UniProtKB - F6TVD7 (F6TVD7_HORSE)
Protein
Receptor protein-tyrosine kinase
Gene
EPHA8
Organism
Equus caballus (Horse)
Status
Functioni
Catalytic activityi
- EC:2.7.10.1ARBA annotation
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 667 | ATPUniRule annotation | 1 | |
Active sitei | 760 | Proton acceptorUniRule annotation | 1 |
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 641 – 649 | ATPUniRule annotation | 9 |
GO - Molecular functioni
- ATP binding Source: UniProtKB-KW
- GPI-linked ephrin receptor activity Source: Ensembl
- transmembrane-ephrin receptor activity Source: GO_Central
- transmembrane receptor protein tyrosine kinase activity Source: GO_Central
GO - Biological processi
- axon guidance Source: GO_Central
- cellular response to follicle-stimulating hormone stimulus Source: Ensembl
- multicellular organism development Source: GO_Central
- neuron remodeling Source: Ensembl
- positive regulation of kinase activity Source: GO_Central
- positive regulation of MAPK cascade Source: Ensembl
- positive regulation of phosphatidylinositol 3-kinase activity Source: Ensembl
- protein autophosphorylation Source: Ensembl
- regulation of cell adhesion mediated by integrin Source: Ensembl
- substrate-dependent cell migration Source: Ensembl
- transmembrane receptor protein tyrosine kinase signaling pathway Source: GO_Central
Keywordsi
Molecular function | Kinase, ReceptorARBA annotation, Transferase, Tyrosine-protein kinaseARBA annotation |
Ligand | ATP-bindingUniRule annotationARBA annotation, Nucleotide-binding |
Names & Taxonomyi
Protein namesi | |
Gene namesi | Name:EPHA8Imported |
Organismi | Equus caballus (Horse)Imported |
Taxonomic identifieri | 9796 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Perissodactyla › Equidae › Equus › |
Proteomesi |
|
Organism-specific databases
VGNCi | VGNC:17622, EPHA8 |
Subcellular locationi
Other locations
- Membrane ARBA annotation; Single-pass type I membrane protein ARBA annotation
Plasma Membrane
- integral component of plasma membrane Source: GO_Central
Other locations
- neuron projection Source: GO_Central
- receptor complex Source: GO_Central
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 543 – 562 | HelicalSequence analysisAdd BLAST | 20 |
Keywords - Cellular componenti
MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 27 | Sequence analysisAdd BLAST | 27 | |
ChainiPRO_5018529400 | 28 – 1002 | Receptor protein-tyrosine kinaseSequence analysisAdd BLAST | 975 |
Keywords - PTMi
Disulfide bondARBA annotation, GlycoproteinARBA annotation, PhosphoproteinARBA annotationProteomic databases
PaxDbi | F6TVD7 |
Expressioni
Gene expression databases
Bgeei | ENSECAG00000022132, Expressed in cerebellum and 4 other tissues |
ExpressionAtlasi | F6TVD7, baseline |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 31 – 209 | Eph LBDInterPro annotationAdd BLAST | 179 | |
Domaini | 328 – 438 | Fibronectin type-IIIInterPro annotationAdd BLAST | 111 | |
Domaini | 439 – 534 | Fibronectin type-IIIInterPro annotationAdd BLAST | 96 | |
Domaini | 635 – 896 | Protein kinaseInterPro annotationAdd BLAST | 262 | |
Domaini | 931 – 991 | SAMInterPro annotationAdd BLAST | 61 |
Keywords - Domaini
RepeatARBA annotation, SignalSequence analysis, Transmembrane, Transmembrane helixSequence analysisARBA annotationPhylogenomic databases
GeneTreei | ENSGT00940000160469 |
HOGENOMi | CLU_000288_141_4_1 |
InParanoidi | F6TVD7 |
TreeFami | TF315608 |
Family and domain databases
CDDi | cd10486, EphR_LBD_A8, 1 hit cd00063, FN3, 2 hits |
Gene3Di | 1.10.150.50, 1 hit 2.60.120.260, 1 hit 2.60.40.10, 2 hits |
InterProi | View protein in InterPro IPR027936, Eph_TM IPR034287, EphA8_rcpt_lig-bd IPR001090, Ephrin_rcpt_lig-bd_dom IPR003961, FN3_dom IPR036116, FN3_sf IPR008979, Galactose-bd-like_sf IPR009030, Growth_fac_rcpt_cys_sf IPR013783, Ig-like_fold IPR011009, Kinase-like_dom_sf IPR000719, Prot_kinase_dom IPR017441, Protein_kinase_ATP_BS IPR001660, SAM IPR013761, SAM/pointed_sf IPR001245, Ser-Thr/Tyr_kinase_cat_dom IPR011641, Tyr-kin_ephrin_A/B_rcpt-like IPR008266, Tyr_kinase_AS IPR020635, Tyr_kinase_cat_dom IPR016257, Tyr_kinase_ephrin_rcpt IPR001426, Tyr_kinase_rcpt_V_CS |
Pfami | View protein in Pfam PF14575, EphA2_TM, 1 hit PF01404, Ephrin_lbd, 1 hit PF00041, fn3, 2 hits PF07714, PK_Tyr_Ser-Thr, 1 hit PF00536, SAM_1, 1 hit |
PIRSFi | PIRSF000666, TyrPK_ephrin_receptor, 1 hit |
PRINTSi | PR00109, TYRKINASE |
SMARTi | View protein in SMART SM00615, EPH_lbd, 1 hit SM01411, Ephrin_rec_like, 1 hit SM00060, FN3, 2 hits SM00454, SAM, 1 hit SM00219, TyrKc, 1 hit |
SUPFAMi | SSF47769, SSF47769, 1 hit SSF49265, SSF49265, 1 hit SSF49785, SSF49785, 1 hit SSF56112, SSF56112, 1 hit SSF57184, SSF57184, 1 hit |
PROSITEi | View protein in PROSITE PS51550, EPH_LBD, 1 hit PS50853, FN3, 2 hits PS00107, PROTEIN_KINASE_ATP, 1 hit PS50011, PROTEIN_KINASE_DOM, 1 hit PS00109, PROTEIN_KINASE_TYR, 1 hit PS00790, RECEPTOR_TYR_KIN_V_1, 1 hit PS00791, RECEPTOR_TYR_KIN_V_2, 1 hit PS50105, SAM_DOMAIN, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
F6TVD7-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MAPARGRLSL ALWVVTAAAA AATCVSAARG EVNLLDTSTI HGDWGWLTYP
60 70 80 90 100
AHGWDSINEV DESFRPIHTY QVCNVMSPNQ NNWLRTSWVP RDGARRVYAE
110 120 130 140 150
IKFTLRDCNS MPGVLGTCKE TFNLYYLESD RDLGSSTQES QFLKIDTIAA
160 170 180 190 200
DESFTGADLG VRRLKLNTEV RGVGPLSKRG FYLAFQDIGA CLAILSLRIY
210 220 230 240 250
YKKCPTMVRN LAAFSEAVTG ADSSSLVEVR GQCVRHSEER DTPKMYCSAE
260 270 280 290 300
GEWLVPIGKC VCSAGYEERR DACVACELGF YKSAPGDQLC ARCPPHSHSA
310 320 330 340 350
APAAQACRCD LSYYRAALDP PSAACTRPPS APVNLISSVN GTSVTLEWAP
360 370 380 390 400
PLDPGGRSDI TYNAVCRRCP WTLDHCETCG SGTRFVPQQT SLVQASLLVA
410 420 430 440 450
NLLAHMNYSF WIEAVNGVSD LSPEPRRAAV VNITTNQAAP SQVVVIRQER
460 470 480 490 500
AGQTSVSLLW QEPEQPNGII LEYEIKYYEK DKEMQSYSTL KAVTTRATVS
510 520 530 540 550
GLKPGTRYVF QVRARTSAGC GRFSQAMEVE TGKPRPRYDT RTIVWICLTL
560 570 580 590 600
ITGLVVLLLL LICKKRHCGY SKAFQDSDEE KMRYQNGQAP PPVFLPLHHP
610 620 630 640 650
PGKIPEPQLC AEPHTYEEPG RAGRSFTREI EASRIHIEKI IGSGESGEVC
660 670 680 690 700
YGWLRVPGQQ DVPVAIKALK AGYTERQRRD FLSEASIMGQ FDHPNIIRLE
710 720 730 740 750
GVVTRGRLAM IVTEYMENGS LDAFLRTHDG QFTVMQLVGM LRGVAAGMRY
760 770 780 790 800
LSDLGYVHRD LAARNVLVDG NLVCKVSDFG LSRVLEDDPD AAYTTTGGKI
810 820 830 840 850
PIRWTAPEAI AFRTFSSASD VWSFGVVMWE VLAYGERPYW NMTNRDVISS
860 870 880 890 900
VEEGYRLPAP MGCPRALHQL MLDCWHKDRA QRPRFSQILS VLDALIRSPE
910 920 930 940 950
TLRATATVSR CPPPAFARSC FDLRGGSGGL TVGDWLDSIR MGRYRDHFAA
960 970 980 990 1000
GGYSSLGMVL RMNAQDVRAL GITLMGHQKK ILGSIQTMRA QLTSTQGPRR
HL
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketA0A3Q2GXZ4 | A0A3Q2GXZ4_HORSE | Receptor protein-tyrosine kinase | EPHA8 | 947 | Annotation score: |
Genome annotation databases
Ensembli | ENSECAT00000024428; ENSECAP00000020293; ENSECAG00000022132 |
Similar proteinsi
Cross-referencesi
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Proteomic databases
PaxDbi | F6TVD7 |
Genome annotation databases
Ensembli | ENSECAT00000024428; ENSECAP00000020293; ENSECAG00000022132 |
Organism-specific databases
VGNCi | VGNC:17622, EPHA8 |
Phylogenomic databases
GeneTreei | ENSGT00940000160469 |
HOGENOMi | CLU_000288_141_4_1 |
InParanoidi | F6TVD7 |
TreeFami | TF315608 |
Gene expression databases
Bgeei | ENSECAG00000022132, Expressed in cerebellum and 4 other tissues |
ExpressionAtlasi | F6TVD7, baseline |
Family and domain databases
CDDi | cd10486, EphR_LBD_A8, 1 hit cd00063, FN3, 2 hits |
Gene3Di | 1.10.150.50, 1 hit 2.60.120.260, 1 hit 2.60.40.10, 2 hits |
InterProi | View protein in InterPro IPR027936, Eph_TM IPR034287, EphA8_rcpt_lig-bd IPR001090, Ephrin_rcpt_lig-bd_dom IPR003961, FN3_dom IPR036116, FN3_sf IPR008979, Galactose-bd-like_sf IPR009030, Growth_fac_rcpt_cys_sf IPR013783, Ig-like_fold IPR011009, Kinase-like_dom_sf IPR000719, Prot_kinase_dom IPR017441, Protein_kinase_ATP_BS IPR001660, SAM IPR013761, SAM/pointed_sf IPR001245, Ser-Thr/Tyr_kinase_cat_dom IPR011641, Tyr-kin_ephrin_A/B_rcpt-like IPR008266, Tyr_kinase_AS IPR020635, Tyr_kinase_cat_dom IPR016257, Tyr_kinase_ephrin_rcpt IPR001426, Tyr_kinase_rcpt_V_CS |
Pfami | View protein in Pfam PF14575, EphA2_TM, 1 hit PF01404, Ephrin_lbd, 1 hit PF00041, fn3, 2 hits PF07714, PK_Tyr_Ser-Thr, 1 hit PF00536, SAM_1, 1 hit |
PIRSFi | PIRSF000666, TyrPK_ephrin_receptor, 1 hit |
PRINTSi | PR00109, TYRKINASE |
SMARTi | View protein in SMART SM00615, EPH_lbd, 1 hit SM01411, Ephrin_rec_like, 1 hit SM00060, FN3, 2 hits SM00454, SAM, 1 hit SM00219, TyrKc, 1 hit |
SUPFAMi | SSF47769, SSF47769, 1 hit SSF49265, SSF49265, 1 hit SSF49785, SSF49785, 1 hit SSF56112, SSF56112, 1 hit SSF57184, SSF57184, 1 hit |
PROSITEi | View protein in PROSITE PS51550, EPH_LBD, 1 hit PS50853, FN3, 2 hits PS00107, PROTEIN_KINASE_ATP, 1 hit PS50011, PROTEIN_KINASE_DOM, 1 hit PS00109, PROTEIN_KINASE_TYR, 1 hit PS00790, RECEPTOR_TYR_KIN_V_1, 1 hit PS00791, RECEPTOR_TYR_KIN_V_2, 1 hit PS50105, SAM_DOMAIN, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | F6TVD7_HORSE | |
Accessioni | F6TVD7Primary (citable) accession number: F6TVD7 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | July 27, 2011 |
Last sequence update: | April 10, 2019 | |
Last modified: | December 2, 2020 | |
This is version 73 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |