UniProtKB - F6TT59 (F6TT59_HUMAN)
Protein
Submitted name:
Retinal-specific phospholipid-transporting ATPase ABCA4
Gene
ABCA4
Organism
Homo sapiens (Human)
Status
Functioni
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 764 – 771 | ATPPROSITE-ProRule annotation | 8 |
GO - Molecular functioni
- ATPase-coupled transmembrane transporter activity Source: InterPro
- ATP binding Source: UniProtKB-UniRule
Keywordsi
Ligand | ATP-bindingPROSITE-ProRule annotationARBA annotation, Nucleotide-binding |
Names & Taxonomyi
Protein namesi | Submitted name: Retinal-specific phospholipid-transporting ATPase ABCA4Imported |
Gene namesi | Name:ABCA4Imported |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:34, ABCA4 |
VEuPathDBi | HostDB:ENSG00000198691.11 |
Subcellular locationi
Other locations
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 165 – 186 | HelicalSequence analysisAdd BLAST | 22 | |
Transmembranei | 472 – 494 | HelicalSequence analysisAdd BLAST | 23 | |
Transmembranei | 524 – 541 | HelicalSequence analysisAdd BLAST | 18 | |
Transmembranei | 553 – 571 | HelicalSequence analysisAdd BLAST | 19 | |
Transmembranei | 583 – 608 | HelicalSequence analysisAdd BLAST | 26 |
Keywords - Cellular componenti
MembraneExpressioni
Gene expression databases
Bgeei | ENSG00000198691, Expressed in pigmented layer of retina and 118 other tissues |
ExpressionAtlasi | F6TT59, baseline and differential |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 730 – 962 | ABC transporterInterPro annotationAdd BLAST | 233 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 76 – 137 | DisorderedSequence analysisAdd BLAST | 62 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 119 – 133 | Pro-richSequence analysisAdd BLAST | 15 |
Keywords - Domaini
Transmembrane, Transmembrane helixSequence analysisPhylogenomic databases
GeneTreei | ENSGT00940000155624 |
HOGENOMi | CLU_000604_19_5_1 |
Family and domain databases
InterProi | View protein in InterPro IPR003593, AAA+_ATPase IPR003439, ABC_transporter-like IPR026082, ABCA IPR027417, P-loop_NTPase |
PANTHERi | PTHR19229, PTHR19229, 1 hit |
Pfami | View protein in Pfam PF00005, ABC_tran, 1 hit |
SMARTi | View protein in SMART SM00382, AAA, 1 hit |
SUPFAMi | SSF52540, SSF52540, 1 hit |
PROSITEi | View protein in PROSITE PS50893, ABC_TRANSPORTER_2, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All
F6TT59-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MDVVLHHVPE AKLVECIGQE LIFLLPNKNF KHRAYASLFR ELEETLADLG
60 70 80 90 100
LSSFGISDTP LEEIFLKVTE DSDSGPLFAG GAQQKRENVN PRHPCLGPRE
110 120 130 140 150
KAGQTPQDSN VCSPGAPAAH PEGQPPPEPE CPGPQLNTGT QLVLQHVQAL
160 170 180 190 200
LVKRFQHTIR SHKDFLAQIV LPATFVFLAL MLSIVIPPFG EYPALTLHPW
210 220 230 240 250
IYGQQYTFFS MDEPGSEQFT VLADVLLNKP GFGNRCLKEG WLPEYPCGNS
260 270 280 290 300
TPWKTPSVSP NITQLFQKQK WTQVNPSPSC RCSTREKLTM LPECPEGAGG
310 320 330 340 350
LPPPQRTQRS TEILQDLTDR NISDFLVKTY PALIRSSLKS KFWVNEQRYG
360 370 380 390 400
GISIGGKLPV VPITGEALVG FLSDLGRIMN VSGGPITREA SKEIPDFLKH
410 420 430 440 450
LETEDNIKVW FNNKGWHALV SFLNVAHNAI LRASLPKDRS PEEYGITVIS
460 470 480 490 500
QPLNLTKEQL SEITVLTTSV DAVVAICVIF SMSFVPASFV LYLIQERVNK
510 520 530 540 550
SKHLQFISGV SPTTYWVTNF LWDIMNYSVS AGLVVGIFIG FQKKAYTSPE
560 570 580 590 600
NLPALVALLL LYGWAVIPMM YPASFLFDVP STAYVALSCA NLFIGINSSA
610 620 630 640 650
ITFILELFEN NRTLLRFNAV LRKLLIVFPH FCLGRGLIDL ALSQAVTDVY
660 670 680 690 700
ARFGEEHSAN PFHWDLIGKN LFAMVVEGVV YFLLTLLVQR HFFLSQWIAE
710 720 730 740 750
PTKEPIVDED DDVAEERQRI ITGGNKTDIL RLHELTKIYP GTSSPAVDRL
760 770 780 790 800
CVGVRPGECF GLLGVNGAGK TTTFKMLTGD TTVTSGDATV AGKSILTNIS
810 820 830 840 850
EVHQNMGYCP QFDAIDELLT GREHLYLYAR LRGVPAEEIE KVANWSIKSL
860 870 880 890 900
GLTVYADCLA GTYSGGNKRK LSTAIALIGC PPLVLLDEPT TGMDPQARRM
910 920 930 940 950
LWNVIVSIIR EGRAVVLTSH SMEECEALCT RLAIMVKGAF RCMGTIQHLK
960 970 980 990 1000
SKFGDGYIVT MKIKSPKDDL LPDLNPVEQF FQGNFPGSVQ RERHYNMLQF
1010 1020 1030 1040 1050
QVSSSSLARI FQLLLSHKDS LLIEEYSVTQ TTLDQVFVNF AKQQTESHDL
1060
PLHPRAAGAS RQAQD
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketP78363 | ABCA4_HUMAN | Retinal-specific phospholipid-trans... | ABCA4 ABCR | 2,273 | Annotation score: | ||
A0A3B3IRV8 | A0A3B3IRV8_HUMAN | Retinal-specific phospholipid-trans... | ABCA4 | 979 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC093579 Genomic DNA No translation available. AC105278 Genomic DNA No translation available. |
Genome annotation databases
Ensembli | ENST00000536513; ENSP00000439707; ENSG00000198691 |
UCSCi | uc057ilb.1, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC093579 Genomic DNA No translation available. AC105278 Genomic DNA No translation available. |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Proteomic databases
PeptideAtlasi | F6TT59 |
PRIDEi | F6TT59 |
Protocols and materials databases
Antibodypediai | 33661, 180 antibodies |
Genome annotation databases
Ensembli | ENST00000536513; ENSP00000439707; ENSG00000198691 |
UCSCi | uc057ilb.1, human |
Organism-specific databases
HGNCi | HGNC:34, ABCA4 |
OpenTargetsi | ENSG00000198691 |
VEuPathDBi | HostDB:ENSG00000198691.11 |
GenAtlasi | Search... |
Phylogenomic databases
GeneTreei | ENSGT00940000155624 |
HOGENOMi | CLU_000604_19_5_1 |
Miscellaneous databases
ChiTaRSi | ABCA4, human |
Gene expression databases
Bgeei | ENSG00000198691, Expressed in pigmented layer of retina and 118 other tissues |
ExpressionAtlasi | F6TT59, baseline and differential |
Family and domain databases
InterProi | View protein in InterPro IPR003593, AAA+_ATPase IPR003439, ABC_transporter-like IPR026082, ABCA IPR027417, P-loop_NTPase |
PANTHERi | PTHR19229, PTHR19229, 1 hit |
Pfami | View protein in Pfam PF00005, ABC_tran, 1 hit |
SMARTi | View protein in SMART SM00382, AAA, 1 hit |
SUPFAMi | SSF52540, SSF52540, 1 hit |
PROSITEi | View protein in PROSITE PS50893, ABC_TRANSPORTER_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | F6TT59_HUMAN | |
Accessioni | F6TT59Primary (citable) accession number: F6TT59 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | October 29, 2014 |
Last sequence update: | October 29, 2014 | |
Last modified: | February 10, 2021 | |
This is version 46 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |