UniProtKB - F6RGB6 (F6RGB6_HORSE)
Protein
Submitted name:
Cytochrome P450 family 2 subfamily U member 1
Gene
CYP2U1
Organism
Equus caballus (Horse)
Status
Functioni
Cofactori
hemeARBA annotation
GO - Molecular functioni
- arachidonic acid omega-hydroxylase activity Source: Ensembl
- heme binding Source: GO_Central
- iron ion binding Source: InterPro
- oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen Source: GO_Central
- steroid hydroxylase activity Source: GO_Central
GO - Biological processi
- exogenous drug catabolic process Source: GO_Central
- omega-hydroxylase P450 pathway Source: Ensembl
- organic acid metabolic process Source: GO_Central
- oxidation-reduction process Source: GO_Central
- xenobiotic metabolic process Source: GO_Central
Keywordsi
Molecular function | MonooxygenaseUniRule annotation, Oxidoreductase |
Ligand | HemeUniRule annotationARBA annotation, Iron, Metal-binding |
Names & Taxonomyi
Protein namesi | Submitted name: Cytochrome P450 family 2 subfamily U member 1Imported |
Gene namesi | Name:CYP2U1Imported |
Organismi | Equus caballus (Horse)Imported |
Taxonomic identifieri | 9796 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Perissodactyla › Equidae › Equus › |
Proteomesi |
|
Organism-specific databases
VGNCi | VGNC:50392, CYP2U1 |
Subcellular locationi
Other locations
- cytoplasm Source: GO_Central
- intracellular membrane-bounded organelle Source: GO_Central
- membrane Source: UniProtKB-KW
Expressioni
Gene expression databases
Bgeei | ENSECAG00000021232, Expressed in oviduct epithelium and 21 other tissues |
ExpressionAtlasi | F6RGB6, baseline |
Family & Domainsi
Sequence similaritiesi
Phylogenomic databases
GeneTreei | ENSGT00940000157714 |
HOGENOMi | CLU_001570_22_2_1 |
InParanoidi | F6RGB6 |
TreeFami | TF352043 |
Family and domain databases
Gene3Di | 1.10.630.10, 1 hit |
InterProi | View protein in InterPro IPR001128, Cyt_P450 IPR017972, Cyt_P450_CS IPR002401, Cyt_P450_E_grp-I IPR008069, Cyt_P450_E_grp-I_CYP2D-like IPR036396, Cyt_P450_sf |
Pfami | View protein in Pfam PF00067, p450, 1 hit |
PRINTSi | PR00463, EP450I PR01686, EP450ICYP2D PR00385, P450 |
SUPFAMi | SSF48264, SSF48264, 1 hit |
PROSITEi | View protein in PROSITE PS00086, CYTOCHROME_P450, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All
F6RGB6-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MGPAEVLLLG LAALLAWAWL RRRRRARGLP PGPTPWPVLG NFGFALLPPR
60 70 80 90 100
LRRGSWLHRR AAGADAAVGP PRLLAGLARE YGSVFSFSLG PHLVVVLNDF
110 120 130 140 150
RSVRQALVQQ AAVFSDRPRM PLVSLVTKEK GIVFAHYGPV WRQQRKFSHS
160 170 180 190 200
TLRHFGLGKL SLEPKIIEEF KYVKEEMQKH GAVPFSPFPI VSKAVSNIIC
210 220 230 240 250
SLCFGQRFDY NDTEFKKMLD LMSRALEICL NTQLLLVNIC SWLYYLPFGP
260 270 280 290 300
FKELRQIEKD ITTFLKKIIK DHRESLDVEN PRDFIDMYLL HMEEERKSNS
310 320 330 340 350
DSSFNEDYLF YIIGDLFFAG TDTTTNSLLW CLLYMSLNPE VQEKVHEEIE
360 370 380 390 400
RVIGPDRAPS LTDKAQMPYT EATIMEVQRL TVVVPLSIPH MTSETTVLQG
410 420 430 440 450
YTIPKGTVVL PNLWSVHRDP AIWEEPDEFH PNRFLDDQGQ LVKKEAFIPF
460 470 480 490 500
GIGKRVCMGE QLAKMELFLM FASLIQSFKF ALPKDSETPL LTGRYGLTLA
510
PHPFNVIISK R
Computationally mapped potential isoform sequencesi
There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketF7CPH9 | F7CPH9_HORSE | Cytochrome P450 family 2 subfamily ... | CYP2U1 | 314 | Annotation score: | ||
A0A3Q2LP46 | A0A3Q2LP46_HORSE | Cytochrome P450 family 2 subfamily ... | CYP2U1 | 428 | Annotation score: | ||
A0A5F5PND9 | A0A5F5PND9_HORSE | Cytochrome P450 family 2 subfamily ... | CYP2U1 | 176 | Annotation score: |
Genome annotation databases
Ensembli | ENSECAT00000022814; ENSECAP00000018872; ENSECAG00000021232 |
Similar proteinsi
Cross-referencesi
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Proteomic databases
PaxDbi | F6RGB6 |
Genome annotation databases
Ensembli | ENSECAT00000022814; ENSECAP00000018872; ENSECAG00000021232 |
Organism-specific databases
VGNCi | VGNC:50392, CYP2U1 |
Phylogenomic databases
GeneTreei | ENSGT00940000157714 |
HOGENOMi | CLU_001570_22_2_1 |
InParanoidi | F6RGB6 |
TreeFami | TF352043 |
Gene expression databases
Bgeei | ENSECAG00000021232, Expressed in oviduct epithelium and 21 other tissues |
ExpressionAtlasi | F6RGB6, baseline |
Family and domain databases
Gene3Di | 1.10.630.10, 1 hit |
InterProi | View protein in InterPro IPR001128, Cyt_P450 IPR017972, Cyt_P450_CS IPR002401, Cyt_P450_E_grp-I IPR008069, Cyt_P450_E_grp-I_CYP2D-like IPR036396, Cyt_P450_sf |
Pfami | View protein in Pfam PF00067, p450, 1 hit |
PRINTSi | PR00463, EP450I PR01686, EP450ICYP2D PR00385, P450 |
SUPFAMi | SSF48264, SSF48264, 1 hit |
PROSITEi | View protein in PROSITE PS00086, CYTOCHROME_P450, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | F6RGB6_HORSE | |
Accessioni | F6RGB6Primary (citable) accession number: F6RGB6 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | July 27, 2011 |
Last sequence update: | April 10, 2019 | |
Last modified: | February 10, 2021 | |
This is version 52 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |