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Protein

Uridine phosphorylase

Gene

UPP2

Organism
Bos taurus (Bovine)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1-phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis.UniRule annotation

Catalytic activityi

Uridine + phosphate = uracil + alpha-D-ribose 1-phosphate.UniRule annotation

Pathwayi: UMP biosynthesis via salvage pathway

This protein is involved in step 1 of the subpathway that synthesizes uracil from uridine (phosphorylase route).UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Uridine phosphorylase (UPP1), Uridine phosphorylase (UPP2), Uridine phosphorylase (UPP1), Uridine phosphorylase (UPP2)
This subpathway is part of the pathway UMP biosynthesis via salvage pathway, which is itself part of Pyrimidine metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes uracil from uridine (phosphorylase route), the pathway UMP biosynthesis via salvage pathway and in Pyrimidine metabolism.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionGlycosyltransferaseUniRule annotation, Transferase

Enzyme and pathway databases

ReactomeiR-BTA-73614 Pyrimidine salvage
R-BTA-73621 Pyrimidine catabolism
UniPathwayi
UPA00574;UER00633

Names & Taxonomyi

Protein namesi
Recommended name:
Uridine phosphorylaseUniRule annotation (EC:2.4.2.3UniRule annotation)
Gene namesi
Name:UPP2Imported
OrganismiBos taurus (Bovine)Imported
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 2

Organism-specific databases

VGNCiVGNC:36689 UPP2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Proteomic databases

PaxDbiF6R7H1

Expressioni

Gene expression databases

BgeeiENSBTAG00000012801 Expressed in 3 organ(s), highest expression level in adult mammalian kidney

Interactioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000017006

Structurei

3D structure databases

ProteinModelPortaliF6R7H1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini61 – 309PNP_UDP_1InterPro annotationAdd BLAST249

Sequence similaritiesi

Belongs to the PNP/UDP phosphorylase family.UniRule annotation

Phylogenomic databases

eggNOGiKOG3728 Eukaryota
COG2820 LUCA
GeneTreeiENSGT00390000004400
InParanoidiF6R7H1
OMAiLDCDQIN
OrthoDBiEOG091G0EIO
TreeFamiTF314310

Family and domain databases

InterProiView protein in InterPro
IPR018016 Nucleoside_phosphorylase_CS
IPR000845 Nucleoside_phosphorylase_d
IPR035994 Nucleoside_phosphorylase_sf
IPR010059 Uridine_phosphorylase_euk
PfamiView protein in Pfam
PF01048 PNP_UDP_1, 1 hit
SUPFAMiSSF53167 SSF53167, 1 hit
TIGRFAMsiTIGR01719 euk_UDPppase, 1 hit
PROSITEiView protein in PROSITE
PS01232 PNP_UDP_1, 1 hit

Sequencei

Sequence statusi: Complete.

F6R7H1-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MASVLPASNT SMRSDRNTYV GKSFVHVKNP YLDSMDEDVL YHLDLGTKTH
60 70 80 90 100
NLPEMFGDVK FVCVGGSPNR MKAFALFMHK ELRLTDSEED IKDICAGTDS
110 120 130 140 150
YCMYKIGPVL SISHGMGIPS ISIMLHELIK LLYHARCSDV IIIRIGTSGG
160 170 180 190 200
IGIAPGSVVI TDEAVDSFFK PRFEQVILDN IVTRSTELDK ELAEEIFNCS
210 220 230 240 250
KEISNFPTLI GHTMCTYDFY EGQGRLDGAL CSFSREKGLD YLKRAYNAGI
260 270 280 290 300
RNIEMESTVF AAMCRLCGLK AAVVCVTLLN RLECDQINSP HDVLVEYQKR
310 320
PQLLISKFIK QRLGLCDQTS
Length:320
Mass (Da):35,736
Last modified:November 16, 2011 - v1
Checksum:i5036A778AA4DC59B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DAAA02004487 Genomic DNA No translation available.
RefSeqiXP_005202511.1, XM_005202454.3
UniGeneiBt.17653

Genome annotation databases

EnsembliENSBTAT00000017006; ENSBTAP00000017006; ENSBTAG00000012801
GeneIDi534937

Similar proteinsi

Entry informationi

Entry nameiF6R7H1_BOVIN
AccessioniPrimary (citable) accession number: F6R7H1
Entry historyiIntegrated into UniProtKB/TrEMBL: November 16, 2011
Last sequence update: November 16, 2011
Last modified: September 12, 2018
This is version 45 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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