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UniProtKB - F6TQF7 (F6TQF7_HORSE)

Entry version 49 (12 Aug 2020)
Sequence version 2 (10 Apr 2019)
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Protein
Submitted name:

Integrin subunit alpha 2b

Gene

ITGA2B

Organism
Equus caballus (Horse)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionIntegrinUniRule annotationARBA annotation, ReceptorUniRule annotationARBA annotation
Biological processCell adhesionUniRule annotationARBA annotation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Integrin subunit alpha 2bImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ITGA2BImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiEquus caballus (Horse)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9796 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Perissodactyla › Equidae › Equus ›
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002281 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 11

Organism-specific databases

Vertebrate Gene Nomenclature Database

More...VGNCi		VGNC:56437, ITGA2B

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei987 – 1009HelicalUniRule annotationAdd BLAST23

Keywords - Cellular componenti

Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 31UniRule annotationAdd BLAST31
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_501837914532 – 1028UniRule annotationAdd BLAST997

Keywords - PTMi

GlycoproteinARBA annotation

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSECAG00000019870, Expressed in bone marrow and 20 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		F6TQF7, baseline

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati37 – 96FG-GAPPROSITE-ProRule annotationAdd BLAST60
Repeati110 – 173FG-GAPPROSITE-ProRule annotationAdd BLAST64
Repeati241 – 296FG-GAPPROSITE-ProRule annotationAdd BLAST56
Repeati297 – 362FG-GAPPROSITE-ProRule annotationAdd BLAST66
Repeati365 – 423FG-GAPPROSITE-ProRule annotationAdd BLAST59
Repeati426 – 487FG-GAPPROSITE-ProRule annotationAdd BLAST62
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini472 – 911Integrin_alpha2InterPro annotationAdd BLAST440

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the integrin alpha chain family.UniRule annotationARBA annotation

Keywords - Domaini

RepeatARBA annotation, SignalUniRule annotationARBA annotation, Transmembrane, Transmembrane helixUniRule annotationARBA annotation

Phylogenomic databases

Ensembl GeneTree

More...GeneTreei		ENSGT00940000160724

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		2.130.10.130, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR013517, FG-GAP
IPR013519, Int_alpha_beta-p
IPR000413, Integrin_alpha
IPR013649, Integrin_alpha-2
IPR018184, Integrin_alpha_C_CS
IPR028994, Integrin_alpha_N
IPR032695, Integrin_dom_sf

Pfam protein domain database

More...Pfami		View protein in Pfam
PF01839, FG-GAP, 2 hits
PF00357, Integrin_alpha, 1 hit
PF08441, Integrin_alpha2, 1 hit

Protein Motif fingerprint database; a protein domain database

More...PRINTSi		PR01185, INTEGRINA

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00191, Int_alpha, 5 hits

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF69179, SSF69179, 3 hits

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS51470, FG_GAP, 6 hits
PS00242, INTEGRIN_ALPHA, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

F6TQF7-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MARALRPLHA LWLLEWMQLL LGPGTAPQAW ALNLDPVRLT FYTGPNGSHF 
        60         70         80         90        100
GFSLDFYKDS RGSVSIVVGA PRTLGRSQEE MGGAFLCPWK AEGGQCTSLS 
       110        120        130        140        150
FDLNDETRNT SSQIFQTFKA QQGLGASVVS WSDYVVACAP WQHWNALEKT 
       160        170        180        190        200
DEAEKTPVGG CFVAQLENGR RAEYSPCRDN IMSHVYSKTY LGERRLPFQA 
       210        220        230        240        250
GELVLGAPGG YYFLGLLARA PIANIVSSYR PGTLLWSVPT QRFTFDSMKP 
       260        270        280        290        300
EYFDGYRGYS VAVGEFDEDL STTEYVFGAP TWSWTLGAVE ILDSNFQMLH 
       310        320        330        340        350
RLHGEQMASY FGHSVAVTDV NGDRRHDLLV GAPLYMERRA DRKLAEVGRV 
       360        370        380        390        400
YLFLQPRSPQ PLGPASLLLT GTRIYGRFGS AIAPLGDLNR DGYNDVAVAA 
       410        420        430        440        450
PYGGPDGRGQ VLVFLGQSEG LSSHPSQVLD SPFSTGSAFG FSLRGATDID 
       460        470        480        490        500
DNGYPDLLVG AYGANKVAVY RAQPVVMVSV QLLVNDSLNP AVKNCVLPQK 
       510        520        530        540        550
KTSVSCFDIQ MCVGVTGHNI PEKLRLNAEL QLDRQKPRQG RRVLLLSSQQ 
       560        570        580        590        600
AGTTLHLDLG GRTSPNCRTI EAFLRDEADF RDKLSPIVLS LNVSLQPEKD 
       610        620        630        640        650
GIAPALVLHG DTHVQEQTRI ILDCGEDDLC VPQLHLTANV TGSPLLIGAD 
       660        670        680        690        700
NVLKLQMDAT NEGEGAYEAE LAVQLPPGAH YMQALSNIEG FERLICDQKK 
       710        720        730        740        750
ENETKVVLCE LGNPMKRNAQ IEITMLVSVE NLEEAGETVS LQLQIRSKNS 
       760        770        780        790        800
KNPNSETLRL HVPVRAEARV ELRGNSLPAS LVVAAEEDDR KNSSDSWGPK 
       810        820        830        840        850
VEHTYELHNN GPGAVRGLRL SLHLPSQSQP SDLLYILDIQ PQGGLQCSPQ 
       860        870        880        890        900
PSPNPLKLDW GLPTPSPSPV YHPRHQRERR EAFLPGPMQP SRLQDPVLVN 
       910        920        930        940        950
CDSAPCTVVQ CELEEMARGQ RAMVTVRAFV WLPSLRQKLL DQFVLQSRAW 
       960        970        980        990       1000
FNVSSLPYAV PTLSLPSGEA LVQTQLLRVL EDRAIPIWWV LVGVLGGLLL 
      1010       1020 
LTLLVVAMWK VGFFKRNRPP LEEDEEDE
Length:1,028
Mass (Da):113,272
Last modified:April 10, 2019 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i477C6177E310CD0A
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F6V3C6F6V3C6_HORSE
Integrin subunit alpha 2b
ITGA2B
1,108Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A3Q2HWD2A0A3Q2HWD2_HORSE
Integrin subunit alpha 2b
ITGA2B
1,070Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENSECAT00000022348; ENSECAP00000018462; ENSECAG00000019870

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

3D structure databases

Database of comparative protein structure models

More...ModBasei		Search...

SWISS-MODEL Interactive Workspace

More...SWISS-MODEL-Workspacei		Submit a new modelling project...

Genome annotation databases

EnsembliENSECAT00000022348; ENSECAP00000018462; ENSECAG00000019870

Organism-specific databases

VGNCiVGNC:56437, ITGA2B

Phylogenomic databases

GeneTreeiENSGT00940000160724

Gene expression databases

BgeeiENSECAG00000019870, Expressed in bone marrow and 20 other tissues
ExpressionAtlasiF6TQF7, baseline

Family and domain databases

Gene3Di2.130.10.130, 1 hit
InterProiView protein in InterPro
IPR013517, FG-GAP
IPR013519, Int_alpha_beta-p
IPR000413, Integrin_alpha
IPR013649, Integrin_alpha-2
IPR018184, Integrin_alpha_C_CS
IPR028994, Integrin_alpha_N
IPR032695, Integrin_dom_sf
PfamiView protein in Pfam
PF01839, FG-GAP, 2 hits
PF00357, Integrin_alpha, 1 hit
PF08441, Integrin_alpha2, 1 hit
PRINTSiPR01185, INTEGRINA
SMARTiView protein in SMART
SM00191, Int_alpha, 5 hits
SUPFAMiSSF69179, SSF69179, 3 hits
PROSITEiView protein in PROSITE
PS51470, FG_GAP, 6 hits
PS00242, INTEGRIN_ALPHA, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiF6TQF7_HORSE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: F6TQF7
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: July 27, 2011
Last sequence update: April 10, 2019
Last modified: August 12, 2020
This is version 49 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteomeImported
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Main funding by: National Institutes of Health

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