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Entry version 58 (29 Sep 2021)
Sequence version 2 (11 Dec 2019)
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Protein

CARD domain-containing protein

Gene

LOC100010741

Organism
Monodelphis domestica (Gray short-tailed opossum)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
CARD domain-containing proteinInterPro annotation
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:LOC100010741Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMonodelphis domestica (Gray short-tailed opossum)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri13616 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaMetatheriaDidelphimorphiaDidelphidaeMonodelphis
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002280 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 4

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

NucleusARBA annotation

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMODG00000000589, Expressed in skeleton of lower jaw and 21 other tissues

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
13616.ENSMODP00000000705

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini436 – 526CARDInterPro annotationAdd BLAST91

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili419 – 439Sequence analysisAdd BLAST21

Keywords - Domaini

Coiled coilSequence analysis, RepeatARBA annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1101, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000154175

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_016347_1_1_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
F6TRQ7

Identification of Orthologs from Complete Genome Data

More...
OMAi
PQCPRVQ

TreeFam database of animal gene trees

More...
TreeFami
TF105356

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00022, BIR, 3 hits
cd14394, UBA_BIRC2_3, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.533.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001370, BIR_rpt
IPR041933, BIRC2/BIRC3_UBA
IPR001315, CARD
IPR011029, DEATH-like_dom_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00653, BIR, 3 hits
PF00619, CARD, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00238, BIR, 3 hits
SM00114, CARD, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF47986, SSF47986, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS01282, BIR_REPEAT_1, 3 hits
PS50143, BIR_REPEAT_2, 3 hits
PS50209, CARD, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

F6TRQ7-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MNLVENIMFL SNMNISNLYE LKYDFSCELY RISTYSAFPV NVPVSERSLA
60 70 80 90 100
RAGFYYTGVN DRVKCFCCGL MLDNWKQGDN AIDKHKQLFP SCAFIQNLTS
110 120 130 140 150
VNNLESNSQS ALSSSLNSAS CSLSPSSEQS GYFSGSYSSF PLEPVTSRGV
160 170 180 190 200
EDLSPLNTSP YSYSMSTEEA RILTYQAWPL TFLSPLDLAR AGFYYIGPGD
210 220 230 240 250
MVACFACGGK LSNWEPKDDA MSEHRRHFPH CPFLESQIQE TSRFNVSNLS
260 270 280 290 300
MQTHAARVKT FVTWPPQIPV HPEQLANAGF YYVGCNDDVK CFCCDGGLRC
310 320 330 340 350
WESGDDPWVE HAKWFPRCEY LIEMKGQQFI NQIQASYPHL LEQLLSTSDV
360 370 380 390 400
PVDENAGLPI IHFGLGENHA EDAVMMNTSA VRSALEMGFQ RRLIKQTVQS
410 420 430 440 450
KILTTGENYK TVSDLVSDLL KAEDETREED EQAEEIESDD LSLIQKNRMA
460 470 480 490 500
LFQHLTCVLP VLNCLLTASV INEQEYDVIK QKTQISLQVR ELIDTIIVKG
510 520 530 540 550
NIAANIFKKC LRDFDPVLYE NLFVEKNMKY IPTEDVSGLP IEEQLRRLQE
560 570 580
ERTVSCMIKE VSVFLSVTSS SLQRMCIFPK KMPYL
Length:585
Mass (Da):66,252
Last modified:December 11, 2019 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i505CCE9B51C73D50
GO

Sequence databases

NCBI Reference Sequences

More...
RefSeqi
XP_016289380.1, XM_016433894.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMODT00000000721; ENSMODP00000000705; ENSMODG00000000589

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
100010741

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
mdo:100010741

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

RefSeqiXP_016289380.1, XM_016433894.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

STRINGi13616.ENSMODP00000000705

Genome annotation databases

EnsembliENSMODT00000000721; ENSMODP00000000705; ENSMODG00000000589
GeneIDi100010741
KEGGimdo:100010741

Phylogenomic databases

eggNOGiKOG1101, Eukaryota
GeneTreeiENSGT00940000154175
HOGENOMiCLU_016347_1_1_1
InParanoidiF6TRQ7
OMAiPQCPRVQ
TreeFamiTF105356

Gene expression databases

BgeeiENSMODG00000000589, Expressed in skeleton of lower jaw and 21 other tissues

Family and domain databases

CDDicd00022, BIR, 3 hits
cd14394, UBA_BIRC2_3, 1 hit
Gene3Di1.10.533.10, 1 hit
InterProiView protein in InterPro
IPR001370, BIR_rpt
IPR041933, BIRC2/BIRC3_UBA
IPR001315, CARD
IPR011029, DEATH-like_dom_sf
PfamiView protein in Pfam
PF00653, BIR, 3 hits
PF00619, CARD, 1 hit
SMARTiView protein in SMART
SM00238, BIR, 3 hits
SM00114, CARD, 1 hit
SUPFAMiSSF47986, SSF47986, 1 hit
PROSITEiView protein in PROSITE
PS01282, BIR_REPEAT_1, 3 hits
PS50143, BIR_REPEAT_2, 3 hits
PS50209, CARD, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiF6TRQ7_MONDO
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: F6TRQ7
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: July 27, 2011
Last sequence update: December 11, 2019
Last modified: September 29, 2021
This is version 58 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteomeImported
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