UniProtKB - F6TJG9 (F6TJG9_HORSE)
Protein
Submitted name:
Hook microtubule tethering protein 3
Gene
HOOK3
Organism
Equus caballus (Horse)
Status
Functioni
GO - Molecular functioni
- microtubule binding Source: InterPro
GO - Biological processi
- cytoplasmic microtubule organization Source: InterPro
- cytoskeleton-dependent intracellular transport Source: InterPro
Names & Taxonomyi
Protein namesi | Submitted name: Hook microtubule tethering protein 3Imported |
Gene namesi | Name:HOOK3Imported |
Organismi | Equus caballus (Horse)Imported |
Taxonomic identifieri | 9796 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Perissodactyla › Equidae › Equus › |
Proteomesi |
|
Organism-specific databases
VGNCi | VGNC:18837, HOOK3 |
Subcellular locationi
Cytoskeleton
- cytoskeleton ARBA annotation
Cytoskeleton
- microtubule Source: UniProtKB-KW
Other locations
- cytoplasm Source: UniProtKB-KW
Keywords - Cellular componenti
Cytoplasm, CytoskeletonARBA annotation, MicrotubuleARBA annotationExpressioni
Gene expression databases
Bgeei | ENSECAG00000020276, Expressed in brainstem and 22 other tissues |
ExpressionAtlasi | F6TJG9, baseline |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 1 – 109 | Calponin-homology (CH)InterPro annotationAdd BLAST | 109 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 671 – 699 | DisorderedSequence analysisAdd BLAST | 29 |
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 154 – 209 | Sequence analysisAdd BLAST | 56 | |
Coiled coili | 227 – 333 | Sequence analysisAdd BLAST | 107 | |
Coiled coili | 337 – 413 | Sequence analysisAdd BLAST | 77 | |
Coiled coili | 472 – 520 | Sequence analysisAdd BLAST | 49 | |
Coiled coili | 524 – 555 | Sequence analysisAdd BLAST | 32 | |
Coiled coili | 559 – 600 | Sequence analysisAdd BLAST | 42 | |
Coiled coili | 613 – 633 | Sequence analysisAdd BLAST | 21 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 671 – 693 | PolarSequence analysisAdd BLAST | 23 |
Sequence similaritiesi
Belongs to the hook family.ARBA annotation
Keywords - Domaini
Coiled coilSequence analysisARBA annotationPhylogenomic databases
GeneTreei | ENSGT00940000158075 |
HOGENOMi | CLU_011214_1_0_1 |
InParanoidi | F6TJG9 |
TreeFami | TF320231 |
Family and domain databases
Gene3Di | 1.10.418.10, 1 hit |
InterProi | View protein in InterPro IPR001715, CH-domain IPR036872, CH_dom_sf IPR008636, Hook_C IPR043936, HOOK_N |
Pfami | View protein in Pfam PF05622, HOOK, 1 hit PF19047, HOOK_N, 1 hit |
PROSITEi | View protein in PROSITE PS50021, CH, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show allAlign All
F6TJG9-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MQIQTFNVDA SCQTVEDLTN GVVMAQVLQK IDPAYFDENW LNRIKTEVGD
60 70 80 90 100
NWRLKISNLK KILKGILDYN HEILGQQIND FTLPDVNLIG EHSDAAELGR
110 120 130 140 150
MLQLILGCAV NCEQKQEYIQ AIMMMEESVQ HVVMTAIQEL MSKESPVSAG
160 170 180 190 200
NDAYVDLDRQ LKKTTEELNE ALSAKEEIAQ RCHELDMQVA ALQEEKSSLL
210 220 230 240 250
AENQILMERL NQSDSIEDPN SPAGRRHLQL QTQLEQLQEE TFRLEAAKDD
260 270 280 290 300
YRIRCEELEK EISELRQQND ELTTLADEAQ SLKDEIDVLR HSSDKVSKLE
310 320 330 340 350
GQVESYKKKL EDLGDLRRQV KLLEEKNTMY MQNTVSLEEE LRKANAARSQ
360 370 380 390 400
LETYKRQVVE LQNRLSEESK KADKLDFEYK RLKEKVDSLQ KEKDRLRTER
410 420 430 440 450
DSLKETIEEL RCVQAQEGQL TTQGLMPLAS QESSDSLAAE IVTPEIREKL
460 470 480 490 500
IRLQHENKML KLNQEGSDNE KIALLQSLLD DANLRKNELE TENRLVNQRL
510 520 530 540 550
LEVQSQVEEL QKSLQDQGSK AEDSVLLKKK LEEHLEKLHE ANNELQKKRA
560 570 580 590 600
IIEDLEPRFN NSSLKIEELQ EALRKKEEEM KQMEERYKKY LEKAKSVIRT
610 620 630 640 650
LDPKQNQGAA PEIQALKNQL QERDRLFHSL EKEYEKTKSQ REMEEKYLVS
660 670 680 690 700
AWYNMGMTLH KKAAEDRLAS TGSGQSFLAR QRQATSTRRS YPGHVQPATA
RNCPCRKVL
Computationally mapped potential isoform sequencesi
There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketA0A3Q2LP63 | A0A3Q2LP63_HORSE | Hook microtubule tethering protein ... | HOOK3 | 794 | Annotation score: | ||
A0A3Q2GVJ9 | A0A3Q2GVJ9_HORSE | Hook microtubule tethering protein ... | HOOK3 | 773 | Annotation score: | ||
A0A5F5PNG8 | A0A5F5PNG8_HORSE | Hook microtubule tethering protein ... | HOOK3 | 724 | Annotation score: | ||
A0A3Q2H3D3 | A0A3Q2H3D3_HORSE | Hook microtubule tethering protein ... | HOOK3 | 739 | Annotation score: |
Genome annotation databases
Ensembli | ENSECAT00000022057; ENSECAP00000018210; ENSECAG00000020276 |
Similar proteinsi
Cross-referencesi
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Proteomic databases
PaxDbi | F6TJG9 |
PRIDEi | F6TJG9 |
Genome annotation databases
Ensembli | ENSECAT00000022057; ENSECAP00000018210; ENSECAG00000020276 |
Organism-specific databases
VGNCi | VGNC:18837, HOOK3 |
Phylogenomic databases
GeneTreei | ENSGT00940000158075 |
HOGENOMi | CLU_011214_1_0_1 |
InParanoidi | F6TJG9 |
TreeFami | TF320231 |
Gene expression databases
Bgeei | ENSECAG00000020276, Expressed in brainstem and 22 other tissues |
ExpressionAtlasi | F6TJG9, baseline |
Family and domain databases
Gene3Di | 1.10.418.10, 1 hit |
InterProi | View protein in InterPro IPR001715, CH-domain IPR036872, CH_dom_sf IPR008636, Hook_C IPR043936, HOOK_N |
Pfami | View protein in Pfam PF05622, HOOK, 1 hit PF19047, HOOK_N, 1 hit |
PROSITEi | View protein in PROSITE PS50021, CH, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | F6TJG9_HORSE | |
Accessioni | F6TJG9Primary (citable) accession number: F6TJG9 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | July 27, 2011 |
Last sequence update: | April 10, 2019 | |
Last modified: | February 10, 2021 | |
This is version 54 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |