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Protein
Submitted name:

Protein inhibitor of-activated STAT 4

Gene

pias4

Organism
Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)
Status
Unreviewed-Annotation score: -Protein predictedi

Functioni

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri319 – 397SP-RING-typePROSITE-ProRule annotationAdd BLAST79

GO - Molecular functioni

Keywordsi

LigandMetal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-XTR-196791 Vitamin D (calciferol) metabolism
R-XTR-3108214 SUMOylation of DNA damage response and repair proteins
R-XTR-3232118 SUMOylation of transcription factors
R-XTR-3232142 SUMOylation of ubiquitinylation proteins
R-XTR-4085377 SUMOylation of SUMOylation proteins
R-XTR-4090294 SUMOylation of intracellular receptors
R-XTR-4615885 SUMOylation of DNA replication proteins
R-XTR-4755510 SUMOylation of immune response proteins
R-XTR-5693565 Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
R-XTR-5693571 Nonhomologous End-Joining (NHEJ)
R-XTR-5693607 Processing of DNA double-strand break ends
R-XTR-69473 G2/M DNA damage checkpoint

Names & Taxonomyi

Protein namesi
Submitted name:
Protein inhibitor of-activated STAT 4Imported
Gene namesi
Name:pias4Imported
OrganismiXenopus tropicalis (Western clawed frog) (Silurana tropicalis)Imported
Taxonomic identifieri8364 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusSilurana
Proteomesi
  • UP000008143 Componenti: Unassembled WGS sequence

Organism-specific databases

XenbaseiXB-GENE-486199 pias4

PTM / Processingi

Proteomic databases

PaxDbiF6T4G7

Expressioni

Gene expression databases

BgeeiENSXETG00000006386 Expressed in 12 organ(s), highest expression level in embryo
ExpressionAtlasiF6T4G7 baseline

Interactioni

Protein-protein interaction databases

STRINGi8364.ENSXETP00000061564

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini12 – 46SAPInterPro annotationAdd BLAST35
Domaini124 – 287PINITInterPro annotationAdd BLAST164
Domaini319 – 397SP-RING-typeInterPro annotationAdd BLAST79

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri319 – 397SP-RING-typePROSITE-ProRule annotationAdd BLAST79

Keywords - Domaini

Zinc-fingerPROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG2169 Eukaryota
ENOG410XQ2E LUCA
GeneTreeiENSGT00550000074410
InParanoidiF6T4G7
OMAiLRICYTD
OrthoDBiEOG091G08G5
TreeFamiTF323787

Family and domain databases

Gene3Di1.10.720.30, 1 hit
2.60.120.780, 1 hit
3.30.40.10, 1 hit
InterProiView protein in InterPro
IPR027224 PIAS4
IPR023321 PINIT
IPR038654 PINIT_sf
IPR003034 SAP_dom
IPR036361 SAP_dom_sf
IPR004181 Znf_MIZ
IPR013083 Znf_RING/FYVE/PHD
PANTHERiPTHR10782:SF9 PTHR10782:SF9, 1 hit
PfamiView protein in Pfam
PF14324 PINIT, 1 hit
PF02891 zf-MIZ, 1 hit
SMARTiView protein in SMART
SM00513 SAP, 1 hit
SUPFAMiSSF68906 SSF68906, 1 hit
PROSITEiView protein in PROSITE
PS51466 PINIT, 1 hit
PS50800 SAP, 1 hit
PS51044 ZF_SP_RING, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.iShow all

F6T4G7-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
NLKLLSLFQN MVMSFRVSDL QMLLGFVGRS KSGLKHELVT RALQLVQFDC
60 70 80 90 100
SPEVFKKIKE LYETRYAKKG TEAISQAPPQ PITSHRAPES LSIHPSYDHG
110 120 130 140 150
VSGPRTSLST PNIDYPSLYG KHVNGLSRLP PKVITKPEVR LVKLPFYDVV
160 170 180 190 200
DELLKPTELV AQNNEKLQDS PCVFVLSPRQ VDLIKNSRDL HPGTKSVQVV
210 220 230 240 250
LRICYTDTSC PQEDQYPPNV AVKVNHNYCS VPGYYPSNKP GVEPKRPCRP
260 270 280 290 300
INLTNLMYLS SASNRVTVTW GNYGKSYSVG LYLVRQRTSS ELLQRLKTIG
310 320 330 340 350
VKHPELCKTL VREKLRLDPD SEIATTGVRV SLICPPLVKM RLTVPCRAET
360 370 380 390 400
CAHLQCFDAV FYLQMNEKKP TWTCPVCDKP ALYDQLIIDG LLSKILSECK
410 420 430 440 450
DADEIEFLAD GSWCPIKAEK ERSSSPVCPI LVLGSQDMMA KLPPPSSTVS
460 470 480 490 500
SENGKPGPDV VDLTLDSSSS SSSSSDEDEE EEEEERPPQK RRCFEKGLLS

AC
Length:502
Mass (Da):56,013
Last modified:July 27, 2011 - v1
Checksum:i3886BBB8E006FDC7
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F6ZR85F6ZR85_XENTR
Protein inhibitor of-activated STAT...
pias4
501Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAMC01114423 Genomic DNA No translation available.
AAMC01114424 Genomic DNA No translation available.
AAMC01114425 Genomic DNA No translation available.
AAMC01114426 Genomic DNA No translation available.
AAMC01114427 Genomic DNA No translation available.
AAMC01114428 Genomic DNA No translation available.
AAMC01114429 Genomic DNA No translation available.

Genome annotation databases

EnsembliENSXETT00000063630; ENSXETP00000061564; ENSXETG00000006386

Similar proteinsi

Entry informationi

Entry nameiF6T4G7_XENTR
AccessioniPrimary (citable) accession number: F6T4G7
Entry historyiIntegrated into UniProtKB/TrEMBL: July 27, 2011
Last sequence update: July 27, 2011
Last modified: September 12, 2018
This is version 41 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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