UniProtKB - F6SR05 (F6SR05_HORSE)
Protein
Kinesin-like protein
Gene
KIF3A
Organism
Equus caballus (Horse)
Status
Functioni
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 100 – 107 | ATPPROSITE-ProRule annotation | 8 |
GO - Molecular functioni
- ATPase activity Source: GO_Central
- ATP binding Source: UniProtKB-UniRule
- microtubule binding Source: GO_Central
- microtubule motor activity Source: GO_Central
GO - Biological processi
- anterograde axonal transport Source: GO_Central
- axon guidance Source: GO_Central
- cilium assembly Source: GO_Central
- microtubule-based movement Source: GO_Central
Keywordsi
Molecular function | Motor proteinPROSITE-ProRule annotation |
Ligand | ATP-bindingPROSITE-ProRule annotationARBA annotation, Nucleotide-binding |
Names & Taxonomyi
Protein namesi | Recommended name: Kinesin-like proteinUniRule annotation |
Gene namesi | Name:KIF3AImported |
Organismi | Equus caballus (Horse)Imported |
Taxonomic identifieri | 9796 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Perissodactyla › Equidae › Equus › |
Proteomesi |
|
Organism-specific databases
VGNCi | VGNC:19418, KIF3A |
Subcellular locationi
Cytoskeleton
- kinesin complex Source: GO_Central
- microtubule Source: GO_Central
Other locations
- axon cytoplasm Source: GOC
Keywords - Cellular componenti
MicrotubuleUniRule annotationExpressioni
Gene expression databases
Bgeei | ENSECAG00000024644, Expressed in brainstem and 22 other tissues |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 14 – 345 | Kinesin motorInterPro annotationAdd BLAST | 332 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 372 – 421 | DisorderedSequence analysisAdd BLAST | 50 | |
Regioni | 664 – 699 | DisorderedSequence analysisAdd BLAST | 36 |
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 423 – 478 | Sequence analysisAdd BLAST | 56 | |
Coiled coili | 487 – 538 | Sequence analysisAdd BLAST | 52 | |
Coiled coili | 553 – 584 | Sequence analysisAdd BLAST | 32 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 382 – 398 | AcidicSequence analysisAdd BLAST | 17 |
Sequence similaritiesi
Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.PROSITE-ProRule annotation
Keywords - Domaini
Coiled coilSequence analysisPhylogenomic databases
GeneTreei | ENSGT00940000156386 |
HOGENOMi | CLU_001485_22_3_1 |
InParanoidi | F6SR05 |
OMAi | HKQAVIV |
OrthoDBi | 862274at2759 |
TreeFami | TF105223 |
Family and domain databases
Gene3Di | 3.40.850.10, 1 hit |
InterProi | View protein in InterPro IPR027640, Kinesin-like_fam IPR019821, Kinesin_motor_CS IPR001752, Kinesin_motor_dom IPR036961, Kinesin_motor_dom_sf IPR027417, P-loop_NTPase |
PANTHERi | PTHR24115, PTHR24115, 1 hit |
Pfami | View protein in Pfam PF00225, Kinesin, 1 hit |
PRINTSi | PR00380, KINESINHEAVY |
SMARTi | View protein in SMART SM00129, KISc, 1 hit |
SUPFAMi | SSF52540, SSF52540, 1 hit |
PROSITEi | View protein in PROSITE PS00411, KINESIN_MOTOR_1, 1 hit PS50067, KINESIN_MOTOR_2, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All
F6SR05-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MPISKSEKPE SCDNVKVVVR CRPLNEREKS MCYKQAVSVD EMRGTITVHK
60 70 80 90 100
TDSSNEPPKT FTFDTVFGPE SKQLDVYNLT ARPIIDSVLE GYNGTIFAYG
110 120 130 140 150
QTGTGKTFTM EGVRAVPELR GIIPNSFAHI FGHIAKAEGD TRFLVRVSYL
160 170 180 190 200
EIYNEEVRDL LGKDQTQRLE VKERPDVGVY IKDLSAYVVN NADDMDRIMT
210 220 230 240 250
LGHKNRSVGA TNMNEHSSRS HAIFTITIEC SEKGVDGNMH VRMGKLHLVD
260 270 280 290 300
LAGSERQAKT GATGQRLKEA TKINLSLSTL GNVISALVDG KSTHVPYRNS
310 320 330 340 350
KLTRLLQDSL GGNSKTMMCA NIGPADYNYD ETISTLRYAN RAKNIKNKAR
360 370 380 390 400
INEDPKDALL RQFQKEIEEL KKKLEEGEEI SGSDISGSEE DDDEEGEIGE
410 420 430 440 450
DGEKKKKRRG KKKVSPDKMV EMQAKIDEER KALETKLDME EEERNKARAE
460 470 480 490 500
LEKREKDLLK AQQEHQSLLE KLSALEKKVI VGGVDLLAKA EEQEKLLEES
510 520 530 540 550
NMELEERRKR AEQLRRELEE KEQERLDIEE KYTSLQEEAQ GKTKKLKKVW
560 570 580 590 600
TMLMAAKSEM ADLQQEHQRE IEGLLENIRQ LSRELRLQML IIDNFIPQDY
610 620 630 640 650
QEMIENYVHW NEDIGEWQLK CVAYTGNNMR KQTPVPDKKE KDPFEVDLSH
660 670 680 690
VYLAYTEESL RQSLMKLERP RTSKGKARPK TGRRKRSAKP ETVIDSLLQ
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketA0A5F5Q0J3 | A0A5F5Q0J3_HORSE | Kinesin-like protein | KIF3A | 726 | Annotation score: | ||
A0A5F5PSZ1 | A0A5F5PSZ1_HORSE | Kinesin-like protein | KIF3A | 702 | Annotation score: |
Sequence databases
RefSeqi | XP_003362868.1, XM_003362820.3 |
Genome annotation databases
Ensembli | ENSECAT00000026635; ENSECAP00000022239; ENSECAG00000024644 |
GeneIDi | 100072851 |
Similar proteinsi
Cross-referencesi
Sequence databases
RefSeqi | XP_003362868.1, XM_003362820.3 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Proteomic databases
PaxDbi | F6SR05 |
Genome annotation databases
Ensembli | ENSECAT00000026635; ENSECAP00000022239; ENSECAG00000024644 |
GeneIDi | 100072851 |
Organism-specific databases
CTDi | 11127 |
VGNCi | VGNC:19418, KIF3A |
Phylogenomic databases
GeneTreei | ENSGT00940000156386 |
HOGENOMi | CLU_001485_22_3_1 |
InParanoidi | F6SR05 |
OMAi | HKQAVIV |
OrthoDBi | 862274at2759 |
TreeFami | TF105223 |
Gene expression databases
Bgeei | ENSECAG00000024644, Expressed in brainstem and 22 other tissues |
Family and domain databases
Gene3Di | 3.40.850.10, 1 hit |
InterProi | View protein in InterPro IPR027640, Kinesin-like_fam IPR019821, Kinesin_motor_CS IPR001752, Kinesin_motor_dom IPR036961, Kinesin_motor_dom_sf IPR027417, P-loop_NTPase |
PANTHERi | PTHR24115, PTHR24115, 1 hit |
Pfami | View protein in Pfam PF00225, Kinesin, 1 hit |
PRINTSi | PR00380, KINESINHEAVY |
SMARTi | View protein in SMART SM00129, KISc, 1 hit |
SUPFAMi | SSF52540, SSF52540, 1 hit |
PROSITEi | View protein in PROSITE PS00411, KINESIN_MOTOR_1, 1 hit PS50067, KINESIN_MOTOR_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | F6SR05_HORSE | |
Accessioni | F6SR05Primary (citable) accession number: F6SR05 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | July 27, 2011 |
Last sequence update: | July 27, 2011 | |
Last modified: | August 12, 2020 | |
This is version 64 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |