UniProtKB - F6RQQ4 (F6RQQ4_HORSE)
Protein
Submitted name:
SOS Ras/Rac guanine nucleotide exchange factor 1
Gene
SOS1
Organism
Equus caballus (Horse)
Status
Functioni
GO - Molecular functioni
- DNA binding Source: InterPro
- guanyl-nucleotide exchange factor activity Source: UniProtKB-KW
- protein heterodimerization activity Source: InterPro
GO - Biological processi
- small GTPase mediated signal transduction Source: InterPro
Keywordsi
Molecular function | Guanine-nucleotide releasing factorPROSITE-ProRule annotationARBA annotation |
Names & Taxonomyi
Protein namesi | Submitted name: SOS Ras/Rac guanine nucleotide exchange factor 1Imported |
Gene namesi | Name:SOS1Imported |
Organismi | Equus caballus (Horse)Imported |
Taxonomic identifieri | 9796 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Perissodactyla › Equidae › Equus › |
Proteomesi |
|
Organism-specific databases
VGNCi | VGNC:23454, SOS1 |
Expressioni
Gene expression databases
Bgeei | ENSECAG00000017604, Expressed in brainstem and 22 other tissues |
ExpressionAtlasi | F6RQQ4, baseline |
Interactioni
GO - Molecular functioni
- guanyl-nucleotide exchange factor activity Source: UniProtKB-KW
- protein heterodimerization activity Source: InterPro
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 200 – 390 | DHInterPro annotationAdd BLAST | 191 | |
Domaini | 443 – 546 | PHInterPro annotationAdd BLAST | 104 | |
Domaini | 597 – 741 | N-terminal Ras-GEFInterPro annotationAdd BLAST | 145 | |
Domaini | 780 – 1019 | Ras-GEFInterPro annotationAdd BLAST | 240 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1019 – 1103 | DisorderedSequence analysisAdd BLAST | 85 | |
Regioni | 1129 – 1333 | DisorderedSequence analysisAdd BLAST | 205 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 1129 – 1143 | PolarSequence analysisAdd BLAST | 15 | |
Compositional biasi | 1147 – 1161 | Pro-richSequence analysisAdd BLAST | 15 | |
Compositional biasi | 1190 – 1206 | PolarSequence analysisAdd BLAST | 17 | |
Compositional biasi | 1252 – 1271 | Pro-richSequence analysisAdd BLAST | 20 | |
Compositional biasi | 1306 – 1321 | PolyampholyteSequence analysisAdd BLAST | 16 |
Phylogenomic databases
GeneTreei | ENSGT00940000155423 |
HOGENOMi | CLU_002744_0_0_1 |
InParanoidi | F6RQQ4 |
OMAi | WFEKCII |
OrthoDBi | 576110at2759 |
TreeFami | TF317296 |
Family and domain databases
CDDi | cd00155, RasGEF, 1 hit cd06224, REM, 1 hit cd00160, RhoGEF, 1 hit |
Gene3Di | 1.10.20.10, 1 hit 1.10.840.10, 2 hits 1.20.900.10, 1 hit 2.30.29.30, 1 hit |
InterProi | View protein in InterPro IPR035899, DBL_dom_sf IPR000219, DH-domain IPR009072, Histone-fold IPR007125, Histone_H2A/H2B/H3 IPR011993, PH-like_dom_sf IPR001849, PH_domain IPR008937, Ras-like_GEF IPR000651, Ras-like_Gua-exchang_fac_N IPR019804, Ras_G-nucl-exch_fac_CS IPR023578, Ras_GEF_dom_sf IPR001895, RASGEF_cat_dom IPR036964, RASGEF_cat_dom_sf |
PANTHERi | PTHR23113, PTHR23113, 1 hit |
Pfami | View protein in Pfam PF00125, Histone, 1 hit PF00169, PH, 1 hit PF00617, RasGEF, 1 hit PF00618, RasGEF_N, 1 hit PF00621, RhoGEF, 1 hit |
SMARTi | View protein in SMART SM00233, PH, 1 hit SM00147, RasGEF, 1 hit SM00229, RasGEFN, 1 hit SM00325, RhoGEF, 1 hit |
SUPFAMi | SSF47113, SSF47113, 1 hit SSF48065, SSF48065, 1 hit SSF48366, SSF48366, 1 hit |
PROSITEi | View protein in PROSITE PS50010, DH_2, 1 hit PS50003, PH_DOMAIN, 1 hit PS00720, RASGEF, 1 hit PS50009, RASGEF_CAT, 1 hit PS50212, RASGEF_NTER, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 7 potential isoforms that are computationally mapped.Show allAlign All
F6RQQ4-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MQAQQLPYEF FSEENAPKWR GLLVPALKKV QGQVHPTLES SDDALQYVEE
60 70 80 90 100
LILQLLNMLC QAQPRSASDV EERVQKSFPH PIDKWAIADA QSAIEKRKRR
110 120 130 140 150
NPLSLPVEKI HPLLKEVLGY KIDHQVSVYI VAVLEYISAD ILKLVGNYVR
160 170 180 190 200
NIRHYEITKQ DIKVAMCADK VLMDMFHQDV EDINILSLTD EEPSTSGEQT
210 220 230 240 250
YYDLVKAFMA EIRQYIRELN LIIKVFREPF VSNSKLFSAN DVENIFSRIV
260 270 280 290 300
DIHELSVKLL GHIEDTVEMT DEGSPHPLVG SCFEDLAEEL AFDPYESYAR
310 320 330 340 350
DILRPGFHDH FLSQLSKPGA ALYLQSIGEG FKEAVQYVLP RLLLAPVYHC
360 370 380 390 400
LHYFELLKQL EEKSEDQEDK ECLKQAITAL LNVQSGMEKI CSKSLAKRRL
410 420 430 440 450
SESACRFYSQ QMKGKQLAIK KMNEIQKNID GWEGKDIGQC CNEFIMEGTL
460 470 480 490 500
TRVGAKHERH IFLFDGLMIC CKSNHGQPRL PGASNAEYRL KEKFFMRKVQ
510 520 530 540 550
INDKDDTSEY KHAFEIILKD ENSVIFSAKS AEEKNNWMAA LISLQYRSTL
560 570 580 590 600
ERMLDVTMLQ EEKEEQMRLP SADVYRFAEP DSEENIIFEE NMQPKAGIPI
610 620 630 640 650
IKAGTVIKLI ERLTYHMYAD PNFVRTFLTT YRSFCKPQEL LSLIIERFEI
660 670 680 690 700
PEPEPTEADR IAIENGDQPL SAELKRFRKE YIQPVQLRVL NVCRHWVEHH
710 720 730 740 750
FYDFERDADL LQRMEEFIGT VRGKAMKKWV ESITKIIQRK KIARDNGPGH
760 770 780 790 800
NITFQSSPPT VEWHISRPGH IETFDLLTLH PIEIARQLTL LESDLYRAVQ
810 820 830 840 850
PSELVGSVWT KEDKEINSPN LLKMIRHTTN LTLWFEKCIV ETENLEERVA
860 870 880 890 900
VVNRIIEILQ VFQELNNFNG VLEVVSAMNS SPVYRLDHTF EQIPSRQKKI
910 920 930 940 950
LEEAHELSED HYKKYLAKLR SINPPCVPFF GIYLTNILKT EEGNPEVLKR
960 970 980 990 1000
HGKDLINFSK RRKVAEITGE IQQYQNQPYC LRVESDIKRF FENLNPMGNS
1010 1020 1030 1040 1050
MEKEFTDYLF NKSLEIEPRN PKPLPRFPKK YSYPLKSPGV RPSNPRPGTM
1060 1070 1080 1090 1100
RHPTPLQQEP RKISYSRIPE SETESTASAP NSPRTPLTPP PASGASSTTD
1110 1120 1130 1140 1150
VCSVFDSDHS SPFHSSSDTV FIQVTLPHGP RSASVSSISL TKGTDEVPVP
1160 1170 1180 1190 1200
PPVPPRRRPE SAPAESSPSK IMSKHLDSPP AIPPRQPTSK AYSPRYSISE
1210 1220 1230 1240 1250
RTSISDPPES PPLLPPREPV RTPDVFSSSP LHLQPPPLGK KSDHGNAFFP
1260 1270 1280 1290 1300
NSPSPFTPPP PQTPSPHGTR RHLPSPPLTQ EVDLHSIAGP PVPPRQSTSQ
1310 1320 1330
HIPKLPPKTY KREHTHPSMH RDGPPLLENA HSS
Computationally mapped potential isoform sequencesi
There are 7 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketA0A5F5PZX2 | A0A5F5PZX2_HORSE | SOS Ras/Rac guanine nucleotide exch... | SOS1 | 1,613 | Annotation score: | ||
F7A245 | F7A245_HORSE | SOS Ras/Rac guanine nucleotide exch... | SOS1 | 1,572 | Annotation score: | ||
A0A5F5PIB2 | A0A5F5PIB2_HORSE | SOS Ras/Rac guanine nucleotide exch... | SOS1 | 1,603 | Annotation score: | ||
A0A5F5PJZ3 | A0A5F5PJZ3_HORSE | SOS Ras/Rac guanine nucleotide exch... | SOS1 | 1,565 | Annotation score: | ||
A0A5F5PLW4 | A0A5F5PLW4_HORSE | SOS Ras/Rac guanine nucleotide exch... | SOS1 | 1,598 | Annotation score: | ||
A0A5F5PW12 | A0A5F5PW12_HORSE | SOS Ras/Rac guanine nucleotide exch... | SOS1 | 1,538 | Annotation score: | ||
A0A3Q2LBU4 | A0A3Q2LBU4_HORSE | SOS Ras/Rac guanine nucleotide exch... | SOS1 | 1,305 | Annotation score: |
Sequence databases
RefSeqi | XP_005600089.1, XM_005600032.2 |
Genome annotation databases
Ensembli | ENSECAT00000019183; ENSECAP00000015689; ENSECAG00000017604 |
GeneIDi | 100053889 |
KEGGi | ecb:100053889 |
Similar proteinsi
Cross-referencesi
Sequence databases
RefSeqi | XP_005600089.1, XM_005600032.2 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Proteomic databases
PaxDbi | F6RQQ4 |
PRIDEi | F6RQQ4 |
Genome annotation databases
Ensembli | ENSECAT00000019183; ENSECAP00000015689; ENSECAG00000017604 |
GeneIDi | 100053889 |
KEGGi | ecb:100053889 |
Organism-specific databases
CTDi | 6654 |
VGNCi | VGNC:23454, SOS1 |
Phylogenomic databases
GeneTreei | ENSGT00940000155423 |
HOGENOMi | CLU_002744_0_0_1 |
InParanoidi | F6RQQ4 |
OMAi | WFEKCII |
OrthoDBi | 576110at2759 |
TreeFami | TF317296 |
Gene expression databases
Bgeei | ENSECAG00000017604, Expressed in brainstem and 22 other tissues |
ExpressionAtlasi | F6RQQ4, baseline |
Family and domain databases
CDDi | cd00155, RasGEF, 1 hit cd06224, REM, 1 hit cd00160, RhoGEF, 1 hit |
Gene3Di | 1.10.20.10, 1 hit 1.10.840.10, 2 hits 1.20.900.10, 1 hit 2.30.29.30, 1 hit |
InterProi | View protein in InterPro IPR035899, DBL_dom_sf IPR000219, DH-domain IPR009072, Histone-fold IPR007125, Histone_H2A/H2B/H3 IPR011993, PH-like_dom_sf IPR001849, PH_domain IPR008937, Ras-like_GEF IPR000651, Ras-like_Gua-exchang_fac_N IPR019804, Ras_G-nucl-exch_fac_CS IPR023578, Ras_GEF_dom_sf IPR001895, RASGEF_cat_dom IPR036964, RASGEF_cat_dom_sf |
PANTHERi | PTHR23113, PTHR23113, 1 hit |
Pfami | View protein in Pfam PF00125, Histone, 1 hit PF00169, PH, 1 hit PF00617, RasGEF, 1 hit PF00618, RasGEF_N, 1 hit PF00621, RhoGEF, 1 hit |
SMARTi | View protein in SMART SM00233, PH, 1 hit SM00147, RasGEF, 1 hit SM00229, RasGEFN, 1 hit SM00325, RhoGEF, 1 hit |
SUPFAMi | SSF47113, SSF47113, 1 hit SSF48065, SSF48065, 1 hit SSF48366, SSF48366, 1 hit |
PROSITEi | View protein in PROSITE PS50010, DH_2, 1 hit PS50003, PH_DOMAIN, 1 hit PS00720, RASGEF, 1 hit PS50009, RASGEF_CAT, 1 hit PS50212, RASGEF_NTER, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | F6RQQ4_HORSE | |
Accessioni | F6RQQ4Primary (citable) accession number: F6RQQ4 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | July 27, 2011 |
Last sequence update: | July 27, 2011 | |
Last modified: | December 2, 2020 | |
This is version 72 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |