UniProtKB - F6TR44 (F6TR44_HORSE)
Protein
Submitted name:
Chloride channel accessory 2
Gene
CLCA2
Organism
Equus caballus (Horse)
Status
Functioni
GO - Molecular functioni
- intracellular calcium activated chloride channel activity Source: GO_Central
- metal ion binding Source: UniProtKB-KW
- metallopeptidase activity Source: UniProtKB-KW
Keywordsi
Molecular function | Hydrolase, MetalloproteaseARBA annotation, Protease |
Ligand | ChlorideARBA annotation, Metal-bindingARBA annotation, ZincARBA annotation |
Protein family/group databases
MEROPSi | M87.003 |
Names & Taxonomyi
Protein namesi | Submitted name: Chloride channel accessory 2Imported |
Gene namesi | Name:CLCA2Imported |
Organismi | Equus caballus (Horse)Imported |
Taxonomic identifieri | 9796 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Perissodactyla › Equidae › Equus › |
Proteomesi |
|
Organism-specific databases
VGNCi | VGNC:16572, CLCA2 |
Subcellular locationi
Plasma Membrane
- integral component of plasma membrane Source: GO_Central
Keywords - Cellular componenti
MembraneExpressioni
Gene expression databases
Bgeei | ENSECAG00000020901, Expressed in zone of skin and 10 other tissues |
ExpressionAtlasi | F6TR44, baseline |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 311 – 483 | VWFAInterPro annotationAdd BLAST | 173 |
Sequence similaritiesi
Belongs to the CLCR family.ARBA annotation
Keywords - Domaini
SignalSequence analysisARBA annotation, Transmembrane, Transmembrane helixSequence analysisPhylogenomic databases
GeneTreei | ENSGT00940000154682 |
HOGENOMi | CLU_005812_0_1_1 |
InParanoidi | F6TR44 |
TreeFami | TF328396 |
Family and domain databases
Gene3Di | 3.40.50.410, 1 hit |
InterProi | View protein in InterPro IPR004727, CLCA_chordata IPR013642, CLCA_N IPR002035, VWF_A IPR036465, vWFA_dom_sf |
Pfami | View protein in Pfam PF08434, CLCA, 1 hit |
SMARTi | View protein in SMART SM00327, VWA, 1 hit |
SUPFAMi | SSF53300, SSF53300, 1 hit |
TIGRFAMsi | TIGR00868, hCaCC, 1 hit |
PROSITEi | View protein in PROSITE PS50234, VWFA, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show allAlign All
F6TR44-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MTHRDNEGLV CSLKFLILLV ALSPELLSLG AGVQLQDNGY DGLLVAINPQ
60 70 80 90 100
VSEDQNLIPN IKKMITEASF CLFNATKRRV FFRNIKILIP ATWKANNYSK
110 120 130 140 150
AKQESYEKAN VIVTDWYGAH GDDPYTLQYR GCGKEGKYIH FTPDFLLNDD
160 170 180 190 200
LTAGYGSRGK VFVHEWAHLR WGVFDEYNNE KPFYINGQNQ IKVTRCSSDI
210 220 230 240 250
TGIFVCEKGP CPQENCIISK LFKEGCMFIY NSTQNATASI MFMQSLSSVV
260 270 280 290 300
EFCNASTHNP EAPNLQNQMC SLRSAWDVIT DSADFRHSSP MSETKLPPPP
310 320 330 340 350
TFSLLQAGDK VVCLVLDVSS KMAEADRLLR LQQAAEFYLM QIVEIHTFVG
360 370 380 390 400
IASFNSKGEI RAQLHQINND DDRKLLVSYL PATVSAEAET SICSGLKKGF
410 420 430 440 450
EVVEKLNGKA HGSVMVLVTS GDDEHVANCL LTVQSSGSTI HTIDLGSSAV
460 470 480 490 500
ENLEELSHLT GGLKFFVPDK SNSNSMIDAF SRISSGTGDI FQQHIQLEST
510 520 530 540 550
GENVQPHYQL KNTVTMDNSV GNDTAFLVTW QTSGPPEIVL ADPSGRKYYT
560 570 580 590 600
DDFVTNLTLQ TARLRIPGTA KPGLWMYTLN NTHDSLQALK VTVTSRASRS
610 620 630 640 650
AVPPATVEAF VERDSTRFPH PMMIYANVRK GFYPILNATV TATIEPEAGD
660 670 680 690 700
PVMLKLFDDG AGADVIKNDG IYSRYFFSFA VNGRYSLKVH VRHSPSMSSL
710 720 730 740 750
THSVPGSHAM YVPGYIANGN IQMNAPRTSV GRSEEEQKWG FSRISSGGSF
760 770 780 790 800
SVLGVPAGPH TDVFPPCKII DLEAVKVEDQ VTLSWTAPGE DFDEGQANSY
810 820 830 840 850
EIRMSKSLQN IQDDFNNAIL VNTSKLTPQQ AGTKEIFTFS PKLFTEGPKY
860 870 880 890 900
QPEGEAQENH RIYVAIRAID RNSLKSAVSN IAQASLFIPP NSAPVLARDR
910 920 930 940
LILKGILTAM GLIGIICLTI VVTHCILNKK KTADNKENGM KLL
Computationally mapped potential isoform sequencesi
There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketA0A5S7NAP8 | A0A5S7NAP8_HORSE | Chloride channel accessory 2 | CLCA2 | 984 | Annotation score: | ||
A0A3Q2LB28 | A0A3Q2LB28_HORSE | Chloride channel accessory 2 | CLCA2 | 924 | Annotation score: | ||
A0A3Q2HLL2 | A0A3Q2HLL2_HORSE | Chloride channel accessory 2 | CLCA2 | 886 | Annotation score: | ||
A0A5F5PXX5 | A0A5F5PXX5_HORSE | Chloride channel accessory 2 | CLCA2 | 908 | Annotation score: |
Genome annotation databases
Ensembli | ENSECAT00000022336; ENSECAP00000018453; ENSECAG00000020901 |
Similar proteinsi
Cross-referencesi
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein family/group databases
MEROPSi | M87.003 |
Proteomic databases
PaxDbi | F6TR44 |
Genome annotation databases
Ensembli | ENSECAT00000022336; ENSECAP00000018453; ENSECAG00000020901 |
Organism-specific databases
VGNCi | VGNC:16572, CLCA2 |
Phylogenomic databases
GeneTreei | ENSGT00940000154682 |
HOGENOMi | CLU_005812_0_1_1 |
InParanoidi | F6TR44 |
TreeFami | TF328396 |
Gene expression databases
Bgeei | ENSECAG00000020901, Expressed in zone of skin and 10 other tissues |
ExpressionAtlasi | F6TR44, baseline |
Family and domain databases
Gene3Di | 3.40.50.410, 1 hit |
InterProi | View protein in InterPro IPR004727, CLCA_chordata IPR013642, CLCA_N IPR002035, VWF_A IPR036465, vWFA_dom_sf |
Pfami | View protein in Pfam PF08434, CLCA, 1 hit |
SMARTi | View protein in SMART SM00327, VWA, 1 hit |
SUPFAMi | SSF53300, SSF53300, 1 hit |
TIGRFAMsi | TIGR00868, hCaCC, 1 hit |
PROSITEi | View protein in PROSITE PS50234, VWFA, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | F6TR44_HORSE | |
Accessioni | F6TR44Primary (citable) accession number: F6TR44 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | July 27, 2011 |
Last sequence update: | April 10, 2019 | |
Last modified: | October 7, 2020 | |
This is version 47 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |