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Entry version 42 (16 Oct 2019)
Sequence version 2 (10 Apr 2019)
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Protein
Submitted name:

Centrosomal protein 250

Gene

CEP250

Organism
Equus caballus (Horse)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Centrosomal protein 250Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:CEP250Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiEquus caballus (Horse)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9796 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaPerissodactylaEquidaeEquus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002281 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 22

Organism-specific databases

Vertebrate Gene Nomenclature Database

More...
VGNCi
VGNC:16414 CEP250

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSECAG00000021188 Expressed in 3 organ(s), highest expression level in liver

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
F6RG59 baseline

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni358 – 382DisorderedSequence analysisAdd BLAST25
Regioni817 – 864DisorderedSequence analysisAdd BLAST48
Regioni1609 – 1629DisorderedSequence analysisAdd BLAST21
Regioni1728 – 1748DisorderedSequence analysisAdd BLAST21
Regioni1848 – 1875DisorderedSequence analysisAdd BLAST28
Regioni1972 – 2000DisorderedSequence analysisAdd BLAST29
Regioni2029 – 2052DisorderedSequence analysisAdd BLAST24
Regioni2130 – 2151DisorderedSequence analysisAdd BLAST22
Regioni2211 – 2255DisorderedSequence analysisAdd BLAST45
Regioni2327 – 2354DisorderedSequence analysisAdd BLAST28

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili96 – 116Sequence analysisAdd BLAST21
Coiled coili124 – 144Sequence analysisAdd BLAST21
Coiled coili253 – 273Sequence analysisAdd BLAST21
Coiled coili278 – 326Sequence analysisAdd BLAST49
Coiled coili403 – 444Sequence analysisAdd BLAST42
Coiled coili459 – 542Sequence analysisAdd BLAST84
Coiled coili571 – 591Sequence analysisAdd BLAST21
Coiled coili606 – 654Sequence analysisAdd BLAST49
Coiled coili662 – 766Sequence analysisAdd BLAST105
Coiled coili871 – 914Sequence analysisAdd BLAST44
Coiled coili932 – 962Sequence analysisAdd BLAST31
Coiled coili967 – 1026Sequence analysisAdd BLAST60
Coiled coili1052 – 1079Sequence analysisAdd BLAST28
Coiled coili1160 – 1278Sequence analysisAdd BLAST119
Coiled coili1286 – 1320Sequence analysisAdd BLAST35
Coiled coili1338 – 1393Sequence analysisAdd BLAST56
Coiled coili1404 – 1497Sequence analysisAdd BLAST94
Coiled coili1530 – 1567Sequence analysisAdd BLAST38
Coiled coili1632 – 1673Sequence analysisAdd BLAST42
Coiled coili1762 – 1842Sequence analysisAdd BLAST81
Coiled coili1906 – 1940Sequence analysisAdd BLAST35
Coiled coili1945 – 1972Sequence analysisAdd BLAST28
Coiled coili2259 – 2279Sequence analysisAdd BLAST21

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi361 – 382PolarSequence analysisAdd BLAST22
Compositional biasi817 – 833PolyampholyteSequence analysisAdd BLAST17
Compositional biasi847 – 864PolyampholyteSequence analysisAdd BLAST18
Compositional biasi1985 – 2000PolyampholyteSequence analysisAdd BLAST16
Compositional biasi2211 – 2226PolyampholyteSequence analysisAdd BLAST16
Compositional biasi2232 – 2250PolarSequence analysisAdd BLAST19

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IFAN Eukaryota
ENOG410XPG3 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000161056

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 5 potential isoforms that are computationally mapped.Show allAlign All

F6RG59-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEKRGSGLNS MKPQPLQLML EEQVLALQQQ MAENQAASWW KLKNSQEVQQ
60 70 80 90 100
RQATLVRKLQ AKVLQYRTWC QELEKRLEAT GGPVPPRWEN VEEPNLEQLL
110 120 130 140 150
IRLEEEQQRC ESLAEVNTQL RLHMEKADVV NKALREDVEK LTVDWSRARD
160 170 180 190 200
ELMRKESQWQ MEQEFFKGYL KGEHGRLLSL WREVVTFRRH FLEMKSATDR
210 220 230 240 250
DLTELKAEHV RLSGSLLTCC LRLTVGAQSR ESDGSGRLDG GEPAQLLLLL
260 270 280 290 300
AKTQELEKEA HDRSQELIQL KSQGELEKAE LQDRVTELSA LLIQSQKQNE
310 320 330 340 350
DYEKMVKALR ETMEILETNH AELMEHEASL SRNAQEEKLS LQQVIKDITQ
360 370 380 390 400
AMVEEGDNMA QGSGHENSLE LDSSGFSSQF DSRDPDKALT LVRSVLTRRR
410 420 430 440 450
QAVQDLRQQL SGCQEAVSFL QQQHNQWEEE GEALRQRLQK LTGERDTLAG
460 470 480 490 500
QTVDLQGEVD SLSKERELLQ KTREELQQQL EVLEQEAWRL RRTNVELQLQ
510 520 530 540 550
GDSAQGEKEE QQEELHLAVR ERERLQETLA GLEARQSESL SELITLREAL
560 570 580 590 600
ESSRLEGELL RQEQTEVTAA LARAEQSIAD LSSSENSLKA EVADLRAATV
610 620 630 640 650
KLSALNEALA LDKVGLSQQL LQLEQENQSV CSRMEAAEQA RSALQVGLAE
660 670 680 690 700
AERSREALWD KSTHLEAQLQ KAEETKAELQ ADLRSIQEEK EEIQEKLSEA
710 720 730 740 750
RHQQEAASAQ LEQLHQEAKR QEEVLARAVQ EKEALVRERA ALEVRLQAVE
760 770 780 790 800
RDRQDLSEQL LGLSSAKELL ENSLFEAQQQ NSLIEVTKGQ LEVQLQTVTQ
810 820 830 840 850
AKEVIQGEVR CLKLELDTER SQAEQERDTA ARQLAQAEQE GQTALQRQKS
860 870 880 890 900
AHEEEVNQLQ EKWEKERSWH QQELDKALES LEREKMELEM RLREQQAETE
910 920 930 940 950
AIRTQREEER AEAESALCQM QLETEKERMS LLETLLQTQK ELTDASQQLE
960 970 980 990 1000
RLRQDMKVQK LKEQETTGML QTQLREAQRE LEQAAQQHRD DLAALQEEGS
1010 1020 1030 1040 1050
SLLQEKIELQ KQVELLKQEV REKEADFLAQ EAHLLEELEA SQVTEQQLRA
1060 1070 1080 1090 1100
SLWAQEAKAA QLQLRLRSTE NQLEALAAEQ QPGHHAQAQL ASLYSVLQQA
1110 1120 1130 1140 1150
LGSVCESRPE LSGGGDSAPS LLGAEPDQNE ARILFKRGPL LTALSAEAVA
1160 1170 1180 1190 1200
SALHKLHQDL WKTQQARDDL RDQAQKLEQR LTDTEAEKNQ VHTELRHLQR
1210 1220 1230 1240 1250
QLSQNQEEKS KWERKQSSLE SELMELHETV ASLQSRLRRA ELQGIEAQNE
1260 1270 1280 1290 1300
RELLQAAKEN LTAQVEHLQV SVAEARAQAS AVGVLEEDLR TARSALKLKN
1310 1320 1330 1340 1350
EEVENERERA QALQEQGELK VAQGRALQEN LAILAHTLSE REGEVETLQG
1360 1370 1380 1390 1400
KIQELETQRE MQKAALEVLS LDLKKRNQEV DLQQEQIQEL EKCRSVLEHL
1410 1420 1430 1440 1450
PMAVQEREQK LTVQREQIKE LEKDRETQRN ILEHQLLELE KKAQVIESQK
1460 1470 1480 1490 1500
GQIQDLKKQL VTLECLALEL EENHHKMECQ QKAIEELEGQ REMQKVALTH
1510 1520 1530 1540 1550
LTLDLEERSQ ELQVQSSQIH ELESHSTLLA RELQEKDQEV KSQREQIEEL
1560 1570 1580 1590 1600
QRQKEHLTQD LERRGQEMLL QKERIQVLED QRTLQTKILE EDLEQIKLSL
1610 1620 1630 1640 1650
RERGRELASQ RQLMQERAEE GKGQSKAQRG SLEHLKLILR DKEKEVECQQ
1660 1670 1680 1690 1700
ERIQELQEHQ DQLEQQLQGL HRKVGETSLL LTQREQEIVV LQQHLQEARE
1710 1720 1730 1740 1750
QEELEKQSLQ GQLEEAQRAL AQRDQELEAL QHQQRQAQGQ EENVKEKTST
1760 1770 1780 1790 1800
LQRALEQAHM TLKQRQGELE DCKDHVRRLQ EELAVEGQRV QALEEVLGDL
1810 1820 1830 1840 1850
RAESQEQEKA LLALQQQCAE QAQKHEEEAR ALQDNWLQAE AMLKERDQEL
1860 1870 1880 1890 1900
DALRADSQSS QHREEAAQGQ AEALQEALSK AQAALQEKEQ HLLGQAELSR
1910 1920 1930 1940 1950
SLEASTATLQ AALDSCQAQA RQLEEALRKR EDEIKDRDLR HQEALQQLQQ
1960 1970 1980 1990 2000
VLAQRDEELR HQKKQMQLLE KSLAQRGGDD VIQEKQNPGQ EREEEERRGL
2010 2020 2030 2040 2050
HESLRELQLI LAQKEEEILE LREAQQEKSL KDSLHSHKAS PVEEPTTKFG
2060 2070 2080 2090 2100
SLGPRLQQEL DRLQVVLRQT EAREIEWREK AQDLALSLAQ SKATVSSLQE
2110 2120 2130 2140 2150
VAMFLQASVL ERDSEQQRLQ DELELTRQAL EKERLHSPGP TSRAERGPRG
2160 2170 2180 2190 2200
EAGVQLGEVS GVEAEPSPGL EEKQLWEQRL EYLQQAVARL EIDRSRLQRH
2210 2220 2230 2240 2250
NVQLRTTLEQ VERERRKLKR DSMRASRTGV LEISEATASS PTQQDGRGGQ
2260 2270 2280 2290 2300
MRSSDAKHMV ELQKEVALLR AQLALERKQK QDYIARSVQT SRELAGLHHS
2310 2320 2330 2340 2350
LSHSLLAVAQ APEATVLEAE TRKLDESLTQ SLTSPGPVLL CPSPGPSATQ

ATSR
Length:2,354
Mass (Da):270,274
Last modified:April 10, 2019 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iBFD4806A5D36660E
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A3Q2I1U6A0A3Q2I1U6_HORSE
Centrosomal protein 250
CEP250
2,396Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F6RGU5F6RGU5_HORSE
Centrosomal protein 250
CEP250
2,407Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A3Q2HBZ7A0A3Q2HBZ7_HORSE
Centrosomal protein 250
CEP250
2,247Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A3Q2HQK8A0A3Q2HQK8_HORSE
Centrosomal protein 250
CEP250
2,379Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A3Q2L120A0A3Q2L120_HORSE
Centrosomal protein 250
CEP250
2,389Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSECAT00000022820; ENSECAP00000018878; ENSECAG00000021188

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Genome annotation databases

EnsembliENSECAT00000022820; ENSECAP00000018878; ENSECAG00000021188

Organism-specific databases

VGNCiVGNC:16414 CEP250

Phylogenomic databases

eggNOGiENOG410IFAN Eukaryota
ENOG410XPG3 LUCA
GeneTreeiENSGT00940000161056

Gene expression databases

BgeeiENSECAG00000021188 Expressed in 3 organ(s), highest expression level in liver
ExpressionAtlasiF6RG59 baseline

Family and domain databases

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiF6RG59_HORSE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: F6RG59
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: July 27, 2011
Last sequence update: April 10, 2019
Last modified: October 16, 2019
This is version 42 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
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Main funding by: National Institutes of Health

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