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UniProtKB - F6SQK7 (F6SQK7_HORSE)

Entry version 64 (07 Oct 2020)
Sequence version 3 (11 Dec 2019)
Previous versions | rss
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Protein
Submitted name:

Uncharacterized protein

Gene

ANK2

Organism
Equus caballus (Horse)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Complete GO annotation on QuickGO ...

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Uncharacterized proteinImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ANK2Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiEquus caballus (Horse)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9796 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Perissodactyla › Equidae › Equus ›
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002281 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Cytoplasm, CytoskeletonARBA annotation

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		F6SQK7

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSECAG00000024436, Expressed in spinal cord and 20 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		F6SQK7, baseline

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini30 – 813ANK_REP_REGIONInterPro annotationAdd BLAST784
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati63 – 95ANKPROSITE-ProRule annotationAdd BLAST33
Repeati96 – 128ANKPROSITE-ProRule annotationAdd BLAST33
Repeati129 – 161ANKPROSITE-ProRule annotationAdd BLAST33
Repeati232 – 264ANKPROSITE-ProRule annotationAdd BLAST33
Repeati265 – 297ANKPROSITE-ProRule annotationAdd BLAST33
Repeati298 – 330ANKPROSITE-ProRule annotationAdd BLAST33
Repeati331 – 363ANKPROSITE-ProRule annotationAdd BLAST33
Repeati364 – 396ANKPROSITE-ProRule annotationAdd BLAST33
Repeati397 – 429ANKPROSITE-ProRule annotationAdd BLAST33
Repeati430 – 462ANKPROSITE-ProRule annotationAdd BLAST33
Repeati463 – 495ANKPROSITE-ProRule annotationAdd BLAST33
Repeati496 – 528ANKPROSITE-ProRule annotationAdd BLAST33
Repeati529 – 561ANKPROSITE-ProRule annotationAdd BLAST33
Repeati562 – 594ANKPROSITE-ProRule annotationAdd BLAST33
Repeati595 – 627ANKPROSITE-ProRule annotationAdd BLAST33
Repeati628 – 660ANKPROSITE-ProRule annotationAdd BLAST33
Repeati661 – 693ANKPROSITE-ProRule annotationAdd BLAST33
Repeati694 – 726ANKPROSITE-ProRule annotationAdd BLAST33
Repeati727 – 759ANKPROSITE-ProRule annotationAdd BLAST33
Repeati760 – 792ANKPROSITE-ProRule annotationAdd BLAST33
Domaini968 – 1156ZU5InterPro annotationAdd BLAST189
Domaini1158 – 1304ZU5InterPro annotationAdd BLAST147
Domaini3570 – 3654DeathInterPro annotationAdd BLAST85

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 34DisorderedSequence analysisAdd BLAST34
Regioni1457 – 1486DisorderedSequence analysisAdd BLAST30
Regioni1649 – 1756DisorderedSequence analysisAdd BLAST108
Regioni1775 – 1986DisorderedSequence analysisAdd BLAST212
Regioni1998 – 2141DisorderedSequence analysisAdd BLAST144
Regioni2193 – 2480DisorderedSequence analysisAdd BLAST288
Regioni2513 – 2798DisorderedSequence analysisAdd BLAST286
Regioni2812 – 2958DisorderedSequence analysisAdd BLAST147
Regioni2976 – 3021DisorderedSequence analysisAdd BLAST46
Regioni3069 – 3107DisorderedSequence analysisAdd BLAST39
Regioni3136 – 3465DisorderedSequence analysisAdd BLAST330
Regioni3550 – 3569DisorderedSequence analysisAdd BLAST20
Regioni3695 – 3714DisorderedSequence analysisAdd BLAST20
Regioni3727 – 3857DisorderedSequence analysisAdd BLAST131

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili3479 – 3499Sequence analysisAdd BLAST21

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi8 – 31PolyampholyteSequence analysisAdd BLAST24
Compositional biasi1649 – 1673PolarSequence analysisAdd BLAST25
Compositional biasi1710 – 1737PolyampholyteSequence analysisAdd BLAST28
Compositional biasi1775 – 1803PolyampholyteSequence analysisAdd BLAST29
Compositional biasi1825 – 1904PolarSequence analysisAdd BLAST80
Compositional biasi1970 – 1984PolarSequence analysisAdd BLAST15
Compositional biasi2007 – 2040PolyampholyteSequence analysisAdd BLAST34
Compositional biasi2041 – 2056PolarSequence analysisAdd BLAST16
Compositional biasi2071 – 2126PolyampholyteSequence analysisAdd BLAST56
Compositional biasi2253 – 2287PolyampholyteSequence analysisAdd BLAST35
Compositional biasi2353 – 2382PolarSequence analysisAdd BLAST30
Compositional biasi2389 – 2403PolarSequence analysisAdd BLAST15
Compositional biasi2523 – 2557PolarSequence analysisAdd BLAST35
Compositional biasi2568 – 2626PolyampholyteSequence analysisAdd BLAST59
Compositional biasi2634 – 2649PolyampholyteSequence analysisAdd BLAST16
Compositional biasi2657 – 2673PolarSequence analysisAdd BLAST17
Compositional biasi2697 – 2724PolarSequence analysisAdd BLAST28
Compositional biasi2725 – 2746PolyampholyteSequence analysisAdd BLAST22
Compositional biasi2760 – 2777PolyampholyteSequence analysisAdd BLAST18
Compositional biasi2815 – 2830PolyampholyteSequence analysisAdd BLAST16
Compositional biasi2838 – 2854PolarSequence analysisAdd BLAST17
Compositional biasi2872 – 2907PolarSequence analysisAdd BLAST36
Compositional biasi2919 – 2958PolarSequence analysisAdd BLAST40
Compositional biasi2998 – 3021PolarSequence analysisAdd BLAST24
Compositional biasi3072 – 3103PolarSequence analysisAdd BLAST32
Compositional biasi3156 – 3170PolarSequence analysisAdd BLAST15
Compositional biasi3179 – 3193AcidicSequence analysisAdd BLAST15
Compositional biasi3195 – 3249PolarSequence analysisAdd BLAST55
Compositional biasi3265 – 3280PolyampholyteSequence analysisAdd BLAST16
Compositional biasi3294 – 3321PolarSequence analysisAdd BLAST28
Compositional biasi3361 – 3379PolarSequence analysisAdd BLAST19
Compositional biasi3381 – 3418PolyampholyteSequence analysisAdd BLAST38
Compositional biasi3443 – 3457PolarSequence analysisAdd BLAST15
Compositional biasi3727 – 3746PolarSequence analysisAdd BLAST20
Compositional biasi3771 – 3802PolarSequence analysisAdd BLAST32

Keywords - Domaini

ANK repeatPROSITE-ProRule annotation, Coiled coilSequence analysis, RepeatARBA annotation

Phylogenomic databases

Ensembl GeneTree

More...GeneTreei		ENSGT00940000155279

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_000134_29_2_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		F6SQK7

TreeFam database of animal gene trees

More...TreeFami		TF351263

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		1.25.40.20, 3 hits

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR002110, Ankyrin_rpt
IPR020683, Ankyrin_rpt-contain_dom
IPR036770, Ankyrin_rpt-contain_sf
IPR040745, Ankyrin_UPA
IPR011029, DEATH-like_dom_sf
IPR000488, Death_domain
IPR000906, ZU5_dom

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00023, Ank, 1 hit
PF12796, Ank_2, 7 hits
PF00531, Death, 1 hit
PF17809, UPA_2, 1 hit
PF00791, ZU5, 2 hits

Protein Motif fingerprint database; a protein domain database

More...PRINTSi		PR01415, ANKYRIN

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00248, ANK, 23 hits
SM00005, DEATH, 1 hit
SM00218, ZU5, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF47986, SSF47986, 1 hit
SSF48403, SSF48403, 3 hits

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50297, ANK_REP_REGION, 1 hit
PS50088, ANK_REPEAT, 20 hits
PS50017, DEATH_DOMAIN, 1 hit
PS51145, ZU5, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 8 potential isoforms that are computationally mapped.Show allAlign All

F6SQK7-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MMNEDAAQKS DSGEKFNGSS QRRKRPKKSD SNASFLRAAR AGNLDKVVEY 
        60         70         80         90        100
LKGGIDINTC NQNGLNALHL AAKEGHVGLV QELLGRGSSV DSATKKGNTA 
       110        120        130        140        150
LHIASLAGQA EVVKVLVKEG ANINAQSQNG FTPLYMAAQE NHIDVVKYLL 
       160        170        180        190        200
ENGANQSTAT EDGFTPLAVA LQQGHNQAVA ILLENDTKGK VRLPALHIAA 
       210        220        230        240        250
RKDDTKSAAL LLQNDHNADV QSKMMVNRTT ESGFTPLHIA AHYGNVNVAT 
       260        270        280        290        300
LLLNRGAAVD FTARNGITPL HVASKRGNTN MVKLLLDRGG QIDAKTRDGL 
       310        320        330        340        350
TPLHCAARSG HDQVVELLLE RGAPLLARTK NGLSPLHMAA QGDHVECVKH 
       360        370        380        390        400
LLQHKAPVDD VTLDYLTALH VAAHCGHYRV TKLLLDKRAN PNARALNGFT 
       410        420        430        440        450
PLHIACKKNR IKVMELLVKY GASIQAITES GLTPIHVAAF MGHLNIVLLL 
       460        470        480        490        500
LQNGASPDVT NIRGETALHM AARAGQVEVV RCLLRNGALV DARAREEQTP 
       510        520        530        540        550
LHIASRLGKT EIVQLLLQHM AHPDAATTNG YTPLHISARE GQVDVASVLL 
       560        570        580        590        600
EAGAAHSLAT KKGFTPLHVA AKYGSLDVAK LLLQRRAAAD SAGKNGLTPL 
       610        620        630        640        650
HVAAHYDNQK VALLLLEKGA SPHATAKNGY TPLHIAAKKN QMQIASTLLN 
       660        670        680        690        700
YGAETNIVTK QGVTPLHLAS QEGHTDMVTL LLDKGANIHM STKSGLTSLH 
       710        720        730        740        750
LAAQEDKVNV ADILTKNGAD QDAHTKLGYT PLIVACHYGN VKMVNFLLKQ 
       760        770        780        790        800
GADVNAKTKN GYTPLHQAAQ QGHTHIINVL LQHGAKPNAT TANGNTALAI 
       810        820        830        840        850
AKRLGYISVV DTLKVVTEEV TTTTTTITEK HKLNVPETMT EVLDVSDEEG 
       860        870        880        890        900
DDTMTGDGGE YLRPEDLKEL GDDSLPSSQF LDGMNYLRYS LEGGRSDSLR 
       910        920        930        940        950
SFSSDRSHTL SHASYLRDSA MIDDTVVIPS HQVSALAKEA ERNSYRLSWG 
       960        970        980        990       1000
TENLDNVALS SSPIHSGFLV SFMVDARGGA MRGCRHNGLR IIIPPRKCTA 
      1010       1020       1030       1040       1050
PTRVTCRLVK RHRLATMPPM VEGEGLASRL IEVGPSGAQF LGKLHLPTAP 
      1060       1070       1080       1090       1100
PPLNEGESLV SRILQLGPPG TKFLGPVIVE IPHFAALRGK ERELVVLRSE 
      1110       1120       1130       1140       1150
NGDSWKEHYC EYTEDELNEI LNGMDEVLDS PEDLEKKRIC RIVTRDFPQY 
      1160       1170       1180       1190       1200
FAVVSRIKQD SNLIGPEGGV LSSTVVPQVQ AVFPEGALTK RIRVGLQAQP 
      1210       1220       1230       1240       1250
MHSELVKKIL GNKATFSPIV TLEPRRRKFH KPITMTIPVP KASSDVMLNG 
      1260       1270       1280       1290       1300
FGGDAPTLRL LCSITGGTTP AQWEDITGTT PLTFVNECVS FTTNVSARFW 
      1310       1320       1330       1340       1350
LIDCRQIQES VTFASQVYRE IICVPYMAKF VVFAKSHDPI EARLRCFCMT 
      1360       1370       1380       1390       1400
DDKVDKTLEQ QENFAEVARS RDVEVLEGKP IYVDCFGNLV PLTKSGQHHI 
      1410       1420       1430       1440       1450
FSFFAFKENR LPLFVKVRDT TQEPCGRLSF MKEPKSTRGL VHQAICNLNI 
      1460       1470       1480       1490       1500
TLPVYTKESE SDQEQEEEID MTSEKNDETE STETSVLKSH LVNEVPVLAS 
      1510       1520       1530       1540       1550
PDLLSEVSEM KQDLIKMTAI LTTDVSERAG SIKVKELVKA AEEEPGEPFE 
      1560       1570       1580       1590       1600
IVERVKEDLE KVNEILRSGT CTRDEASAPR ARSERELVEE EWVIISDEEI 
      1610       1620       1630       1640       1650
EEARQKAPLE ITEYPCVEVR IDKETKEEVE KDSTGLVNYL TEDLNSYVSP 
      1660       1670       1680       1690       1700
HGEQLQPAQE MAGETSQAPA VGRSSENEGK DAHPDETQIP QKQQKPSLGI 
      1710       1720       1730       1740       1750
KKPVRRKLKE KQKQKEESLQ ASTEKTELTK GSSEESLDED LGLAPEPVPA 
      1760       1770       1780       1790       1800
VKATSPLIEE TPIGSIKDKV KALQKRVEDE QKGRSKLPIR VKGKEDVPKK 
      1810       1820       1830       1840       1850
IVHRTHPAVS PSLKAEKHTP ASPASKTERH SSLSSSAKTE RHPPVSPSSK 
      1860       1870       1880       1890       1900
TEKHSPVSPS AKTERHSPVS SSSKTEKHSP VSPSTKTERH SPVSSSTKTE 
      1910       1920       1930       1940       1950
RHPPVSPSGK TDKRPPISPS GRPEKHSPVS PGRTEKRSPV SPAGRIERHP 
      1960       1970       1980       1990       2000
PVSALGKTEK HLPVSPSGKT EKQPPVSPTS KTERIEETMS VRELMKAFQS 
      2010       2020       2030       2040       2050
GQDPSKHKAG LFEHKSAKQK QPQEKGKVRV EKEKGQMLTQ RETQRTESQT 
      2060       2070       2080       2090       2100
IKRGQKILVT GASESKRGVR ASSLGFKKEE TVGEKEKGVS HKTPEPVRSA 
      2110       2120       2130       2140       2150
PEEESHKENE VPKEKPAEEQ GDMDLQISPD RKASTDFSDV IKQELEDNEK 
      2160       2170       2180       2190       2200
YQQFRLSEEP EKAQLHLDQV LTSPFNTTFP LDYVKDEFLP ALSLPSGALD 
      2210       2220       2230       2240       2250
GSSESPKHEG VAGSPCGSLM EGTPQISSEE SYKHEGLAET PETSPESLSF 
      2260       2270       2280       2290       2300
SPKKSEEPVR EENETTKLET PREIHLEKEH PSTKDVPDGS EEPGAAVTEG 
      2310       2320       2330       2340       2350
TEPSAECLLK EATLDPSKDT SSKQEGDYLD SNSVSLAKET PKGLAEEASC 
      2360       2370       2380       2390       2400
DEGQPTYVSS ALKAQTDTEA QGSTTTKPSD ETKASPLPDV SVKTGTGTEP 
      2410       2420       2430       2440       2450
KPQGVVRSPQ GLELALPSRD SEVFSPGADE SFAVSHKDSL EASPVLEDNS 
      2460       2470       2480       2490       2500
SHKTPDSLEP SPLKESPCRD SLESSPVEPK MKAGILSSHF PLPAAVAKTE 
      2510       2520       2530       2540       2550
LFTEVASMRS RLLRDPDGSA EDDSLEQTSL MESSGKSPLS PDTPSSEEIS 
      2560       2570       2580       2590       2600
YEVTPKATDA STPKPAVIHE CAEEDDLENG EKKRFTPEEE MFKMVTKIKT 
      2610       2620       2630       2640       2650
FDELEQEAKQ KRDYRKEPKQ EESSSSSEPD ADSSADVDEP KHMESAEEES 
      2660       2670       2680       2690       2700
EVPVAVTSES RKASSSSESE PELTQLKKGA DSGLLPEPVI RVQPPSPLPS 
      2710       2720       2730       2740       2750
SIDSNSSPEE VQFQPIVSKQ YTFKMNEDTQ EESGKSEEEK VCESHLPEDS 
      2760       2770       2780       2790       2800
QTVSTEGPDM SYDDLKRDDD QPKIYDDHGC EAGSPSSPAT PISSGLHSSC 
      2810       2820       2830       2840       2850
AHDISEQLVI HKEALPLQDA EEKDTEGELD VSGLESPQVE GPSESSSSPS 
      2860       2870       2880       2890       2900
SLPRCLASER KELDEDLVSP SSPTKVEATK TDQAFESLPK DCSTEDSSIT 
      2910       2920       2930       2940       2950
PQTDRLSVDV PVSDPAETDE ISDPQTISPY ENVPSQSFFS SEESKTQTDA 
      2960       2970       2980       2990       3000
SHTSFHSSEV CSVTVTSSVA EVAVESSSSR TVSSKESNFE DQNMELESKQ 
      3010       3020       3030       3040       3050
ESTLWEMQSD GAPSSVESTI PNTSAVVGEK ISKVIITKTD VDSDSWSEIR 
      3060       3070       3080       3090       3100
EDDEAFEARV KEEEQKIFGL MVDRQSQGTT PDTTPARTPT EEGTPTSEQN 
      3110       3120       3130       3140       3150
PFLFQEGKLF EMTRSGAIDM TKRSYADESF HFFQIGQESS EETLSEDMKG 
      3160       3170       3180       3190       3200
VSTGAEPPQL ETSAESLALS QSKEPVDDEA DLLPDDLSEE VEEIPSSDAQ 
      3210       3220       3230       3240       3250
LNSQMEISAS AETSTEDATS AEPEDLPTTQ VSDTPPKSSV KQTSCPDSPE 
      3260       3270       3280       3290       3300
PAVQVHLDFS TVTRSVYSDR EDDSPDSSPE EQKSVIEIPT APMESVPSTE 
      3310       3320       3330       3340       3350
SKSKIPIRTI PTSTPAPPSA EDENSLSEDV PPSLDEESKE DETKPKSKIP 
      3360       3370       3380       3390       3400
VKAPVQRVEQ QLLVLDSSLQ KTVAPQGQDV TSRARDDRSK SESDADPLDS 
      3410       3420       3430       3440       3450
KAKSPVKTRS YTETETESGE KAEELELESE EGATRTKIFA SRLPVKSKST 
      3460       3470       3480       3490       3500
TSSCREDTSP TKDSKEHFLD LYRNSIEFFE EISDEASKLV DRLTQSEREQ 
      3510       3520       3530       3540       3550
ELVSDDESSS ALEVSVIENL PPVETEHSIP EDIFDTRPIW DESIETLIER 
      3560       3570       3580       3590       3600
IPDENGHDHA EDQQDEQERT EERLAYIADH LGFSWTELAR ELDFTEEQIH 
      3610       3620       3630       3640       3650
QIRIENPNSL QDQSHALLKY WLERDGKHAT DTSLIECLTK INRMDIVHLL 
      3660       3670       3680       3690       3700
ETSTEPLQEH MSHSYAEIEQ TITLDHSEGF SVLQEELCLA QQKQKEEEQA 
      3710       3720       3730       3740       3750
ASKEGEPCDQ PPIVSEEDIS VGYSTFQDYI PKTDGDSSTT ELLPQTHKEE 
      3760       3770       3780       3790       3800
VQQDFSGKMQ DLPEKSPPDH QQEYFVTTPG TEVSETQKAT AASGSPSKTP 
      3810       3820       3830       3840       3850
EEITTPPEEE RPYLQTPTPS EQGDSPIVQE PEEPLAQREE SPRKTSLVIV 
      3860       3870       3880       3890       3900
ESADDQPQAF ERLEEDAAFQ KGDDMPDIPP ESVTEEEYID EHGHTVVKKV 
      3910       3920       3930       3940       3950
TRKIIKRYVS SDGTEKEEIT VQGLPQDPVD VEEGDGYSKV IKRVVLKSDT 

ALSEDSNE
Length:3,958
Mass (Da):433,637
Last modified:December 11, 2019 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iCC1E3C2BA01BF0B2
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 8 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A3Q2GZG4A0A3Q2GZG4_HORSE
Uncharacterized protein
ANK2
4,164Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F6SQP2F6SQP2_HORSE
Uncharacterized protein
ANK2
4,137Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A3Q2GU11A0A3Q2GU11_HORSE
Uncharacterized protein
ANK2
4,077Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A3Q2H3M0A0A3Q2H3M0_HORSE
Uncharacterized protein
ANK2
4,143Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A3Q2HCE8A0A3Q2HCE8_HORSE
Uncharacterized protein
ANK2
4,156Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A3Q2HHV3A0A3Q2HHV3_HORSE
Uncharacterized protein
ANK2
4,141Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A3Q2HPB7A0A3Q2HPB7_HORSE
Uncharacterized protein
ANK2
4,069Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A3Q2I396A0A3Q2I396_HORSE
Uncharacterized protein
ANK2
4,098Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENSECAT00000026644; ENSECAP00000022247; ENSECAG00000024436

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

3D structure databases

Database of comparative protein structure models

More...ModBasei		Search...

SWISS-MODEL Interactive Workspace

More...SWISS-MODEL-Workspacei		Submit a new modelling project...

Proteomic databases

PaxDbiF6SQK7

Genome annotation databases

EnsembliENSECAT00000026644; ENSECAP00000022247; ENSECAG00000024436

Phylogenomic databases

GeneTreeiENSGT00940000155279
HOGENOMiCLU_000134_29_2_1
InParanoidiF6SQK7
TreeFamiTF351263

Gene expression databases

BgeeiENSECAG00000024436, Expressed in spinal cord and 20 other tissues
ExpressionAtlasiF6SQK7, baseline

Family and domain databases

Gene3Di1.25.40.20, 3 hits
InterProiView protein in InterPro
IPR002110, Ankyrin_rpt
IPR020683, Ankyrin_rpt-contain_dom
IPR036770, Ankyrin_rpt-contain_sf
IPR040745, Ankyrin_UPA
IPR011029, DEATH-like_dom_sf
IPR000488, Death_domain
IPR000906, ZU5_dom
PfamiView protein in Pfam
PF00023, Ank, 1 hit
PF12796, Ank_2, 7 hits
PF00531, Death, 1 hit
PF17809, UPA_2, 1 hit
PF00791, ZU5, 2 hits
PRINTSiPR01415, ANKYRIN
SMARTiView protein in SMART
SM00248, ANK, 23 hits
SM00005, DEATH, 1 hit
SM00218, ZU5, 1 hit
SUPFAMiSSF47986, SSF47986, 1 hit
SSF48403, SSF48403, 3 hits
PROSITEiView protein in PROSITE
PS50297, ANK_REP_REGION, 1 hit
PS50088, ANK_REPEAT, 20 hits
PS50017, DEATH_DOMAIN, 1 hit
PS51145, ZU5, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiF6SQK7_HORSE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: F6SQK7
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: July 27, 2011
Last sequence update: December 11, 2019
Last modified: October 7, 2020
This is version 64 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteomeImported
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