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Entry version 45 (10 Feb 2021)
Sequence version 2 (10 Apr 2019)
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Protein
Submitted name:

Kinetochore associated 1

Gene

KNTC1

Organism
Equus caballus (Horse)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Kinetochore associated 1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:KNTC1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiEquus caballus (Horse)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9796 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaPerissodactylaEquidaeEquus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002281 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 8

Organism-specific databases

Vertebrate Gene Nomenclature Database

More...
VGNCi
VGNC:19502, KNTC1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
F6STV8

PRoteomics IDEntifications database

More...
PRIDEi
F6STV8

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSECAG00000021072, Expressed in trophectoderm and 21 other tissues

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini487 – 772Rod_CInterPro annotationAdd BLAST286
Domaini1580 – 2128Rod_CInterPro annotationAdd BLAST549

Phylogenomic databases

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000007883

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_231522_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
F6STV8

TreeFam database of animal gene trees

More...
TreeFami
TF101176

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR019527, RZZ-complex_KNTC1/ROD_C
IPR036322, WD40_repeat_dom_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF10493, Rod_C, 2 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF50978, SSF50978, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

F6STV8-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MWNDIELLTS DDTGSGYLSV GSRKEHGTAL YQVDLLAKVT SEKASLNPRI
60 70 80 90 100
QACSLSDGFI VVADQSVILL DGICRSLQLH LIFDTEVDVV GLCQEGKFLL
110 120 130 140 150
VGERSGNLHL IHVTSKQTLL TNAFVQKTND EDQCTYRNLV IEKDSSNEGT
160 170 180 190 200
YYMLLLTNNG FFCITNLQLV KIQQAIENAD FNKAKKLQGQ IKSRFISTEN
210 220 230 240 250
YHSLGCLNLV AGDLASEIPV IIGGTGSCAF SKWEPDSSKE GMTVKNVIDA
260 270 280 290 300
EIIEGAKKFQ LIDNLLFVLD TDNVLSLWDI YTLTPIWNWS SLHIEDFLLT
310 320 330 340 350
TEADSPSSVT WQGITNLKLV ALTTTTNKKM KNLMVYSLPT MEILYSLEVS
360 370 380 390 400
SISSLVQTGI STDTIYLLEG ICKNDPKLSE DSVSVLVLRC LTEALPENRL
410 420 430 440 450
SRLLHKHRFA EAESFAIQFG LDVELVYKVK SNDILEKLAL NSVDTSEQTE
460 470 480 490 500
WQTLVDEAKE NLHKIQDDEF VVNYCLEAQW ITYETTQEML NYAKARLLKK
510 520 530 540 550
EDKTVPIYSD GLKEVLRAHA KLTTFYGAFG PEKFSGSSWI EFLNNEDDLK
560 570 580 590 600
DIFLQLREGN LVCAQYLWLR HRANFESRFD VKMLENLLNS ISTPVSLQKL
610 620 630 640 650
CPWLRNDVIP FVRKTVPEGQ KILAKWLEQA ARNLELTDKA NWPENGLQLA
660 670 680 690 700
EVFFTAEKPD ELGLASSWHW ISLKDYQNTE EVCQLRTLVN NLRELITLHR
710 720 730 740 750
KYNCKLTLSD FEKENTTTIV FRMFDKVLAP ELIPSILEKF IRVYMREHDL
760 770 780 790 800
QEEELLLLYI EDLLKRCSSK STSLFETAWE AKAMAVIGCL SDTDLIFDAV
810 820 830 840 850
LKIMYAAMVP WSAAVEQLVK QHLEMDHPKV KLLQESYKLM EMKKLLRGYG
860 870 880 890 900
IREVNLLNKE IMRVVRYILK QDVPSSLEDA LKVAQAYMLS DDEIYSLRII
910 920 930 940 950
DLIDREQGED CVPLLRSLPP AEAEKTAQRV IIWARLALQE EPDNSKEDKA
960 970 980 990 1000
WRMSVAKTSV DILKILRDAL KDNLQKKDEC EEILKLFKSV ASLQENFEVF
1010 1020 1030 1040 1050
LPFGDYSNSS LVAELREQYI KAHEVAQATH KPRSTAEPVA AEKSLSTESK
1060 1070 1080 1090 1100
LHRQALALQV SRQELEAELT LRALNNGNAE TALRKCRDLF KYHCNTDTGK
1110 1120 1130 1140 1150
LLFLTCQKLC QMLANDVPMT TPVGLNLPSE IHNLACQAAT ICSPDFLLDA
1160 1170 1180 1190 1200
LELCKYTLTA VELSRQCQMD DCGILMKTSF GTHKDPYEEW SYSDFFSEDG
1210 1220 1230 1240 1250
IVLESQMVLP VIYELISSLV PLAESRRHPL DSASLPYCSI SEGDGLILPI
1260 1270 1280 1290 1300
INSISALLQN LQESSQWELA LRFVVGSFGT CLQHSVSNFM NASLSEKLFG
1310 1320 1330 1340 1350
TATLVKPKHV VTELKEKAVM FVRGNATTLL HKVFNCRLVD LDLALGYCTL
1360 1370 1380 1390 1400
LPQKEVFENL WKLIDKAWQN YDKILAISLV GSQLASLYQE IEMELKFREL
1410 1420 1430 1440 1450
STDAQWGIRL GKLGISFQPV FRQHFLTKKD LIKALVENID MDTSLILEYC
1460 1470 1480 1490 1500
STFQLDCDAA LQLFIETLLQ NTNASQSQGD ASTESTRQQH SKLLAKAIEM
1510 1520 1530 1540 1550
VPLLTSTKDL VISLSGILHK LDPYDYDMIE IVLKVIERAD EKITNININQ
1560 1570 1580 1590 1600
ALSLLKHLKS YRRISPPVDV EYQYMLEHVI TLPSAAQTRL PFHLIFFGTA
1610 1620 1630 1640 1650
QNFWKILSTE LSEESFPTLL LISKLMKFSL DTLYMSTAKH VFEKKLKPKL
1660 1670 1680 1690 1700
LKLTQAKSST LINKEITRIT QTIESYLLSI VNPEWAVAIA ISLAQDIPEG
1710 1720 1730 1740 1750
SFKMSSLKFC LYLAERWLQN IPSQDETREK AEALLKKLHV QYRRSGTEAV
1760 1770 1780 1790 1800
LIAHKLNTAE YLRLIGKPAH LIVSLYEHPS VNQRIQNSSG TDYPDIHAAA
1810 1820 1830 1840 1850
KEIAEVNEIN LEKVWDMLLE KWLCPSTKPG EKPSELFELQ EDEALQRVLY
1860 1870 1880 1890 1900
LLLSRPIDYS SRMLFVFATS ATTTLGMRQL TFAHRTRALQ CLLYLADKET
1910 1920 1930 1940 1950
IESLFKKPIE EVKSYLKCIT FMASFETLNI PITYELFCNS PKEGMIKGLW
1960 1970 1980 1990 2000
KNHSHEATAV RLVTELCLEY KIYDLQLWNG LLQKLLGFSM IPYLRKVLTA
2010 2020 2030 2040 2050
ISSIHSLWQV PYFSKAWQRV VQIPLLSASC PLSSSQLSDC CESLIAVLEC
2060 2070 2080 2090 2100
PVSDDLDMIG VARQYVQLEL PAFALACLML MPHSEKRHQQ IKNFLGSCNP
2110 2120 2130 2140 2150
QIILQQLEEH MSTGQLAGFS HQIRNLILNN VINKKDFGIL AKTKYFQMLK
2160 2170 2180 2190 2200
LHTMNTNNIT DLVNYLANEL SLDEASVFIT EYAKHRGKPV PPDAAPCEIL

KMFLSGS
Length:2,207
Mass (Da):250,614
Last modified:April 10, 2019 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i264C9BD2C75C4450
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F6W4H3F6W4H3_HORSE
Kinetochore associated 1
KNTC1
2,177Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSECAT00000029082; ENSECAP00000022994; ENSECAG00000021072

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Proteomic databases

PaxDbiF6STV8
PRIDEiF6STV8

Genome annotation databases

EnsembliENSECAT00000029082; ENSECAP00000022994; ENSECAG00000021072

Organism-specific databases

VGNCiVGNC:19502, KNTC1

Phylogenomic databases

GeneTreeiENSGT00390000007883
HOGENOMiCLU_231522_0_0_1
InParanoidiF6STV8
TreeFamiTF101176

Gene expression databases

BgeeiENSECAG00000021072, Expressed in trophectoderm and 21 other tissues

Family and domain databases

InterProiView protein in InterPro
IPR019527, RZZ-complex_KNTC1/ROD_C
IPR036322, WD40_repeat_dom_sf
PfamiView protein in Pfam
PF10493, Rod_C, 2 hits
SUPFAMiSSF50978, SSF50978, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiF6STV8_HORSE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: F6STV8
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: July 27, 2011
Last sequence update: April 10, 2019
Last modified: February 10, 2021
This is version 45 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Technical termi

Reference proteomeImported
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