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Entry version 57 (17 Jun 2020)
Sequence version 2 (10 Apr 2019)
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Protein
Submitted name:

Protein kinase, DNA-activated, catalytic subunit

Gene

PRKDC

Organism
Equus caballus (Horse)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionKinase, Serine/threonine-protein kinaseSAAS annotation, Transferase
LigandATP-bindingSAAS annotation, Nucleotide-binding

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Protein kinase, DNA-activated, catalytic subunitImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:PRKDCImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiEquus caballus (Horse)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9796 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaPerissodactylaEquidaeEquus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002281 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 9

Organism-specific databases

Vertebrate Gene Nomenclature Database

More...
VGNCi
VGNC:21853 PRKDC

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSECAG00000020168 Expressed in liver and 2 other tissues

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini2913 – 3545FATInterPro annotationAdd BLAST633
Domaini3754 – 4017PI3K/PI4KInterPro annotationAdd BLAST264
Domaini4132 – 4164FATCInterPro annotationAdd BLAST33

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni2697 – 2723DisorderedSequence analysisAdd BLAST27
Regioni3207 – 3226DisorderedSequence analysisAdd BLAST20

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili2965 – 2985Sequence analysisAdd BLAST21

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the PI3/PI4-kinase family.SAAS annotation

Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0891 Eukaryota
COG5032 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000155633

Family and domain databases

Conserved Domains Database

More...
CDDi
cd05172 PIKKc_DNA-PK, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.1070.11, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR016024 ARM-type_fold
IPR037706 DNA-PK_dom
IPR003152 FATC_dom
IPR011009 Kinase-like_dom_sf
IPR012582 NUC194
IPR000403 PI3/4_kinase_cat_dom
IPR036940 PI3/4_kinase_cat_sf
IPR018936 PI3/4_kinase_CS
IPR003151 PIK-rel_kinase_FAT
IPR014009 PIK_FAT

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF02259 FAT, 1 hit
PF02260 FATC, 1 hit
PF08163 NUC194, 1 hit
PF00454 PI3_PI4_kinase, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM01343 FATC, 1 hit
SM01344 NUC194, 1 hit
SM00146 PI3Kc, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48371 SSF48371, 3 hits
SSF56112 SSF56112, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51189 FAT, 1 hit
PS51190 FATC, 1 hit
PS00915 PI3_4_KINASE_1, 1 hit
PS00916 PI3_4_KINASE_2, 1 hit
PS50290 PI3_4_KINASE_3, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 7 potential isoforms that are computationally mapped.Show allAlign All

F6RWW4-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAHSGSGLQS FLMQLQESLS AADRCSAAMA GYHLIRGLGQ ECMLSTGPAV
60 70 80 90 100
LALQTSLVFS KDFGLLVFVR KSLSIDEFRD CREEILKFLY IFLEKIGQKI
110 120 130 140 150
TPYSLDIKNT CTSVYTKDKA AKCKIPALDL LIKLLQTLRS SRLMDEFRVG
160 170 180 190 200
ELFTKFYGEL ALKTKIPDTV LEKIYELLGV LGEVHPSEMI SNSEQLFRAF
210 220 230 240 250
LGELKSQMTS TVREPKLPVL AGCLKGLSSL MCNFTKSMEE DPQTSREIFD
260 270 280 290 300
FALKAIRPQI DLKRYAVPLA GLCLFTLHAS QFSTCLLENY VSLFEVLSKW
310 320 330 340 350
CGHTNIELKK AAHSALESFL KQVSFMVAKD AERHKNKLQY FMEQFYGIIR
360 370 380 390 400
NMDSNSKDLS IAIRGYGLFA GPCKVINAKD VDFMYVELIQ RCKQLFLTQT
410 420 430 440 450
DTVDDHIYQM PSFLQSIASV LLYLDTIPEV YTPVLEHLMV VQIDSFPQYS
460 470 480 490 500
PKMQPVCCRA IVKVFLALAE KGPVLWNCIS TVVHQGLIRI CSKPVVFQKG
510 520 530 540 550
AGSESEDYHT SEEARTGKWK MPTYKDYLDL FRYLLSCDQM MDSLLADEAF
560 570 580 590 600
LFVNSSLHSL NRLLYDEFVK SVLKIVEKLD LTLEKQNVGE QEDETEATGV
610 620 630 640 650
WVIPTSDPAA NLHPAKPKDF SAFINLVEFC REILPEKHVE FFEPWVYSFA
660 670 680 690 700
YELILQSTRL PLISGFYKLL SVAVRNAKKM KYFEGVGPKS QKQSPEDLEK
710 720 730 740 750
YSCFALFAKF SKEVSIKMKQ YKDELLASCL TFILSLPHDI IELDVRAYVP
760 770 780 790 800
ALQMAFKLGL SYTPLAEVGL NALEEWSGYI CKHVIQPYYK DILPSLDGYL
810 820 830 840 850
KTSVLSDETK NSWQVSALSR AAQKGFNKVV LKHLTKTKSI SSNEALSLEE
860 870 880 890 900
VRIRVVRILG SLGGQINKNL VTAASSDEMM KKCVAWDREK RLRFAVPFME
910 920 930 940 950
MKPVIYLDLF LPRVTELALS ASDRQTKVAA CEFLHSMVMF MLGKATQMPE
960 970 980 990 1000
DGQGSPPMYQ LYKRTFPVLL RLACDVDQVT RQLYEPLVMQ LIHWFTNNKK
1010 1020 1030 1040 1050
FESQDTVALL ETILDGIVDP VDSTLRDFCG QCIQEFLKWS IKQTTPQQQE
1060 1070 1080 1090 1100
KSPVNTKSLF KRLYSFALHP NAFKRLGASL AFNNIYREFR EEESLVEQFV
1110 1120 1130 1140 1150
FEALVTYMES LALAHTDEKS LGTIQQCCDA IDHLSLIIEK KHVSLNKAKK
1160 1170 1180 1190 1200
RRLPRGFPPA TSLCLLDVVQ WLLANCGRPQ TECRHKSIEL FYKFVTLLPG
1210 1220 1230 1240 1250
NKSPFLWLKD IIKKEDISFL INTFEGGGRG CDRPSGILAQ PTLFHLQGPF
1260 1270 1280 1290 1300
SLRAALQWMD MLLAALECYN TFIEEKTLEA PKVLGTETQS SLWKAVAFFL
1310 1320 1330 1340 1350
ESIAMHDIMA AEKYFGTGAT GNRPSPQEGE RYNYSKCTIV VRIMEFTTTL
1360 1370 1380 1390 1400
LSTSPEGWKL LEKDVCNTNL MKLLVKTLCE PSSIGFNIGD VAVMNYLPSV
1410 1420 1430 1440 1450
CTNLMKALKK SPYKDILEMH LKEKITAQSI EELCAVDLYC PDACVDRARL
1460 1470 1480 1490 1500
ASVVSACKQL HRAGFLCVII PSQSADQHHS IGTKLLSLVY KSIAPGDEQQ
1510 1520 1530 1540 1550
CLPSLDPNCK RLASGLLELA FAFGGLCEHL VSLLLDTTVL SMPSRGGSQK
1560 1570 1580 1590 1600
NIVSFSHGEY FYSLFSETIN TELLKNLDLA VLELMKSSVD NPKMVSNVLN
1610 1620 1630 1640 1650
GMLDQSFRDR TSEKHQGLKL ATIILQNWKK CDSWWAKDSA PESKMAVLTL
1660 1670 1680 1690 1700
LAKILQIDSS VCFNTNHCMF PEVFTTYVSL LADSKLDLHL KGQAIILLPF
1710 1720 1730 1740 1750
FTSLTGGSLE DLKVVLENLI VSNFPMKSEE FPPGTLQYSN YVDCMKKFLD
1760 1770 1780 1790 1800
ALELSESPML LQLMTEILCR EQQHVMEELF QSTFKKIARK SSCITQLGLL
1810 1820 1830 1840 1850
ESVYRMFRRD DLLSNITRQA FVDRSLLTLL WHCSLNALRE FFSKIVVEAI
1860 1870 1880 1890 1900
NVLKSRFIKL NESAFDTQIT KKMGYYKMLD VMYSRLPKDD VHSKESKINQ
1910 1920 1930 1940 1950
VFHGSCITEG SELTKTLIKL CYDAFTENMA GENQLLERRR LYHCAAYNCA
1960 1970 1980 1990 2000
ISVVCCVFNE LKFYQGFLFT EKPEKNLLIF ENLIDLKRCY TFPIEVEVPM
2010 2020 2030 2040 2050
ERKKKYLEIR KEAREAASGD SDGPRYISSL SYLADSSLSE EMSQFDFSTG
2060 2070 2080 2090 2100
VQSYSYSSQD PKSTTAHFRR QKHKESMIQD DILELEMDEL NQHECMATMT
2110 2120 2130 2140 2150
ALIKHMQRNQ ILPKEEEGSV PRNLPPWMKF LHDKLGNPSI SLNIRLFLAK
2160 2170 2180 2190 2200
LVINTEEVFR PYARYWLSPL LQLVVSGNNG GEGIHYMVVE IVVIILSWTG
2210 2220 2230 2240 2250
LATPIGVPKD EVLANRLLHF LMKHVFHQKR AVFRHNLEII KTLVECWKDC
2260 2270 2280 2290 2300
LSIPYRLIFE KFSSTDPNSK DNSVGIQLLG IVMANNLPPY DPKCGIESIK
2310 2320 2330 2340 2350
YFQALVNNMS FVKYREVYAA AAEVLGLVLR YITERENILE ESVCELVIKQ
2360 2370 2380 2390 2400
LKQHQNTMED KFIVCLNKAV KNFPPLADRF MNTVFFLLPK FHGVMKTLCL
2410 2420 2430 2440 2450
EVVLCRAEEI TDLYLQLKSK DFIQVMRHRD DERQKVCLDI IYKMMAKLKP
2460 2470 2480 2490 2500
VELRELLNPV VEFISHPSPV CREQMYNILM WIHDNYRDPE SQADDDSQEI
2510 2520 2530 2540 2550
FKLAKDVLIQ GLIDENPGLQ LIIRNFWSHE TRLPSNTLDR LLALNSLYSP
2560 2570 2580 2590 2600
KIEAHFLSLA TDFLLEMTSV SPDYSNPMFE HPLSECKFQE YTIDSDWRFR
2610 2620 2630 2640 2650
STVLTPMFIE TQASQSALQT RTQEGSLSAR GVMTGQIRAT QQQYDFTPTQ
2660 2670 2680 2690 2700
NTDGRSSFNW LTGNSIDPLV DFTVSSSSDS LSSSLLFAHK RSEKSQRVPL
2710 2720 2730 2740 2750
KSVGPDFGKK RLGLPGDEVD NKAKGTDNRA EILRLRRRFL KDREKLSLIY
2760 2770 2780 2790 2800
ARKGVAEQKR EKEIKSELKM KHDAQVILYR SYRQGDLPDI QIKYSSLITP
2810 2820 2830 2840 2850
LQAVAQRDPI IAKQLFGSLF SGIIKEMDKY KTMSEKNNIT QKLLQDFNNF
2860 2870 2880 2890 2900
LNTTVSFFPP FISCIQEISC QHADLLSLNP ASVSASCLAS LQQPVGVRLL
2910 2920 2930 2940 2950
EEALLHLLPE EPPAKRVRGR PCLYPDFVRW MELAKLYRSI GEYDILRGIF
2960 2970 2980 2990 3000
NSEIGTKQVT QNALLAEARN DYSEAVKQYN EALNKQEWVD GEPMEAEKDF
3010 3020 3030 3040 3050
WELASLDCYN QLAEWKSLAY CSTVSVDSAN PPDLNKMWNE PFYQETYLPY
3060 3070 3080 3090 3100
MIRSKLKLLL QGEGDQSLLT FIDEAVSKEL QKVLVELHYS QELSLLYILQ
3110 3120 3130 3140 3150
DDVDRAKYYI ENCIRIFMQS YSSIDVLLER SRLTKLQSLQ TLIEIQEFIS
3160 3170 3180 3190 3200
FISKQGNLSS QIPLKRLLKT WTNRYPDAKM DPMNIWDDII TNRCFFLSKI
3210 3220 3230 3240 3250
EEKLTLPPDD HSMNTDGDED SSDRMKVQEQ EEDIYSLIKS CKFSMKMKMI
3260 3270 3280 3290 3300
ESARKQKNFS LAMKLLKELH KESKTRDDWL VKWVQSYCRL SHSRSQTQNR
3310 3320 3330 3340 3350
PEQILTVLKT VSLLDENTSS YLSKNIPVSR DHNILLGTTY RIIANALSSD
3360 3370 3380 3390 3400
PTCLAEIGES KARRILELSG SSLENAEEVI AGLYQRVLHH LSEAVRIAEE
3410 3420 3430 3440 3450
EAQPFTRGQE PAVGVIDAYM TLVDFCDQQL RKEEESSSVT ESVQLQMYPA
3460 3470 3480 3490 3500
LVVDKMLKAL RLHSNEARLK FPRLLQIIEQ YPEETLSLMT KEISSIPCWQ
3510 3520 3530 3540 3550
FIGWISHMVA LLDKEEAVAV HRTVEEIADN YPQAMVYPFI ISSESYSFKD
3560 3570 3580 3590 3600
TSTGYKNKEF VERIKIKLDQ GGVIQDFINA LEQLSHPEML FKDWTDDIKV
3610 3620 3630 3640 3650
ELEKNPVNRK NIEKMYEKMY ATLGDPQAPG LGAFRRRFIQ AFGKEFDKHF
3660 3670 3680 3690 3700
GRGGSKLPGM KPREFSDITN SLFSKMCEVS KPPGNLKECS PWMSDFKVEF
3710 3720 3730 3740 3750
LRSELEIPGQ YDGKGKPVPE YHARIAGFDE RIKVMASMRK PKRIIIRGHD
3760 3770 3780 3790 3800
EREYPFLVKG GEDLRQDQRI EQLFEVMNVI LSQDATCSQR SMQLKTYQVI
3810 3820 3830 3840 3850
PMTSRLGLIE WIENTFTLKE LLLSNMSQEE KAACTSDPKA PPFEYRDWLT
3860 3870 3880 3890 3900
KMSGKCDVGA YMLMYKGASR TETVTSFRKR ESKVPADLLK RAFVKMSTSP
3910 3920 3930 3940 3950
EAFLTLRSHF ARSHALICIS HWILGIGDRH LNNFLVSMET GGVIGIDFGH
3960 3970 3980 3990 4000
AFGSATQFLP VPELMPFRLT RQFINLMLPM KETGVMYSIM VHALRAFRSQ
4010 4020 4030 4040 4050
SNLLANTMDV FVKEPSFDWK HFLKVTFEII WPENQIKDVT RRGNMDPLVM
4060 4070 4080 4090 4100
NFEQKMLKKG GSWIQEINVT EKNWYPRQKI HYAKRKLAGA NPAVITCDEL
4110 4120 4130 4140 4150
LLGHEKVAAF GDYVAVARGS EDHNIRAQEL ESDLSEEAQV KCLIDQATDP
4160
NILGRTWIGW EPWM
Length:4,164
Mass (Da):475,876
Last modified:April 10, 2019 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iFE2E2C1C65A5EB8D
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 7 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A3Q2HIG2A0A3Q2HIG2_HORSE
Protein kinase, DNA-activated, cata...
PRKDC
4,166Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F6RGR8F6RGR8_HORSE
Protein kinase, DNA-activated, cata...
PRKDC
4,083Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F6Q1K5F6Q1K5_HORSE
Protein kinase, DNA-activated, cata...
PRKDC
4,097Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F6RG31F6RG31_HORSE
Protein kinase, DNA-activated, cata...
PRKDC
4,145Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A3Q2I0M9A0A3Q2I0M9_HORSE
Protein kinase, DNA-activated, cata...
PRKDC
4,113Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A3Q2L6Q7A0A3Q2L6Q7_HORSE
Protein kinase, DNA-activated, cata...
PRKDC
4,088Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A3Q2HH65A0A3Q2HH65_HORSE
Protein kinase, DNA-activated, cata...
PRKDC
4,112Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSECAT00000022846; ENSECAP00000018902; ENSECAG00000020168

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

3D structure databases

Database of comparative protein structure models

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ModBasei
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SWISS-MODEL Interactive Workspace

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SWISS-MODEL-Workspacei
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Genome annotation databases

EnsembliENSECAT00000022846; ENSECAP00000018902; ENSECAG00000020168

Organism-specific databases

VGNCiVGNC:21853 PRKDC

Phylogenomic databases

eggNOGiKOG0891 Eukaryota
COG5032 LUCA
GeneTreeiENSGT00940000155633

Gene expression databases

BgeeiENSECAG00000020168 Expressed in liver and 2 other tissues

Family and domain databases

CDDicd05172 PIKKc_DNA-PK, 1 hit
Gene3Di1.10.1070.11, 1 hit
InterProiView protein in InterPro
IPR016024 ARM-type_fold
IPR037706 DNA-PK_dom
IPR003152 FATC_dom
IPR011009 Kinase-like_dom_sf
IPR012582 NUC194
IPR000403 PI3/4_kinase_cat_dom
IPR036940 PI3/4_kinase_cat_sf
IPR018936 PI3/4_kinase_CS
IPR003151 PIK-rel_kinase_FAT
IPR014009 PIK_FAT
PfamiView protein in Pfam
PF02259 FAT, 1 hit
PF02260 FATC, 1 hit
PF08163 NUC194, 1 hit
PF00454 PI3_PI4_kinase, 1 hit
SMARTiView protein in SMART
SM01343 FATC, 1 hit
SM01344 NUC194, 1 hit
SM00146 PI3Kc, 1 hit
SUPFAMiSSF48371 SSF48371, 3 hits
SSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS51189 FAT, 1 hit
PS51190 FATC, 1 hit
PS00915 PI3_4_KINASE_1, 1 hit
PS00916 PI3_4_KINASE_2, 1 hit
PS50290 PI3_4_KINASE_3, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiF6RWW4_HORSE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: F6RWW4
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: July 27, 2011
Last sequence update: April 10, 2019
Last modified: June 17, 2020
This is version 57 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteomeImported
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