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UniProtKB - F6S7N6 (F6S7N6_MACMU)
Protein
Submitted name:
Sorbin and SH3 domain containing 2
Gene
SORBS2
Organism
Macaca mulatta (Rhesus macaque)
Status
Functioni
GO - Biological processi
- actin filament organization Source: InterPro
- Notch signaling pathway Source: GO_Central
Names & Taxonomyi
Protein namesi | Submitted name: Sorbin and SH3 domain containing 2 |
Gene namesi | Name:SORBS2Imported |
Organismi | Macaca mulatta (Rhesus macaque)Imported |
Taxonomic identifieri | 9544 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Cercopithecidae › Cercopithecinae › Macaca |
Proteomesi |
|
Organism-specific databases
VEuPathDBi | HostDB:ENSMMUG00000015733 |
VGNCi | VGNC:77767, SORBS2 |
Subcellular locationi
Other locations
- focal adhesion ARBA annotation
Plasma Membrane
- plasma membrane Source: GO_Central
Other locations
- cytoplasm Source: UniProtKB-KW
- dendrite Source: GO_Central
- focal adhesion Source: UniProtKB-SubCell
- neuronal cell body Source: GO_Central
- synapse Source: GO_Central
Keywords - Cellular componenti
CytoplasmARBA annotation, MembraneARBA annotationExpressioni
Gene expression databases
Bgeei | ENSMMUG00000015733, Expressed in heart and 24 other tissues |
ExpressionAtlasi | F6S7N6, baseline |
Structurei
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 166 – 227 | SoHoInterPro annotationAdd BLAST | 62 | |
Domaini | 962 – 1021 | SH3InterPro annotationAdd BLAST | 60 | |
Domaini | 1037 – 1098 | SH3InterPro annotationAdd BLAST | 62 | |
Domaini | 1140 – 1199 | SH3InterPro annotationAdd BLAST | 60 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 25 – 96 | DisorderedSequence analysisAdd BLAST | 72 | |
Regioni | 133 – 154 | DisorderedSequence analysisAdd BLAST | 22 | |
Regioni | 235 – 412 | DisorderedSequence analysisAdd BLAST | 178 | |
Regioni | 921 – 968 | DisorderedSequence analysisAdd BLAST | 48 | |
Regioni | 1101 – 1127 | DisorderedSequence analysisAdd BLAST | 27 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 25 – 62 | Polar residuesSequence analysisAdd BLAST | 38 | |
Compositional biasi | 77 – 96 | Polar residuesSequence analysisAdd BLAST | 20 | |
Compositional biasi | 235 – 264 | Polar residuesSequence analysisAdd BLAST | 30 | |
Compositional biasi | 267 – 282 | Pro residuesSequence analysisAdd BLAST | 16 | |
Compositional biasi | 283 – 313 | Basic and acidic residuesSequence analysisAdd BLAST | 31 | |
Compositional biasi | 326 – 346 | Polar residuesSequence analysisAdd BLAST | 21 | |
Compositional biasi | 371 – 406 | Polar residuesSequence analysisAdd BLAST | 36 | |
Compositional biasi | 950 – 968 | Basic and acidic residuesSequence analysisAdd BLAST | 19 |
Keywords - Domaini
SH3 domainPROSITE-ProRule annotationARBA annotationPhylogenomic databases
eggNOGi | KOG4225, Eukaryota |
GeneTreei | ENSGT00940000157056 |
HOGENOMi | CLU_003951_1_0_1 |
InParanoidi | F6S7N6 |
TreeFami | TF320680 |
Family and domain databases
InterProi | View protein in InterPro IPR036028, SH3-like_dom_sf IPR001452, SH3_domain IPR003127, SoHo_dom IPR028506, Sorbin_SH3 IPR013087, Znf_C2H2_type |
PANTHERi | PTHR14167:SF56, PTHR14167:SF56, 1 hit |
Pfami | View protein in Pfam PF00018, SH3_1, 2 hits PF14604, SH3_9, 1 hit PF02208, Sorb, 1 hit |
PRINTSi | PR00452, SH3DOMAIN |
SMARTi | View protein in SMART SM00326, SH3, 3 hits SM00459, Sorb, 1 hit |
SUPFAMi | SSF50044, SSF50044, 3 hits |
PROSITEi | View protein in PROSITE PS50002, SH3, 3 hits PS50831, SOHO, 1 hit PS00028, ZINC_FINGER_C2H2_1, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 9 potential isoforms that are computationally mapped.Show allAlign All
F6S7N6-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MNTDSGGCAR KRAAMSVTLT SVKRVQSSPN LLAAGRDSQS PDSAWRSYND
60 70 80 90 100
GNQETLNGDA TYSSLAAKGF RSVRPNLQDK RSPTQSQITV NGNSGGAVSP
110 120 130 140 150
MSYYQRPFSP SAYSLPASLN SSIVMQHGTS LDSTETYPQH AHSLDGTTSS
160 170 180 190 200
SVPLYRSSEE EKRVTVIKAP HYPGIGPVDE SGIPTAIRTT VDRPKDWYKT
210 220 230 240 250
MFKQIHMVHK PDDDTDMYHT PYTYNAGLYN PPYSAQSHPA AKTQTYRPLS
260 270 280 290 300
KSHSDNSTNA FKDASSPVPP PHVPPPVPPL RPRDRSSTEK HDWDPPDRKV
310 320 330 340 350
DTRKFRSEPR SIFEYEPGKS SILQHERPAS LYQSSIDRSL ERPMSSASMA
360 370 380 390 400
SDFRKRRKSE PAVGPPRGLG DQSVSRTSPG RADLPGSSAT LTKSFTSSSP
410 420 430 440 450
SSPSRAKGGD DSKMCPSLCS YSGLNGNPSS ELDYCSTYRQ HLDVPRDSPR
460 470 480 490 500
AISFKNGWQM ARQNAEIWSS TEETVSPKMK SRSCDDLLND DCDSFPDPKI
510 520 530 540 550
KSESMGSLLC DEDSKDSCRR AWGSPYIQEV RSAGRSRIRH RSAHNAPGFL
560 570 580 590 600
KMYKKMHRIN RKDLMNSEVI CSVKSRILQY ESEQQHKGLL QAWSQSSTEE
610 620 630 640 650
VPRDMVPTRI SEFEKLIQKS KSMPNLGDDM LSPVTLEPPQ NGLCPKRRFS
660 670 680 690 700
IEYLLEEENQ SGHPSQGQRG CTSNALVPIH IEVTSDEQPR AHVEFSDSDQ
710 720 730 740 750
DGVVSDHSDY IHVEGSSFCS ESDFDHFSFT SSESFYGSSH HHHHHHHHHH
760 770 780 790 800
RHLISSCKGR CPASYTRFTT MLKHERARHE NPEEPRRQEM DPGLSKLAFL
810 820 830 840 850
VSPVPFRRKR NSAPKKQTEK ATCKASVFEA LDSALKDICD QIKAEKKRGS
860 870 880 890 900
LPDNSILHRL ISELLPDVPE RNSSLRALRR SPLHQPLHPL PQDGAIHCPP
910 920 930 940 950
YQNDCGRMPH SASFQDVDTA NNYHHQDRGG ALQGRESPRS YSSTLTDTGR
960 970 980 990 1000
STPRERRGTP EKEKLPAKAV YDFKAQTSKE LSFKKGDTVY ILRKIDQNWY
1010 1020 1030 1040 1050
EGEHHGRVGI FPISYVEKLT PPEKAQPARP PPPAQPGEIG EAIAKYNFSA
1060 1070 1080 1090 1100
DTNVELSLRK GDRVILLKRV DQNWYEGKIP GTNRQGIFPV SYVEVVKKNT
1110 1120 1130 1140 1150
KGAEDYPDPP MPHSYSSDRI HSLSSNKPQR PVFTHENIQG GGEPFQALYN
1160 1170 1180 1190
YTPRNEDELE LRESDVIDVM EKCDDGWFVG TSRRTKFFGT FPGNYVKRL
Computationally mapped potential isoform sequencesi
There are 9 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketF6S6Y5 | F6S6Y5_MACMU | Sorbin and SH3 domain containing 2 | SORBS2 | 1,180 | Annotation score: | ||
F6S7M6 | F6S7M6_MACMU | Sorbin and SH3 domain containing 2 | SORBS2 | 659 | Annotation score: | ||
A0A1D5Q6U1 | A0A1D5Q6U1_MACMU | Sorbin and SH3 domain containing 2 | SORBS2 | 709 | Annotation score: | ||
A0A5F7ZAS8 | A0A5F7ZAS8_MACMU | Sorbin and SH3 domain containing 2 | SORBS2 | 1,221 | Annotation score: | ||
A0A5F7ZCW2 | A0A5F7ZCW2_MACMU | Sorbin and SH3 domain containing 2 | SORBS2 | 1,246 | Annotation score: | ||
A0A5F7ZKA3 | A0A5F7ZKA3_MACMU | Sorbin and SH3 domain containing 2 | SORBS2 | 1,185 | Annotation score: | ||
A0A5F8AFR9 | A0A5F8AFR9_MACMU | Sorbin and SH3 domain containing 2 | SORBS2 | 1,231 | Annotation score: | ||
A0A5F8AQJ0 | A0A5F8AQJ0_MACMU | Sorbin and SH3 domain containing 2 | SORBS2 | 1,170 | Annotation score: | ||
A0A5F8AU28 | A0A5F8AU28_MACMU | Sorbin and SH3 domain containing 2 | SORBS2 | 791 | Annotation score: |
Genome annotation databases
Ensembli | ENSMMUT00000022085.4; ENSMMUP00000020658.4; ENSMMUG00000015733.4 |
Similar proteinsi
Cross-referencesi
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
STRINGi | 9544.ENSMMUP00000020658 |
Genome annotation databases
Ensembli | ENSMMUT00000022085.4; ENSMMUP00000020658.4; ENSMMUG00000015733.4 |
Organism-specific databases
VEuPathDBi | HostDB:ENSMMUG00000015733 |
VGNCi | VGNC:77767, SORBS2 |
Phylogenomic databases
eggNOGi | KOG4225, Eukaryota |
GeneTreei | ENSGT00940000157056 |
HOGENOMi | CLU_003951_1_0_1 |
InParanoidi | F6S7N6 |
TreeFami | TF320680 |
Gene expression databases
Bgeei | ENSMMUG00000015733, Expressed in heart and 24 other tissues |
ExpressionAtlasi | F6S7N6, baseline |
Family and domain databases
InterProi | View protein in InterPro IPR036028, SH3-like_dom_sf IPR001452, SH3_domain IPR003127, SoHo_dom IPR028506, Sorbin_SH3 IPR013087, Znf_C2H2_type |
PANTHERi | PTHR14167:SF56, PTHR14167:SF56, 1 hit |
Pfami | View protein in Pfam PF00018, SH3_1, 2 hits PF14604, SH3_9, 1 hit PF02208, Sorb, 1 hit |
PRINTSi | PR00452, SH3DOMAIN |
SMARTi | View protein in SMART SM00326, SH3, 3 hits SM00459, Sorb, 1 hit |
SUPFAMi | SSF50044, SSF50044, 3 hits |
PROSITEi | View protein in PROSITE PS50002, SH3, 3 hits PS50831, SOHO, 1 hit PS00028, ZINC_FINGER_C2H2_1, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | F6S7N6_MACMU | |
Accessioni | F6S7N6Primary (citable) accession number: F6S7N6 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | July 27, 2011 |
Last sequence update: | December 11, 2019 | |
Last modified: | May 25, 2022 | |
This is version 68 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |