UniProtKB - F6R6Z6 (F6R6Z6_HORSE)
Protein
Epithelial cell adhesion molecule
Gene
EPCAM
Organism
Equus caballus (Horse)
Status
Functioni
Caution
Lacks conserved residue(s) required for the propagation of feature annotation.PROSITE-ProRule annotation
GO - Molecular functioni
- cadherin binding involved in cell-cell adhesion Source: GO_Central
- protein-containing complex binding Source: Ensembl
GO - Biological processi
- negative regulation of cell-cell adhesion mediated by cadherin Source: Ensembl
- positive regulation of stem cell proliferation Source: Ensembl
- positive regulation of transcription by RNA polymerase II Source: Ensembl
- signal transduction involved in regulation of gene expression Source: Ensembl
- stem cell differentiation Source: Ensembl
- ureteric bud development Source: Ensembl
Names & Taxonomyi
Protein namesi | Recommended name: Epithelial cell adhesion moleculeARBA annotationAlternative name(s): Tumor-associated calcium signal transducer 1ARBA annotation |
Gene namesi | Name:EPCAMImported |
Organismi | Equus caballus (Horse)Imported |
Taxonomic identifieri | 9796 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Perissodactyla › Equidae › Equus › |
Proteomesi |
|
Organism-specific databases
VGNCi | VGNC:17614, EPCAM |
Subcellular locationi
Plasma membrane
- Cell membrane ARBA annotation; Single-pass type I membrane protein ARBA annotation
- Lateral cell membrane ARBA annotation; Single-pass type I membrane protein ARBA annotation
Other locations
- tight junction ARBA annotation
- Membrane ARBA annotation; Single-pass type I membrane protein ARBA annotation
Plasma Membrane
- apical plasma membrane Source: Ensembl
- basolateral plasma membrane Source: Ensembl
- lateral plasma membrane Source: UniProtKB-SubCell
Other locations
- bicellular tight junction Source: GO_Central
- cell surface Source: Ensembl
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 263 – 286 | HelicalSequence analysisAdd BLAST | 24 |
Keywords - Cellular componenti
Cell junction, Cell membraneARBA annotation, Membrane, Tight junctionARBA annotationPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 20 | Sequence analysisAdd BLAST | 20 | |
ChainiPRO_5018772751 | 21 – 311 | Epithelial cell adhesion moleculeSequence analysisAdd BLAST | 291 |
Keywords - PTMi
Disulfide bondARBA annotationProteomic databases
PaxDbi | F6R6Z6 |
Expressioni
Gene expression databases
Bgeei | ENSECAG00000024630, Expressed in endometrium and 21 other tissues |
Interactioni
GO - Molecular functioni
- cadherin binding involved in cell-cell adhesion Source: GO_Central
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 60 – 132 | Thyroglobulin type-1InterPro annotationAdd BLAST | 73 |
Sequence similaritiesi
Belongs to the EPCAM family.ARBA annotation
Keywords - Domaini
RepeatARBA annotation, SignalSequence analysis, Transmembrane, Transmembrane helixSequence analysisARBA annotationPhylogenomic databases
GeneTreei | ENSGT00390000018245 |
HOGENOMi | CLU_075326_0_0_1 |
InParanoidi | F6R6Z6 |
TreeFami | TF332767 |
Family and domain databases
CDDi | cd00191, TY, 1 hit |
Gene3Di | 4.10.800.10, 1 hit |
InterProi | View protein in InterPro IPR043406, EPCAM/Trop-2 IPR041630, EpCAM_N IPR000716, Thyroglobulin_1 IPR036857, Thyroglobulin_1_sf |
PANTHERi | PTHR14168, PTHR14168, 1 hit |
Pfami | View protein in Pfam PF18635, EpCAM_N, 1 hit PF00086, Thyroglobulin_1, 1 hit |
SMARTi | View protein in SMART SM00211, TY, 1 hit |
SUPFAMi | SSF57610, SSF57610, 1 hit |
PROSITEi | View protein in PROSITE PS00484, THYROGLOBULIN_1_1, 1 hit PS51162, THYROGLOBULIN_1_2, 1 hit |
i Sequence
Sequence statusi: Complete.
F6R6Z6-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MAPLQVLAFA LLLLAATAAA QKDCICENYK LTTNCSVNMY GQCQCTSLGT
60 70 80 90 100
QNSVICSKLA SKCLVMKAEM THSKSGRRVK PEGAIQNNDG LYDPDCDEKG
110 120 130 140 150
LFKAKQCNGT AMCWCVNTAG VRRTDKDSEI SCLERVRTYW IIIELKHKTR
160 170 180 190 200
EKPYDVQSLQ NALKETITNR YQLDPKYIAD ILYENDIITI DLMQNSSQKT
210 220 230 240 250
QNDVDIADVA YYFEKDVKDE SLFHSNRMDL RVNGEQLDLD PGRTSIYYVD
260 270 280 290 300
EKPPEFSMQG LQAGIIAVIV VVIIAIIAGI VVLVISRKNR MAKYEKAEVK
310
EMGEMHRELN A
Genome annotation databases
Ensembli | ENSECAT00000026563; ENSECAP00000022171; ENSECAG00000024630 |
Similar proteinsi
Cross-referencesi
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Proteomic databases
PaxDbi | F6R6Z6 |
Genome annotation databases
Ensembli | ENSECAT00000026563; ENSECAP00000022171; ENSECAG00000024630 |
Organism-specific databases
VGNCi | VGNC:17614, EPCAM |
Phylogenomic databases
GeneTreei | ENSGT00390000018245 |
HOGENOMi | CLU_075326_0_0_1 |
InParanoidi | F6R6Z6 |
TreeFami | TF332767 |
Gene expression databases
Bgeei | ENSECAG00000024630, Expressed in endometrium and 21 other tissues |
Family and domain databases
CDDi | cd00191, TY, 1 hit |
Gene3Di | 4.10.800.10, 1 hit |
InterProi | View protein in InterPro IPR043406, EPCAM/Trop-2 IPR041630, EpCAM_N IPR000716, Thyroglobulin_1 IPR036857, Thyroglobulin_1_sf |
PANTHERi | PTHR14168, PTHR14168, 1 hit |
Pfami | View protein in Pfam PF18635, EpCAM_N, 1 hit PF00086, Thyroglobulin_1, 1 hit |
SMARTi | View protein in SMART SM00211, TY, 1 hit |
SUPFAMi | SSF57610, SSF57610, 1 hit |
PROSITEi | View protein in PROSITE PS00484, THYROGLOBULIN_1_1, 1 hit PS51162, THYROGLOBULIN_1_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | F6R6Z6_HORSE | |
Accessioni | F6R6Z6Primary (citable) accession number: F6R6Z6 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | July 27, 2011 |
Last sequence update: | April 10, 2019 | |
Last modified: | October 7, 2020 | |
This is version 47 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |