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Entry version 64 (07 Oct 2020)
Sequence version 3 (11 Dec 2019)
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Protein
Submitted name:

Uncharacterized protein

Gene

ANK2

Organism
Equus caballus (Horse)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Uncharacterized proteinImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ANK2Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiEquus caballus (Horse)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9796 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaPerissodactylaEquidaeEquus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002281 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Cytoplasm, CytoskeletonARBA annotation

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
F6SQK7

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSECAG00000024436, Expressed in spinal cord and 20 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
F6SQK7, baseline

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini30 – 813ANK_REP_REGIONInterPro annotationAdd BLAST784
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati63 – 95ANKPROSITE-ProRule annotationAdd BLAST33
Repeati96 – 128ANKPROSITE-ProRule annotationAdd BLAST33
Repeati129 – 161ANKPROSITE-ProRule annotationAdd BLAST33
Repeati232 – 264ANKPROSITE-ProRule annotationAdd BLAST33
Repeati265 – 297ANKPROSITE-ProRule annotationAdd BLAST33
Repeati298 – 330ANKPROSITE-ProRule annotationAdd BLAST33
Repeati331 – 363ANKPROSITE-ProRule annotationAdd BLAST33
Repeati364 – 396ANKPROSITE-ProRule annotationAdd BLAST33
Repeati397 – 429ANKPROSITE-ProRule annotationAdd BLAST33
Repeati430 – 462ANKPROSITE-ProRule annotationAdd BLAST33
Repeati463 – 495ANKPROSITE-ProRule annotationAdd BLAST33
Repeati496 – 528ANKPROSITE-ProRule annotationAdd BLAST33
Repeati529 – 561ANKPROSITE-ProRule annotationAdd BLAST33
Repeati562 – 594ANKPROSITE-ProRule annotationAdd BLAST33
Repeati595 – 627ANKPROSITE-ProRule annotationAdd BLAST33
Repeati628 – 660ANKPROSITE-ProRule annotationAdd BLAST33
Repeati661 – 693ANKPROSITE-ProRule annotationAdd BLAST33
Repeati694 – 726ANKPROSITE-ProRule annotationAdd BLAST33
Repeati727 – 759ANKPROSITE-ProRule annotationAdd BLAST33
Repeati760 – 792ANKPROSITE-ProRule annotationAdd BLAST33
Domaini968 – 1156ZU5InterPro annotationAdd BLAST189
Domaini1158 – 1304ZU5InterPro annotationAdd BLAST147
Domaini3570 – 3654DeathInterPro annotationAdd BLAST85

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 34DisorderedSequence analysisAdd BLAST34
Regioni1457 – 1486DisorderedSequence analysisAdd BLAST30
Regioni1649 – 1756DisorderedSequence analysisAdd BLAST108
Regioni1775 – 1986DisorderedSequence analysisAdd BLAST212
Regioni1998 – 2141DisorderedSequence analysisAdd BLAST144
Regioni2193 – 2480DisorderedSequence analysisAdd BLAST288
Regioni2513 – 2798DisorderedSequence analysisAdd BLAST286
Regioni2812 – 2958DisorderedSequence analysisAdd BLAST147
Regioni2976 – 3021DisorderedSequence analysisAdd BLAST46
Regioni3069 – 3107DisorderedSequence analysisAdd BLAST39
Regioni3136 – 3465DisorderedSequence analysisAdd BLAST330
Regioni3550 – 3569DisorderedSequence analysisAdd BLAST20
Regioni3695 – 3714DisorderedSequence analysisAdd BLAST20
Regioni3727 – 3857DisorderedSequence analysisAdd BLAST131

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili3479 – 3499Sequence analysisAdd BLAST21

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi8 – 31PolyampholyteSequence analysisAdd BLAST24
Compositional biasi1649 – 1673PolarSequence analysisAdd BLAST25
Compositional biasi1710 – 1737PolyampholyteSequence analysisAdd BLAST28
Compositional biasi1775 – 1803PolyampholyteSequence analysisAdd BLAST29
Compositional biasi1825 – 1904PolarSequence analysisAdd BLAST80
Compositional biasi1970 – 1984PolarSequence analysisAdd BLAST15
Compositional biasi2007 – 2040PolyampholyteSequence analysisAdd BLAST34
Compositional biasi2041 – 2056PolarSequence analysisAdd BLAST16
Compositional biasi2071 – 2126PolyampholyteSequence analysisAdd BLAST56
Compositional biasi2253 – 2287PolyampholyteSequence analysisAdd BLAST35
Compositional biasi2353 – 2382PolarSequence analysisAdd BLAST30
Compositional biasi2389 – 2403PolarSequence analysisAdd BLAST15
Compositional biasi2523 – 2557PolarSequence analysisAdd BLAST35
Compositional biasi2568 – 2626PolyampholyteSequence analysisAdd BLAST59
Compositional biasi2634 – 2649PolyampholyteSequence analysisAdd BLAST16
Compositional biasi2657 – 2673PolarSequence analysisAdd BLAST17
Compositional biasi2697 – 2724PolarSequence analysisAdd BLAST28
Compositional biasi2725 – 2746PolyampholyteSequence analysisAdd BLAST22
Compositional biasi2760 – 2777PolyampholyteSequence analysisAdd BLAST18
Compositional biasi2815 – 2830PolyampholyteSequence analysisAdd BLAST16
Compositional biasi2838 – 2854PolarSequence analysisAdd BLAST17
Compositional biasi2872 – 2907PolarSequence analysisAdd BLAST36
Compositional biasi2919 – 2958PolarSequence analysisAdd BLAST40
Compositional biasi2998 – 3021PolarSequence analysisAdd BLAST24
Compositional biasi3072 – 3103PolarSequence analysisAdd BLAST32
Compositional biasi3156 – 3170PolarSequence analysisAdd BLAST15
Compositional biasi3179 – 3193AcidicSequence analysisAdd BLAST15
Compositional biasi3195 – 3249PolarSequence analysisAdd BLAST55
Compositional biasi3265 – 3280PolyampholyteSequence analysisAdd BLAST16
Compositional biasi3294 – 3321PolarSequence analysisAdd BLAST28
Compositional biasi3361 – 3379PolarSequence analysisAdd BLAST19
Compositional biasi3381 – 3418PolyampholyteSequence analysisAdd BLAST38
Compositional biasi3443 – 3457PolarSequence analysisAdd BLAST15
Compositional biasi3727 – 3746PolarSequence analysisAdd BLAST20
Compositional biasi3771 – 3802PolarSequence analysisAdd BLAST32

Keywords - Domaini

ANK repeatPROSITE-ProRule annotation, Coiled coilSequence analysis, RepeatARBA annotation

Phylogenomic databases

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000155279

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_000134_29_2_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
F6SQK7

TreeFam database of animal gene trees

More...
TreeFami
TF351263

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.25.40.20, 3 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR002110, Ankyrin_rpt
IPR020683, Ankyrin_rpt-contain_dom
IPR036770, Ankyrin_rpt-contain_sf
IPR040745, Ankyrin_UPA
IPR011029, DEATH-like_dom_sf
IPR000488, Death_domain
IPR000906, ZU5_dom

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00023, Ank, 1 hit
PF12796, Ank_2, 7 hits
PF00531, Death, 1 hit
PF17809, UPA_2, 1 hit
PF00791, ZU5, 2 hits

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR01415, ANKYRIN

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00248, ANK, 23 hits
SM00005, DEATH, 1 hit
SM00218, ZU5, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF47986, SSF47986, 1 hit
SSF48403, SSF48403, 3 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50297, ANK_REP_REGION, 1 hit
PS50088, ANK_REPEAT, 20 hits
PS50017, DEATH_DOMAIN, 1 hit
PS51145, ZU5, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 8 potential isoforms that are computationally mapped.Show allAlign All

F6SQK7-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MMNEDAAQKS DSGEKFNGSS QRRKRPKKSD SNASFLRAAR AGNLDKVVEY
60 70 80 90 100
LKGGIDINTC NQNGLNALHL AAKEGHVGLV QELLGRGSSV DSATKKGNTA
110 120 130 140 150
LHIASLAGQA EVVKVLVKEG ANINAQSQNG FTPLYMAAQE NHIDVVKYLL
160 170 180 190 200
ENGANQSTAT EDGFTPLAVA LQQGHNQAVA ILLENDTKGK VRLPALHIAA
210 220 230 240 250
RKDDTKSAAL LLQNDHNADV QSKMMVNRTT ESGFTPLHIA AHYGNVNVAT
260 270 280 290 300
LLLNRGAAVD FTARNGITPL HVASKRGNTN MVKLLLDRGG QIDAKTRDGL
310 320 330 340 350
TPLHCAARSG HDQVVELLLE RGAPLLARTK NGLSPLHMAA QGDHVECVKH
360 370 380 390 400
LLQHKAPVDD VTLDYLTALH VAAHCGHYRV TKLLLDKRAN PNARALNGFT
410 420 430 440 450
PLHIACKKNR IKVMELLVKY GASIQAITES GLTPIHVAAF MGHLNIVLLL
460 470 480 490 500
LQNGASPDVT NIRGETALHM AARAGQVEVV RCLLRNGALV DARAREEQTP
510 520 530 540 550
LHIASRLGKT EIVQLLLQHM AHPDAATTNG YTPLHISARE GQVDVASVLL
560 570 580 590 600
EAGAAHSLAT KKGFTPLHVA AKYGSLDVAK LLLQRRAAAD SAGKNGLTPL
610 620 630 640 650
HVAAHYDNQK VALLLLEKGA SPHATAKNGY TPLHIAAKKN QMQIASTLLN
660 670 680 690 700
YGAETNIVTK QGVTPLHLAS QEGHTDMVTL LLDKGANIHM STKSGLTSLH
710 720 730 740 750
LAAQEDKVNV ADILTKNGAD QDAHTKLGYT PLIVACHYGN VKMVNFLLKQ
760 770 780 790 800
GADVNAKTKN GYTPLHQAAQ QGHTHIINVL LQHGAKPNAT TANGNTALAI
810 820 830 840 850
AKRLGYISVV DTLKVVTEEV TTTTTTITEK HKLNVPETMT EVLDVSDEEG
860 870 880 890 900
DDTMTGDGGE YLRPEDLKEL GDDSLPSSQF LDGMNYLRYS LEGGRSDSLR
910 920 930 940 950
SFSSDRSHTL SHASYLRDSA MIDDTVVIPS HQVSALAKEA ERNSYRLSWG
960 970 980 990 1000
TENLDNVALS SSPIHSGFLV SFMVDARGGA MRGCRHNGLR IIIPPRKCTA
1010 1020 1030 1040 1050
PTRVTCRLVK RHRLATMPPM VEGEGLASRL IEVGPSGAQF LGKLHLPTAP
1060 1070 1080 1090 1100
PPLNEGESLV SRILQLGPPG TKFLGPVIVE IPHFAALRGK ERELVVLRSE
1110 1120 1130 1140 1150
NGDSWKEHYC EYTEDELNEI LNGMDEVLDS PEDLEKKRIC RIVTRDFPQY
1160 1170 1180 1190 1200
FAVVSRIKQD SNLIGPEGGV LSSTVVPQVQ AVFPEGALTK RIRVGLQAQP
1210 1220 1230 1240 1250
MHSELVKKIL GNKATFSPIV TLEPRRRKFH KPITMTIPVP KASSDVMLNG
1260 1270 1280 1290 1300
FGGDAPTLRL LCSITGGTTP AQWEDITGTT PLTFVNECVS FTTNVSARFW
1310 1320 1330 1340 1350
LIDCRQIQES VTFASQVYRE IICVPYMAKF VVFAKSHDPI EARLRCFCMT
1360 1370 1380 1390 1400
DDKVDKTLEQ QENFAEVARS RDVEVLEGKP IYVDCFGNLV PLTKSGQHHI
1410 1420 1430 1440 1450
FSFFAFKENR LPLFVKVRDT TQEPCGRLSF MKEPKSTRGL VHQAICNLNI
1460 1470 1480 1490 1500
TLPVYTKESE SDQEQEEEID MTSEKNDETE STETSVLKSH LVNEVPVLAS
1510 1520 1530 1540 1550
PDLLSEVSEM KQDLIKMTAI LTTDVSERAG SIKVKELVKA AEEEPGEPFE
1560 1570 1580 1590 1600
IVERVKEDLE KVNEILRSGT CTRDEASAPR ARSERELVEE EWVIISDEEI
1610 1620 1630 1640 1650
EEARQKAPLE ITEYPCVEVR IDKETKEEVE KDSTGLVNYL TEDLNSYVSP
1660 1670 1680 1690 1700
HGEQLQPAQE MAGETSQAPA VGRSSENEGK DAHPDETQIP QKQQKPSLGI
1710 1720 1730 1740 1750
KKPVRRKLKE KQKQKEESLQ ASTEKTELTK GSSEESLDED LGLAPEPVPA
1760 1770 1780 1790 1800
VKATSPLIEE TPIGSIKDKV KALQKRVEDE QKGRSKLPIR VKGKEDVPKK
1810 1820 1830 1840 1850
IVHRTHPAVS PSLKAEKHTP ASPASKTERH SSLSSSAKTE RHPPVSPSSK
1860 1870 1880 1890 1900
TEKHSPVSPS AKTERHSPVS SSSKTEKHSP VSPSTKTERH SPVSSSTKTE
1910 1920 1930 1940 1950
RHPPVSPSGK TDKRPPISPS GRPEKHSPVS PGRTEKRSPV SPAGRIERHP
1960 1970 1980 1990 2000
PVSALGKTEK HLPVSPSGKT EKQPPVSPTS KTERIEETMS VRELMKAFQS
2010 2020 2030 2040 2050
GQDPSKHKAG LFEHKSAKQK QPQEKGKVRV EKEKGQMLTQ RETQRTESQT
2060 2070 2080 2090 2100
IKRGQKILVT GASESKRGVR ASSLGFKKEE TVGEKEKGVS HKTPEPVRSA
2110 2120 2130 2140 2150
PEEESHKENE VPKEKPAEEQ GDMDLQISPD RKASTDFSDV IKQELEDNEK
2160 2170 2180 2190 2200
YQQFRLSEEP EKAQLHLDQV LTSPFNTTFP LDYVKDEFLP ALSLPSGALD
2210 2220 2230 2240 2250
GSSESPKHEG VAGSPCGSLM EGTPQISSEE SYKHEGLAET PETSPESLSF
2260 2270 2280 2290 2300
SPKKSEEPVR EENETTKLET PREIHLEKEH PSTKDVPDGS EEPGAAVTEG
2310 2320 2330 2340 2350
TEPSAECLLK EATLDPSKDT SSKQEGDYLD SNSVSLAKET PKGLAEEASC
2360 2370 2380 2390 2400
DEGQPTYVSS ALKAQTDTEA QGSTTTKPSD ETKASPLPDV SVKTGTGTEP
2410 2420 2430 2440 2450
KPQGVVRSPQ GLELALPSRD SEVFSPGADE SFAVSHKDSL EASPVLEDNS
2460 2470 2480 2490 2500
SHKTPDSLEP SPLKESPCRD SLESSPVEPK MKAGILSSHF PLPAAVAKTE
2510 2520 2530 2540 2550
LFTEVASMRS RLLRDPDGSA EDDSLEQTSL MESSGKSPLS PDTPSSEEIS
2560 2570 2580 2590 2600
YEVTPKATDA STPKPAVIHE CAEEDDLENG EKKRFTPEEE MFKMVTKIKT
2610 2620 2630 2640 2650
FDELEQEAKQ KRDYRKEPKQ EESSSSSEPD ADSSADVDEP KHMESAEEES
2660 2670 2680 2690 2700
EVPVAVTSES RKASSSSESE PELTQLKKGA DSGLLPEPVI RVQPPSPLPS
2710 2720 2730 2740 2750
SIDSNSSPEE VQFQPIVSKQ YTFKMNEDTQ EESGKSEEEK VCESHLPEDS
2760 2770 2780 2790 2800
QTVSTEGPDM SYDDLKRDDD QPKIYDDHGC EAGSPSSPAT PISSGLHSSC
2810 2820 2830 2840 2850
AHDISEQLVI HKEALPLQDA EEKDTEGELD VSGLESPQVE GPSESSSSPS
2860 2870 2880 2890 2900
SLPRCLASER KELDEDLVSP SSPTKVEATK TDQAFESLPK DCSTEDSSIT
2910 2920 2930 2940 2950
PQTDRLSVDV PVSDPAETDE ISDPQTISPY ENVPSQSFFS SEESKTQTDA
2960 2970 2980 2990 3000
SHTSFHSSEV CSVTVTSSVA EVAVESSSSR TVSSKESNFE DQNMELESKQ
3010 3020 3030 3040 3050
ESTLWEMQSD GAPSSVESTI PNTSAVVGEK ISKVIITKTD VDSDSWSEIR
3060 3070 3080 3090 3100
EDDEAFEARV KEEEQKIFGL MVDRQSQGTT PDTTPARTPT EEGTPTSEQN
3110 3120 3130 3140 3150
PFLFQEGKLF EMTRSGAIDM TKRSYADESF HFFQIGQESS EETLSEDMKG
3160 3170 3180 3190 3200
VSTGAEPPQL ETSAESLALS QSKEPVDDEA DLLPDDLSEE VEEIPSSDAQ
3210 3220 3230 3240 3250
LNSQMEISAS AETSTEDATS AEPEDLPTTQ VSDTPPKSSV KQTSCPDSPE
3260 3270 3280 3290 3300
PAVQVHLDFS TVTRSVYSDR EDDSPDSSPE EQKSVIEIPT APMESVPSTE
3310 3320 3330 3340 3350
SKSKIPIRTI PTSTPAPPSA EDENSLSEDV PPSLDEESKE DETKPKSKIP
3360 3370 3380 3390 3400
VKAPVQRVEQ QLLVLDSSLQ KTVAPQGQDV TSRARDDRSK SESDADPLDS
3410 3420 3430 3440 3450
KAKSPVKTRS YTETETESGE KAEELELESE EGATRTKIFA SRLPVKSKST
3460 3470 3480 3490 3500
TSSCREDTSP TKDSKEHFLD LYRNSIEFFE EISDEASKLV DRLTQSEREQ
3510 3520 3530 3540 3550
ELVSDDESSS ALEVSVIENL PPVETEHSIP EDIFDTRPIW DESIETLIER
3560 3570 3580 3590 3600
IPDENGHDHA EDQQDEQERT EERLAYIADH LGFSWTELAR ELDFTEEQIH
3610 3620 3630 3640 3650
QIRIENPNSL QDQSHALLKY WLERDGKHAT DTSLIECLTK INRMDIVHLL
3660 3670 3680 3690 3700
ETSTEPLQEH MSHSYAEIEQ TITLDHSEGF SVLQEELCLA QQKQKEEEQA
3710 3720 3730 3740 3750
ASKEGEPCDQ PPIVSEEDIS VGYSTFQDYI PKTDGDSSTT ELLPQTHKEE
3760 3770 3780 3790 3800
VQQDFSGKMQ DLPEKSPPDH QQEYFVTTPG TEVSETQKAT AASGSPSKTP
3810 3820 3830 3840 3850
EEITTPPEEE RPYLQTPTPS EQGDSPIVQE PEEPLAQREE SPRKTSLVIV
3860 3870 3880 3890 3900
ESADDQPQAF ERLEEDAAFQ KGDDMPDIPP ESVTEEEYID EHGHTVVKKV
3910 3920 3930 3940 3950
TRKIIKRYVS SDGTEKEEIT VQGLPQDPVD VEEGDGYSKV IKRVVLKSDT

ALSEDSNE
Length:3,958
Mass (Da):433,637
Last modified:December 11, 2019 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iCC1E3C2BA01BF0B2
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 8 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A3Q2GZG4A0A3Q2GZG4_HORSE
Uncharacterized protein
ANK2
4,164Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F6SQP2F6SQP2_HORSE
Uncharacterized protein
ANK2
4,137Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A3Q2GU11A0A3Q2GU11_HORSE
Uncharacterized protein
ANK2
4,077Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A3Q2H3M0A0A3Q2H3M0_HORSE
Uncharacterized protein
ANK2
4,143Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A3Q2HCE8A0A3Q2HCE8_HORSE
Uncharacterized protein
ANK2
4,156Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A3Q2HHV3A0A3Q2HHV3_HORSE
Uncharacterized protein
ANK2
4,141Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A3Q2HPB7A0A3Q2HPB7_HORSE
Uncharacterized protein
ANK2
4,069Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A3Q2I396A0A3Q2I396_HORSE
Uncharacterized protein
ANK2
4,098Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENSECAT00000026644; ENSECAP00000022247; ENSECAG00000024436

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

3D structure databases

Database of comparative protein structure models

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ModBasei
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SWISS-MODEL Interactive Workspace

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SWISS-MODEL-Workspacei
Submit a new modelling project...

Proteomic databases

PaxDbiF6SQK7

Genome annotation databases

EnsembliENSECAT00000026644; ENSECAP00000022247; ENSECAG00000024436

Phylogenomic databases

GeneTreeiENSGT00940000155279
HOGENOMiCLU_000134_29_2_1
InParanoidiF6SQK7
TreeFamiTF351263

Gene expression databases

BgeeiENSECAG00000024436, Expressed in spinal cord and 20 other tissues
ExpressionAtlasiF6SQK7, baseline

Family and domain databases

Gene3Di1.25.40.20, 3 hits
InterProiView protein in InterPro
IPR002110, Ankyrin_rpt
IPR020683, Ankyrin_rpt-contain_dom
IPR036770, Ankyrin_rpt-contain_sf
IPR040745, Ankyrin_UPA
IPR011029, DEATH-like_dom_sf
IPR000488, Death_domain
IPR000906, ZU5_dom
PfamiView protein in Pfam
PF00023, Ank, 1 hit
PF12796, Ank_2, 7 hits
PF00531, Death, 1 hit
PF17809, UPA_2, 1 hit
PF00791, ZU5, 2 hits
PRINTSiPR01415, ANKYRIN
SMARTiView protein in SMART
SM00248, ANK, 23 hits
SM00005, DEATH, 1 hit
SM00218, ZU5, 1 hit
SUPFAMiSSF47986, SSF47986, 1 hit
SSF48403, SSF48403, 3 hits
PROSITEiView protein in PROSITE
PS50297, ANK_REP_REGION, 1 hit
PS50088, ANK_REPEAT, 20 hits
PS50017, DEATH_DOMAIN, 1 hit
PS51145, ZU5, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiF6SQK7_HORSE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: F6SQK7
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: July 27, 2011
Last sequence update: December 11, 2019
Last modified: October 7, 2020
This is version 64 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteomeImported
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