UniProtKB - F6TVA0 (F6TVA0_HORSE)
Protein
Submitted name:
5'-nucleotidase, cytosolic II
Gene
NT5C2
Organism
Equus caballus (Horse)
Status
Functioni
Cofactori
Mg2+UniRule annotationNote: Binds 1 Mg2+ ion per subunit.UniRule annotation
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Active sitei | 66 | NucleophileUniRule annotation | 1 | |
Metal bindingi | 66 | MagnesiumUniRule annotation | 1 | |
Active sitei | 68 | Proton donorUniRule annotation | 1 | |
Metal bindingi | 68 | Magnesium; via carbonyl oxygenUniRule annotation | 1 | |
Binding sitei | 141 | Allosteric activator 1UniRule annotation | 1 | |
Binding sitei | 176 | Allosteric activator 2UniRule annotation | 1 | |
Metal bindingi | 373 | MagnesiumUniRule annotation | 1 | |
Binding sitei | 376 | Allosteric activator 2UniRule annotation | 1 | |
Binding sitei | 458 | Allosteric activator 1; via carbonyl oxygenUniRule annotation | 1 | |
Binding sitei | 475 | Allosteric activator 2UniRule annotation | 1 |
GO - Molecular functioni
- hydrolase activity Source: UniProtKB-KW
- metal ion binding Source: UniProtKB-KW
Keywordsi
Molecular function | HydrolaseARBA annotation |
Ligand | MagnesiumUniRule annotationARBA annotation, Metal-bindingUniRule annotationARBA annotation |
Names & Taxonomyi
Protein namesi | Submitted name: 5'-nucleotidase, cytosolic IIImported |
Gene namesi | Name:NT5C2Imported |
Organismi | Equus caballus (Horse)Imported |
Taxonomic identifieri | 9796 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Perissodactyla › Equidae › Equus › |
Proteomesi |
|
Organism-specific databases
VGNCi | VGNC:20913, NT5C2 |
Expressioni
Gene expression databases
Bgeei | ENSECAG00000022574, Expressed in blood and 23 other tissues |
ExpressionAtlasi | F6TVA0, baseline |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 559 – 586 | DisorderedSequence analysisAdd BLAST | 28 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 570 – 586 | AcidicSequence analysisAdd BLAST | 17 |
Sequence similaritiesi
Belongs to the 5'(3')-deoxyribonucleotidase family.ARBA annotation
Phylogenomic databases
GeneTreei | ENSGT00940000162369 |
HOGENOMi | CLU_017845_3_0_1 |
InParanoidi | F6TVA0 |
TreeFami | TF315266 |
Family and domain databases
Gene3Di | 3.40.50.1000, 2 hits |
InterProi | View protein in InterPro IPR036412, HAD-like_sf IPR008380, HAD-SF_hydro_IG_5-nucl IPR023214, HAD_sf IPR016695, Pur_nucleotidase |
PANTHERi | PTHR12103, PTHR12103, 1 hit |
Pfami | View protein in Pfam PF05761, 5_nucleotid, 1 hit |
PIRSFi | PIRSF017434, Purine_5'-nucleotidase, 1 hit |
SUPFAMi | SSF56784, SSF56784, 1 hit |
TIGRFAMsi | TIGR02244, HAD-IG-Ncltidse, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 7 potential isoforms that are computationally mapped.Show allAlign All
F6TVA0-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MAKKYITNSA YKQNKMTSWS DRLQNAADMP ANMDKHALKK YRREAFHRVF
60 70 80 90 100
VNRSLAMEKI KCFGFDMDYT LAVYKSPEYE SLGFELTVER LVSIGYPQEL
110 120 130 140 150
LSFAYDSTFP TRGLVFDTLY GNLLKVDAYG NLLVCAHGFN FIRGSQVAAQ
160 170 180 190 200
KRPETREQYP NKFIQRDDTE RFYILNTLFN LPETYLLACL VDFFTNCPRY
210 220 230 240 250
TSCETGFKDG DLFMSYRSMF QDVRDAVDWV HYKGSLKEKT LENLEKYVVK
260 270 280 290 300
DGKLPLLLSR MKEVGKVFLA TNSDYKYTDK IMTYLFDFPH GPKPGSSHRP
310 320 330 340 350
WQSYFDLILV DARKPLFFGE GTVLRQVDTK TGKLKIGTYT GPLQHGIVYS
360 370 380 390 400
GGSSDTICDL LGAKGKDILY IGDHIFGDIL KSKKRQGWRT FLVIPELAQE
410 420 430 440 450
LHVWTDKSSL FEELQSLDVF LAELYKHLDS SSNERPDISS IQRRIKKVTH
460 470 480 490 500
DMDMCYGMMG SLFRSGSRQT LFASQVMRYA DLYAASFINL LYYPFSYLFR
510 520 530 540 550
AAHVLMPHES TVEHIHVDIN EMESPLATRN RTSVDFKDTD YKRHQLTRSI
560 570 580
SEIKPPNLFP LAPQEITHCH DEDDDEEEEE EEEEEE
Computationally mapped potential isoform sequencesi
There are 7 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketA0A3Q2HN48 | A0A3Q2HN48_HORSE | 5'-nucleotidase, cytosolic II | NT5C2 | 600 | Annotation score: | ||
A0A3Q2GVX1 | A0A3Q2GVX1_HORSE | 5'-nucleotidase, cytosolic II | NT5C2 | 543 | Annotation score: | ||
A0A3Q2HJ75 | A0A3Q2HJ75_HORSE | 5'-nucleotidase, cytosolic II | NT5C2 | 614 | Annotation score: | ||
A0A3Q2HTD4 | A0A3Q2HTD4_HORSE | 5'-nucleotidase, cytosolic II | NT5C2 | 583 | Annotation score: | ||
A0A3Q2I3E1 | A0A3Q2I3E1_HORSE | 5'-nucleotidase, cytosolic II | NT5C2 | 532 | Annotation score: | ||
A0A3Q2I5Y9 | A0A3Q2I5Y9_HORSE | 5'-nucleotidase, cytosolic II | NT5C2 | 522 | Annotation score: | ||
A0A5F5PSS9 | A0A5F5PSS9_HORSE | 5'-nucleotidase, cytosolic II | NT5C2 | 557 | Annotation score: |
Genome annotation databases
Ensembli | ENSECAT00000024433; ENSECAP00000020297; ENSECAG00000022574 |
Similar proteinsi
Cross-referencesi
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Proteomic databases
PaxDbi | F6TVA0 |
PRIDEi | F6TVA0 |
Genome annotation databases
Ensembli | ENSECAT00000024433; ENSECAP00000020297; ENSECAG00000022574 |
Organism-specific databases
VGNCi | VGNC:20913, NT5C2 |
Phylogenomic databases
GeneTreei | ENSGT00940000162369 |
HOGENOMi | CLU_017845_3_0_1 |
InParanoidi | F6TVA0 |
TreeFami | TF315266 |
Gene expression databases
Bgeei | ENSECAG00000022574, Expressed in blood and 23 other tissues |
ExpressionAtlasi | F6TVA0, baseline |
Family and domain databases
Gene3Di | 3.40.50.1000, 2 hits |
InterProi | View protein in InterPro IPR036412, HAD-like_sf IPR008380, HAD-SF_hydro_IG_5-nucl IPR023214, HAD_sf IPR016695, Pur_nucleotidase |
PANTHERi | PTHR12103, PTHR12103, 1 hit |
Pfami | View protein in Pfam PF05761, 5_nucleotid, 1 hit |
PIRSFi | PIRSF017434, Purine_5'-nucleotidase, 1 hit |
SUPFAMi | SSF56784, SSF56784, 1 hit |
TIGRFAMsi | TIGR02244, HAD-IG-Ncltidse, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | F6TVA0_HORSE | |
Accessioni | F6TVA0Primary (citable) accession number: F6TVA0 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | July 27, 2011 |
Last sequence update: | April 10, 2019 | |
Last modified: | October 7, 2020 | |
This is version 54 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |