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UniProtKB - F6RQQ0 (F6RQQ0_MONDO)

Entry version 50 (07 Apr 2021)
Sequence version 3 (11 Dec 2019)
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Protein
Submitted name:

PR/SET domain 11

Gene

PRDM11

Organism
Monodelphis domestica (Gray short-tailed opossum)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Complete GO annotation on QuickGO ...

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
PR/SET domain 11Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:PRDM11Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMonodelphis domestica (Gray short-tailed opossum)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri13616 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Metatheria › Didelphimorphia › Didelphidae › Monodelphis
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002280 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 5

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSMODG00000019874, Expressed in cerebellum and 20 other tissues

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...STRINGi		13616.ENSMODP00000024799

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini114 – 225SETInterPro annotationAdd BLAST112

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni31 – 56DisorderedSequence analysisAdd BLAST26
Regioni243 – 265DisorderedSequence analysisAdd BLAST23
Regioni348 – 399DisorderedSequence analysisAdd BLAST52

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili418 – 438Sequence analysisAdd BLAST21
Coiled coili909 – 929Sequence analysisAdd BLAST21

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG2461, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000159837

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_010729_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		F6RQQ0

Identification of Orthologs from Complete Genome Data

More...OMAi		DIRAIRW

TreeFam database of animal gene trees

More...TreeFami		TF316279

Family and domain databases

Conserved Domains Database

More...CDDi		cd19195, PR-SET_PRDM11, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR044405, PRDM11_PR/SET
IPR001214, SET_dom

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50280, SET, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

F6RQQ0-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTENLKACLA HTQASMGEMV TVKTEVCSPR RDQEYGQPCS GRPDPPSMEV 
        60         70         80         90        100
EPKKPKGKRE LIMTKSFQQV DFWFCESCQE YFVDECPNHG PPVFVSDTPV 
       110        120        130        140        150
PMGIPDRAAL TIPPGMEVVK EASGQSDVRC MNEVIPKGHI FGPYEGQIST 
       160        170        180        190        200
QDKSAGFFSW LIVDKNNHYK SIDGTDETKA NWMRYVVISR EEREQNLMAF 
       210        220        230        240        250
QHSEKIYFRV CRDIRPGERL RVWYSEDYMK RLHSMSQETI QRNLTRGDKK 
       260        270        280        290        300
LQREKPEKAL DHQEDLRGPL QLTVLRHGKS AYKRGFDEVD AHPPPKKKKI 
       310        320        330        340        350
DLIFKDVLEA SLETSKIEEH PLAPGTPLVL RKAPKFHTED VYDQCGMAIS 
       360        370        380        390        400
HGPQDLSRNQ GEKEWKAPQG ASYGPSKDTS LLEDEEEEPS SFKADSPAEA 
       410        420        430        440        450
SLASDLHELP TTSFCPNCIR LKKKIRELQA ELDMLKSGKL PEPPLLPPQV 
       460        470        480        490        500
PELPEFSDPT ASESVVSVPT MLEDDDQEVD SADESVSNEM ITATDEPSKM 
       510        520        530        540        550
SSATGRRIRR FKQEWLKKFW FLRYSPTLNE MWCHVCRQYT VQSSRTSAFI 
       560        570        580        590        600
IGSKQFKIHT IKLHSQSNLH KKCLQLYKLR MHPEKTEEMC RNMTLLFNTA 
       610        620        630        640        650
YHLALEGRPY FDFRPLAELL RKCELKVVDQ YMNEGDCQIL IHHIARALRE 
       660        670        680        690        700
DLVERIRQSP FLSIILDGQS DDILADTVAV YVQYTSSDGP PATEFLSLQE 
       710        720        730        740        750
LGFSTTDSYL QALDRAFSSL GIRLQDEKPT IGLGVDGANI TASLRASMFM 
       760        770        780        790        800
TIRKTLPWLL CLPFMVHRPH LEILDAISGK ELPCLEELEN NLKQLLSFYR 
       810        820        830        840        850
YSPRLMCELR LTASTLCEET EFLGDIRAVR WIIGEQNVLN ALIKDYLEVV 
       860        870        880        890        900
AHLKDVSGQT QRADASAIAL ALLQFLMDYQ SIKLIYFLLD VIAVLSRLAY 
       910        920        930        940        950
IFQGEYLLVS QVDDKIEEAI QEISRLADSP GEYLQEFEEN FRESFNGVAV 
       960        970        980        990       1000
KNLRVAEAKF QSIREKICQK TQVILAQRFD SRSRTFVKAC QVFDLAAWPR 
      1010       1020       1030       1040       1050
STEELMSYGK EDMIQIFDHL ETIPSFSREI CREGMDPRGS LLMEWRELKA 
      1060       1070       1080       1090       1100
DYYTKNGFKD LISHICKYKQ RFPLLNKIIQ ILKVLPTSTA CCEKGRVALQ 
      1110       1120       1130       1140       1150
RVRKNNRSRL TLEQLSDLLT IAVNGPPIAN FDAKRALDSW FEEKSGNSYT 
      1160       1170       1180 
LSAEVLSRMS ALDQKPMLPT MDHGSEFYSD L
Length:1,181
Mass (Da):135,044
Last modified:December 11, 2019 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iDE267B5B6C1B0D4A
GO

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENSMODT00000025239; ENSMODP00000024799; ENSMODG00000019874

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

3D structure databases

Database of comparative protein structure models

More...ModBasei		Search...

SWISS-MODEL Interactive Workspace

More...SWISS-MODEL-Workspacei		Submit a new modelling project...

Protein-protein interaction databases

STRINGi13616.ENSMODP00000024799

Genome annotation databases

EnsembliENSMODT00000025239; ENSMODP00000024799; ENSMODG00000019874

Phylogenomic databases

eggNOGiKOG2461, Eukaryota
GeneTreeiENSGT00940000159837
HOGENOMiCLU_010729_0_0_1
InParanoidiF6RQQ0
OMAiDIRAIRW
TreeFamiTF316279

Gene expression databases

BgeeiENSMODG00000019874, Expressed in cerebellum and 20 other tissues

Family and domain databases

CDDicd19195, PR-SET_PRDM11, 1 hit
InterProiView protein in InterPro
IPR044405, PRDM11_PR/SET
IPR001214, SET_dom
PROSITEiView protein in PROSITE
PS50280, SET, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiF6RQQ0_MONDO
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: F6RQQ0
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: July 27, 2011
Last sequence update: December 11, 2019
Last modified: April 7, 2021
This is version 50 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteomeImported
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Main funding by: National Institutes of Health

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