UniProtKB - F6RUE3 (F6RUE3_HORSE)
Protein
Mediator of RNA polymerase II transcription subunit 31
Gene
MED31
Organism
Equus caballus (Horse)
Status
Functioni
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.UniRule annotation
GO - Molecular functioni
- transcription coregulator activity Source: InterPro
GO - Biological processi
- limb development Source: Ensembl
- negative regulation of fibroblast proliferation Source: Ensembl
- regulation of transcription by RNA polymerase II Source: GO_Central
Keywordsi
Molecular function | ActivatorUniRule annotationARBA annotation |
Biological process | Transcription, Transcription regulationUniRule annotation |
Names & Taxonomyi
Protein namesi | Recommended name: Mediator of RNA polymerase II transcription subunit 31UniRule annotation |
Gene namesi | Name:MED31Imported |
Organismi | Equus caballus (Horse)Imported |
Taxonomic identifieri | 9796 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Perissodactyla › Equidae › Equus › |
Proteomesi |
|
Organism-specific databases
VGNCi | VGNC:56442, MED31 |
Subcellular locationi
Nucleus
- Nucleus UniRule annotationARBA annotation
Nucleus
- core mediator complex Source: GO_Central
- mediator complex Source: GO_Central
Keywords - Cellular componenti
NucleusUniRule annotationARBA annotationExpressioni
Gene expression databases
Bgeei | ENSECAG00000024998, Expressed in trophectoderm and 22 other tissues |
Interactioni
Subunit structurei
Component of the Mediator complex.
UniRule annotationFamily & Domainsi
Sequence similaritiesi
Phylogenomic databases
GeneTreei | ENSGT00390000015531 |
HOGENOMi | CLU_071681_5_1_1 |
InParanoidi | F6RUE3 |
OMAi | QILLWQH |
OrthoDBi | 1480492at2759 |
TreeFami | TF105799 |
Family and domain databases
Gene3Di | 1.10.10.1340, 1 hit |
InterProi | View protein in InterPro IPR038089, Med31_sf IPR008831, Mediator_Med31 |
PANTHERi | PTHR13186, PTHR13186, 1 hit |
Pfami | View protein in Pfam PF05669, Med31, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
F6RUE3-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MAAAVAMETD DAGNRLRFQL ELEFVQCLAN PNYLNFLAQR GYFKDKAFVN
60 70 80 90 100
YLKYLLYWKE PEYAKYLKYP QCLHMLELLQ YEHFRKELVN AQCAKFIDEQ
110 120 130
QILHWQHYSR KRMRLQQALA EQQQQNNTSG K
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketA0A5F5PPZ0 | A0A5F5PPZ0_HORSE | Mediator of RNA polymerase II trans... | MED31 | 43 | Annotation score: |
Genome annotation databases
Ensembli | ENSECAT00000026972; ENSECAP00000022555; ENSECAG00000024998 |
Similar proteinsi
Cross-referencesi
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Proteomic databases
PaxDbi | F6RUE3 |
Genome annotation databases
Ensembli | ENSECAT00000026972; ENSECAP00000022555; ENSECAG00000024998 |
Organism-specific databases
VGNCi | VGNC:56442, MED31 |
Phylogenomic databases
GeneTreei | ENSGT00390000015531 |
HOGENOMi | CLU_071681_5_1_1 |
InParanoidi | F6RUE3 |
OMAi | QILLWQH |
OrthoDBi | 1480492at2759 |
TreeFami | TF105799 |
Gene expression databases
Bgeei | ENSECAG00000024998, Expressed in trophectoderm and 22 other tissues |
Family and domain databases
Gene3Di | 1.10.10.1340, 1 hit |
InterProi | View protein in InterPro IPR038089, Med31_sf IPR008831, Mediator_Med31 |
PANTHERi | PTHR13186, PTHR13186, 1 hit |
Pfami | View protein in Pfam PF05669, Med31, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | F6RUE3_HORSE | |
Accessioni | F6RUE3Primary (citable) accession number: F6RUE3 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | July 27, 2011 |
Last sequence update: | July 27, 2011 | |
Last modified: | February 10, 2021 | |
This is version 41 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |