UniProtKB - F6RST7 (F6RST7_HORSE)
Protein
3-keto-steroid reductase
Gene
HSD17B7
Organism
Equus caballus (Horse)
Status
Functioni
Catalytic activityi
- EC:1.1.1.270ARBA annotation
: zymosterol biosynthesis Pathwayi
This protein is involved in step 5 of the subpathway that synthesizes zymosterol from lanosterol.ARBA annotationProteins known to be involved in the 6 steps of the subpathway in this organism are:
- no protein annotated in this organism
- no protein annotated in this organism
- no protein annotated in this organism
- no protein annotated in this organism
- 3-keto-steroid reductase (HSD17B7)
- no protein annotated in this organism
View all proteins of this organism that are known to be involved in the subpathway that synthesizes zymosterol from lanosterol, the pathway zymosterol biosynthesis and in Steroid biosynthesis.
GO - Molecular functioni
- 3-keto sterol reductase activity Source: GO_Central
- 5alpha-androstane-3beta,17beta-diol dehydrogenase activity Source: Ensembl
- estradiol 17-beta-dehydrogenase activity Source: Ensembl
GO - Biological processi
- androgen metabolic process Source: Ensembl
- brain development Source: Ensembl
- cell differentiation Source: Ensembl
- cholesterol biosynthetic process Source: GO_Central
- embryonic organ development Source: Ensembl
- embryonic skeletal system development Source: Ensembl
- estrogen biosynthetic process Source: Ensembl
Keywordsi
Molecular function | OxidoreductaseARBA annotation |
Biological process | Lipid biosynthesis, Lipid metabolism, Steroid biosynthesisARBA annotation |
Ligand | NADPARBA annotation |
Enzyme and pathway databases
UniPathwayi | UPA00770;UER00758 |
Names & Taxonomyi
Protein namesi | |
Gene namesi | Name:HSD17B7Imported |
Organismi | Equus caballus (Horse)Imported |
Taxonomic identifieri | 9796 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Perissodactyla › Equidae › Equus › |
Proteomesi |
|
Organism-specific databases
VGNCi | VGNC:18888, HSD17B7 |
Subcellular locationi
Endoplasmic reticulum
- endoplasmic reticulum Source: GO_Central
- endoplasmic reticulum membrane Source: Ensembl
Other locations
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 238 – 259 | HelicalSequence analysisAdd BLAST | 22 |
Keywords - Cellular componenti
MembraneExpressioni
Gene expression databases
Bgeei | ENSECAG00000024992, Expressed in trophectoderm and 22 other tissues |
Family & Domainsi
Sequence similaritiesi
Keywords - Domaini
Transmembrane, Transmembrane helixSequence analysisPhylogenomic databases
GeneTreei | ENSGT00390000013340 |
HOGENOMi | CLU_029944_2_0_1 |
InParanoidi | F6RST7 |
TreeFami | TF105433 |
Family and domain databases
CDDi | cd08941, 3KS_SDR_c, 1 hit |
InterProi | View protein in InterPro IPR042829, HSD17B7/Erg27 IPR036291, NAD(P)-bd_dom_sf IPR002347, SDR_fam |
Pfami | View protein in Pfam PF00106, adh_short, 1 hit |
PRINTSi | PR00081, GDHRDH |
SUPFAMi | SSF51735, SSF51735, 1 hit |
i Sequence
Sequence statusi: Complete.
F6RST7-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
ARKVVLITGA SSGVGLALCK RLLEEDNGLH LCLACRNMSK ADAVRTALLA
60 70 80 90 100
SYPTAEVTTV QVDVSNLPSV FQASKELKQR FPRLDYVYLN AGIMPNPQLN
110 120 130 140 150
IKALFSGLFS RKVIHMFSTA EGLLTQDDKV TADGLQEVFE TNVFGHFILI
160 170 180 190 200
QELEPLLCHS DSPSRLIWTS SRNAKKSNFS LEDFQHSKGQ EPYSSSKYAI
210 220 230 240 250
DLLSLALNRN CNQQGLYSSV LCPGTMLTNL TYGILPPFIW TLLMPFILLL
260 270 280 290 300
RFFASAFTLT PYNGTEAMVW LFHQKPESLD PLAKYLSSTT GFGRNYVMTQ
310 320 330
KMDLDEDTAE KFYQKLLELE KHIRVTIHKT DDQ
Genome annotation databases
Ensembli | ENSECAT00000026988; ENSECAP00000022571; ENSECAG00000024992 |
Similar proteinsi
Cross-referencesi
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Proteomic databases
PaxDbi | F6RST7 |
Genome annotation databases
Ensembli | ENSECAT00000026988; ENSECAP00000022571; ENSECAG00000024992 |
Organism-specific databases
VGNCi | VGNC:18888, HSD17B7 |
Phylogenomic databases
GeneTreei | ENSGT00390000013340 |
HOGENOMi | CLU_029944_2_0_1 |
InParanoidi | F6RST7 |
TreeFami | TF105433 |
Enzyme and pathway databases
UniPathwayi | UPA00770;UER00758 |
Gene expression databases
Bgeei | ENSECAG00000024992, Expressed in trophectoderm and 22 other tissues |
Family and domain databases
CDDi | cd08941, 3KS_SDR_c, 1 hit |
InterProi | View protein in InterPro IPR042829, HSD17B7/Erg27 IPR036291, NAD(P)-bd_dom_sf IPR002347, SDR_fam |
Pfami | View protein in Pfam PF00106, adh_short, 1 hit |
PRINTSi | PR00081, GDHRDH |
SUPFAMi | SSF51735, SSF51735, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | F6RST7_HORSE | |
Accessioni | F6RST7Primary (citable) accession number: F6RST7 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | July 27, 2011 |
Last sequence update: | December 11, 2019 | |
Last modified: | February 10, 2021 | |
This is version 53 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |