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Entry version 40 (12 Aug 2020)
Sequence version 1 (27 Jul 2011)
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Protein
Submitted name:

AT-rich interaction domain 2

Gene

ARID2

Organism
Ornithorhynchus anatinus (Duckbill platypus)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
AT-rich interaction domain 2Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ARID2Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiOrnithorhynchus anatinus (Duckbill platypus)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9258 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaMonotremataOrnithorhynchidaeOrnithorhynchus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002279 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - PTMi

PhosphoproteinARBA annotation

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSOANG00000010834, Expressed in testis and 8 other tissues

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
9258.ENSOANP00000017166

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini292 – 371RFX-type winged-helixInterPro annotationAdd BLAST80

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni393 – 413DisorderedSequence analysisAdd BLAST21
Regioni587 – 618DisorderedSequence analysisAdd BLAST32
Regioni665 – 699DisorderedSequence analysisAdd BLAST35
Regioni732 – 827DisorderedSequence analysisAdd BLAST96
Regioni1028 – 1113DisorderedSequence analysisAdd BLAST86
Regioni1192 – 1226DisorderedSequence analysisAdd BLAST35
Regioni1351 – 1370DisorderedSequence analysisAdd BLAST20
Regioni1378 – 1405DisorderedSequence analysisAdd BLAST28
Regioni1481 – 1507DisorderedSequence analysisAdd BLAST27

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi672 – 687PolarSequence analysisAdd BLAST16
Compositional biasi736 – 767PolarSequence analysisAdd BLAST32
Compositional biasi774 – 798PolarSequence analysisAdd BLAST25
Compositional biasi1028 – 1044PolyampholyteSequence analysisAdd BLAST17
Compositional biasi1048 – 1104PolarSequence analysisAdd BLAST57
Compositional biasi1483 – 1503PolarSequence analysisAdd BLAST21

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG2312, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000016138

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_003714_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
F6RQM7

TreeFam database of animal gene trees

More...
TreeFami
TF106406

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.10.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR016024, ARM-type_fold
IPR003150, DNA-bd_RFX
IPR036388, WH-like_DNA-bd_sf
IPR036390, WH_DNA-bd_sf
IPR013087, Znf_C2H2_type

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF02257, RFX_DNA_binding, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF46785, SSF46785, 1 hit
SSF48371, SSF48371, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51526, RFX_DBD, 1 hit
PS00028, ZINC_FINGER_C2H2_1, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

F6RQM7-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
YLQFWKDIVD DNEVRDLISD RNKSPEGTSQ EWIWESLFHP PRKLGINDIE
60 70 80 90 100
GQRVLQIAVI LRNLSFEEGN VKLLAANRTC LRFLLLSAHS HFISLRQLGL
110 120 130 140 150
DTLGNIAAEL LLDPVDFKTT HLMFHTVTKC LMSRDRFLKM RGMEILGNLC
160 170 180 190 200
KAEDNGVLIC EYVDQESYRE IICHLTLPDV LLVISTLEVL YMLTEMGDVA
210 220 230 240 250
CTKIAKVDKS IDMLVCLVSM DIQMFGPEAL SAVKLIEHQS TNHQVLSEIR
260 270 280 290 300
PQAAEHAQSP AHGAAVPASR TVVGQHVVPP PGIVEIDSEK FACQWLNAYF
310 320 330 340 350
EVNPDCSVSR AEMYSEYLST CSKLARGGIL TSTGFYKCLR TVFPNHSVKR
360 370 380 390 400
VEDPNNNGQA HIHVVGVKRR AIPLPIQMYF QQQPASTPVV RVDSVPDVSS
410 420 430 440 450
TPSPAGGIPH GPQPLGTHFP RTAVTNQSST LTATQMSFPI QGVHTVAQTV
460 470 480 490 500
SRIPHNPSVH TQQQPNATVT VIQNKAPISC EVVKATVIQS SLQQSAVPVS
510 520 530 540 550
IAVGGGAAQA SLVQNHTAGP QPVTVVSSQT LLHHPPVLQQ QSPLHAVVPG
560 570 580 590 600
QIPSGTPVTV IQQAVPPSHI FGRVQNIPAC TSAVSQGQPL LTTSPQPVVQ
610 620 630 640 650
TSSPQPPPGS QQQQQQQDTV LIAPQQYVTT SASNIVSAPS VQSFQVAAGQ
660 670 680 690 700
MVTIAGVPGP QASRVGFQNI APKPLPSQQG PSSVVPQPIQ QATPPPQQSV
710 720 730 740 750
VIVSQPAQQG QTYAPAIHQI VLANPAAIPA GPPVQLTGQP SVTPSSSPSP
760 770 780 790 800
GPAAASQVPT VMSPSPSAPQ SQGPPPTVSQ MLSVKRQQQQ QQQQQHPHHP
810 820 830 840 850
PAPSQPQVQV QQPQPGGAGV GQPASGESSL IKQLLLPKRG PSTPGGKLIL
860 870 880 890 900
PAPQLPPPNN ARAPSPQVVY QVANNQAPGF GVQGQSPAQQ LLVGQQNVQL
910 920 930 940 950
VQGAIPPQGG VQTVPISNLQ ILPGPLISNS PATIFQGTSG NQVTITVVPN
960 970 980 990 1000
TSFATATVSQ GNAAQIIGPA GISVGGPPAG VGLQVQTLPA AQAPPAGQSP
1010 1020 1030 1040 1050
CAAAAAVVAT PPFKGDKIIC QKEEEAKEAT GLHVHERKIE VMENPSCRRG
1060 1070 1080 1090 1100
GANTSNGDTK ESDVQQAGSI LNGRKYSDSS LPPSNSGKTP NEANQCSQIR
1110 1120 1130 1140 1150
NGPSLELGEN GAPGKQVVEQ MDTQEIRGDL KKPLVNGICD FDKGDGSHFS
1160 1170 1180 1190 1200
KNIPNHKSSN HVGNGELCPA EQQGDSDAIQ QDTAKGDQVE RISNGPTLTL
1210 1220 1230 1240 1250
GGSPAGGGIP EAANLATQQP GGPNTDLSNG PLVSSLNSDV PQQRPSVVVS
1260 1270 1280 1290 1300
PHSTASVIQG HQIVAVPHPG PRASHAPLAS GARSTNGTAE CKTVKRPAEE
1310 1320 1330 1340 1350
NDRETVPGIP NKVGVRIVTI SDPNNAGCSA TMVAVPAGAD PSTVAKVAIE
1360 1370 1380 1390 1400
SAAQQKQQHP PTYVQSVVTQ STPVTPTQAV QVQGPHGGSQ PAPYGASSQP
1410 1420 1430 1440 1450
AEQTKKPGQN FMCLWQSCQK WFQTPSQVFY HAATEHGGKD VYPGQCLWEG
1460 1470 1480 1490 1500
CEPFQRQRFS FITHLQDKHC SRDALLAGLK QDEPGQTGNQ KPSNKQPAAG
1510 1520 1530 1540 1550
STASAPRAQK AIVNHPSAAL MALRRGSRNL VFRDFTDEKE GPITKHIRLT
1560 1570 1580 1590 1600
AALILKNIGK YSECGRRLLK RHENNLSVLA ISNMEASSTL AKCLYELNFT
1610
VQSKEQDKDS EMLQ
Length:1,614
Mass (Da):170,957
Last modified:July 27, 2011 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i6B0213576172D1E0
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A6I8NCA4A0A6I8NCA4_ORNAN
AT-rich interaction domain 2
ARID2
1,845Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A6I8PDE9A0A6I8PDE9_ORNAN
AT-rich interaction domain 2
ARID2
196Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSOANT00000017169; ENSOANP00000017166; ENSOANG00000010834

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

STRINGi9258.ENSOANP00000017166

Genome annotation databases

EnsembliENSOANT00000017169; ENSOANP00000017166; ENSOANG00000010834

Phylogenomic databases

eggNOGiKOG2312, Eukaryota
GeneTreeiENSGT00390000016138
HOGENOMiCLU_003714_0_0_1
InParanoidiF6RQM7
TreeFamiTF106406

Gene expression databases

BgeeiENSOANG00000010834, Expressed in testis and 8 other tissues

Family and domain databases

Gene3Di1.10.10.10, 1 hit
InterProiView protein in InterPro
IPR016024, ARM-type_fold
IPR003150, DNA-bd_RFX
IPR036388, WH-like_DNA-bd_sf
IPR036390, WH_DNA-bd_sf
IPR013087, Znf_C2H2_type
PfamiView protein in Pfam
PF02257, RFX_DNA_binding, 1 hit
SUPFAMiSSF46785, SSF46785, 1 hit
SSF48371, SSF48371, 1 hit
PROSITEiView protein in PROSITE
PS51526, RFX_DBD, 1 hit
PS00028, ZINC_FINGER_C2H2_1, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiF6RQM7_ORNAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: F6RQM7
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: July 27, 2011
Last sequence update: July 27, 2011
Last modified: August 12, 2020
This is version 40 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteomeImported
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