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UniProtKB - F6TLV3 (F6TLV3_MOUSE)

Entry version 57 (12 Aug 2020)
Sequence version 1 (27 Jul 2011)
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Protein
Submitted name:

Fibronectin type-III domain-containing protein 3A

Gene

Fndc3a

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Fibronectin type-III domain-containing protein 3AImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Fndc3aImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 14

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...MGIi		MGI:1196463, Fndc3a

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei1130 – 1153HelicalSequence analysisAdd BLAST24

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		F6TLV3

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		F6TLV3

MaxQB - The MaxQuant DataBase

More...MaxQBi		F6TLV3

PeptideAtlas

More...PeptideAtlasi		F6TLV3

PRoteomics IDEntifications database

More...PRIDEi		F6TLV3

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSMUSG00000033487, Expressed in islet of Langerhans and 306 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		F6TLV3, baseline and differential

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini224 – 325Fibronectin type-IIIInterPro annotationAdd BLAST102
Domaini329 – 421Fibronectin type-IIIInterPro annotationAdd BLAST93
Domaini425 – 518Fibronectin type-IIIInterPro annotationAdd BLAST94
Domaini522 – 616Fibronectin type-IIIInterPro annotationAdd BLAST95
Domaini620 – 713Fibronectin type-IIIInterPro annotationAdd BLAST94
Domaini717 – 807Fibronectin type-IIIInterPro annotationAdd BLAST91
Domaini819 – 906Fibronectin type-IIIInterPro annotationAdd BLAST88
Domaini907 – 1001Fibronectin type-IIIInterPro annotationAdd BLAST95
Domaini1005 – 1107Fibronectin type-IIIInterPro annotationAdd BLAST103

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni61 – 83DisorderedSequence analysisAdd BLAST23
Regioni117 – 213DisorderedSequence analysisAdd BLAST97

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi124 – 154PolyampholyteSequence analysisAdd BLAST31
Compositional biasi175 – 200PolarSequence analysisAdd BLAST26

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

Ensembl GeneTree

More...GeneTreei		ENSGT00940000159319

Identification of Orthologs from Complete Genome Data

More...OMAi		AYFVAQD

Family and domain databases

Conserved Domains Database

More...CDDi		cd00063, FN3, 9 hits

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		2.60.40.10, 9 hits

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR003961, FN3_dom
IPR036116, FN3_sf
IPR013783, Ig-like_fold

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00041, fn3, 7 hits

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00060, FN3, 9 hits

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF49265, SSF49265, 6 hits

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50853, FN3, 9 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Fragment.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

F6TLV3-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
XLFAGCCSCR NKMSGPAQVP MMSPNGSVPP IYVPPGYAPQ VIEDNGVRRV 
        60         70         80         90        100
VVVPQSPEFH PGGHTVIHRS PHPPLPGFIP VPTMMPPPPR HMYSPVTGAG 
       110        120        130        140        150
DMATQYMPQY QSSQVYADVD AHSTHGRSNF RDERSSKTYE RLQKKLKDRQ 
       160        170        180        190        200
GTQKDKMSSP PPSPQKCPSP ISEHNGLIKG QNASGGNTGS ARNRSGRGRS 
       210        220        230        240        250
CTQVDPEMEE KDEETKAFEA FLSNIVKPVA SDIQARTVLL TWSPPSSFIN 
       260        270        280        290        300
GEVNETAVPE LFNYEVLVSS TGKEGKYRSV YIGEETSVTL NDLKPATDYH 
       310        320        330        340        350
AKVQAESNSI KGIPSEAESF TTLSCEPDPP NAPRIANRTK NSLTLQWKAP 
       360        370        380        390        400
SDNGSKIQSF ILEWDEGKGN GEFCQCYMGS QKQFKITKLS PAMGCKFRLS 
       410        420        430        440        450
AKNDYGVSDF SEEVLYYTSG CAPSVPASPV LTKAGVTWLS LQWTKPSGTP 
       460        470        480        490        500
SDEGISYILE MEEETSGYGF KPKYDGEDLA YTVKNLRRST KYKFKVIAYN 
       510        520        530        540        550
SEGKSNPSEV VEFSTCPDKP GVPVKPSVKG KIHSHGFKIT WDPPKDNGGA 
       560        570        580        590        600
PINKYVVEMA EGSNGNKWDM IYSGTTREHL CDRLTPGCYY RLRVYCISDG 
       610        620        630        640        650
GQSAVSESLL VQTPAVPPGP CLPPRLQGRP KAKEIQLRWG PPQVDGGSPI 
       660        670        680        690        700
SCYAVEMTPA DKDEPRDVYQ GSEVECTVGS LLPGKTYSFR LRAANRIGFG 
       710        720        730        740        750
PFSEKYDITT APGPPDQCRP PQVTCRSATC AQVNWEIPLS NGTDVTEYRL 
       760        770        780        790        800
EWGGVEGSMQ MCYCGPGLSC ELKGLSPATT YYCRVQAMSV VGAGPFSEVV 
       810        820        830        840        850
ACVTPPSVPA IVTCLQEISD DDIEYPHYSP STCLAISWKE PYDHGSEILA 
       860        870        880        890        900
YSIDLGDKQP LTVGKMTSYI IDSLQPDTTY RIRIQALNSL GAGPFSHTIK 
       910        920        930        940        950
LKTKPLPPDP PRLECVAFNH QNLKLKWGEG TPKTLSTDAV QYHLQMEDRN 
       960        970        980        990       1000
GRFVSLYRGP CHTYKVQRLS ESTSYKFCIQ ACNEAGEGPL SQEYVFTTPK 
      1010       1020       1030       1040       1050
SLPAALKAPK IEKINDHICE ITWEYLQPMK GDPVIYNLQV MVGKDSEFKQ 
      1060       1070       1080       1090       1100
IYKGPDTSFR YSSLQLNCEY RFRVCAIRQC QDPTGHQDLV GPYSTTVFFI 
      1110       1120       1130       1140       1150
SQRTEPPASS NKDSVDSART RRTLSDEQCA AVILVVFAFF SILIAFIIQY 

FVIK
Length:1,154
Mass (Da):127,253
Last modified:July 27, 2011 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iA527771CC2A341E8
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q8BX90FND3A_MOUSE
Fibronectin type-III domain-contain...
Fndc3a D14Ertd453e, Fndc3, Kiaa0970
1,198Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E0CXY0E0CXY0_MOUSE
Fibronectin type-III domain-contain...
Fndc3a
540Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section is used for sequence fragments to indicate that the residue at the extremity of the sequence is not the actual terminal residue in the complete protein sequence.<p><a href='/help/non_ter' target='_top'>More...</a></p>Non-terminal residuei1Imported1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AC158981 Genomic DNA No translation available.
AC165423 Genomic DNA No translation available.
CT010579 Genomic DNA No translation available.

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENSMUST00000162825; ENSMUSP00000124218; ENSMUSG00000033487

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC158981 Genomic DNA No translation available.
AC165423 Genomic DNA No translation available.
CT010579 Genomic DNA No translation available.

3D structure databases

Database of comparative protein structure models

More...ModBasei		Search...

Proteomic databases

EPDiF6TLV3
jPOSTiF6TLV3
MaxQBiF6TLV3
PeptideAtlasiF6TLV3
PRIDEiF6TLV3

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		2293, 119 antibodies

Genome annotation databases

EnsembliENSMUST00000162825; ENSMUSP00000124218; ENSMUSG00000033487

Organism-specific databases

MGIiMGI:1196463, Fndc3a

Phylogenomic databases

GeneTreeiENSGT00940000159319
OMAiAYFVAQD

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		Fndc3a, mouse

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSMUSG00000033487, Expressed in islet of Langerhans and 306 other tissues
ExpressionAtlasiF6TLV3, baseline and differential

Family and domain databases

CDDicd00063, FN3, 9 hits
Gene3Di2.60.40.10, 9 hits
InterProiView protein in InterPro
IPR003961, FN3_dom
IPR036116, FN3_sf
IPR013783, Ig-like_fold
PfamiView protein in Pfam
PF00041, fn3, 7 hits
SMARTiView protein in SMART
SM00060, FN3, 9 hits
SUPFAMiSSF49265, SSF49265, 6 hits
PROSITEiView protein in PROSITE
PS50853, FN3, 9 hits

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiF6TLV3_MOUSE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: F6TLV3
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: July 27, 2011
Last sequence update: July 27, 2011
Last modified: August 12, 2020
This is version 57 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Proteomics identificationCombined sources, Reference proteomeImported
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