UniProtKB - F6TQF7 (F6TQF7_HORSE)
Protein
Submitted name:
Integrin subunit alpha 2b
Gene
ITGA2B
Organism
Equus caballus (Horse)
Status
Functioni
GO - Biological processi
- cell adhesion Source: UniProtKB-KW
- integrin-mediated signaling pathway Source: UniProtKB-KW
Keywordsi
Molecular function | IntegrinUniRule annotationARBA annotation, ReceptorUniRule annotationARBA annotation |
Biological process | Cell adhesionUniRule annotationARBA annotation |
Names & Taxonomyi
Protein namesi | Submitted name: Integrin subunit alpha 2bImported |
Gene namesi | Name:ITGA2BImported |
Organismi | Equus caballus (Horse)Imported |
Taxonomic identifieri | 9796 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Perissodactyla › Equidae › Equus › |
Proteomesi |
|
Organism-specific databases
VGNCi | VGNC:56437, ITGA2B |
Subcellular locationi
Other locations
- Membrane UniRule annotationARBA annotation; Single-pass type I membrane protein UniRule annotationARBA annotation
Plasma Membrane
- integrin complex Source: InterPro
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 987 – 1009 | HelicalUniRule annotationAdd BLAST | 23 |
Keywords - Cellular componenti
MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 31 | UniRule annotationAdd BLAST | 31 | |
ChainiPRO_5018379145 | 32 – 1028 | UniRule annotationAdd BLAST | 997 |
Keywords - PTMi
GlycoproteinARBA annotationExpressioni
Gene expression databases
Bgeei | ENSECAG00000019870, Expressed in bone marrow and 20 other tissues |
ExpressionAtlasi | F6TQF7, baseline |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Repeati | 37 – 96 | FG-GAPPROSITE-ProRule annotationAdd BLAST | 60 | |
Repeati | 110 – 173 | FG-GAPPROSITE-ProRule annotationAdd BLAST | 64 | |
Repeati | 241 – 296 | FG-GAPPROSITE-ProRule annotationAdd BLAST | 56 | |
Repeati | 297 – 362 | FG-GAPPROSITE-ProRule annotationAdd BLAST | 66 | |
Repeati | 365 – 423 | FG-GAPPROSITE-ProRule annotationAdd BLAST | 59 | |
Repeati | 426 – 487 | FG-GAPPROSITE-ProRule annotationAdd BLAST | 62 | |
Domaini | 472 – 911 | Integrin_alpha2InterPro annotationAdd BLAST | 440 |
Sequence similaritiesi
Keywords - Domaini
RepeatARBA annotation, SignalUniRule annotationARBA annotation, Transmembrane, Transmembrane helixUniRule annotationARBA annotationPhylogenomic databases
GeneTreei | ENSGT00940000160724 |
Family and domain databases
Gene3Di | 2.130.10.130, 1 hit |
InterProi | View protein in InterPro IPR013517, FG-GAP IPR013519, Int_alpha_beta-p IPR000413, Integrin_alpha IPR013649, Integrin_alpha-2 IPR018184, Integrin_alpha_C_CS IPR028994, Integrin_alpha_N IPR032695, Integrin_dom_sf |
Pfami | View protein in Pfam PF01839, FG-GAP, 2 hits PF00357, Integrin_alpha, 1 hit PF08441, Integrin_alpha2, 1 hit |
PRINTSi | PR01185, INTEGRINA |
SMARTi | View protein in SMART SM00191, Int_alpha, 5 hits |
SUPFAMi | SSF69179, SSF69179, 3 hits |
PROSITEi | View protein in PROSITE PS51470, FG_GAP, 6 hits PS00242, INTEGRIN_ALPHA, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All
F6TQF7-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MARALRPLHA LWLLEWMQLL LGPGTAPQAW ALNLDPVRLT FYTGPNGSHF
60 70 80 90 100
GFSLDFYKDS RGSVSIVVGA PRTLGRSQEE MGGAFLCPWK AEGGQCTSLS
110 120 130 140 150
FDLNDETRNT SSQIFQTFKA QQGLGASVVS WSDYVVACAP WQHWNALEKT
160 170 180 190 200
DEAEKTPVGG CFVAQLENGR RAEYSPCRDN IMSHVYSKTY LGERRLPFQA
210 220 230 240 250
GELVLGAPGG YYFLGLLARA PIANIVSSYR PGTLLWSVPT QRFTFDSMKP
260 270 280 290 300
EYFDGYRGYS VAVGEFDEDL STTEYVFGAP TWSWTLGAVE ILDSNFQMLH
310 320 330 340 350
RLHGEQMASY FGHSVAVTDV NGDRRHDLLV GAPLYMERRA DRKLAEVGRV
360 370 380 390 400
YLFLQPRSPQ PLGPASLLLT GTRIYGRFGS AIAPLGDLNR DGYNDVAVAA
410 420 430 440 450
PYGGPDGRGQ VLVFLGQSEG LSSHPSQVLD SPFSTGSAFG FSLRGATDID
460 470 480 490 500
DNGYPDLLVG AYGANKVAVY RAQPVVMVSV QLLVNDSLNP AVKNCVLPQK
510 520 530 540 550
KTSVSCFDIQ MCVGVTGHNI PEKLRLNAEL QLDRQKPRQG RRVLLLSSQQ
560 570 580 590 600
AGTTLHLDLG GRTSPNCRTI EAFLRDEADF RDKLSPIVLS LNVSLQPEKD
610 620 630 640 650
GIAPALVLHG DTHVQEQTRI ILDCGEDDLC VPQLHLTANV TGSPLLIGAD
660 670 680 690 700
NVLKLQMDAT NEGEGAYEAE LAVQLPPGAH YMQALSNIEG FERLICDQKK
710 720 730 740 750
ENETKVVLCE LGNPMKRNAQ IEITMLVSVE NLEEAGETVS LQLQIRSKNS
760 770 780 790 800
KNPNSETLRL HVPVRAEARV ELRGNSLPAS LVVAAEEDDR KNSSDSWGPK
810 820 830 840 850
VEHTYELHNN GPGAVRGLRL SLHLPSQSQP SDLLYILDIQ PQGGLQCSPQ
860 870 880 890 900
PSPNPLKLDW GLPTPSPSPV YHPRHQRERR EAFLPGPMQP SRLQDPVLVN
910 920 930 940 950
CDSAPCTVVQ CELEEMARGQ RAMVTVRAFV WLPSLRQKLL DQFVLQSRAW
960 970 980 990 1000
FNVSSLPYAV PTLSLPSGEA LVQTQLLRVL EDRAIPIWWV LVGVLGGLLL
1010 1020
LTLLVVAMWK VGFFKRNRPP LEEDEEDE
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketF6V3C6 | F6V3C6_HORSE | Integrin subunit alpha 2b | ITGA2B | 1,108 | Annotation score: | ||
A0A3Q2HWD2 | A0A3Q2HWD2_HORSE | Integrin subunit alpha 2b | ITGA2B | 1,070 | Annotation score: |
Genome annotation databases
Ensembli | ENSECAT00000022348; ENSECAP00000018462; ENSECAG00000019870 |
Similar proteinsi
Cross-referencesi
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Genome annotation databases
Ensembli | ENSECAT00000022348; ENSECAP00000018462; ENSECAG00000019870 |
Organism-specific databases
VGNCi | VGNC:56437, ITGA2B |
Phylogenomic databases
GeneTreei | ENSGT00940000160724 |
Gene expression databases
Bgeei | ENSECAG00000019870, Expressed in bone marrow and 20 other tissues |
ExpressionAtlasi | F6TQF7, baseline |
Family and domain databases
Gene3Di | 2.130.10.130, 1 hit |
InterProi | View protein in InterPro IPR013517, FG-GAP IPR013519, Int_alpha_beta-p IPR000413, Integrin_alpha IPR013649, Integrin_alpha-2 IPR018184, Integrin_alpha_C_CS IPR028994, Integrin_alpha_N IPR032695, Integrin_dom_sf |
Pfami | View protein in Pfam PF01839, FG-GAP, 2 hits PF00357, Integrin_alpha, 1 hit PF08441, Integrin_alpha2, 1 hit |
PRINTSi | PR01185, INTEGRINA |
SMARTi | View protein in SMART SM00191, Int_alpha, 5 hits |
SUPFAMi | SSF69179, SSF69179, 3 hits |
PROSITEi | View protein in PROSITE PS51470, FG_GAP, 6 hits PS00242, INTEGRIN_ALPHA, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | F6TQF7_HORSE | |
Accessioni | F6TQF7Primary (citable) accession number: F6TQF7 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | July 27, 2011 |
Last sequence update: | April 10, 2019 | |
Last modified: | August 12, 2020 | |
This is version 49 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |