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Protein
Submitted name:

TBC1 domain family member 8B

Gene

TBC1D8B

Organism
Ornithorhynchus anatinus (Duckbill platypus)
Status
Unreviewed-Annotation score: -Protein predictedi

Functioni

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.PROSITE-ProRule annotation

GO - Molecular functioni

GO - Biological processi

Names & Taxonomyi

Protein namesi
Submitted name:
TBC1 domain family member 8BImported
Gene namesi
Name:TBC1D8BImported
OrganismiOrnithorhynchus anatinus (Duckbill platypus)Imported
Taxonomic identifieri9258 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaMonotremataOrnithorhynchidaeOrnithorhynchus
Proteomesi
  • UP000002279 Componenti: Chromosome 6

Subcellular locationi

Expressioni

Gene expression databases

BgeeiENSOANG00000011642 Expressed in 6 organ(s), highest expression level in liver

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9258.ENSOANP00000018444

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini390 – 577Rab-GAP TBCInterPro annotationAdd BLAST188
Domaini761 – 796EF-handInterPro annotationAdd BLAST36

Phylogenomic databases

eggNOGiKOG4347 Eukaryota
COG5210 LUCA
GeneTreeiENSGT00760000119137
InParanoidiF6T2I3
OrthoDBiEOG091G00RI
TreeFamiTF313145

Family and domain databases

CDDicd13350 PH-GRAM1_TBC1D8B, 1 hit
cd13352 PH-GRAM2_TBC1D8B, 1 hit
Gene3Di2.30.29.30, 2 hits
InterProiView protein in InterPro
IPR011992 EF-hand-dom_pair
IPR002048 EF_hand_dom
IPR004182 GRAM
IPR011993 PH-like_dom_sf
IPR000195 Rab-GTPase-TBC_dom
IPR035969 Rab-GTPase_TBC_sf
IPR036012 TBC1D8B_PH-GRAM1
IPR036015 TBC1D8B_PH-GRAM2
PfamiView protein in Pfam
PF02893 GRAM, 2 hits
PF00566 RabGAP-TBC, 1 hit
SMARTiView protein in SMART
SM00568 GRAM, 2 hits
SM00164 TBC, 1 hit
SUPFAMiSSF47473 SSF47473, 1 hit
SSF47923 SSF47923, 2 hits
PROSITEiView protein in PROSITE
PS50222 EF_HAND_2, 1 hit
PS50086 TBC_RABGAP, 1 hit

Sequencei

Sequence statusi: Complete.

F6T2I3-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKTLSVFDSN EDITSFVQGK IRGLIAEEGK GSFVKEDDPE KFREALLKFE
60 70 80 90 100
KCFGLAEQEK LVTYYSCSYW RGRVPCQGWL YLSTNFLSFY SFLLGSEIKL
110 120 130 140 150
VISWDAISKL EKTSNAILTE SIHVCTRGED HYFSMFLHIN ETFLLMEQLA
160 170 180 190 200
NYAVRRLFDK ETFENDPVLR DPLQITKRGL ENRAHSEQFN AFFRLPKEET
210 220 230 240 250
LKEVHECFLW IPFSHFNTHG KMCISENYIC FASQDGNLCS VIIPLREVLA
260 270 280 290 300
VETTDHSNKA VIICIKGKTA FRFTEVRDFE QLLAKLRLKC GASLSPQHDT
310 320 330 340 350
IGPEVAISSE TDSAPDSYEG RFGAGQKDCS KTVSTEALMT VFHPQDLENL
360 370 380 390 400
DSKMLKEKMK EQLWNILFVE CGRGVSMFRT KKTRDLVVRG IPETLRGELW
410 420 430 440 450
LLFSGAVNDM ATNPGYYAEV VERSLGTCTL ATDEIERDLR RSLPEHPAFQ
460 470 480 490 500
SDTGISALRR VLTAYAYRNP KIGYCQAMNI LTSVLLLYAK EEEAFWLLVA
510 520 530 540 550
VCERMLPDYF NRRIIGALVD QAVFEELIRD HLPQLTEHMI DMTFFSSVSL
560 570 580 590 600
SWFLTLFISV LPIESAVNVV DCFFFDGIKA ILQLGLAVLD YNMDKLLSCR
610 620 630 640 650
DDAEAVTILN RFFDNVTNKD SPLPSTVQQG SNTSDAKSSH TKVDVTDLIR
660 670 680 690 700
ESNEKYGDIR YEDVHSMRCR NRLYVIQTLE DTTKQNVLRV VSQDVKFSLR
710 720 730 740 750
DLEELYDLFK KEHFYSCYWS LNSPVLKHHD SSLPYLEQYQ IDCLQFRVLY
760 770 780 790 800
HLLSPWSYSA NRDSLALWTF RLLDENSDCL INFKEFSCAL DIMYNGSFTE
810 820 830 840 850
KLKLLFKLHI PPAFTEVESQ SPSKGTELSK EELIRFSQLH VSSSAEDQGP
860 870 880 890 900
DSVKKSPEKG KGKVDIQAYL KQWQDELLKK EENVKDLPRM DQLQFIQFSR
910 920 930 940 950
TLYNLFHGDP EEELLYRSVA VVTSLLLKME EVGRKLHSPL SPAEDPSAEA
960 970 980 990 1000
GERLQDTTIQ QATKVLASPR EEHEWSFAFE QILASLLNEP VLVRFFEKPI
1010 1020
DVKAKLEQAK SSQLRARTRV
Length:1,020
Mass (Da):117,142
Last modified:January 9, 2013 - v2
Checksum:i5D1FFFE6143C5F57
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAPN01018297 Genomic DNA No translation available.

Genome annotation databases

EnsembliENSOANT00000018447; ENSOANP00000018444; ENSOANG00000011642

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAPN01018297 Genomic DNA No translation available.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9258.ENSOANP00000018444

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSOANT00000018447; ENSOANP00000018444; ENSOANG00000011642

Phylogenomic databases

eggNOGiKOG4347 Eukaryota
COG5210 LUCA
GeneTreeiENSGT00760000119137
InParanoidiF6T2I3
OrthoDBiEOG091G00RI
TreeFamiTF313145

Gene expression databases

BgeeiENSOANG00000011642 Expressed in 6 organ(s), highest expression level in liver

Family and domain databases

CDDicd13350 PH-GRAM1_TBC1D8B, 1 hit
cd13352 PH-GRAM2_TBC1D8B, 1 hit
Gene3Di2.30.29.30, 2 hits
InterProiView protein in InterPro
IPR011992 EF-hand-dom_pair
IPR002048 EF_hand_dom
IPR004182 GRAM
IPR011993 PH-like_dom_sf
IPR000195 Rab-GTPase-TBC_dom
IPR035969 Rab-GTPase_TBC_sf
IPR036012 TBC1D8B_PH-GRAM1
IPR036015 TBC1D8B_PH-GRAM2
PfamiView protein in Pfam
PF02893 GRAM, 2 hits
PF00566 RabGAP-TBC, 1 hit
SMARTiView protein in SMART
SM00568 GRAM, 2 hits
SM00164 TBC, 1 hit
SUPFAMiSSF47473 SSF47473, 1 hit
SSF47923 SSF47923, 2 hits
PROSITEiView protein in PROSITE
PS50222 EF_HAND_2, 1 hit
PS50086 TBC_RABGAP, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiF6T2I3_ORNAN
AccessioniPrimary (citable) accession number: F6T2I3
Entry historyiIntegrated into UniProtKB/TrEMBL: July 27, 2011
Last sequence update: January 9, 2013
Last modified: September 12, 2018
This is version 39 of the entry and version 2 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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