UniProtKB - F6SIC3 (F6SIC3_HORSE)
Protein
Submitted name:
Splicing factor 3b subunit 4
Gene
SF3B4
Organism
Equus caballus (Horse)
Status
Functioni
GO - Molecular functioni
- RNA binding Source: UniProtKB-UniRule
- splicing factor binding Source: Ensembl
GO - Biological processi
- mRNA splicing, via spliceosome Source: Ensembl
- positive regulation of mRNA splicing, via spliceosome Source: GO_Central
Keywordsi
Molecular function | RNA-bindingPROSITE-ProRule annotationARBA annotation |
Names & Taxonomyi
Protein namesi | Submitted name: Splicing factor 3b subunit 4Imported |
Gene namesi | Name:SF3B4Imported |
Organismi | Equus caballus (Horse)Imported |
Taxonomic identifieri | 9796 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Perissodactyla › Equidae › Equus › |
Proteomesi |
|
Organism-specific databases
VGNCi | VGNC:22891, SF3B4 |
Subcellular locationi
Nucleus
- Nucleus ARBA annotation
Nucleus
- nucleolus Source: GO_Central
- spliceosomal complex Source: GO_Central
- U12-type spliceosomal complex Source: GO_Central
- U2-type precatalytic spliceosome Source: Ensembl
Keywords - Cellular componenti
NucleusARBA annotationExpressioni
Gene expression databases
Bgeei | ENSECAG00000024737, Expressed in inner cell mass and 22 other tissues |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 207 – 424 | DisorderedSequence analysisAdd BLAST | 218 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 232 – 274 | Pro-richSequence analysisAdd BLAST | 43 | |
Compositional biasi | 327 – 424 | Pro-richSequence analysisAdd BLAST | 98 |
Sequence similaritiesi
Belongs to the SF3B4 family.ARBA annotation
Keywords - Domaini
RepeatARBA annotationPhylogenomic databases
GeneTreei | ENSGT00870000136537 |
HOGENOMi | CLU_012062_21_0_1 |
InParanoidi | F6SIC3 |
TreeFami | TF300890 |
Family and domain databases
CDDi | cd12334, RRM1_SF3B4, 1 hit cd12335, RRM2_SF3B4, 1 hit |
Gene3Di | 3.30.70.330, 2 hits |
InterProi | View protein in InterPro IPR012677, Nucleotide-bd_a/b_plait_sf IPR035979, RBD_domain_sf IPR000504, RRM_dom IPR034158, SF3B4_RRM1 IPR034159, SF3B4_RRM2 |
Pfami | View protein in Pfam PF00076, RRM_1, 2 hits |
SMARTi | View protein in SMART SM00360, RRM, 2 hits |
SUPFAMi | SSF54928, SSF54928, 1 hit |
PROSITEi | View protein in PROSITE PS50102, RRM, 2 hits |
i Sequence
Sequence statusi: Complete.
F6SIC3-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MAAGPISERN QDATVYVGGL DEKVSEPLLW ELFLQAGPVV NTHMPKDRVT
60 70 80 90 100
GQHQGYGFVE FLSEEDADYA IKIMNMIKLY GKPIRVNKAS AHNKNLDVGA
110 120 130 140 150
NIFIGNLDPE IDEKLLYDTF SAFGVILQTP KIMRDPDTGN SKGYAFINFA
160 170 180 190 200
SFDASDAAIE AMNGQYLCNR PITVSYAFKK DSKGERHGSA AERLLAAQNP
210 220 230 240 250
LSQADRPHQL FADAPPPPSA PNPVVSSLGS GLPPPGMPPP GSFPPPVPPP
260 270 280 290 300
GALPPGIPPA MPPPPMPPGA GGHGPPSAGT PGAGHPGHGH SHPHPFPPGG
310 320 330 340 350
MPHPGMSQMQ LAHHGPHGLG HPHAGPPGSG GQPPPRPPPG MPHPGPPPMG
360 370 380 390 400
MPPRGPPFGS PMGHPGPMPP HGMRGPPPLM PPHGYTGPPR PPPYGYQRGP
410 420
LPPPRPTPRP PVPPRGPLRG PLPQ
Genome annotation databases
Ensembli | ENSECAT00000026683; ENSECAP00000022284; ENSECAG00000024737 |
Similar proteinsi
Cross-referencesi
3D structure databases
SMRi | F6SIC3 |
ModBasei | Search... |
Proteomic databases
PaxDbi | F6SIC3 |
PRIDEi | F6SIC3 |
Genome annotation databases
Ensembli | ENSECAT00000026683; ENSECAP00000022284; ENSECAG00000024737 |
Organism-specific databases
VGNCi | VGNC:22891, SF3B4 |
Phylogenomic databases
GeneTreei | ENSGT00870000136537 |
HOGENOMi | CLU_012062_21_0_1 |
InParanoidi | F6SIC3 |
TreeFami | TF300890 |
Gene expression databases
Bgeei | ENSECAG00000024737, Expressed in inner cell mass and 22 other tissues |
Family and domain databases
CDDi | cd12334, RRM1_SF3B4, 1 hit cd12335, RRM2_SF3B4, 1 hit |
Gene3Di | 3.30.70.330, 2 hits |
InterProi | View protein in InterPro IPR012677, Nucleotide-bd_a/b_plait_sf IPR035979, RBD_domain_sf IPR000504, RRM_dom IPR034158, SF3B4_RRM1 IPR034159, SF3B4_RRM2 |
Pfami | View protein in Pfam PF00076, RRM_1, 2 hits |
SMARTi | View protein in SMART SM00360, RRM, 2 hits |
SUPFAMi | SSF54928, SSF54928, 1 hit |
PROSITEi | View protein in PROSITE PS50102, RRM, 2 hits |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | F6SIC3_HORSE | |
Accessioni | F6SIC3Primary (citable) accession number: F6SIC3 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | July 27, 2011 |
Last sequence update: | April 10, 2019 | |
Last modified: | October 7, 2020 | |
This is version 56 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |