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Entry version 61 (02 Jun 2021)
Sequence version 2 (11 Dec 2019)
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Protein

DH domain-containing protein

Gene

ARHGEF10

Organism
Monodelphis domestica (Gray short-tailed opossum)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
DH domain-containing proteinInterPro annotation
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ARHGEF10Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMonodelphis domestica (Gray short-tailed opossum)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri13616 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaMetatheriaDidelphimorphiaDidelphidaeMonodelphis
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002280 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMODG00000014194, Expressed in spermatid and 21 other tissues

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
13616.ENSMODP00000017746

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini405 – 592DHInterPro annotationAdd BLAST188

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni20 – 89DisorderedSequence analysisAdd BLAST70
Regioni110 – 134DisorderedSequence analysisAdd BLAST25
Regioni169 – 199DisorderedSequence analysisAdd BLAST31
Regioni1212 – 1241DisorderedSequence analysisAdd BLAST30
Regioni1263 – 1287DisorderedSequence analysisAdd BLAST25

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili291 – 311Sequence analysisAdd BLAST21
Coiled coili315 – 338Sequence analysisAdd BLAST24
Coiled coili575 – 606Sequence analysisAdd BLAST32

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi68 – 82Polar residuesSequence analysisAdd BLAST15
Compositional biasi118 – 132Polar residuesSequence analysisAdd BLAST15
Compositional biasi175 – 189Polar residuesSequence analysisAdd BLAST15

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3522, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000153798

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_001213_1_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
F6TRD9

TreeFam database of animal gene trees

More...
TreeFami
TF331430

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00160, RhoGEF, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.20.900.10, 1 hit
2.130.10.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR030632, ARHGEF10
IPR039919, ARHGEF10/ARHGEF17
IPR035899, DBL_dom_sf
IPR000219, DH-domain
IPR015943, WD40/YVTN_repeat-like_dom_sf
IPR036322, WD40_repeat_dom_sf

The PANTHER Classification System

More...
PANTHERi
PTHR12877, PTHR12877, 1 hit
PTHR12877:SF14, PTHR12877:SF14, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00621, RhoGEF, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00325, RhoGEF, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48065, SSF48065, 1 hit
SSF50978, SSF50978, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50010, DH_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

F6TRD9-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSAKKLIYNY CALENEFKSA TNNNEEEEEQ FDFDSGDEIP EADRQAHLPS
60 70 80 90 100
SESDSKGFAE NKEVPSTGEC SEDGNETGGD NSQAAEAGKL PVHMKVNPYS
110 120 130 140 150
VINITPFQEK EQLSPDPGAE EENSSSSVPS VYSVPVPCGY AVPSNLPLIL
160 170 180 190 200
PAYSSPIIIR TLSVDEEVDT QEVTEESHFN SLSSEDPPNS EDQVNKEDSP
210 220 230 240 250
LAKWVADPAN TAWMENPEEV IYDDVPRENS DSEPEEMIYD DVENGDEGGN
260 270 280 290 300
SSLDYGWSSS EFESYEEQSD SECKNGIPSS FLRGNHKKQL SHDLTRLKEH
310 320 330 340 350
YEKKMKDLMA NTVGAVEIQQ LKQKHELKMQ KLMRAAKEGT KDGLEKTKAA
360 370 380 390 400
VKKGRSFIRT KSFVSNEHRS CLQEEELNLF IDVDCVHTEA IMTPMPEGLS
410 420 430 440 450
QQQVVRRYIL GSVVESEKNY VDALKRILEQ YEKPLSEMEP KVLSERKLKM
460 470 480 490 500
VFYRIKEILQ CHSMFQIALA SRVSEWDSVE MIGDVFVASF SKSMVLDAYS
510 520 530 540 550
EYVNNFSTAV GILKKTCATK PAFLEFLKQC QESSPDRITL YGLMMKPIQR
560 570 580 590 600
FPQFILLLQD MLKNTTKGHP DRLPLQMALT ELETLAEKLN ERKRDADQRC
610 620 630 640 650
EIKQIAKAIN ERYLNKLLSS GNRYLVRSDD MVETVYNDRG EIVKTKERRL
660 670 680 690 700
FMLNDVLMCA TVSARTSHES SGAVSTSQRY LLKWSVPLGH VEVIEYSSGQ
710 720 730 740 750
GQGENSRYPQ AHSTESIIVV ANAKPHKLYM GPGQLYHDLQ NLLHDLNVVG
760 770 780 790 800
QISQLIGNLK GNYQNLNQSV AHDWTSGLQK LIMKKEDEIR AADCCRIQLQ
810 820 830 840 850
LPGKQDKSGR PTFFTAVFNT FTPVIKQSWI NNLQMAKLAL EEENHLGWFC
860 870 880 890 900
VEDDGNQIKK EKHPLLVKHM PVMVAKQQEF KIECAAYNPE PYLGNETEPD
910 920 930 940 950
SFSMQHGFLW IGSCTNQMGQ IAIISFQHSS PKVIECFNVE SRILCMVYIP
960 970 980 990 1000
VDEKHKESKV TSDSETVVGK TSDVPTICLG TEEGSISIYK SSQGSKKVRL
1010 1020 1030 1040 1050
QHFFTPEKST VMSLTCTSQY LYAGLVNGNV VVYTKTEDGS WNSEPQKVVK
1060 1070 1080 1090 1100
LSVLPVRSLL MMEDTIWAAS GGQVFIINIE THSIENHLEA HQEEGMVISH
1110 1120 1130 1140 1150
MAVAGVGIWI AFTSGSTLRL FHTETLKHLQ DINIATPIHH MMSGQQRVSV
1160 1170 1180 1190 1200
TSLLVCHGLL MVGTNLGIIV SLPVPRLQGI PKVTGRGMVS YHAHNGPVKF
1210 1220 1230 1240 1250
LVTATALNRK NNSHSRNSLL PNAEAQDEEQ KDLLPNELPG SCLNQSTPDS
1260 1270 1280 1290 1300
AVWLGDSVGS IPPKSDLSSS SGSLTLSHGS NSLEHGPEDS TIYELLKDPN
1310 1320 1330 1340 1350
IALKGKSHQF KKSKASSVLV ICGGQGHRRV NKKAKQQRQD ELGSSVMVWQ

IPLLNI
Length:1,356
Mass (Da):151,505
Last modified:December 11, 2019 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i0600313D3DA266A5
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A5F8GXK8A0A5F8GXK8_MONDO
DH domain-containing protein
ARHGEF10
1,357Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A5F8G496A0A5F8G496_MONDO
DH domain-containing protein
ARHGEF10
1,318Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

NCBI Reference Sequences

More...
RefSeqi
XP_007476281.1, XM_007476219.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMODT00000018074; ENSMODP00000017746; ENSMODG00000014194

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
100032494

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

RefSeqiXP_007476281.1, XM_007476219.2

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

STRINGi13616.ENSMODP00000017746

Genome annotation databases

EnsembliENSMODT00000018074; ENSMODP00000017746; ENSMODG00000014194
GeneIDi100032494

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
9639

Phylogenomic databases

eggNOGiKOG3522, Eukaryota
GeneTreeiENSGT00940000153798
HOGENOMiCLU_001213_1_0_1
InParanoidiF6TRD9
TreeFamiTF331430

Gene expression databases

BgeeiENSMODG00000014194, Expressed in spermatid and 21 other tissues

Family and domain databases

CDDicd00160, RhoGEF, 1 hit
Gene3Di1.20.900.10, 1 hit
2.130.10.10, 1 hit
InterProiView protein in InterPro
IPR030632, ARHGEF10
IPR039919, ARHGEF10/ARHGEF17
IPR035899, DBL_dom_sf
IPR000219, DH-domain
IPR015943, WD40/YVTN_repeat-like_dom_sf
IPR036322, WD40_repeat_dom_sf
PANTHERiPTHR12877, PTHR12877, 1 hit
PTHR12877:SF14, PTHR12877:SF14, 1 hit
PfamiView protein in Pfam
PF00621, RhoGEF, 1 hit
SMARTiView protein in SMART
SM00325, RhoGEF, 1 hit
SUPFAMiSSF48065, SSF48065, 1 hit
SSF50978, SSF50978, 1 hit
PROSITEiView protein in PROSITE
PS50010, DH_2, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiF6TRD9_MONDO
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: F6TRD9
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: July 27, 2011
Last sequence update: December 11, 2019
Last modified: June 2, 2021
This is version 61 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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