UniProtKB - F6TIX2 (F6TIX2_HORSE)
Protein
Submitted name:
G2/M-phase specific E3 ubiquitin protein ligase
Gene
G2E3
Organism
Equus caballus (Horse)
Status
Functioni
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Active sitei | 666 | Glycyl thioester intermediatePROSITE-ProRule annotation | 1 |
GO - Molecular functioni
- metal ion binding Source: UniProtKB-KW
- ubiquitin-protein transferase activity Source: InterPro
Keywordsi
Biological process | Ubl conjugation pathwayPROSITE-ProRule annotationARBA annotation |
Ligand | Metal-bindingARBA annotation, ZincARBA annotation |
Names & Taxonomyi
Protein namesi | Submitted name: G2/M-phase specific E3 ubiquitin protein ligaseImported |
Gene namesi | Name:G2E3Imported |
Organismi | Equus caballus (Horse)Imported |
Taxonomic identifieri | 9796 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Perissodactyla › Equidae › Equus › |
Proteomesi |
|
Organism-specific databases
VGNCi | VGNC:18177, G2E3 |
Subcellular locationi
Cytosol
- cytosol Source: Ensembl
Golgi apparatus
- Golgi apparatus Source: Ensembl
Nucleus
- nucleus Source: GO_Central
Expressioni
Gene expression databases
Bgeei | ENSECAG00000020895, Expressed in testis and 22 other tissues |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 11 – 128 | PHD-typeInterPro annotationAdd BLAST | 118 | |
Domaini | 529 – 692 | HECTInterPro annotationAdd BLAST | 164 |
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 678 – 698 | Sequence analysisAdd BLAST | 21 |
Keywords - Domaini
Coiled coilSequence analysisPhylogenomic databases
GeneTreei | ENSGT00950000182865 |
HOGENOMi | CLU_024258_2_0_1 |
InParanoidi | F6TIX2 |
OMAi | NFNPSYT |
OrthoDBi | 199998at2759 |
TreeFami | TF325426 |
Family and domain databases
CDDi | cd15669, ePHD_PHF7_G2E3_like, 1 hit cd15496, PHD_PHF7_G2E3_like, 1 hit |
Gene3Di | 3.30.40.10, 2 hits |
InterProi | View protein in InterPro IPR034732, EPHD IPR000569, HECT_dom IPR035983, Hect_E3_ubiquitin_ligase IPR042013, PHF7/G2E3_ePHD IPR042012, PHF7/G2E3_PHD IPR019786, Zinc_finger_PHD-type_CS IPR011011, Znf_FYVE_PHD IPR001965, Znf_PHD IPR013083, Znf_RING/FYVE/PHD |
Pfami | View protein in Pfam PF00632, HECT, 1 hit |
SMARTi | View protein in SMART SM00119, HECTc, 1 hit SM00249, PHD, 2 hits |
SUPFAMi | SSF56204, SSF56204, 1 hit SSF57903, SSF57903, 1 hit |
PROSITEi | View protein in PROSITE PS51805, EPHD, 1 hit PS50237, HECT, 1 hit PS01359, ZF_PHD_1, 1 hit |
i Sequence
Sequence statusi: Complete.
F6TIX2-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MNEKKPGDSQ NLACVFCRKN DDCPNKYGEK KTNEKWNLTV HYYCLLMSSG
60 70 80 90 100
IWQRGKEEEG VYGFLIEDIR KEVTRASKLK CCICKKTGAS IGCVAPRCKR
110 120 130 140 150
SYHFPCGLQR ECIFQFTGNF ASFCWKHRPV QIITSNNYKD SLPCTICLEF
160 170 180 190 200
VEPIPTYSIL RSPCCKNAWF HRDCLQVQAI NAGVFFFRCT ICNNSDIFQK
210 220 230 240 250
EMLRMGIHIP EKDASWELEE NAYQELLQHY ERCDVRRCRC KEGRDYNAPN
260 270 280 290 300
SKWEIKRCQC CGSSGTHLAC SSLRSWEQNW ECLECRGILY NSGDFQKPKK
310 320 330 340 350
HALPNTNNVG ITDCLLEESS PKLPRQSPGA QRKDLLRQGS KFRRDIATII
360 370 380 390 400
IELGFQIKRK TKKLYINKAK IWNSALDGFR NQNFNPSYSI EVVYVNENDN
410 420 430 440 450
FGREHPGSKQ EFLSLLMQHL ENSPLFEGSL SKNLSLNSQA LKDNLYYEAG
460 470 480 490 500
KMLAISLVHG GPSPGFFSKT LFDCLVYGPE NTQPILDDVS DFDVAQIVMR
510 520 530 540 550
VNAATNTADL NSITNEFYNY LELIGCLRII TSLSDKYMLA KDILDYHVIK
560 570 580 590 600
RVQAPFESFK QGLKTLGVLE KIQSYPEAFY SLFCHKPENL SAKVLSDLFT
610 620 630 640 650
VHTLSDVQAL GFWNSYLQAV EDGKSATTVE DILSFTTGCN SIPPAGFKPT
660 670 680 690 700
PSLECLHMDF PVGNKCNNCL ALPITNTYKE FQENMDFAIR NTLRLEKEES
SHYIEH
Sequence databases
RefSeqi | XP_001489219.1, XM_001489169.3 |
Genome annotation databases
Ensembli | ENSECAT00000022357; ENSECAP00000018471; ENSECAG00000020895 |
GeneIDi | 100049939 |
KEGGi | ecb:100049939 |
Similar proteinsi
Cross-referencesi
Sequence databases
RefSeqi | XP_001489219.1, XM_001489169.3 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Proteomic databases
PaxDbi | F6TIX2 |
Genome annotation databases
Ensembli | ENSECAT00000022357; ENSECAP00000018471; ENSECAG00000020895 |
GeneIDi | 100049939 |
KEGGi | ecb:100049939 |
Organism-specific databases
CTDi | 55632 |
VGNCi | VGNC:18177, G2E3 |
Phylogenomic databases
GeneTreei | ENSGT00950000182865 |
HOGENOMi | CLU_024258_2_0_1 |
InParanoidi | F6TIX2 |
OMAi | NFNPSYT |
OrthoDBi | 199998at2759 |
TreeFami | TF325426 |
Gene expression databases
Bgeei | ENSECAG00000020895, Expressed in testis and 22 other tissues |
Family and domain databases
CDDi | cd15669, ePHD_PHF7_G2E3_like, 1 hit cd15496, PHD_PHF7_G2E3_like, 1 hit |
Gene3Di | 3.30.40.10, 2 hits |
InterProi | View protein in InterPro IPR034732, EPHD IPR000569, HECT_dom IPR035983, Hect_E3_ubiquitin_ligase IPR042013, PHF7/G2E3_ePHD IPR042012, PHF7/G2E3_PHD IPR019786, Zinc_finger_PHD-type_CS IPR011011, Znf_FYVE_PHD IPR001965, Znf_PHD IPR013083, Znf_RING/FYVE/PHD |
Pfami | View protein in Pfam PF00632, HECT, 1 hit |
SMARTi | View protein in SMART SM00119, HECTc, 1 hit SM00249, PHD, 2 hits |
SUPFAMi | SSF56204, SSF56204, 1 hit SSF57903, SSF57903, 1 hit |
PROSITEi | View protein in PROSITE PS51805, EPHD, 1 hit PS50237, HECT, 1 hit PS01359, ZF_PHD_1, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | F6TIX2_HORSE | |
Accessioni | F6TIX2Primary (citable) accession number: F6TIX2 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | July 27, 2011 |
Last sequence update: | December 11, 2019 | |
Last modified: | December 2, 2020 | |
This is version 71 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |