain
IPR001331, GDS_CDC24_CS
IPR002219, PE/DAG-bd
IPR011993, PH-like_dom_sf
IPR001849, PH_domain
IPR037832, PH_Vav
IPR000980, SH2
IPR036860, SH2_dom_sf
IPR036028, SH3-like_dom_sf
IPR001452, SH3_domain
IPR035880, VAV2_SH2
IPR035733, VAV2_SH3_1
IPR035732, VAV2_SH3_2
PfamiView protein in Pfam
PF00130, C1_1, 1 hit
PF11971, CAMSAP_CH, 1 hit
PF00169, PH, 1 hit
PF00621, RhoGEF, 1 hit
PF00017, SH2, 1 hit
PF07653, SH3_2, 2 hits
PRINTSiPR00401, SH2DOMAIN
PR00452, SH3DOMAIN
SMARTiView protein in SMART
SM00109, C1, 1 hit
SM00033, CH, 1 hit
SM00233, PH, 1 hit
SM00325, RhoGEF, 1 hit
SM00252, SH2, 1 hit
SM00326, SH3, 2 hits
SUPFAMiSSF47576, SSF47576, 1 hit
SSF48065, SSF48065, 1 hit
SSF50044, SSF50044, 2 hits
SSF55550, SSF55550, 1 hit
PROSITEiView protein in PROSITE
PS50021, CH, 1 hit
PS00741, DH_1, 1 hit
PS50010, DH_2, 1 hit
PS50003, PH_DOMAIN, 1 hit
PS50001, SH2, 1 hit
PS50002, SH3, 2 hits
PS00479, ZF_DAG_PE_1, 1 hit
PS50081, ZF_DAG_PE_2, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiF6TWZ5_HORSE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: F6TWZ5
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: July 27, 2011
Last sequence update: April 10, 2019
Last modified: September 29, 2021
This is version 74 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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