UniProtKB - F6TJM7 (F6TJM7_HORSE)
Protein
Dipeptidase
Gene
DPEP1
Organism
Equus caballus (Horse)
Status
Functioni
Independently of its dipeptidase activity acts as an adhesion receptor for neutrophils recruitement from bloodstream into inflammed lungs and liver.ARBA annotation
Catalytic activityi
Cofactori
Zn2+UniRule annotationARBA annotation
GO - Molecular functioni
- beta-lactamase activity Source: UniProtKB-EC
- cysteine-type endopeptidase inhibitor activity involved in apoptotic process Source: UniProtKB
- metallodipeptidase activity Source: UniProtKB
- modified amino acid binding Source: UniProtKB
- zinc ion binding Source: UniProtKB
GO - Biological processi
- antibiotic metabolic process Source: UniProtKB
- cellular response to drug Source: UniProtKB
- homocysteine metabolic process Source: UniProtKB
- lipid metabolic process Source: UniProtKB-KW
- negative regulation of apoptotic process Source: UniProtKB
- negative regulation of cell migration Source: UniProtKB
- negative regulation of cysteine-type endopeptidase activity involved in apoptotic process Source: UniProtKB
Keywordsi
Molecular function | DipeptidaseUniRule annotationARBA annotation, Hydrolase, MetalloproteaseUniRule annotation, Protease |
Biological process | Lipid metabolismARBA annotation |
Ligand | Metal-bindingUniRule annotation, ZincUniRule annotation |
Protein family/group databases
MEROPSi | M19.001 |
Names & Taxonomyi
Protein namesi | |
Gene namesi | Name:DPEP1Imported |
Organismi | Equus caballus (Horse)Imported |
Taxonomic identifieri | 9796 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Perissodactyla › Equidae › Equus › |
Proteomesi |
|
Organism-specific databases
VGNCi | VGNC:49047, DPEP1 |
Subcellular locationi
Plasma membrane
- Apical cell membrane ARBA annotation; GPI-anchor ARBA annotation
- Cell membrane ARBA annotation; GPI-anchor ARBA annotation
Other locations
- Membrane UniRule annotationARBA annotation; GPI-anchor UniRule annotationARBA annotation
Plasma Membrane
- apical plasma membrane Source: UniProtKB-SubCell
- plasma membrane Source: UniProtKB
Other locations
- anchored component of membrane Source: UniProtKB-UniRule
- apical part of cell Source: UniProtKB
Keywords - Cellular componenti
Cell membraneARBA annotation, MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 16 | UniRule annotationAdd BLAST | 16 | |
ChainiPRO_5005129936 | 17 – 410 | DipeptidaseUniRule annotationAdd BLAST | 394 |
Keywords - PTMi
Disulfide bondUniRule annotation, Glycoprotein, GPI-anchorUniRule annotationARBA annotation, LipoproteinProteomic databases
PaxDbi | F6TJM7 |
PRIDEi | F6TJM7 |
Expressioni
Gene expression databases
Bgeei | ENSECAG00000022966, Expressed in adult mammalian kidney and 7 other tissues |
Interactioni
Subunit structurei
Homodimer; disulfide-linked.
UniRule annotationARBA annotationFamily & Domainsi
Sequence similaritiesi
Keywords - Domaini
SignalUniRule annotationARBA annotationPhylogenomic databases
GeneTreei | ENSGT00940000159615 |
HOGENOMi | CLU_031404_4_2_1 |
InParanoidi | F6TJM7 |
OMAi | HLDHMRE |
OrthoDBi | 1272387at2759 |
TreeFami | TF324523 |
Family and domain databases
CDDi | cd01301, rDP_like, 1 hit |
InterProi | View protein in InterPro IPR000180, Dipep_AS IPR028536, Dpep1 IPR032466, Metal_Hydrolase IPR008257, Pept_M19 |
PANTHERi | PTHR10443, PTHR10443, 1 hit PTHR10443:SF38, PTHR10443:SF38, 1 hit |
Pfami | View protein in Pfam PF01244, Peptidase_M19, 1 hit |
SUPFAMi | SSF51556, SSF51556, 1 hit |
PROSITEi | View protein in PROSITE PS00869, RENAL_DIPEPTIDASE_1, 1 hit PS51365, RENAL_DIPEPTIDASE_2, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
F6TJM7-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MWTSWWLWPL VAICTADQFR DQAERIMQGT PVIDGHNDLP WQLLKMFNNQ
60 70 80 90 100
LRDERANLTT LASTHTNIPK LKAGFVGGQF WSAYVPCDTQ NKDAVRRTLE
110 120 130 140 150
QIDVVHRMCQ MYPETFVCVT NSTGIRQAFQ EGRVASLVGV EGGHSIDSSL
160 170 180 190 200
AVLRALYHLG MRYLTLTHSC NTPWADNWLV DTGEDKAQSQ GLSLFGQTVL
210 220 230 240 250
KEMNRLGVMI DLAHVSVATM KAALELSKAP VIFSHSSAYS LCAHRRNVPD
260 270 280 290 300
DVLQLVKQTG SLVMVNFYND YVACQREANL SQVADHLDYI KNVAGAEAVG
310 320 330 340 350
FGGDYDGVSR VPSGLEDVSK YPDLVAELLR RQWTEAEIRG ALADNLLRVF
360 370 380 390 400
EAVEEASDHM QTPEEEPIPL DKLEPSCRTK YGYSQAPSLH RQLGALLASL
410
ALLPLGLCLL
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketA0A3Q2HKP2 | A0A3Q2HKP2_HORSE | Dipeptidase | DPEP1 | 497 | Annotation score: |
Sequence databases
RefSeqi | XP_001488357.2, XM_001488307.3 |
Genome annotation databases
Ensembli | ENSECAT00000024690; ENSECAP00000020521; ENSECAG00000022966 |
GeneIDi | 100052197 |
KEGGi | ecb:100052197 |
Similar proteinsi
Cross-referencesi
Sequence databases
RefSeqi | XP_001488357.2, XM_001488307.3 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein family/group databases
MEROPSi | M19.001 |
Proteomic databases
PaxDbi | F6TJM7 |
PRIDEi | F6TJM7 |
Genome annotation databases
Ensembli | ENSECAT00000024690; ENSECAP00000020521; ENSECAG00000022966 |
GeneIDi | 100052197 |
KEGGi | ecb:100052197 |
Organism-specific databases
CTDi | 1800 |
VGNCi | VGNC:49047, DPEP1 |
Phylogenomic databases
GeneTreei | ENSGT00940000159615 |
HOGENOMi | CLU_031404_4_2_1 |
InParanoidi | F6TJM7 |
OMAi | HLDHMRE |
OrthoDBi | 1272387at2759 |
TreeFami | TF324523 |
Gene expression databases
Bgeei | ENSECAG00000022966, Expressed in adult mammalian kidney and 7 other tissues |
Family and domain databases
CDDi | cd01301, rDP_like, 1 hit |
InterProi | View protein in InterPro IPR000180, Dipep_AS IPR028536, Dpep1 IPR032466, Metal_Hydrolase IPR008257, Pept_M19 |
PANTHERi | PTHR10443, PTHR10443, 1 hit PTHR10443:SF38, PTHR10443:SF38, 1 hit |
Pfami | View protein in Pfam PF01244, Peptidase_M19, 1 hit |
SUPFAMi | SSF51556, SSF51556, 1 hit |
PROSITEi | View protein in PROSITE PS00869, RENAL_DIPEPTIDASE_1, 1 hit PS51365, RENAL_DIPEPTIDASE_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | F6TJM7_HORSE | |
Accessioni | F6TJM7Primary (citable) accession number: F6TJM7 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | July 27, 2011 |
Last sequence update: | July 27, 2011 | |
Last modified: | December 2, 2020 | |
This is version 60 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |