UniProtKB - F6RLA7 (F6RLA7_HORSE)
Protein
Submitted name:
Matrix metallopeptidase 24
Gene
MMP24
Organism
Equus caballus (Horse)
Status
Functioni
Cofactori
Protein has several cofactor binding sites:Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Active sitei | 218 | UniRule annotation | 1 |
GO - Molecular functioni
- metalloendopeptidase activity Source: InterPro
- zinc ion binding Source: InterPro
Keywordsi
Molecular function | Hydrolase, MetalloproteaseARBA annotation, Protease |
Ligand | CalciumARBA annotation, Metal-bindingARBA annotation, ZincARBA annotation |
Protein family/group databases
MEROPSi | M10.023 |
Names & Taxonomyi
Protein namesi | Submitted name: Matrix metallopeptidase 24Imported |
Gene namesi | Name:MMP24Imported |
Organismi | Equus caballus (Horse)Imported |
Taxonomic identifieri | 9796 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Perissodactyla › Equidae › Equus › |
Proteomesi |
|
Organism-specific databases
VGNCi | VGNC:20231, MMP24 |
Subcellular locationi
Extracellular region or secreted
- extracellular matrix Source: InterPro
Plasma Membrane
- integral component of plasma membrane Source: InterPro
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 537 – 558 | HelicalSequence analysisAdd BLAST | 22 |
Keywords - Cellular componenti
MembranePTM / Processingi
Keywords - PTMi
Cleavage on pair of basic residuesARBA annotation, ZymogenARBA annotationProteomic databases
PaxDbi | F6RLA7 |
Expressioni
Gene expression databases
Bgeei | ENSECAG00000024778, Expressed in cerebellum and 13 other tissues |
ExpressionAtlasi | F6RLA7, baseline |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 94 – 263 | ZnMcInterPro annotationAdd BLAST | 170 | |
Repeati | 312 – 360 | HemopexinPROSITE-ProRule annotationAdd BLAST | 49 | |
Repeati | 361 – 406 | HemopexinPROSITE-ProRule annotationAdd BLAST | 46 | |
Repeati | 408 – 456 | HemopexinPROSITE-ProRule annotationAdd BLAST | 49 | |
Repeati | 457 – 504 | HemopexinPROSITE-ProRule annotationAdd BLAST | 48 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 258 – 314 | DisorderedSequence analysisAdd BLAST | 57 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 282 – 298 | PolyampholyteSequence analysisAdd BLAST | 17 |
Sequence similaritiesi
Belongs to the peptidase M10A family.ARBA annotation
Keywords - Domaini
RepeatARBA annotation, SignalARBA annotation, Transmembrane, Transmembrane helixSequence analysisARBA annotationPhylogenomic databases
GeneTreei | ENSGT00940000158315 |
HOGENOMi | CLU_015489_8_1_1 |
InParanoidi | F6RLA7 |
TreeFami | TF352396 |
Family and domain databases
CDDi | cd00094, HX, 1 hit cd04278, ZnMc_MMP, 1 hit |
Gene3Di | 2.110.10.10, 1 hit 3.40.390.10, 1 hit |
InterProi | View protein in InterPro IPR000585, Hemopexin-like_dom IPR036375, Hemopexin-like_dom_sf IPR018487, Hemopexin-like_repeat IPR018486, Hemopexin_CS IPR033739, M10A_MMP IPR024079, MetalloPept_cat_dom_sf IPR028723, MMP24 IPR001818, Pept_M10_metallopeptidase IPR021190, Pept_M10A IPR021805, Pept_M10A_metallopeptidase_C IPR006026, Peptidase_Metallo IPR002477, Peptidoglycan-bd-like IPR036365, PGBD-like_sf |
PANTHERi | PTHR10201:SF138, PTHR10201:SF138, 1 hit |
Pfami | View protein in Pfam PF11857, DUF3377, 1 hit PF00045, Hemopexin, 4 hits PF00413, Peptidase_M10, 1 hit PF01471, PG_binding_1, 1 hit |
PIRSFi | PIRSF001191, Peptidase_M10A_matrix, 1 hit |
PRINTSi | PR00138, MATRIXIN |
SMARTi | View protein in SMART SM00120, HX, 4 hits SM00235, ZnMc, 1 hit |
SUPFAMi | SSF47090, SSF47090, 1 hit SSF50923, SSF50923, 1 hit |
PROSITEi | View protein in PROSITE PS00024, HEMOPEXIN, 1 hit PS51642, HEMOPEXIN_2, 4 hits |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
F6RLA7-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MPAFSSIMHP FLSRVFQNWL KSYGYLLPYD SRASALHSGK ALQSAVSTMQ
60 70 80 90 100
QFYGIPVTGV LDQTTIEWMK KPRCGVPDHP HLSRRRRNKR YALTGQKWRQ
110 120 130 140 150
KHITYSIHNY TPKVGELDTR KAIRQAFDVW QKVTPLTFEE VPYHEIKSDR
160 170 180 190 200
KEADIMIFFA SGFHGDSSPF DGEGGFLAHA YFPGPGIGGD THFDSDEPWT
210 220 230 240 250
LGNANHDGND LFLVAVHELG HALGLEHSND PSAIMAPFYQ YMETHNFKLP
260 270 280 290 300
QDDLQGIQKI YGPPAEPLEP TRPLPTLPVR RIHSPSERKH ERQPRPPRPP
310 320 330 340 350
LGDRPSTPGA KPNICDGNFN TVALFRGEMF VFKDRWFWRL RNNRVQEGYP
360 370 380 390 400
MQIEQFWKGL PARIDAAYER ADGRFVFFKG DKYWVFKEVT VEPGYPHSLG
410 420 430 440 450
ELGSCLPREG IDTALRWEPV GKTYFFKGER YWRYSEERRA TDPGYPKPIT
460 470 480 490 500
VWKGIPQAPQ GAFISKEGYY TYFYKGRDYW KFDNQKLSVE PGYPRNILRD
510 520 530 540 550
WMGCNQKEVE RRKERRLPQD DVDIMVTIND VPGSVNAVAV VIPCILSLCI
560 570 580
LVLVYTIFQF KNKAGPQPVT YYKRPVQEWV
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketA0A3Q2H3H6 | A0A3Q2H3H6_HORSE | Matrix metallopeptidase 24 | MMP24 | 591 | Annotation score: |
Genome annotation databases
Ensembli | ENSECAT00000026723; ENSECAP00000022321; ENSECAG00000024778 |
Similar proteinsi
Cross-referencesi
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein family/group databases
MEROPSi | M10.023 |
Proteomic databases
PaxDbi | F6RLA7 |
Genome annotation databases
Ensembli | ENSECAT00000026723; ENSECAP00000022321; ENSECAG00000024778 |
Organism-specific databases
VGNCi | VGNC:20231, MMP24 |
Phylogenomic databases
GeneTreei | ENSGT00940000158315 |
HOGENOMi | CLU_015489_8_1_1 |
InParanoidi | F6RLA7 |
TreeFami | TF352396 |
Gene expression databases
Bgeei | ENSECAG00000024778, Expressed in cerebellum and 13 other tissues |
ExpressionAtlasi | F6RLA7, baseline |
Family and domain databases
CDDi | cd00094, HX, 1 hit cd04278, ZnMc_MMP, 1 hit |
Gene3Di | 2.110.10.10, 1 hit 3.40.390.10, 1 hit |
InterProi | View protein in InterPro IPR000585, Hemopexin-like_dom IPR036375, Hemopexin-like_dom_sf IPR018487, Hemopexin-like_repeat IPR018486, Hemopexin_CS IPR033739, M10A_MMP IPR024079, MetalloPept_cat_dom_sf IPR028723, MMP24 IPR001818, Pept_M10_metallopeptidase IPR021190, Pept_M10A IPR021805, Pept_M10A_metallopeptidase_C IPR006026, Peptidase_Metallo IPR002477, Peptidoglycan-bd-like IPR036365, PGBD-like_sf |
PANTHERi | PTHR10201:SF138, PTHR10201:SF138, 1 hit |
Pfami | View protein in Pfam PF11857, DUF3377, 1 hit PF00045, Hemopexin, 4 hits PF00413, Peptidase_M10, 1 hit PF01471, PG_binding_1, 1 hit |
PIRSFi | PIRSF001191, Peptidase_M10A_matrix, 1 hit |
PRINTSi | PR00138, MATRIXIN |
SMARTi | View protein in SMART SM00120, HX, 4 hits SM00235, ZnMc, 1 hit |
SUPFAMi | SSF47090, SSF47090, 1 hit SSF50923, SSF50923, 1 hit |
PROSITEi | View protein in PROSITE PS00024, HEMOPEXIN, 1 hit PS51642, HEMOPEXIN_2, 4 hits |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | F6RLA7_HORSE | |
Accessioni | F6RLA7Primary (citable) accession number: F6RLA7 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | July 27, 2011 |
Last sequence update: | April 10, 2019 | |
Last modified: | October 7, 2020 | |
This is version 72 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |