UniProtKB - F6T845 (F6T845_HORSE)
Protein
Submitted name:
Myosin XVIIIA
Gene
MYO18A
Organism
Equus caballus (Horse)
Status
Functioni
Caution
Lacks conserved residue(s) required for the propagation of feature annotation.PROSITE-ProRule annotation
GO - Molecular functioni
- actin filament binding Source: InterPro
- ATP binding Source: UniProtKB-UniRule
- DNA binding Source: InterPro
- DNA-dependent ATPase activity Source: InterPro
- motor activity Source: UniProtKB-UniRule
GO - Biological processi
- DNA metabolic process Source: InterPro
Keywordsi
Molecular function | Actin-bindingPROSITE-ProRule annotation, Motor protein, MyosinPROSITE-ProRule annotationARBA annotation |
Ligand | ATP-bindingPROSITE-ProRule annotationARBA annotation, Nucleotide-binding |
Names & Taxonomyi
Protein namesi | Submitted name: Myosin XVIIIAImported |
Gene namesi | Name:MYO18AImported |
Organismi | Equus caballus (Horse)Imported |
Taxonomic identifieri | 9796 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Perissodactyla › Equidae › Equus › |
Proteomesi |
|
Organism-specific databases
VGNCi | VGNC:20496, MYO18A |
Expressioni
Gene expression databases
Bgeei | ENSECAG00000020855, Expressed in gluteus medius and 23 other tissues |
ExpressionAtlasi | F6T845, baseline |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 220 – 311 | PDZInterPro annotationAdd BLAST | 92 | |
Domaini | 349 – 401 | Myosin N-terminal SH3-likeInterPro annotationAdd BLAST | 53 | |
Domaini | 405 – 1185 | Myosin motorInterPro annotationAdd BLAST | 781 | |
Domaini | 542 – 607 | RECA_3InterPro annotationAdd BLAST | 66 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 34 | DisorderedSequence analysisAdd BLAST | 34 | |
Regioni | 140 – 167 | DisorderedSequence analysisAdd BLAST | 28 | |
Regioni | 723 – 742 | DisorderedSequence analysisAdd BLAST | 20 | |
Regioni | 1450 – 1480 | DisorderedSequence analysisAdd BLAST | 31 | |
Regioni | 1852 – 1901 | DisorderedSequence analysisAdd BLAST | 50 | |
Regioni | 1959 – 2054 | DisorderedSequence analysisAdd BLAST | 96 |
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 1249 – 1304 | Sequence analysisAdd BLAST | 56 | |
Coiled coili | 1312 – 1353 | Sequence analysisAdd BLAST | 42 | |
Coiled coili | 1509 – 1588 | Sequence analysisAdd BLAST | 80 | |
Coiled coili | 1594 – 1642 | Sequence analysisAdd BLAST | 49 | |
Coiled coili | 1658 – 1678 | Sequence analysisAdd BLAST | 21 | |
Coiled coili | 1713 – 1810 | Sequence analysisAdd BLAST | 98 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 140 – 164 | PolarSequence analysisAdd BLAST | 25 | |
Compositional biasi | 1959 – 1985 | PolyampholyteSequence analysisAdd BLAST | 27 | |
Compositional biasi | 1999 – 2014 | PolarSequence analysisAdd BLAST | 16 | |
Compositional biasi | 2016 – 2031 | PolyampholyteSequence analysisAdd BLAST | 16 | |
Compositional biasi | 2034 – 2054 | PolarSequence analysisAdd BLAST | 21 |
Sequence similaritiesi
Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.PROSITE-ProRule annotationARBA annotation
Keywords - Domaini
Coiled coilSequence analysisARBA annotationPhylogenomic databases
GeneTreei | ENSGT00940000155768 |
HOGENOMi | CLU_000192_1_0_1 |
InParanoidi | F6T845 |
OMAi | EAWHETE |
OrthoDBi | 34123at2759 |
TreeFami | TF339614 |
Family and domain databases
CDDi | cd01386, MYSc_Myo18, 1 hit |
Gene3Di | 2.30.42.10, 1 hit 3.40.850.10, 1 hit 4.10.270.10, 1 hit |
InterProi | View protein in InterPro IPR000048, IQ_motif_EF-hand-BS IPR036961, Kinesin_motor_dom_sf IPR031244, MYO18A IPR001609, Myosin_head_motor_dom IPR027401, Myosin_IQ_contain_sf IPR004009, Myosin_N IPR002928, Myosin_tail IPR036064, MYSc_Myo18 IPR027417, P-loop_NTPase IPR001478, PDZ IPR036034, PDZ_sf IPR020587, RecA_monomer-monomer_interface |
PANTHERi | PTHR45615:SF13, PTHR45615:SF13, 1 hit |
Pfami | View protein in Pfam PF00063, Myosin_head, 2 hits PF01576, Myosin_tail_1, 1 hit PF00595, PDZ, 1 hit |
PRINTSi | PR00193, MYOSINHEAVY |
SMARTi | View protein in SMART SM00015, IQ, 1 hit SM00242, MYSc, 1 hit SM00228, PDZ, 1 hit |
SUPFAMi | SSF50156, SSF50156, 1 hit SSF52540, SSF52540, 1 hit |
PROSITEi | View protein in PROSITE PS50096, IQ, 1 hit PS51456, MYOSIN_MOTOR, 1 hit PS50106, PDZ, 1 hit PS50163, RECA_3, 1 hit PS51844, SH3_LIKE, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 7 potential isoforms that are computationally mapped.Show allAlign All
F6T845-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MFNLMKKDKD KDGGRKEKKE KKEKKERMSA AELRSLEEMS LRRGFFNLNR
60 70 80 90 100
SSKRESKTRL EISNPIPIKV ASGSDLHLTD IDSDSNRGSV ILDSGHLSTA
110 120 130 140 150
SSSDDLKGEE GSFRGSVLQR AAKFGSLAKQ NSQMIVKRFS FSQRSRDESA
160 170 180 190 200
SETSTPSEHS AAPSPQVEAR TLEGQLMQHP GPGIPRPAPR SRVPELVTKR
210 220 230 240 250
FPADLRLPPV VPPPLPALRE LELQRRPTGD FGFSLRRTTM LDRGPEGQVY
260 270 280 290 300
RRVVHFAEPG AGTKDVALGL VPGDRLMEIN GHNVESKSRD EIVEMIRQSG
310 320 330 340 350
DSVRLKVQPI PELSELSRSW LRSGEGTRRE PANVKTEEQI AAEEAWYETE
360 370 380 390 400
KVWLVHKDGF SLASQLKSEE LSLPEGKVRV KLDHDGAILD VDEDDVEKAN
410 420 430 440 450
APSCDRLEDL ASLVYLNESS VLHTLRQRYG ASLLYTYAGP SLLVLSPRGA
460 470 480 490 500
PAVYSEKVMH MFKGCRREDM APHIYAVAQN AYRAMLMSRQ DQSIILLGSS
510 520 530 540 550
GSGKTTSCQH LVQYLATIAG TSGNKVFSVE KWQALYTLLE AFGNSPTIMN
560 570 580 590 600
GNATRFSQIL SLDFDQAGQV ASASIQTMLL EKLRVARRPA SEATFNIFYY
610 620 630 640 650
LLACGDGTLR TELHLNHLAE NNVFGIVPLA KPEEKQKAAQ QFSKLQTAMK
660 670 680 690 700
VLGISPDEQK ACWLILAAIY HLGAAGATKE AAEAGRKQFA RHEWAQKAAY
710 720 730 740 750
LLGCSLEELS SAIFKHQHKG GTLQRSTSFR QGPEESGLGD GTGPKLSALE
760 770 780 790 800
CLEGMASGLY SELFTLLVSL VNRALKSSQH SLCSMMIVDT PGFQNPEQGG
810 820 830 840 850
SARGASFEEL CHNYAQDRLQ RLFHERTFVQ ELERYKEENI ELAFDDLEPA
860 870 880 890 900
TDDSVAAVDQ ASHQSLVRSL ARTDEARGLL WLLEEEALVP GATEDALLER
910 920 930 940 950
LFSYYGPQEG DKKGQSPLLR SSKPHHFLLG HSHGTNWVEY NVAGWLSYTK
960 970 980 990 1000
QNPATQNAPR LLQDSQKKII SNLFLGRAGS ATVLSGSIAG LEGGSQLALR
1010 1020 1030 1040 1050
RATSMRKTFT TGMAAVKKKS LCIQIKLQVD ALIDTIKKSK LHFVHCFLPV
1060 1070 1080 1090 1100
AEGWAGEPRS ASSRRVSSSS ELDLPSGDHC EAGLLQLDVP LLRAQLRGSR
1110 1120 1130 1140 1150
LLDAMRMYRQ GYPDHMVFSE FRRRFDVLAP HLTKKHGRNY IVVDERRAVE
1160 1170 1180 1190 1200
ELLESLDLEK SSCCMGLSRV FFRAGTLARL EEQRDDQTSR NLTLFQAACR
1210 1220 1230 1240 1250
GFLARQHFKK RKIQDLAIRC VQKNIKKNKG VKDWPWWKLF TTVRPLIEVQ
1260 1270 1280 1290 1300
LSEEQIRNRD EEIQQLRSKL EKVEKERNEL RLNSDRLETR ISELTSELTD
1310 1320 1330 1340 1350
ERNTGESASQ LLDAETAERL RAEKEMKELQ TQYDALKKQM EVMEMEVMEA
1360 1370 1380 1390 1400
RLIRAAEING EVDDDDTGGE WRLKYERAVR EVDFTKKRLQ QEFEDKLEVE
1410 1420 1430 1440 1450
QQNKRQLERR LGDLQADSDE SQRALQQLKK KCQRLTAELQ DTKLHLEGQQ
1460 1470 1480 1490 1500
VRNHELEKKQ RRFDSELSQA HEEAQREKLQ REKLQREKDM LLAEAFSLKQ
1510 1520 1530 1540 1550
QLEEKDMDIA GFTQKVVSLE AELQDISSQE SKDEASLAKV KKQLRDLEAK
1560 1570 1580 1590 1600
VKDQEEELDE QAGTIQMLEQ AKLRLEMEME RMRQTHSKEM ESRDEEVEEA
1610 1620 1630 1640 1650
RQSCQKKLKQ MEVQLEEEYE DKQKVLREKR ELESKLTTLS DQVNQRDFES
1660 1670 1680 1690 1700
EKRLRKDLKR TKALLADAQI MLDHLKNNAP SKREIAQLKN QLEESEFTCA
1710 1720 1730 1740 1750
AAVKARKAME VEIEDLHLQI DDIAKAKTAL EEQLSRLQRE KNEIQNRLEE
1760 1770 1780 1790 1800
DQEDMNELMK KHKAAVAQAS RDLAQMNDLQ AQLEEANKEK QELQEKLQTL
1810 1820 1830 1840 1850
QSQVEFLEQS MVDKSLVSRQ EAKIRELETR LEFERTQVKR LESLASRLKE
1860 1870 1880 1890 1900
NMEKLTEERD QRIAAENREK EQNKRLQRQL RDTKEEMGEL ARKEAEASRK
1910 1920 1930 1940 1950
KHELEMDLES LEAANQSLQA DLKLAFKRIG DLQAAIEDEM ESDENEDLIN
1960 1970 1980 1990 2000
SLQDMVTKYQ KRKNKPEGES DVDSELEDRV DGVKSWLSKN KGPSKAASDD
2010 2020 2030 2040 2050
GSLKSSSPTS YWKSPAPDRS DDEHDPPDST ARPRYSHNYL SDSDTEAKPM
ETNP
Computationally mapped potential isoform sequencesi
There are 7 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketA0A3Q2HTL6 | A0A3Q2HTL6_HORSE | Myosin XVIIIA | MYO18A | 2,432 | Annotation score: | ||
A0A3Q2GST5 | A0A3Q2GST5_HORSE | Myosin XVIIIA | MYO18A | 2,016 | Annotation score: | ||
A0A3Q2I0Z1 | A0A3Q2I0Z1_HORSE | Myosin XVIIIA | MYO18A | 2,428 | Annotation score: | ||
A0A3Q2ICX5 | A0A3Q2ICX5_HORSE | Myosin XVIIIA | MYO18A | 2,417 | Annotation score: | ||
A0A3Q2L723 | A0A3Q2L723_HORSE | Myosin XVIIIA | MYO18A | 2,402 | Annotation score: | ||
A0A5F5Q2S5 | A0A5F5Q2S5_HORSE | Myosin XVIIIA | MYO18A | 2,002 | Annotation score: | ||
A0A5F5Q4T0 | A0A5F5Q4T0_HORSE | Myosin XVIIIA | MYO18A | 1,870 | Annotation score: |
Sequence databases
RefSeqi | XP_003362477.1, XM_003362429.3 |
Genome annotation databases
Ensembli | ENSECAT00000022672; ENSECAP00000018749; ENSECAG00000020855 |
GeneIDi | 100059638 |
Similar proteinsi
Cross-referencesi
Sequence databases
RefSeqi | XP_003362477.1, XM_003362429.3 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Proteomic databases
PaxDbi | F6T845 |
PRIDEi | F6T845 |
Genome annotation databases
Ensembli | ENSECAT00000022672; ENSECAP00000018749; ENSECAG00000020855 |
GeneIDi | 100059638 |
Organism-specific databases
CTDi | 399687 |
VGNCi | VGNC:20496, MYO18A |
Phylogenomic databases
GeneTreei | ENSGT00940000155768 |
HOGENOMi | CLU_000192_1_0_1 |
InParanoidi | F6T845 |
OMAi | EAWHETE |
OrthoDBi | 34123at2759 |
TreeFami | TF339614 |
Gene expression databases
Bgeei | ENSECAG00000020855, Expressed in gluteus medius and 23 other tissues |
ExpressionAtlasi | F6T845, baseline |
Family and domain databases
CDDi | cd01386, MYSc_Myo18, 1 hit |
Gene3Di | 2.30.42.10, 1 hit 3.40.850.10, 1 hit 4.10.270.10, 1 hit |
InterProi | View protein in InterPro IPR000048, IQ_motif_EF-hand-BS IPR036961, Kinesin_motor_dom_sf IPR031244, MYO18A IPR001609, Myosin_head_motor_dom IPR027401, Myosin_IQ_contain_sf IPR004009, Myosin_N IPR002928, Myosin_tail IPR036064, MYSc_Myo18 IPR027417, P-loop_NTPase IPR001478, PDZ IPR036034, PDZ_sf IPR020587, RecA_monomer-monomer_interface |
PANTHERi | PTHR45615:SF13, PTHR45615:SF13, 1 hit |
Pfami | View protein in Pfam PF00063, Myosin_head, 2 hits PF01576, Myosin_tail_1, 1 hit PF00595, PDZ, 1 hit |
PRINTSi | PR00193, MYOSINHEAVY |
SMARTi | View protein in SMART SM00015, IQ, 1 hit SM00242, MYSc, 1 hit SM00228, PDZ, 1 hit |
SUPFAMi | SSF50156, SSF50156, 1 hit SSF52540, SSF52540, 1 hit |
PROSITEi | View protein in PROSITE PS50096, IQ, 1 hit PS51456, MYOSIN_MOTOR, 1 hit PS50106, PDZ, 1 hit PS50163, RECA_3, 1 hit PS51844, SH3_LIKE, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | F6T845_HORSE | |
Accessioni | F6T845Primary (citable) accession number: F6T845 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | July 27, 2011 |
Last sequence update: | December 11, 2019 | |
Last modified: | August 12, 2020 | |
This is version 66 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |