UniProtKB - F6R5P4 (F6R5P4_MOUSE)
Protein
C-C motif chemokine
Gene
Ccl17
Organism
Mus musculus (Mouse)
Status
Functioni
GO - Molecular functioni
- CCR4 chemokine receptor binding Source: MGI
- CCR chemokine receptor binding Source: GO_Central
- chemokine activity Source: GO_Central
- cytokine activity Source: MGI
GO - Biological processi
- antimicrobial humoral immune response mediated by antimicrobial peptide Source: MGI
- cellular defense response Source: MGI
- cellular response to interferon-gamma Source: GO_Central
- cellular response to interleukin-1 Source: GO_Central
- cellular response to tumor necrosis factor Source: GO_Central
- chemokine-mediated signaling pathway Source: GO_Central
- chemotaxis Source: MGI
- G protein-coupled receptor signaling pathway Source: GO_Central
- inflammatory response Source: GO_Central
- killing of cells of other organism Source: MGI
- lymphocyte chemotaxis Source: GO_Central
- monocyte chemotaxis Source: GO_Central
- negative regulation of myoblast differentiation Source: MGI
- neutrophil chemotaxis Source: GO_Central
- positive regulation of ERK1 and ERK2 cascade Source: GO_Central
- positive regulation of GTPase activity Source: GO_Central
- signal transduction Source: MGI
Keywordsi
Molecular function | CytokineUniRule annotationARBA annotation |
Biological process | ChemotaxisUniRule annotationARBA annotation |
Enzyme and pathway databases
Reactomei | R-MMU-380108, Chemokine receptors bind chemokines |
Names & Taxonomyi
Protein namesi | Recommended name: C-C motif chemokineUniRule annotation |
Gene namesi | Name:Ccl17Imported |
Organismi | Mus musculus (Mouse)Imported |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:1329039, Ccl17 |
Subcellular locationi
Extracellular region or secreted
- Secreted UniRule annotation
Extracellular region or secreted
- extracellular space Source: GO_Central
Keywords - Cellular componenti
SecretedUniRule annotationPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 33 | UniRule annotationAdd BLAST | 33 | |
ChainiPRO_5005129866 | 34 – 103 | C-C motif chemokineUniRule annotationAdd BLAST | 70 |
Proteomic databases
PaxDbi | F6R5P4 |
Expressioni
Gene expression databases
Bgeei | ENSMUSG00000031780, Expressed in gonadal ridge and 94 other tissues |
Interactioni
Binary interactionsi
F6R5P4
With | #Exp. | IntAct |
---|---|---|
Ccl5 [P30882] | 4 | EBI-20561031,EBI-20314992 |
GO - Molecular functioni
- CCR4 chemokine receptor binding Source: MGI
- CCR chemokine receptor binding Source: GO_Central
- chemokine activity Source: GO_Central
- cytokine activity Source: MGI
Protein-protein interaction databases
IntActi | F6R5P4, 4 interactors |
STRINGi | 10090.ENSMUSP00000034232 |
Miscellaneous databases
RNActi | F6R5P4, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 40 – 98 | SCYInterPro annotationAdd BLAST | 59 |
Sequence similaritiesi
Keywords - Domaini
SignalUniRule annotationPhylogenomic databases
eggNOGi | ENOG502SWZ0, Eukaryota |
GeneTreei | ENSGT00970000193327 |
HOGENOMi | CLU_141716_6_0_1 |
InParanoidi | F6R5P4 |
OMAi | ECCLDYF |
OrthoDBi | 1594204at2759 |
TreeFami | TF334888 |
Family and domain databases
InterProi | View protein in InterPro IPR039809, Chemokine_b/g/d IPR000827, Chemokine_CC_CS IPR001811, Chemokine_IL8-like_dom IPR036048, Interleukin_8-like_sf |
PANTHERi | PTHR12015, PTHR12015, 1 hit |
Pfami | View protein in Pfam PF00048, IL8, 1 hit |
SMARTi | View protein in SMART SM00199, SCY, 1 hit |
SUPFAMi | SSF54117, SSF54117, 1 hit |
PROSITEi | View protein in PROSITE PS00472, SMALL_CYTOKINES_CC, 1 hit |
i Sequence
Sequence statusi: Complete.
F6R5P4-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MKTFTSAFGT MRSLQMLLLA ALLLGTFLQH ARAARATNVG RECCLDYFKG
60 70 80 90 100
AIPIRKLVSW YKTSVECSRD AIVFLTVQGK LICADPKDKH VKKAIRLVKN
PRP
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC129606 Genomic DNA No translation available. |
RefSeqi | NP_035462.2, NM_011332.3 XP_006530845.1, XM_006530782.3 XP_006530846.1, XM_006530783.2 XP_017168112.1, XM_017312623.1 |
Genome annotation databases
Ensembli | ENSMUST00000034232; ENSMUSP00000034232; ENSMUSG00000031780 |
GeneIDi | 20295 |
KEGGi | mmu:20295 |
UCSCi | uc009mwz.2, mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC129606 Genomic DNA No translation available. |
RefSeqi | NP_035462.2, NM_011332.3 XP_006530845.1, XM_006530782.3 XP_006530846.1, XM_006530783.2 XP_017168112.1, XM_017312623.1 |
3D structure databases
SMRi | F6R5P4 |
ModBasei | Search... |
Protein-protein interaction databases
IntActi | F6R5P4, 4 interactors |
STRINGi | 10090.ENSMUSP00000034232 |
Proteomic databases
PaxDbi | F6R5P4 |
Protocols and materials databases
Antibodypediai | 3752, 510 antibodies |
Genome annotation databases
Ensembli | ENSMUST00000034232; ENSMUSP00000034232; ENSMUSG00000031780 |
GeneIDi | 20295 |
KEGGi | mmu:20295 |
UCSCi | uc009mwz.2, mouse |
Organism-specific databases
CTDi | 6361 |
MGIi | MGI:1329039, Ccl17 |
Phylogenomic databases
eggNOGi | ENOG502SWZ0, Eukaryota |
GeneTreei | ENSGT00970000193327 |
HOGENOMi | CLU_141716_6_0_1 |
InParanoidi | F6R5P4 |
OMAi | ECCLDYF |
OrthoDBi | 1594204at2759 |
TreeFami | TF334888 |
Enzyme and pathway databases
Reactomei | R-MMU-380108, Chemokine receptors bind chemokines |
Miscellaneous databases
BioGRID-ORCSi | 20295, 0 hits in 19 CRISPR screens |
RNActi | F6R5P4, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000031780, Expressed in gonadal ridge and 94 other tissues |
Family and domain databases
InterProi | View protein in InterPro IPR039809, Chemokine_b/g/d IPR000827, Chemokine_CC_CS IPR001811, Chemokine_IL8-like_dom IPR036048, Interleukin_8-like_sf |
PANTHERi | PTHR12015, PTHR12015, 1 hit |
Pfami | View protein in Pfam PF00048, IL8, 1 hit |
SMARTi | View protein in SMART SM00199, SCY, 1 hit |
SUPFAMi | SSF54117, SSF54117, 1 hit |
PROSITEi | View protein in PROSITE PS00472, SMALL_CYTOKINES_CC, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | F6R5P4_MOUSE | |
Accessioni | F6R5P4Primary (citable) accession number: F6R5P4 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | July 27, 2011 |
Last sequence update: | October 3, 2012 | |
Last modified: | December 2, 2020 | |
This is version 71 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |