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Protein
Submitted name:

Prostasin preproprotein

Gene

PRSS8

Organism
Macaca mulatta (Rhesus macaque)
Status
Unreviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  • serine-type endopeptidase activity Source: InterPro
  • sodium channel regulator activity Source: GO_Central

GO - Biological processi

Keywordsi

Molecular functionHydrolase, Protease, Serine proteaseUniRule annotation

Protein family/group databases

MEROPSiS01.159

Names & Taxonomyi

Protein namesi
Submitted name:
Prostasin preproproteinImported
Gene namesi
Name:PRSS8Imported
OrganismiMacaca mulatta (Rhesus macaque)Imported
Taxonomic identifieri9544 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniCercopithecidaeCercopithecinaeMacaca
Proteomesi
  • UP000006718 Componenti: Chromosome 20

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 29Sequence analysisAdd BLAST29
ChainiPRO_501509109130 – 343Sequence analysisAdd BLAST314

Keywords - PTMi

Disulfide bondSAAS annotation

Expressioni

Gene expression databases

BgeeiENSMMUG00000002031 Expressed in 12 organ(s), highest expression level in rectum

Interactioni

Protein-protein interaction databases

STRINGi9544.ENSMMUP00000002716

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini45 – 286Peptidase S1InterPro annotationAdd BLAST242

Sequence similaritiesi

Belongs to the peptidase S1 family.SAAS annotation

Keywords - Domaini

SignalSequence analysis

Phylogenomic databases

eggNOGiKOG3627 Eukaryota
COG5640 LUCA
GeneTreeiENSGT00900000140825
InParanoidiF6TMC3
KOiK08664
OrthoDBiEOG091G0AH5
TreeFamiTF351676

Family and domain databases

CDDicd00190 Tryp_SPc, 1 hit
InterProiView protein in InterPro
IPR009003 Peptidase_S1_PA
IPR001314 Peptidase_S1A
IPR001254 Trypsin_dom
IPR018114 TRYPSIN_HIS
IPR033116 TRYPSIN_SER
PfamiView protein in Pfam
PF00089 Trypsin, 1 hit
PRINTSiPR00722 CHYMOTRYPSIN
SMARTiView protein in SMART
SM00020 Tryp_SPc, 1 hit
SUPFAMiSSF50494 SSF50494, 1 hit
PROSITEiView protein in PROSITE
PS50240 TRYPSIN_DOM, 1 hit
PS00134 TRYPSIN_HIS, 1 hit
PS00135 TRYPSIN_SER, 1 hit

Sequencei

Sequence statusi: Complete.

F6TMC3-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MVQNGVLGPG QLGAVAILLY LGLFRSGTGA EGAEAPCGVA PQARITGGSN
60 70 80 90 100
AVPGQWPWQV SITYEGVHVC GGSLVSEKWV LSAAHCFPSE HSKESYEVRL
110 120 130 140 150
GAHQLDSYSE DAKVSTVEYI ITHPSYLQEG SQGDIALLQL SSPVTFSRYI
160 170 180 190 200
RPICLPAANA SFPNGLHCTV TGWGHVAPSV SLPAPKPLQQ LEVPLISRET
210 220 230 240 250
CNCLYNIDAK PEEPHFVQED MVCAGYVEGG KDACQGDSGG PLSCPVEGLW
260 270 280 290 300
YLTGIVSWGD ACGARNRPGV YTLASSYASW IQSKATELQP RVVPQTQESQ
310 320 330 340
PDSNLCSSHL AFNSAPAQGL LRPILSLPLG LALGLLSPWL SEH
Length:343
Mass (Da):36,405
Last modified:November 30, 2016 - v2
Checksum:i48B0E31EBCBBCBBE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
JSUE03026100 Genomic DNA No translation available.
JSUE03026101 Genomic DNA No translation available.
JU476439 mRNA Translation: AFH33243.1
RefSeqiNP_001253517.1, NM_001266588.1
UniGeneiMmu.35612

Genome annotation databases

EnsembliENSMMUT00000002873; ENSMMUP00000002716; ENSMMUG00000002031
GeneIDi713176
KEGGimcc:713176

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
JSUE03026100 Genomic DNA No translation available.
JSUE03026101 Genomic DNA No translation available.
JU476439 mRNA Translation: AFH33243.1
RefSeqiNP_001253517.1, NM_001266588.1
UniGeneiMmu.35612

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9544.ENSMMUP00000002716

Protein family/group databases

MEROPSiS01.159

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMMUT00000002873; ENSMMUP00000002716; ENSMMUG00000002031
GeneIDi713176
KEGGimcc:713176

Organism-specific databases

CTDi5652

Phylogenomic databases

eggNOGiKOG3627 Eukaryota
COG5640 LUCA
GeneTreeiENSGT00900000140825
InParanoidiF6TMC3
KOiK08664
OrthoDBiEOG091G0AH5
TreeFamiTF351676

Gene expression databases

BgeeiENSMMUG00000002031 Expressed in 12 organ(s), highest expression level in rectum

Family and domain databases

CDDicd00190 Tryp_SPc, 1 hit
InterProiView protein in InterPro
IPR009003 Peptidase_S1_PA
IPR001314 Peptidase_S1A
IPR001254 Trypsin_dom
IPR018114 TRYPSIN_HIS
IPR033116 TRYPSIN_SER
PfamiView protein in Pfam
PF00089 Trypsin, 1 hit
PRINTSiPR00722 CHYMOTRYPSIN
SMARTiView protein in SMART
SM00020 Tryp_SPc, 1 hit
SUPFAMiSSF50494 SSF50494, 1 hit
PROSITEiView protein in PROSITE
PS50240 TRYPSIN_DOM, 1 hit
PS00134 TRYPSIN_HIS, 1 hit
PS00135 TRYPSIN_SER, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiF6TMC3_MACMU
AccessioniPrimary (citable) accession number: F6TMC3
Secondary accession number(s): H9ZBC7
Entry historyiIntegrated into UniProtKB/TrEMBL: July 27, 2011
Last sequence update: November 30, 2016
Last modified: November 7, 2018
This is version 53 of the entry and version 2 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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