UniProtKB - F6T1P3 (F6T1P3_XENTR)
Protein
Submitted name:
Nuclear factor of activated T cells 1
Gene
nfatc1
Organism
Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)
Status
Functioni
GO - Molecular functioni
- chromatin binding Source: GO_Central
- DNA-binding transcription factor activity Source: GO_Central
- RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: GO_Central
- transcription factor binding Source: GO_Central
GO - Biological processi
- calcineurin-NFAT signaling cascade Source: GO_Central
- cytokine production Source: GO_Central
- positive regulation of transcription by RNA polymerase II Source: GO_Central
Enzyme and pathway databases
Reactomei | R-XTR-2025928, Calcineurin activates NFAT R-XTR-2871809, FCERI mediated Ca+2 mobilization R-XTR-4086398, Ca2+ pathway R-XTR-5607763, CLEC7A (Dectin-1) induces NFAT activation |
Names & Taxonomyi
Protein namesi | Submitted name: Nuclear factor of activated T cells 1Imported |
Gene namesi | Name:nfatc1Imported |
Organismi | Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)Imported |
Taxonomic identifieri | 8364 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Amphibia › Batrachia › Anura › Pipoidea › Pipidae › Xenopodinae › Xenopus › Silurana |
Proteomesi |
|
Organism-specific databases
Xenbasei | XB-GENE-876756, nfatc1 |
Subcellular locationi
Cytosol
- cytosol Source: GO_Central
Nucleus
- nucleus Source: GO_Central
Other locations
- integral component of membrane Source: UniProtKB-KW
- transcription regulator complex Source: GO_Central
Expressioni
Gene expression databases
Bgeei | ENSXETG00000000853, Expressed in skeletal muscle tissue and 12 other tissues |
Interactioni
GO - Molecular functioni
- transcription factor binding Source: GO_Central
Protein-protein interaction databases
STRINGi | 8364.ENSXETP00000001898 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 399 – 581 | RHDInterPro annotationAdd BLAST | 183 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 187 – 285 | DisorderedSequence analysisAdd BLAST | 99 | |
Regioni | 326 – 356 | DisorderedSequence analysisAdd BLAST | 31 | |
Regioni | 771 – 830 | DisorderedSequence analysisAdd BLAST | 60 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 341 – 356 | PolarSequence analysisAdd BLAST | 16 | |
Compositional biasi | 771 – 824 | PolarSequence analysisAdd BLAST | 54 |
Phylogenomic databases
eggNOGi | ENOG502QTX8, Eukaryota |
GeneTreei | ENSGT00940000157616 |
HOGENOMi | CLU_010185_1_0_1 |
InParanoidi | F6T1P3 |
TreeFami | TF326480 |
Family and domain databases
Gene3Di | 2.60.40.10, 1 hit 2.60.40.340, 1 hit |
InterProi | View protein in InterPro IPR013783, Ig-like_fold IPR014756, Ig_E-set IPR008366, NFAT IPR015647, NFAT1 IPR008967, p53-like_TF_DNA-bd IPR011539, RHD_DNA_bind_dom IPR037059, RHD_DNA_bind_dom_sf |
PANTHERi | PTHR12533, PTHR12533, 2 hits PTHR12533:SF5, PTHR12533:SF5, 2 hits |
Pfami | View protein in Pfam PF00554, RHD_DNA_bind, 1 hit |
PRINTSi | PR01789, NUCFACTORATC |
SUPFAMi | SSF49417, SSF49417, 1 hit SSF81296, SSF81296, 1 hit |
PROSITEi | View protein in PROSITE PS50254, REL_2, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 12 potential isoforms that are computationally mapped.Show allAlign All
F6T1P3-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSAPREEPEL DFDYLFEYEY NKGEQLGGTD REHFNYASSN LSASLSLGVT
60 70 80 90 100
NSSLSNPCHG LQSSNPVISI IPSSSHPPGY GGNLDSEATG YYLSPSIRPV
110 120 130 140 150
GPPALESPRI EITSCLAMHP NHNQFFNEPD IEEAIPQAKR IHSTATLNLP
160 170 180 190 200
NVDTYRDPSC LSPASSLSSR SCNSEASSFE SNYSYPFTSP QTSPWQSPCV
210 220 230 240 250
SPKTTDPEEG YQRSMVTCTL LSSPRHSPST SPRTSISEEN WLNAPSSRPS
260 270 280 290 300
SPCIKRKYSL NGRQTSYSPH HSPTPSPHNS PRVSVTDETW LGNTHQYTSS
310 320 330 340 350
AIVAAINALT TDPTDMNDGI PIKSRKTAAD HTPNMSLKTE PVCDDHSTMS
360 370 380 390 400
STNDLSPDDY SGFHHIRKGN FCDQYLSVPQ QSYQWAKPKN ISPTSYLSPS
410 420 430 440 450
LPALDWHLPS QSGPYELRIE VQPKSHHRAH YETEGSRGAV KASTGGHPIV
460 470 480 490 500
QLHGYLENEP LTIQLFIGTA DDRLLRPHAF YQVHRITGKT VSTTSHETII
510 520 530 540 550
SNTKVLEIPL LPENNMRAII DCAGILKLRN SDIELRKGET DIGRKNTRVR
560 570 580 590 600
LVFRVHIPQA NGRTLTLQVA SNPIECSQRS AQELPLVEKQ STDNFPVIGG
610 620 630 640 650
KKMILNGHNF HPDSKVIFVE KAPVPIIKTE PTDDYESAQT CVPMSQGLTQ
660 670 680 690 700
LSKPYYSQQI MMPPDPGSCL VSGFTSCQQR NTVMSSSPIS SPKLHDLSAS
710 720 730 740 750
AYNKCISNPG HTQLGLQQTT GGVPTIQEVP RSIVGHPSSP DQSSPIMLQP
760 770 780 790 800
QVSLHQSSSC PLGFQQTVYP NSPSSPVPSI TQEPSYLQPC SPTHSAVIGQ
810 820 830 840 850
PQHQHQKVQR NESPNSQPLS LPELHEDSNH NLAPIPVTIK REPEELDQLY
860 870
LDDGNKICCS DLSENGELAL LTAVI
Computationally mapped potential isoform sequencesi
There are 12 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketF6T5A2 | F6T5A2_XENTR | Ribonuclease P/MRP 30kDa subunit | nfatc1 rpp30, TEgg004n22.1-001 | 265 | Annotation score: | ||
A0A6I8SA77 | A0A6I8SA77_XENTR | Nuclear factor of activated T cells... | nfatc1 | 826 | Annotation score: | ||
A0A6I8Q8D5 | A0A6I8Q8D5_XENTR | Nuclear factor of activated T cells... | nfatc1 | 937 | Annotation score: | ||
A0A6I8QJN6 | A0A6I8QJN6_XENTR | Nuclear factor of activated T cells... | nfatc1 | 896 | Annotation score: | ||
A0A6I8QTZ7 | A0A6I8QTZ7_XENTR | Nuclear factor of activated T cells... | nfatc1 | 825 | Annotation score: | ||
A0A6I8S1A5 | A0A6I8S1A5_XENTR | Nuclear factor of activated T cells... | nfatc1 | 930 | Annotation score: | ||
A0A6I8PRL5 | A0A6I8PRL5_XENTR | Nuclear factor of activated T cells... | nfatc1 | 870 | Annotation score: | ||
A0A6I8QZ32 | A0A6I8QZ32_XENTR | Ribonuclease P/MRP 30kDa subunit | rpp30 | 259 | Annotation score: | ||
A0A6I8ST00 | A0A6I8ST00_XENTR | Ribonuclease P/MRP 30kDa subunit | rpp30 | 303 | Annotation score: | ||
A0A6I8SV69 | A0A6I8SV69_XENTR | Ribonuclease P/MRP 30kDa subunit | rpp30 | 284 | Annotation score: | ||
There are more potential isoformsShow all |
Genome annotation databases
Ensembli | ENSXETT00000001898; ENSXETP00000001898; ENSXETG00000000853 |
Similar proteinsi
Cross-referencesi
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
STRINGi | 8364.ENSXETP00000001898 |
Proteomic databases
PaxDbi | F6T1P3 |
Genome annotation databases
Ensembli | ENSXETT00000001898; ENSXETP00000001898; ENSXETG00000000853 |
Organism-specific databases
Xenbasei | XB-GENE-876756, nfatc1 |
Phylogenomic databases
eggNOGi | ENOG502QTX8, Eukaryota |
GeneTreei | ENSGT00940000157616 |
HOGENOMi | CLU_010185_1_0_1 |
InParanoidi | F6T1P3 |
TreeFami | TF326480 |
Enzyme and pathway databases
Reactomei | R-XTR-2025928, Calcineurin activates NFAT R-XTR-2871809, FCERI mediated Ca+2 mobilization R-XTR-4086398, Ca2+ pathway R-XTR-5607763, CLEC7A (Dectin-1) induces NFAT activation |
Gene expression databases
Bgeei | ENSXETG00000000853, Expressed in skeletal muscle tissue and 12 other tissues |
Family and domain databases
Gene3Di | 2.60.40.10, 1 hit 2.60.40.340, 1 hit |
InterProi | View protein in InterPro IPR013783, Ig-like_fold IPR014756, Ig_E-set IPR008366, NFAT IPR015647, NFAT1 IPR008967, p53-like_TF_DNA-bd IPR011539, RHD_DNA_bind_dom IPR037059, RHD_DNA_bind_dom_sf |
PANTHERi | PTHR12533, PTHR12533, 2 hits PTHR12533:SF5, PTHR12533:SF5, 2 hits |
Pfami | View protein in Pfam PF00554, RHD_DNA_bind, 1 hit |
PRINTSi | PR01789, NUCFACTORATC |
SUPFAMi | SSF49417, SSF49417, 1 hit SSF81296, SSF81296, 1 hit |
PROSITEi | View protein in PROSITE PS50254, REL_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | F6T1P3_XENTR | |
Accessioni | F6T1P3Primary (citable) accession number: F6T1P3 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | July 27, 2011 |
Last sequence update: | December 2, 2020 | |
Last modified: | February 10, 2021 | |
This is version 57 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |