UniProtKB - F6TI31 (F6TI31_HORSE)
Protein
Nicotinamide-nucleotide adenylyltransferase
Gene
NMNAT1
Organism
Equus caballus (Horse)
Status
Functioni
Catalytic activityi
: NAD(+) biosynthesis Pathwayi
This protein is involved in step 1 of the subpathway that synthesizes NAD(+) from nicotinamide D-ribonucleotide.UniRule annotationARBA annotationProteins known to be involved in this subpathway in this organism are:
- Nicotinamide-nucleotide adenylyltransferase (NMNAT1), Nicotinamide-nucleotide adenylyltransferase (NMNAT3)
View all proteins of this organism that are known to be involved in the subpathway that synthesizes NAD(+) from nicotinamide D-ribonucleotide, the pathway NAD(+) biosynthesis and in Cofactor biosynthesis.
GO - Molecular functioni
- ATP binding Source: UniProtKB-KW
- identical protein binding Source: Ensembl
- nicotinamide-nucleotide adenylyltransferase activity Source: GO_Central
- nicotinate-nucleotide adenylyltransferase activity Source: GO_Central
GO - Biological processi
- ATP generation from poly-ADP-D-ribose Source: Ensembl
- NAD biosynthetic process Source: GO_Central
- negative regulation of neuron death Source: Ensembl
- response to wounding Source: Ensembl
Keywordsi
Molecular function | NucleotidyltransferaseUniRule annotation, Transferase |
Biological process | Pyridine nucleotide biosynthesisUniRule annotation |
Ligand | ATP-bindingUniRule annotation, NADUniRule annotation, Nucleotide-binding |
Enzyme and pathway databases
UniPathwayi | UPA00253;UER00600 |
Names & Taxonomyi
Protein namesi | |
Gene namesi | Name:NMNAT1Imported |
Organismi | Equus caballus (Horse)Imported |
Taxonomic identifieri | 9796 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Perissodactyla › Equidae › Equus › |
Proteomesi |
|
Organism-specific databases
VGNCi | VGNC:20780, NMNAT1 |
Subcellular locationi
Nucleus
- nuclear body Source: Ensembl
- nucleus Source: GO_Central
Expressioni
Gene expression databases
Bgeei | ENSECAG00000020988, Expressed in gluteus medius and 22 other tissues |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 12 – 230 | CTP_transf_likeInterPro annotationAdd BLAST | 219 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 107 – 126 | DisorderedSequence analysisAdd BLAST | 20 |
Sequence similaritiesi
Phylogenomic databases
GeneTreei | ENSGT00950000183179 |
HOGENOMi | CLU_033366_3_0_1 |
OMAi | PAHHRVI |
OrthoDBi | 1308027at2759 |
TreeFami | TF315035 |
Family and domain databases
InterProi | View protein in InterPro IPR004821, Cyt_trans-like IPR005248, NadD/NMNAT |
Pfami | View protein in Pfam PF01467, CTP_transf_like, 1 hit |
TIGRFAMsi | TIGR00482, TIGR00482, 1 hit |
i Sequence
Sequence statusi: Complete.
F6TI31-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MENSEKTELV LLACGSFNPI TNMHLRLFEL AKDYMNGTGK YKVIKGIISP
60 70 80 90 100
VGDAYKKKGL ISAHHRVFMA QLATKNSEWV EVDTWESLQK EWVETAKVLR
110 120 130 140 150
HHQEKLEASS CGNEQGSPVL ERPGRKRKWA EQRQDFSQKK SLEPKTKGVP
160 170 180 190 200
KVKLLCGADL LESFGVPNLW KSEDITQIVR DYGLICITRA GNDAQKFIYE
210 220 230 240 250
SDVLWKYQNN IHLVNEWITN DISSTKIRQA LRRGQSIRYL VPDLVQEYIE
260 270 280
KHDLYTSESE ERNVGVILAP LQRNMAEANS
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | JL616281 mRNA Translation: AEH58488.1 |
RefSeqi | NP_001296336.1, NM_001309407.1 XP_005607602.1, XM_005607545.2 |
Genome annotation databases
Ensembli | ENSECAT00000022379; ENSECAP00000018493; ENSECAG00000020988 |
GeneIDi | 100057371 |
KEGGi | ecb:100057371 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | JL616281 mRNA Translation: AEH58488.1 |
RefSeqi | NP_001296336.1, NM_001309407.1 XP_005607602.1, XM_005607545.2 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Genome annotation databases
Ensembli | ENSECAT00000022379; ENSECAP00000018493; ENSECAG00000020988 |
GeneIDi | 100057371 |
KEGGi | ecb:100057371 |
Organism-specific databases
CTDi | 64802 |
VGNCi | VGNC:20780, NMNAT1 |
Phylogenomic databases
GeneTreei | ENSGT00950000183179 |
HOGENOMi | CLU_033366_3_0_1 |
OMAi | PAHHRVI |
OrthoDBi | 1308027at2759 |
TreeFami | TF315035 |
Enzyme and pathway databases
UniPathwayi | UPA00253;UER00600 |
Gene expression databases
Bgeei | ENSECAG00000020988, Expressed in gluteus medius and 22 other tissues |
Family and domain databases
InterProi | View protein in InterPro IPR004821, Cyt_trans-like IPR005248, NadD/NMNAT |
Pfami | View protein in Pfam PF01467, CTP_transf_like, 1 hit |
TIGRFAMsi | TIGR00482, TIGR00482, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | F6TI31_HORSE | |
Accessioni | F6TI31Primary (citable) accession number: F6TI31 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | July 27, 2011 |
Last sequence update: | July 27, 2011 | |
Last modified: | December 2, 2020 | |
This is version 62 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |