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Entry version 52 (02 Dec 2020)
Sequence version 2 (10 Apr 2019)
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Protein

Reverse transcriptase domain-containing protein

Gene
N/A
Organism
Equus caballus (Horse)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Reverse transcriptase domain-containing proteinInterPro annotation
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiEquus caballus (Horse)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9796 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaPerissodactylaEquidaeEquus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002281 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 7

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
F6T4Q3

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSECAG00000020829, Expressed in triceps brachii and 4 other tissues

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini468 – 743Reverse transcriptaseInterPro annotationAdd BLAST276

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 21DisorderedSequence analysisAdd BLAST21

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili128 – 148Sequence analysisAdd BLAST21
Coiled coili277 – 297Sequence analysisAdd BLAST21

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

Ensembl GeneTree

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GeneTreei
ENSGT01010000222261

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
CLU_000680_1_1_1

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
F6T4Q3

TreeFam database of animal gene trees

More...
TreeFami
TF341604

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.60.10.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR043502, DNA/RNA_pol_sf
IPR036691, Endo/exonu/phosph_ase_sf
IPR000477, RT_dom

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00078, RVT_1, 1 hit

Superfamily database of structural and functional annotation

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SUPFAMi
SSF56219, SSF56219, 1 hit
SSF56672, SSF56672, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50878, RT_POL, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

F6T4Q3-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDQRTRPNNM LPPGNTPQPQ RHRLRVKRWR TILQANNEQK KAGVTILISD
60 70 80 90 100
KVDFKAKQIK KDKEGQYIMI KGTLHQEDIT LINIHAPNTG APKFIKQLLI
110 120 130 140 150
ELKEDINNNT IIVGDLNTPL TPMDRTSRQK INKEIIELNE KLDQMDLIDI
160 170 180 190 200
YRTLHPKTGG YTFFSSAHGT FSRIDHILGN KANINKYKRV EIISSIFSDH
210 220 230 240 250
NAMKLEINYK KKAEKGAKMW RLNNTLLNKQ WIIEEIKEEI KYYLETNENE
260 270 280 290 300
NTTYQIIWDA AKAVLRGKFI TIQAHLTKQE KAHISNLKRH LTELEKEEQT
310 320 330 340 350
KPRVSRRREI IKIRAEINDI ETKKTIERIN ETQSWFFERI NKIDKPLARL
360 370 380 390 400
TKKRREKPQI NKIRNERGEI TTDTNEIQEI IREYYEKQYA NKLNNLEGMD
410 420 430 440 450
KFLDSYNLPK LNQEEMENLN RPITSKDIET VIKNLPQNKS PGPDSFSGEF
460 470 480 490 500
YQTFKEDLIP ILLKLFQKIE KDGVLPNTFY EANITLIPKP DKEKTKKENY
510 520 530 540 550
RPISLMNIDA KILNKILANR IQQYIKKSIH HDQVGFIPGT QGCFNIRKSI
560 570 580 590 600
NVIHYINKMK NKNHMIISID AEKAFDKIQH PFMIKTLSKM GIEGKCLNII
610 620 630 640 650
KAIYDRPTAN IILNGQKLKA IPLRTGTRQG CPLSPLLFNI VLEVLARAIR
660 670 680 690 700
QEKEIKGIQI GNEEVKLSLF ADDMILYIEK PKESIEKLLE IINNYSKVAG
710 720 730 740 750
YKINVLKSVA FLYTNNQLTE KELKNSIPFT IATKRIKYLG INLTKEVKDL
760 770 780 790 800
YNENYKTFLK EIGDDIKRWK DIPCTWIGRI NIVKMSILPK AIYRFNAFPI
810 820 830 840 850
RIPRTFFTEI EQTILKFIWG NKRPRIAKAI LSKKNKAGGI TIPDFKTYYK
860 870 880 890 900
ATVIKTAWYW YKNRSTDQWN RIESPEIKPH IYGQLIFDKG AEGLQWRKES
910 920 930 940 950
LFNKWCWENW TATCKRLKID HSFSPHTKIN SKWIKDLKIR PETISLLEKN
960 970 980 990 1000
IGSTLFDISF KRIFSDTVTP QLRETIERIN KWDFIRLKSF FKERENRIEK
1010 1020 1030 1040 1050
KQLTNWEKIC TSHLSDKGLI SIIYKELTLL NNKKTNNPIK KWAEDMNRHF
1060 1070 1080 1090 1100
SKEDMNMANR HMKRCSSSLI IREMQIKTTL RYHLTPVRLA KTSKTKSDKC
1110 1120 1130 1140 1150
WRGCGEKGTL IHCWWACKLV QPLWKTVWRF LKKLKIEIPY DPAIPLLGIY
1160 1170 1180 1190 1200
PKNLKSEISR VRCTPMFIAA LFTIAKTWNQ PTCPETDDWI KKMWYIYTME
1210 1220 1230 1240
YYSAIKKDKI GPFTATRMDL EGIMLSEISQ SEKDELYMTP LIGGS
Length:1,245
Mass (Da):146,287
Last modified:April 10, 2019 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iDF7DB1A60BCDC1F3
GO

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSECAT00000022114; ENSECAP00000018254; ENSECAG00000034679

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

3D structure databases

Database of comparative protein structure models

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ModBasei
Search...

SWISS-MODEL Interactive Workspace

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SWISS-MODEL-Workspacei
Submit a new modelling project...

Proteomic databases

PaxDbiF6T4Q3

Genome annotation databases

EnsembliENSECAT00000022114; ENSECAP00000018254; ENSECAG00000034679

Phylogenomic databases

GeneTreeiENSGT01010000222261
HOGENOMiCLU_000680_1_1_1
InParanoidiF6T4Q3
TreeFamiTF341604

Gene expression databases

BgeeiENSECAG00000020829, Expressed in triceps brachii and 4 other tissues

Family and domain databases

Gene3Di3.60.10.10, 1 hit
InterProiView protein in InterPro
IPR043502, DNA/RNA_pol_sf
IPR036691, Endo/exonu/phosph_ase_sf
IPR000477, RT_dom
PfamiView protein in Pfam
PF00078, RVT_1, 1 hit
SUPFAMiSSF56219, SSF56219, 1 hit
SSF56672, SSF56672, 1 hit
PROSITEiView protein in PROSITE
PS50878, RT_POL, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiF6T4Q3_HORSE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: F6T4Q3
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: July 27, 2011
Last sequence update: April 10, 2019
Last modified: December 2, 2020
This is version 52 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteomeImported
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