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Protein

Protein disulfide-isomerase

Gene

PDIA4

Organism
Monodelphis domestica (Gray short-tailed opossum)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

Catalyzes the rearrangement of -S-S- bonds in proteins.UniRule annotation

GO - Molecular functioni

  • peptide disulfide oxidoreductase activity Source: Ensembl
  • protein disulfide isomerase activity Source: GO_Central

GO - Biological processi

Keywordsi

Molecular functionIsomeraseUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Protein disulfide-isomeraseUniRule annotation (EC:5.3.4.1UniRule annotation)
Gene namesi
Name:PDIA4Imported
OrganismiMonodelphis domestica (Gray short-tailed opossum)Imported
Taxonomic identifieri13616 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaMetatheriaDidelphimorphiaDidelphidaeMonodelphis
Proteomesi
  • UP000002280 Componenti: Chromosome 8

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 22UniRule annotationAdd BLAST22
ChainiPRO_500512990423 – 647Protein disulfide-isomeraseUniRule annotationAdd BLAST625

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi208 ↔ 211Redox-activeUniRule annotation
Disulfide bondi557 ↔ 560Redox-activeUniRule annotation

Keywords - PTMi

Disulfide bondUniRule annotationSAAS annotation

Expressioni

Gene expression databases

BgeeiENSMODG00000001864 Expressed in 8 organ(s), highest expression level in placenta

Interactioni

Protein-protein interaction databases

STRINGi13616.ENSMODP00000002274

Structurei

3D structure databases

ProteinModelPortaliF6SNH9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini40 – 171ThioredoxinInterPro annotationAdd BLAST132
Domaini173 – 303ThioredoxinInterPro annotationAdd BLAST131
Domaini494 – 638ThioredoxinInterPro annotationAdd BLAST145

Sequence similaritiesi

Belongs to the protein disulfide isomerase family.UniRule annotationSAAS annotation

Keywords - Domaini

Redox-active centerUniRule annotationSAAS annotation, RepeatSAAS annotation, SignalUniRule annotation

Phylogenomic databases

eggNOGiKOG0190 Eukaryota
COG0526 LUCA
GeneTreeiENSGT00930000150840
InParanoidiF6SNH9
OMAiTQFWRNK
OrthoDBiEOG091G05J9
TreeFamiTF106382

Family and domain databases

InterProiView protein in InterPro
IPR005788 Disulphide_isomerase
IPR005792 Prot_disulphide_isomerase
IPR017068 Protein_diS-isomerase_A4
IPR036249 Thioredoxin-like_sf
IPR017937 Thioredoxin_CS
IPR013766 Thioredoxin_domain
PfamiView protein in Pfam
PF00085 Thioredoxin, 3 hits
PIRSFiPIRSF036862 Disulphide_isom_A4, 1 hit
SUPFAMiSSF52833 SSF52833, 5 hits
TIGRFAMsiTIGR01130 ER_PDI_fam, 1 hit
TIGR01126 pdi_dom, 3 hits
PROSITEiView protein in PROSITE
PS00194 THIOREDOXIN_1, 3 hits
PS51352 THIOREDOXIN_2, 3 hits

Sequencei

Sequence statusi: Complete.

F6SNH9-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MRLRKPCLLV LLLGLAQLLV LASTHEAGED SFTKDDTIDE EEEEEEEDYD
60 70 80 90 100
EDEDEDDSQV KEENGVLVLN DDNFDTFVAD RDTVLLEFYA PWCGHCKQFA
110 120 130 140 150
PVYEKIAKTL QENDPPIPVA KIDATAASAL ASRYDVGGYP TIKILKKGQV
160 170 180 190 200
VDYDGSRTEN DIVAKVKEIS QPNWTPPPEM TLVLTKDNFD EVVNDADIIL
210 220 230 240 250
VEFYAPWCGH CKKLAPEYEK AAKELSKRSP PIPLAKVDAI AETDLAKRFD
260 270 280 290 300
VTGYPTLKIF RKGKAFDYSG PREKYGIVDY MIEQSEPPSK EILGVKQVQE
310 320 330 340 350
FLKDGSDVII IGIFKDADDQ GYQLYQDIAN NMREDYKFHH TFNNEVAKFL
360 370 380 390 400
KVSFGKLVVM QPEKFHSKYE RKINVLDIQE STDGAAIKDH LVKHAVPLVG
410 420 430 440 450
HRTISNDAKR YAKRPLVVVY YTVDFSFDYR VATQYWRNKV LEVAKDFPEY
460 470 480 490 500
TFAIADEDDY SSEVKDLGLS DSGEDINVAI LAEGGKKYAM EPEEFDSDML
510 520 530 540 550
RDFVLSFKKG KLKAIVKSQP VPKNNKGPIT IVVGKTFDSI VMDPKSDVLI
560 570 580 590 600
EFYAPWCGHC KQLEPVYTEL GKKYKHQKNL VIAKMDATAN DVTNDHYKVD
610 620 630 640
GFPTIYFAPS TDKNNPIKFE NEQRDLEHLS AFVEEHSTKL SRTKEEL
Length:647
Mass (Da):73,517
Last modified:January 9, 2013 - v2
Checksum:i3042F028C05F128D
GO

Sequence databases

RefSeqiXP_007504590.1, XM_007504528.1

Genome annotation databases

EnsembliENSMODT00000002321; ENSMODP00000002274; ENSMODG00000001864
GeneIDi100014120

Similar proteinsi

Cross-referencesi

Sequence databases

RefSeqiXP_007504590.1, XM_007504528.1

3D structure databases

ProteinModelPortaliF6SNH9
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi13616.ENSMODP00000002274

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMODT00000002321; ENSMODP00000002274; ENSMODG00000001864
GeneIDi100014120

Organism-specific databases

CTDi9601

Phylogenomic databases

eggNOGiKOG0190 Eukaryota
COG0526 LUCA
GeneTreeiENSGT00930000150840
InParanoidiF6SNH9
OMAiTQFWRNK
OrthoDBiEOG091G05J9
TreeFamiTF106382

Gene expression databases

BgeeiENSMODG00000001864 Expressed in 8 organ(s), highest expression level in placenta

Family and domain databases

InterProiView protein in InterPro
IPR005788 Disulphide_isomerase
IPR005792 Prot_disulphide_isomerase
IPR017068 Protein_diS-isomerase_A4
IPR036249 Thioredoxin-like_sf
IPR017937 Thioredoxin_CS
IPR013766 Thioredoxin_domain
PfamiView protein in Pfam
PF00085 Thioredoxin, 3 hits
PIRSFiPIRSF036862 Disulphide_isom_A4, 1 hit
SUPFAMiSSF52833 SSF52833, 5 hits
TIGRFAMsiTIGR01130 ER_PDI_fam, 1 hit
TIGR01126 pdi_dom, 3 hits
PROSITEiView protein in PROSITE
PS00194 THIOREDOXIN_1, 3 hits
PS51352 THIOREDOXIN_2, 3 hits
ProtoNetiSearch...

Entry informationi

Entry nameiF6SNH9_MONDO
AccessioniPrimary (citable) accession number: F6SNH9
Entry historyiIntegrated into UniProtKB/TrEMBL: July 27, 2011
Last sequence update: January 9, 2013
Last modified: November 7, 2018
This is version 65 of the entry and version 2 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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