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Entry version 40 (11 Dec 2019)
Sequence version 2 (10 Apr 2019)
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Protein
Submitted name:

Apoptosis associated tyrosine kinase

Gene

AATK

Organism
Equus caballus (Horse)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Apoptosis associated tyrosine kinaseImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:AATKImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiEquus caballus (Horse)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9796 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaPerissodactylaEquidaeEquus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002281 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 11

Organism-specific databases

Vertebrate Gene Nomenclature Database

More...
VGNCi
VGNC:58508 AATK

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 20Sequence analysisAdd BLAST20
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_501865772621 – 1391Sequence analysisAdd BLAST1371

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
F6QYD4

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSECAG00000021405 Expressed in 2 organ(s), highest expression level in prefrontal cortex

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini135 – 405Protein kinaseInterPro annotationAdd BLAST271

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni565 – 589DisorderedSequence analysisAdd BLAST25
Regioni659 – 712DisorderedSequence analysisAdd BLAST54
Regioni743 – 763DisorderedSequence analysisAdd BLAST21
Regioni792 – 1122DisorderedSequence analysisAdd BLAST331
Regioni1150 – 1219DisorderedSequence analysisAdd BLAST70
Regioni1267 – 1391DisorderedSequence analysisAdd BLAST125

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi693 – 712PolarSequence analysisAdd BLAST20
Compositional biasi849 – 874PolarSequence analysisAdd BLAST26
Compositional biasi912 – 929PolarSequence analysisAdd BLAST18
Compositional biasi966 – 982PolyampholyteSequence analysisAdd BLAST17
Compositional biasi994 – 1008PolarSequence analysisAdd BLAST15
Compositional biasi1179 – 1195AcidicSequence analysisAdd BLAST17
Compositional biasi1330 – 1344Pro-richSequence analysisAdd BLAST15
Compositional biasi1358 – 1374PolarSequence analysisAdd BLAST17

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Domaini

SignalSequence analysis

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IGQE Eukaryota
ENOG410XQFM LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000154244

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
F6QYD4

Family and domain databases

Conserved Domains Database

More...
CDDi
cd05087 PTKc_Aatyk1, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR011009 Kinase-like_dom_sf
IPR042817 LMTK1_c
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR001245 Ser-Thr/Tyr_kinase_cat_dom
IPR008266 Tyr_kinase_AS

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF07714 Pkinase_Tyr, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00109 TYRKINASE

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF56112 SSF56112, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00109 PROTEIN_KINASE_TYR, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

F6QYD4-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPAALLALAM SSSFFNPSFA FSSHFDPDGA PLSELSWSSS LAVVAVSFSG
60 70 80 90 100
LFTVIALMLA CLCCKKGGIG FKEFENAEGE EYAADFSVQG SPVVAAPNGP
110 120 130 140 150
DVYVLPLTEV SLPMAKQPGR SVQLLKSTDL GRHSLLYLEE IGHGWFGKVF
160 170 180 190 200
LGEVNSGISS SQVVVKELKA SASVQEQMQF LEEAQPYRAL QHSNLLQCLA
210 220 230 240 250
QCAEVTPYLL VMEFCPMGDL KGYLRSFRVA ESMPPDPLTL QRMACEVACG
260 270 280 290 300
VLHLHRNNYV HSDLALRNCL LTADLTVKIG DYGLSHGKYR EDYFVTADQL
310 320 330 340 350
WVPLRWIAPE LVDEVHCNLL VVDQTKASNV WSLGVTIWEL FELGTQPYPH
360 370 380 390 400
HSDRQVLAYA VREQQLKLPK PQLPLTLSDR WYEVMQFCWL QPEQRPTAEE
410 420 430 440 450
VHLLLSYLCA KGATEAEEEF ERRWRSLRPG GGGAGPGPGA AGLALGGAGE
460 470 480 490 500
LAAASSFPLL EQFAGDGFHA DGDDVLTVTE TSRGLNFEYK WEAGRGAEAF
510 520 530 540 550
PLPGGAPSPG RAARLQELCA PDGAPPGVVP VLSAHSPSVG SEYFIRLEEP
560 570 580 590 600
TPAAGHDLDC AGCALSPRGT TPHPDPGDHD SDSDGSTATS LAMEPLLGHA
610 620 630 640 650
PPADGPWGHC DYYSCRSGAR DPPCSSRSPS PSPRALMLAE PGAEDTDWGA
660 670 680 690 700
AAFCPPFFED PLGTSPSGSS GARLSPGAEE LGEAEARKAA QHRHWSSNVS
710 720 730 740 750
ANNNSSSRAA ESWDPGYASS YSDCCPGMKQ TLQAVPELVH PLAPEDPREP
760 770 780 790 800
LLGPKGPSSG QEPGCCLGLP DLCPAEDLAS ATCLVTTPWT EAAVSGGDSP
810 820 830 840 850
QAEPRLAEEA EGSAGLQLPL PSIPSPSREG ALLPAEEASA PAALPASPTP
860 870 880 890 900
AGSQLTATEP AKTLDSSSSS LELEAPGSED EDTTEATSGI FTDLSSDGPQ
910 920 930 940 950
AEKPEVTPAF RSLQKQVGTP DSLDSLDIPS SASDGGCEVF SPSAVGTPGG
960 970 980 990 1000
QPRALDSGYD TENYESPEFV LKDAHELCEP EAFGELASEG ESPGPETRLS
1010 1020 1030 1040 1050
TSLGGLSEKN PYRDSAYFSD LDPEPEPSLG PEEKPGGVQA PGPELDLESM
1060 1070 1080 1090 1100
HSPGLQPAQP FLEPGVSTEA QGAGPREVPP LPLSEDSFPE PSACPTGPRQ
1110 1120 1130 1140 1150
ETPWALGPAQ VPPEPSSGRS KIFLLTPVPL SSEGHRAELQ EAPGLLSGLA
1160 1170 1180 1190 1200
LKERTGGPSA PRAPLCLALP GLPTAPEGRS EEEEDDSDDS DESDEELRCY
1210 1220 1230 1240 1250
SIQEPSEESE EEVPPVPVVV AESQSARNLR SLLKMPSLLS EAFCEDLERK
1260 1270 1280 1290 1300
KKAVSFFDDV TVYLFDQESP TRELGEPFPG SKESPPAFLA GSPSSPSAPG
1310 1320 1330 1340 1350
RRRRADRSPD GSAAEAGAAF EWDDGFPLAP APEPAAPAPA APRKPAASGP
1360 1370 1380 1390
FSRFTVSPAP ASRFSITQVS DSDAGSVGGP AAGAGGSCKE A
Length:1,391
Mass (Da):146,534
Last modified:April 10, 2019 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i5E8532B8158A7EF5
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A3Q2HSH8A0A3Q2HSH8_HORSE
Apoptosis associated tyrosine kinas...
AATK
1,484Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A5F5PPV7A0A5F5PPV7_HORSE
Apoptosis associated tyrosine kinas...
AATK
1,434Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSECAT00000022757; ENSECAP00000018820; ENSECAG00000021405

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Proteomic databases

PaxDbiF6QYD4

Genome annotation databases

EnsembliENSECAT00000022757; ENSECAP00000018820; ENSECAG00000021405

Organism-specific databases

VGNCiVGNC:58508 AATK

Phylogenomic databases

eggNOGiENOG410IGQE Eukaryota
ENOG410XQFM LUCA
GeneTreeiENSGT00940000154244
InParanoidiF6QYD4

Gene expression databases

BgeeiENSECAG00000021405 Expressed in 2 organ(s), highest expression level in prefrontal cortex

Family and domain databases

CDDicd05087 PTKc_Aatyk1, 1 hit
InterProiView protein in InterPro
IPR011009 Kinase-like_dom_sf
IPR042817 LMTK1_c
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR001245 Ser-Thr/Tyr_kinase_cat_dom
IPR008266 Tyr_kinase_AS
PfamiView protein in Pfam
PF07714 Pkinase_Tyr, 1 hit
PRINTSiPR00109 TYRKINASE
SUPFAMiSSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00109 PROTEIN_KINASE_TYR, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiF6QYD4_HORSE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: F6QYD4
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: July 27, 2011
Last sequence update: April 10, 2019
Last modified: December 11, 2019
This is version 40 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteomeImported
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